GB1411184A - Polypeptides process for preparing them and their use as polyvalent isoinhibitors - Google Patents

Polypeptides process for preparing them and their use as polyvalent isoinhibitors

Info

Publication number
GB1411184A
GB1411184A GB95973A GB95973A GB1411184A GB 1411184 A GB1411184 A GB 1411184A GB 95973 A GB95973 A GB 95973A GB 95973 A GB95973 A GB 95973A GB 1411184 A GB1411184 A GB 1411184A
Authority
GB
United Kingdom
Prior art keywords
polypeptides
mixture
triethanolamine
jan
isoinhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB95973A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of GB1411184A publication Critical patent/GB1411184A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1411184 Enzyme inhibitors BEHRING- WERKE AG 8 Jan 1973 [8 Jan 1972] 959/73 Heading C3H [Also in Division A5] Polypeptides obtainable from sea-anemones are polyvalent isoinhibitors of enzymes, including the proteinases and esterases of blood cells and plasma, and they have molecular weights in the range 5500-7000, isoelectric points of from pH 6.0 to 9.5, and the following amino acid composition: aspartic acid (6 residues), threonine (1), serine (3-5), glutamic acid (4-5), proline (2-3), glycine (6-7), alanine (2), cysteine (6), valine (4), isoleucine (1-2), leucine (2-3), tyrosine (3), phenylalanine (2-3), lysine (3-4), histidine (1-2) and arginine (5-7). The specification discloses the amino acid profiles and molecular weights of four particular polypeptides fractionated from the mixture of polypeptides obtained by extracting sea anemones of the species (Anemonia sulcata, precipitating the extract and enriching the precipitate all in known manner. The fractionation is carried out on a carboxymethyl cellulose column at a weakly alkaline pH value. A linear gradient of a triethanolamine/hydrochloric acid/sodium chloride mixture and a triethanolamine/hydrochloric acid mixture, is used as eluant.
GB95973A 1972-01-08 1973-01-08 Polypeptides process for preparing them and their use as polyvalent isoinhibitors Expired GB1411184A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19722200828 DE2200828A1 (en) 1972-01-08 1972-01-08 POLYVALENT ISOINHIBITORS AND PROCEDURES FOR THEIR PRODUCTION

Publications (1)

Publication Number Publication Date
GB1411184A true GB1411184A (en) 1975-10-22

Family

ID=5832591

Family Applications (1)

Application Number Title Priority Date Filing Date
GB95973A Expired GB1411184A (en) 1972-01-08 1973-01-08 Polypeptides process for preparing them and their use as polyvalent isoinhibitors

Country Status (8)

Country Link
JP (1) JPS4877011A (en)
BE (1) BE793765A (en)
CH (1) CH592107A5 (en)
DE (1) DE2200828A1 (en)
FR (1) FR2181656B1 (en)
GB (1) GB1411184A (en)
LU (1) LU66792A1 (en)
NL (1) NL7300065A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4059694A (en) * 1976-05-05 1977-11-22 The University Of Hawaii Cardiotonic agent
US4103004A (en) * 1977-08-29 1978-07-25 University Of Hawaii Cardiotonic agent
US4166113A (en) * 1977-08-29 1979-08-28 University Of Hawaii Cardiotonic agent

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4059694A (en) * 1976-05-05 1977-11-22 The University Of Hawaii Cardiotonic agent
US4103004A (en) * 1977-08-29 1978-07-25 University Of Hawaii Cardiotonic agent
US4166113A (en) * 1977-08-29 1979-08-28 University Of Hawaii Cardiotonic agent

Also Published As

Publication number Publication date
DE2200828A1 (en) 1973-07-19
BE793765A (en) 1973-07-09
JPS4877011A (en) 1973-10-17
FR2181656B1 (en) 1976-06-25
CH592107A5 (en) 1977-10-14
LU66792A1 (en) 1974-08-19
FR2181656A1 (en) 1973-12-07
NL7300065A (en) 1973-07-10

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee