ES2076192T3 - Farmacos soportados con proporcion de disolucion incrementada, y un proceso para su preparacion. - Google Patents

Farmacos soportados con proporcion de disolucion incrementada, y un proceso para su preparacion.

Info

Publication number
ES2076192T3
ES2076192T3 ES89121865T ES89121865T ES2076192T3 ES 2076192 T3 ES2076192 T3 ES 2076192T3 ES 89121865 T ES89121865 T ES 89121865T ES 89121865 T ES89121865 T ES 89121865T ES 2076192 T3 ES2076192 T3 ES 2076192T3
Authority
ES
Spain
Prior art keywords
preparation
increased dissolution
mixture
support material
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89121865T
Other languages
English (en)
Inventor
Mara Lucia Lovrecich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vectorpharma International SpA
Original Assignee
Vectorpharma International SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vectorpharma International SpA filed Critical Vectorpharma International SpA
Application granted granted Critical
Publication of ES2076192T3 publication Critical patent/ES2076192T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/797—Lipid particle
    • Y10S977/798—Lipid particle having internalized material
    • Y10S977/799—Containing biological material
    • Y10S977/801—Drug
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Electroluminescent Light Sources (AREA)
  • Control Of El Displays (AREA)
  • Apparatus For Radiation Diagnosis (AREA)

Abstract

SE PRESENTAN MEDICAMENTOS PREPARADOS MEDIANTE UN PROCESO QUE COMPRENDE LA MEZCLA DEL MEDICAMENTO CON UN MATERIAL DE SOPORTE EN CONDICIONES SECAS, LA PULVERIZACION DE LA MEZCLA EN UN MOLINO CUYA CAMARA SE ENCUENTRA SATURADA CON EL VAPOR DE UNO O MAS SOLVENTES CAPACES DE SOLUBILIZAR EL MEDICAMENTO O DE SER ABSORBIDOS SOBRE LA SUPERFICIE DEL MATERIAL DE SOPORTE, EL SECADO AL VACIO DEL PRODUCTO OBTENIDO, Y SU TAMIZACION. LOS MEDICAMENTOS OBTENIDOS DE ESTA FORMA TIENEN UN PUNTO DE FUSION REDUCIDO, Y UNA RELACION DE DISOLUCION
ES89121865T 1988-11-28 1989-11-27 Farmacos soportados con proporcion de disolucion incrementada, y un proceso para su preparacion. Expired - Lifetime ES2076192T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8822770A IT1227626B (it) 1988-11-28 1988-11-28 Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione

Publications (1)

Publication Number Publication Date
ES2076192T3 true ES2076192T3 (es) 1995-11-01

Family

ID=11200272

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89121865T Expired - Lifetime ES2076192T3 (es) 1988-11-28 1989-11-27 Farmacos soportados con proporcion de disolucion incrementada, y un proceso para su preparacion.

Country Status (16)

Country Link
US (2) US5354560A (es)
EP (1) EP0371431B1 (es)
JP (1) JP2823170B2 (es)
KR (1) KR900007398A (es)
AT (1) ATE123940T1 (es)
CA (1) CA2004064C (es)
DE (1) DE68923157T2 (es)
DK (1) DK175684B1 (es)
ES (1) ES2076192T3 (es)
FI (1) FI895693A0 (es)
HU (1) HU203468B (es)
IL (1) IL92454A (es)
IT (1) IT1227626B (es)
PT (1) PT92416B (es)
RU (2) RU1837868C (es)
YU (1) YU221189A (es)

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EP0371431A3 (en) 1991-10-09
DE68923157T2 (de) 1995-11-09
KR900007398A (ko) 1990-06-01
FI895693A0 (fi) 1989-11-28
IT1227626B (it) 1991-04-23
DK595889D0 (da) 1989-11-27
US5354560A (en) 1994-10-11
RU2097027C1 (ru) 1997-11-27
HUT52366A (en) 1990-07-28
EP0371431B1 (en) 1995-06-21
JP2823170B2 (ja) 1998-11-11
CA2004064C (en) 2000-02-08
YU221189A (en) 1991-06-30
HU896191D0 (en) 1990-02-28
RU1837868C (ru) 1993-08-30
JPH02184621A (ja) 1990-07-19
IL92454A (en) 1994-06-24
CA2004064A1 (en) 1990-05-28
IL92454A0 (en) 1990-08-31
US5449521A (en) 1995-09-12
PT92416A (pt) 1990-05-31
IT8822770A0 (it) 1988-11-28
DK175684B1 (da) 2005-01-17
DK595889A (da) 1990-05-29
DE68923157D1 (de) 1995-07-27
HU203468B (en) 1991-08-28
PT92416B (pt) 1995-08-09
EP0371431A2 (en) 1990-06-06
ATE123940T1 (de) 1995-07-15

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