ES2019703B3 - Procedimiento de sintesis industrial del perindopril y de sus principales intermediarios de sintesis - Google Patents

Procedimiento de sintesis industrial del perindopril y de sus principales intermediarios de sintesis

Info

Publication number
ES2019703B3
ES2019703B3 ES88402339T ES88402339T ES2019703B3 ES 2019703 B3 ES2019703 B3 ES 2019703B3 ES 88402339 T ES88402339 T ES 88402339T ES 88402339 T ES88402339 T ES 88402339T ES 2019703 B3 ES2019703 B3 ES 2019703B3
Authority
ES
Spain
Prior art keywords
synthesis
perindopril
industrial
intermediaries
main
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88402339T
Other languages
English (en)
Inventor
Michel Vincent
Jean Baliarda
Bernard Marchand
Georges Remond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9354991&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2019703(B3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2019703B3 publication Critical patent/ES2019703B3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Casting Devices For Molds (AREA)
  • Bending Of Plates, Rods, And Pipes (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
ES88402339T 1987-09-17 1988-09-16 Procedimiento de sintesis industrial del perindopril y de sus principales intermediarios de sintesis Expired - Lifetime ES2019703B3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8712896A FR2620709B1 (fr) 1987-09-17 1987-09-17 Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese

Publications (1)

Publication Number Publication Date
ES2019703B3 true ES2019703B3 (es) 1991-07-01

Family

ID=9354991

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88402339T Expired - Lifetime ES2019703B3 (es) 1987-09-17 1988-09-16 Procedimiento de sintesis industrial del perindopril y de sus principales intermediarios de sintesis

Country Status (15)

Country Link
US (1) US4914214A (es)
EP (1) EP0308341B1 (es)
JP (1) JPH01110696A (es)
AT (1) ATE59047T1 (es)
CA (1) CA1336348C (es)
DE (1) DE3861275D1 (es)
DK (1) DK171470B1 (es)
ES (1) ES2019703B3 (es)
FR (1) FR2620709B1 (es)
GR (1) GR3001539T3 (es)
IE (1) IE61453B1 (es)
NZ (1) NZ226224A (es)
OA (1) OA08915A (es)
PT (1) PT88527B (es)
ZA (1) ZA886932B (es)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
US5212319A (en) * 1990-02-26 1993-05-18 Eli Lilly And Company Intermediates to 4-amino-hexahydrobenz[cd]indoles and processes therefor
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
AU2007203451B2 (en) * 2000-07-06 2010-09-02 Les Laboratoires Servier Pharmaceutical composition containing a crystalline form of perindopril tert-butylamine salt
AR036187A1 (es) * 2001-07-24 2004-08-18 Adir Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
DE60220877T2 (de) * 2002-01-30 2008-04-10 Les Laboratoires Servier Verfahren zur Herstellung von hochreinem Perindopril und Zwischenverbindungen nützlich in der Synthese
JP2005519098A (ja) * 2002-03-01 2005-06-30 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 変形性関節症の治療方法
GB2395195A (en) * 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
WO2004065368A1 (ja) * 2003-01-21 2004-08-05 Ohara Chemical Industries, Ltd. トランドラプリル合成中間体の製造方法
EP1403275B1 (fr) * 2003-02-28 2005-10-19 Les Laboratoires Servier Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
ATE395913T1 (de) * 2003-02-28 2008-06-15 Servier S A Lab Verfahren zur herstellung von perindopril
DE60301980T2 (de) * 2003-02-28 2006-07-27 Les Laboratoires Servier Verfahren zur Synthese des (2S,3aS,7aS)-perhydroindol-2-carbonsäures und seiner Estern, Verwendung in der Synthese von Perindopril
GB0305066D0 (en) * 2003-03-06 2003-04-09 Ibm System and method for publish/subscribe messaging
SI1348684T1 (sl) * 2003-04-09 2006-06-30 Servier Lab Nov postopek sinteze (2s)-indolin-2-karboksilne kisline in uporaba pri sintezi perindoprila
WO2004099138A2 (en) * 2003-05-12 2004-11-18 Cipla Limited Process for the preparation of perindopril
SI21507A (sl) * 2003-05-16 2004-12-31 LEK farmacevtska dru�ba d.d. Postopek za pripravo spojin z ace inhibitornim delovanjem
PL1636185T3 (pl) 2003-06-24 2012-12-31 Servier Lab Nowe formy krystaliczne peryndoprylu erbuminy
DE60313391T2 (de) * 2003-06-30 2008-01-17 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutisch geeigneten Salze
PT1675827E (pt) * 2003-10-21 2010-02-15 Servier Lab Novo processo para preparação de perindopril erbumina cristalina
US20050171165A1 (en) * 2003-11-12 2005-08-04 Bhirud Shekhar B. Process for the preparation of perindopril
SI1420028T1 (sl) * 2003-11-19 2007-06-30 Servier Lab Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
PT1422236E (pt) * 2003-11-19 2007-05-31 Servier Lab Processo de síntese do perindopril e dos seus sais farmacêuticamente aceitáveis
EP1420030A3 (fr) * 2003-12-10 2004-05-26 Les Laboratoires Servier Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
SI21703A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
EA011712B1 (ru) * 2004-03-29 2009-04-28 Ле Лаборатуар Сервье Способ производства твёрдой фармацевтической композиции
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
US20050250706A1 (en) * 2004-05-07 2005-11-10 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
WO2005108365A1 (en) * 2004-05-07 2005-11-17 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
US20060178422A1 (en) * 2004-05-31 2006-08-10 Ashok Kumar Process for making (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl] amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
JP4547245B2 (ja) * 2004-12-16 2010-09-22 株式会社パーマケム・アジア ペリンドプリルエルブミンのｉ型結晶、及びその製造方法
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
SI1679072T1 (sl) 2005-01-06 2009-02-28 Ipca Lab Ltd Postopek za sintezo derivatov (2S,3aS,7aS)-1-(S)-alanil-oktahidro-1H-indol-2-karboksilne kisline inuporaba v sintezi perindoprila
MY138209A (en) * 2005-03-11 2009-05-29 Servier Lab New (y) crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it.
ZA200708802B (en) * 2005-03-14 2009-01-28 Servier Lab An improved process for the purification of perindopril
US7291745B2 (en) * 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2008545006A (ja) * 2005-07-05 2008-12-11 シプラ・リミテッド Ａｃｅ阻害剤の合成方法
CA2615691C (en) * 2005-07-25 2015-11-10 Lek Pharmaceuticals D.D. Process for the preparation of crystalline perindopril
US20070032661A1 (en) * 2005-08-03 2007-02-08 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of perindopril
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
EA200600630A1 (ru) * 2006-04-20 2007-02-27 ИСМАГИЛОВ, Искандар Халиуллович ζ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА
EP1864973A1 (en) * 2006-06-09 2007-12-12 Sochinaz SA Process for the preparation of perindopril and salts thereof
WO2008114270A1 (en) * 2007-03-22 2008-09-25 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
CN101514180B (zh) * 2008-02-20 2012-08-01 上海医药工业研究院 培哚普利叔丁铵盐的ⅰ晶型及其制备方法
DK2318365T3 (en) 2008-06-24 2015-11-23 Mylan Lab Ltd NOVEL polymorphic forms of perindopril (L) -arginine AND PROCESS FOR PREPARATION THEREOF
GB0910692D0 (en) 2009-06-20 2009-08-05 Teva Pharma Compound
SI23149A (sl) 2009-09-21 2011-03-31 Silverstone Pharma Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
PT105315B (pt) 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas
FR2985512B1 (fr) * 2012-01-05 2014-06-20 Servier Lab Procede de preparation du sel de l-arginine du perindopril
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
CN106631977A (zh) * 2016-11-11 2017-05-10 上海雅本化学有限公司 一种s‑吲哚啉‑2‑羧酸合成的优化方法
CN108752259A (zh) * 2018-07-04 2018-11-06 南京方生和医药科技有限公司 培哚普利消旋体及其中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3360065D1 (en) * 1982-03-08 1985-03-28 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
DE3431541A1 (de) * 1984-08-28 1986-03-06 Hoechst Ag, 6230 Frankfurt Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung

Also Published As

Publication number Publication date
DK515188A (da) 1989-03-18
JPH01110696A (ja) 1989-04-27
FR2620709B1 (fr) 1990-09-07
OA08915A (fr) 1989-10-31
CA1336348C (fr) 1995-07-18
DE3861275D1 (de) 1991-01-24
IE61453B1 (en) 1994-11-02
IE882806L (en) 1989-03-17
DK171470B1 (da) 1996-11-11
AU2236288A (en) 1989-03-23
US4914214A (en) 1990-04-03
JPH0543717B2 (es) 1993-07-02
DK515188D0 (da) 1988-09-15
PT88527B (pt) 1993-03-31
ATE59047T1 (de) 1990-12-15
EP0308341A1 (fr) 1989-03-22
ZA886932B (en) 1989-05-30
FR2620709A1 (fr) 1989-03-24
EP0308341B1 (fr) 1990-12-12
GR3001539T3 (en) 1992-11-23
AU608363B2 (en) 1991-03-28
NZ226224A (en) 1990-09-26
PT88527A (pt) 1988-10-01

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