ES2019703B3 - Procedimiento de sintesis industrial del perindopril y de sus principales intermediarios de sintesis - Google Patents

Procedimiento de sintesis industrial del perindopril y de sus principales intermediarios de sintesis

Info

Publication number
ES2019703B3
ES2019703B3 ES88402339T ES88402339T ES2019703B3 ES 2019703 B3 ES2019703 B3 ES 2019703B3 ES 88402339 T ES88402339 T ES 88402339T ES 88402339 T ES88402339 T ES 88402339T ES 2019703 B3 ES2019703 B3 ES 2019703B3
Authority
ES
Spain
Prior art keywords
synthesis
perindopril
industrial
intermediaries
main
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88402339T
Other languages
English (en)
Spanish (es)
Inventor
Michel Vincent
Jean Baliarda
Bernard Marchand
Georges Remond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9354991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2019703(B3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2019703B3 publication Critical patent/ES2019703B3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Bending Of Plates, Rods, And Pipes (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Casting Devices For Molds (AREA)
ES88402339T 1987-09-17 1988-09-16 Procedimiento de sintesis industrial del perindopril y de sus principales intermediarios de sintesis Expired - Lifetime ES2019703B3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8712896A FR2620709B1 (fr) 1987-09-17 1987-09-17 Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese

Publications (1)

Publication Number Publication Date
ES2019703B3 true ES2019703B3 (es) 1991-07-01

Family

ID=9354991

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88402339T Expired - Lifetime ES2019703B3 (es) 1987-09-17 1988-09-16 Procedimiento de sintesis industrial del perindopril y de sus principales intermediarios de sintesis

Country Status (15)

Country Link
US (1) US4914214A (OSRAM)
EP (1) EP0308341B1 (OSRAM)
JP (1) JPH01110696A (OSRAM)
AT (1) ATE59047T1 (OSRAM)
CA (1) CA1336348C (OSRAM)
DE (1) DE3861275D1 (OSRAM)
DK (1) DK171470B1 (OSRAM)
ES (1) ES2019703B3 (OSRAM)
FR (1) FR2620709B1 (OSRAM)
GR (1) GR3001539T3 (OSRAM)
IE (1) IE61453B1 (OSRAM)
NZ (1) NZ226224A (OSRAM)
OA (1) OA08915A (OSRAM)
PT (1) PT88527B (OSRAM)
ZA (1) ZA886932B (OSRAM)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
US5212319A (en) * 1990-02-26 1993-05-18 Eli Lilly And Company Intermediates to 4-amino-hexahydrobenz[cd]indoles and processes therefor
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
AU2007203451B2 (en) * 2000-07-06 2010-09-02 Les Laboratoires Servier Pharmaceutical composition containing a crystalline form of perindopril tert-butylamine salt
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
AR036187A1 (es) * 2001-07-24 2004-08-18 Adir Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
DK1333026T3 (da) * 2002-01-30 2007-10-22 Servier Lab Fremgangsmåde til fremstilling af perindopril med höj renhed og nyttige mellemforbindelser til syntesen
MXPA04005557A (es) * 2002-03-01 2005-05-17 Warner Lambert Co Metodo para tratar la osteoartritis.
GB2395195A (en) * 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
JPWO2004065368A1 (ja) * 2003-01-21 2006-05-18 大原薬品工業株式会社 トランドラプリル合成中間体の製造方法
DK1338591T3 (da) * 2003-02-28 2006-01-23 Servier Lab Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og estere heraf samt anvendelse heraf ved syntese af perindopril
ATE395913T1 (de) * 2003-02-28 2008-06-15 Servier S A Lab Verfahren zur herstellung von perindopril
DE60301930T2 (de) * 2003-02-28 2006-07-27 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salze
GB0305066D0 (en) * 2003-03-06 2003-04-09 Ibm System and method for publish/subscribe messaging
ES2260585T3 (es) * 2003-04-09 2006-11-01 Les Laboratoires Servier Nuevo procedimiento de sintesis del acido (2s)-indolin-2-carboxilico y su aplicacion a la sintesis de perindopril.
WO2004099138A2 (en) * 2003-05-12 2004-11-18 Cipla Limited Process for the preparation of perindopril
SI21507A (sl) * 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
KR20060035636A (ko) 2003-06-24 2006-04-26 르 라보레또레 쎄르비에르 신규한 결정형의 페린도프릴 에르부민
EP1362864B1 (fr) * 2003-06-30 2007-04-25 Les Laboratoires Servier Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
ATE452124T1 (de) * 2003-10-21 2010-01-15 Servier Lab Verfahren zur herstellung kristallinem perindopril erbumin
US20050171165A1 (en) * 2003-11-12 2005-08-04 Bhirud Shekhar B. Process for the preparation of perindopril
PT1422236E (pt) * 2003-11-19 2007-05-31 Servier Lab Processo de síntese do perindopril e dos seus sais farmacêuticamente aceitáveis
ES2282586T3 (es) * 2003-11-19 2007-10-16 Les Laboratoires Servier Procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
EP1420030A3 (fr) * 2003-12-10 2004-05-26 Les Laboratoires Servier Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
SI21703A (en) 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
WO2005094793A1 (en) * 2004-03-29 2005-10-13 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for preparing a solid pharmaceutical composition
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
US20050250706A1 (en) * 2004-05-07 2005-11-10 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
WO2005108365A1 (en) * 2004-05-07 2005-11-17 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
US20060178422A1 (en) * 2004-05-31 2006-08-10 Ashok Kumar Process for making (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl] amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
JP4547245B2 (ja) * 2004-12-16 2010-09-22 株式会社パーマケム・アジア ペリンドプリルエルブミンのｉ型結晶、及びその製造方法
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
DK1679072T5 (da) 2005-01-06 2009-04-20 Ipca Lab Ltd Fremgangsmåde til syntese af (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse i syntesen af perindopril
MY138209A (en) * 2005-03-11 2009-05-29 Servier Lab New (y) crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it.
AU2005329237B2 (en) * 2005-03-14 2011-09-01 Les Laboratoires Servier An improved process for the purification of perindopril
US7291745B2 (en) * 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
EP1899300A2 (en) * 2005-07-05 2008-03-19 Cipla Limited Process for the synthesis of the ace inhibitor trandolapril
SI1910287T1 (sl) * 2005-07-25 2012-09-28 Lek Pharmaceuticals D.D. Postopek za pripravo kristalnega perindoprila
US20070032661A1 (en) * 2005-08-03 2007-02-08 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of perindopril
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
EA200600630A1 (ru) * 2006-04-20 2007-02-27 ИСМАГИЛОВ, Искандар Халиуллович ζ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА
EP1864973A1 (en) * 2006-06-09 2007-12-12 Sochinaz SA Process for the preparation of perindopril and salts thereof
WO2008114270A1 (en) * 2007-03-22 2008-09-25 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
CN101514180B (zh) * 2008-02-20 2012-08-01 上海医药工业研究院 培哚普利叔丁铵盐的ⅰ晶型及其制备方法
PL2318365T3 (pl) 2008-06-24 2016-02-29 Mylan Laboratories Ltd Nowe odmiany polimorficzne (L) argininianu peryndoprylu i sposoby ich wytwarzania
GB0910692D0 (en) 2009-06-20 2009-08-05 Teva Pharma Compound
SI23149A (sl) 2009-09-21 2011-03-31 Silverstone Pharma Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
PT105315B (pt) 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas
FR2985512B1 (fr) * 2012-01-05 2014-06-20 Servier Lab Procede de preparation du sel de l-arginine du perindopril
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN106631977A (zh) * 2016-11-11 2017-05-10 上海雅本化学有限公司 一种s‑吲哚啉‑2‑羧酸合成的优化方法
CN108752259A (zh) * 2018-07-04 2018-11-06 南京方生和医药科技有限公司 培哚普利消旋体及其中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3360065D1 (en) * 1982-03-08 1985-03-28 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung

Also Published As

Publication number Publication date
EP0308341B1 (fr) 1990-12-12
IE61453B1 (en) 1994-11-02
EP0308341A1 (fr) 1989-03-22
AU2236288A (en) 1989-03-23
FR2620709B1 (fr) 1990-09-07
CA1336348C (fr) 1995-07-18
DK515188D0 (da) 1988-09-15
AU608363B2 (en) 1991-03-28
GR3001539T3 (en) 1992-11-23
FR2620709A1 (fr) 1989-03-24
NZ226224A (en) 1990-09-26
ZA886932B (en) 1989-05-30
DK515188A (da) 1989-03-18
US4914214A (en) 1990-04-03
IE882806L (en) 1989-03-17
ATE59047T1 (de) 1990-12-15
JPH01110696A (ja) 1989-04-27
DE3861275D1 (de) 1991-01-24
PT88527B (pt) 1993-03-31
OA08915A (fr) 1989-10-31
DK171470B1 (da) 1996-11-11
PT88527A (pt) 1988-10-01
JPH0543717B2 (OSRAM) 1993-07-02

Similar Documents

Publication Publication Date Title
ES2019703B3 (es) Procedimiento de sintesis industrial del perindopril y de sus principales intermediarios de sintesis
ATE98376T1 (de) Synthetische htlv-iii-peptid-zusammensetzungen und ihre verwendung.
ATE96033T1 (de) Mittel zur behandlung von arthrosen.
KR880700080A (ko) Aids 관련질병의 검출을 위한 합성항원
DE3578340D1 (de) Molekulare klone des genoms von htlv-iii.
HUP0000318A2 (hu) Tumorvakcina és eljárás előállítására
ES2010727A6 (es) Metodo para producir lineas celulares que producen anticuerpos monoclonales reactivos frente a determinantes antigenicos de gp110 o de p25 de hiv.
SE7905922L (sv) N-(diaminofosfinyl)-arylkarboxamider
LU79069A1 (fr) Procede de preparation de nouveaux oligopeptides trifluoromethylees derives de la l-alanine
Saltman et al. Co‐oligopeptides of aromatic amino acids and glycine with variable distance between the aromatic residues. VII. Enzymatic synthesis of N‐protected peptide amides
DK52987D0 (da) Dna-fragmenter af humant papillomavirus og fremgangsmaade til in vitro diagnosticering af papillomavirusinfektioner
Goldberger et al. NH2-terminal sequence analysis of pro-C4, the precursor of the fourth component of guinea pig complement.
ES2057579T3 (es) Peptidos e1 y c de rubeola.
ES2028890T3 (es) Procedimiento de sintesis estereoespecifica de derivados del indol.
FR2408580A1 (fr) Compositions de polypeptides contenant la sequence l-arginine-l-lysine-(acide l-aspartique)-l-valine-l-tyrosine, leur procede d'obtention et compositions therapeutiques en comportant
NO872671D0 (no) 4-benzyloksy-3-pyrrolin-2-on-1-yl-acetamid, fremstilling og anvendelse derav.
DK33076A (da) Middel til afprovning af bakteriers folsomhed overfor antifolatmidler og fremgangsmade til fremstilling af renset thymidin-phosphorylase af bakteriel oprindelse
JPS5419966A (en) Production of pyroglutamine peptide
GB1411184A (en) Polypeptides process for preparing them and their use as polyvalent isoinhibitors
EP0241004A3 (en) Chromophoric peptides, process for their preparation and their use to identify peptidylglycin-alpha-amidifying monooxygenase
SE8004659L (sv) Forfarande for syntes av 2-isopropylaminopyrimidin
DK532179A (da) 7,8,9,10-tetrahydrotieno (3,2-e) pyrido (4,3-b)-indoler deres fremstilling og anvendelse til behandling af centralnervesystemet
SU471204A1 (ru) Вибрационна площадка
GB822192A (en) Improvements in or relating to the production of photographic emulsions
JPS55127353A (en) Gamma-rearrangement of alpha-glutamylpeptide