ATE84705T1 - Ein freifliessendes granulat, enthaltend ibuprofen und ein herstellunsgverfahren. - Google Patents

Ein freifliessendes granulat, enthaltend ibuprofen und ein herstellunsgverfahren.

Info

Publication number
ATE84705T1
ATE84705T1 AT88908546T AT88908546T ATE84705T1 AT E84705 T1 ATE84705 T1 AT E84705T1 AT 88908546 T AT88908546 T AT 88908546T AT 88908546 T AT88908546 T AT 88908546T AT E84705 T1 ATE84705 T1 AT E84705T1
Authority
AT
Austria
Prior art keywords
carboxymethylcellulose
ibuprofen
lubricant
manufacture
free
Prior art date
Application number
AT88908546T
Other languages
English (en)
Inventor
Larry E Denton
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE84705T1 publication Critical patent/ATE84705T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
AT88908546T 1987-09-17 1988-08-24 Ein freifliessendes granulat, enthaltend ibuprofen und ein herstellunsgverfahren. ATE84705T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/097,850 US4837031A (en) 1987-09-17 1987-09-17 Compositions containing ibuprofen
PCT/US1988/002945 WO1989002266A1 (en) 1987-09-17 1988-08-24 A free-flowing granular composition containing ibuprofen and a method for its preparation
EP88908546A EP0377658B1 (de) 1987-09-17 1988-08-24 Ein freifliessendes granulat, enthaltend ibuprofen und ein herstellunsgverfahren

Publications (1)

Publication Number Publication Date
ATE84705T1 true ATE84705T1 (de) 1993-02-15

Family

ID=22265432

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88908546T ATE84705T1 (de) 1987-09-17 1988-08-24 Ein freifliessendes granulat, enthaltend ibuprofen und ein herstellunsgverfahren.

Country Status (7)

Country Link
US (1) US4837031A (de)
EP (1) EP0377658B1 (de)
AT (1) ATE84705T1 (de)
AU (1) AU623610B2 (de)
CA (1) CA1309351C (de)
DE (1) DE3877764T2 (de)
WO (1) WO1989002266A1 (de)

Families Citing this family (48)

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US5225192A (en) * 1988-10-17 1993-07-06 Vectorpharma International S.P.A. Poorly soluble medicaments supported on polymer substances in a form suitable for increasing their dissolving rate
US5569469A (en) * 1984-10-16 1996-10-29 Vectorpharma International, S.P.A. Poorly soluble medicaments supported on polymer substances in a form suitable for increasing their dissolving rate
FR2602423B1 (fr) * 1986-08-08 1989-05-05 Ethypharm Sa Procede de preparation d'un medicament a base de fenofibrate, medicament obtenu par ce procede
ATE108996T1 (de) * 1988-02-25 1994-08-15 Brocades Pharma Bv Verfahren zur herstellung eines pharmazeutischen granulats.
JP2514078B2 (ja) * 1988-08-22 1996-07-10 エスエス製薬株式会社 圧縮成型製剤
IT1227626B (it) * 1988-11-28 1991-04-23 Vectorpharma Int Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione
US4911921A (en) * 1989-02-02 1990-03-27 Mallinckrodt, Inc. High ibuprofen content granulations
DE3922441A1 (de) * 1989-07-07 1991-01-17 Pharmatrans Sanaq Ag Ibuprofen- und s-(+)-ibuprofen-zubereitungen und verfahren zu ihrer herstellung
NZ234587A (en) * 1989-08-04 1991-11-26 Mcneil Ppc Inc A chewable pharmaceutical tablet of compressed coated granules
CA2063141C (en) * 1989-08-04 1997-03-04 Edward J. Roche Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets
US5009895A (en) * 1990-02-02 1991-04-23 Merck & Co., Inc. Sustained release with high and low viscosity HPMC
US5460825A (en) * 1990-05-23 1995-10-24 Mcneil-Ppc, Inc. Taste mask coatings for preparing chewable pharmaceutical tablets
US5075114A (en) * 1990-05-23 1991-12-24 Mcneil-Ppc, Inc. Taste masking and sustained release coatings for pharmaceuticals
US5087454A (en) * 1990-07-30 1992-02-11 American Home Products Corporation Ibuprofen tablet
US5260072A (en) * 1990-08-30 1993-11-09 Mcneil-Ppc, Inc. Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets
BE1004461A5 (fr) * 1991-01-30 1992-11-24 Wellcome Found Comprimes dispersables dans l'eau.
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
SE9101603L (sv) * 1991-05-27 1992-09-21 Bengt Hjalmar Aagerup Med Firm Metod foer att framstaella reproducerbara partiklar av definierad storlek
GB9119052D0 (en) * 1991-09-06 1991-10-23 Boots Co Plc Pharmaceutical compositions
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
US5609883A (en) * 1994-09-16 1997-03-11 Advanced Technology Pharmaceuticals Corporation Compressed tablet transitory lubricant system
US5560927A (en) * 1995-07-28 1996-10-01 Isp Investments Inc. Co-processing method for making a free-flowing compressible powder and tablet therefrom
US5686133A (en) * 1996-01-31 1997-11-11 Port Systems, L.L.C. Water soluble pharmaceutical coating and method for producing coated pharmaceuticals
GB9603699D0 (en) * 1996-02-21 1996-04-17 Boots Co Plc Therapeutic composition
US6348216B1 (en) * 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
US6361794B1 (en) 1996-06-12 2002-03-26 Basf Corporation Method of making ibuprofen and narcotic analgesic composition
US6248391B1 (en) * 1997-07-16 2001-06-19 Bpsi Holdings, Inc. Bright white film coatings and film coating compositions therefor
US5962488A (en) * 1998-04-08 1999-10-05 Roberts Laboratories, Inc. Stable pharmaceutical formulations for treating internal bowel syndrome containing isoxazole derivatives
IT1301966B1 (it) 1998-07-30 2000-07-20 Zambon Spa Composizioni farmaceutiche ad attivita' analgesica
FR2785538B1 (fr) 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
US6251945B1 (en) 1999-01-14 2001-06-26 Knoll Aktiengesellschaft Pharmaceutical mixture comprising a combination of a profen and other active compounds
DE50001734D1 (de) * 2000-10-24 2003-05-15 Fit Gmbh Coprozessiertes Sprengmittelgranulat
PT1492511E (pt) 2002-04-09 2009-04-09 Flamel Tech Sa Formulação farmacêutica oral na forma de suspensão aquosa de microcápsulas para libertação modificada de princípio(s) activo(s)
US20040131740A1 (en) * 2002-11-27 2004-07-08 Woodhouse James F. Edible transfer tattoos
RU2254854C2 (ru) * 2003-09-08 2005-06-27 Открытое акционерное общество "Акционерное курганское общество медицинских препаратов и изделий "Синтез" Анальгезирующий, жаропонижающий, противовоспалительный препарат и способ его получения
JP5248733B2 (ja) * 2003-11-28 2013-07-31 エスエス製薬株式会社 揮散防止型固形製剤およびその製造方法
EP1765296A2 (de) * 2004-06-30 2007-03-28 Albemarle Corporation Granulat mit hohem ibuprofen-gehalt und seine herstellung und verwendung
MX2007014872A (es) 2005-05-26 2008-02-15 Dainippon Sumitomo Pharma Co Composicion farmaceutica.
US9023400B2 (en) * 2006-05-24 2015-05-05 Flamel Technologies Prolonged-release multimicroparticulate oral pharmaceutical form
US20080014228A1 (en) * 2006-07-14 2008-01-17 Olivia Darmuzey Solid form
US20080311162A1 (en) * 2007-05-16 2008-12-18 Olivia Darmuzey Solid form
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
EP2207533B1 (de) * 2007-10-10 2021-01-06 Avantor Performance Materials, LLC Direkt komprimierbarer granularer und mikrokristalliner hilfsstoff auf zellulosebasis mit hoher funktionalität, verfahren zu seiner herstellung und seine verwendung
EP2070520A1 (de) 2007-12-11 2009-06-17 LEK Pharmaceuticals D.D. Pharmazeutische Zusammensetzung mit mindestens einem Wirkstoff und einem in einem sauren Medium quellenden Bindemittel
US20130115250A1 (en) * 2009-05-13 2013-05-09 Wyeth Llc Burst Drug Release Compositions
JP2010189443A (ja) * 2010-06-07 2010-09-02 Ss Pharmaceut Co Ltd 揮散防止型固形製剤およびその製造方法
CN109966268A (zh) * 2019-04-04 2019-07-05 吉林市吴太感康药业有限公司 一种布洛芬缓释胶囊的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1390032A (en) * 1971-08-27 1975-04-09 Sterling Winthrop Group Ltd Pharmaceutical compositions
JPS58403B2 (ja) * 1975-07-24 1983-01-06 武田薬品工業株式会社 Ｌ− アスコルビンサンセイザイノ セイゾウホウ
US4439453A (en) * 1980-12-22 1984-03-27 Monsanto Company Directly compressible acetaminophen granulation
US4562024A (en) * 1982-07-06 1985-12-31 Sterling Drug Inc. Process for preparing granulate containing poorly compressible medicinally active matter
US4555399A (en) * 1983-11-18 1985-11-26 Key Pharmaceuticals, Inc. Aspirin tablet
GB2155330B (en) * 1984-03-08 1988-01-27 Squibb & Sons Inc Solvent granulation technique for forming solid formulations of nystatin
CA1261260A (en) * 1984-04-16 1989-09-26 Anil Salpekar Directly compressible codeine salt compositions
US4661521A (en) * 1984-04-30 1987-04-28 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
US4609675A (en) * 1984-08-17 1986-09-02 The Upjohn Company Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing
US4775535A (en) * 1986-04-04 1988-10-04 Hans Lowey Method of preparing controlled long-acting pharmaceutical formulations in unit dosage form having uniform and comparable bioavailability characteristics

Also Published As

Publication number Publication date
EP0377658A1 (de) 1990-07-18
CA1309351C (en) 1992-10-27
DE3877764D1 (de) 1993-03-04
DE3877764T2 (de) 1993-05-13
US4837031A (en) 1989-06-06
EP0377658B1 (de) 1993-01-20
AU2385188A (en) 1989-04-17
WO1989002266A1 (en) 1989-03-23
AU623610B2 (en) 1992-05-21

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Legal Events

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