PT88527A - Procede de synthese industrielle du perindopril et des principaux intermediaires de synthese - Google Patents
Procede de synthese industrielle du perindopril et des principaux intermediaires de syntheseInfo
- Publication number
- PT88527A PT88527A PT88527A PT8852788A PT88527A PT 88527 A PT88527 A PT 88527A PT 88527 A PT88527 A PT 88527A PT 8852788 A PT8852788 A PT 8852788A PT 88527 A PT88527 A PT 88527A
- Authority
- PT
- Portugal
- Prior art keywords
- synthese
- perindopril
- intermediaires
- procede
- industrielle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Bending Of Plates, Rods, And Pipes (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Casting Devices For Molds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8712896A FR2620709B1 (fr) | 1987-09-17 | 1987-09-17 | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
Publications (2)
Publication Number | Publication Date |
---|---|
PT88527A true PT88527A (pt) | 1988-10-01 |
PT88527B PT88527B (pt) | 1993-03-31 |
Family
ID=9354991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT88527A PT88527B (pt) | 1987-09-17 | 1988-09-16 | Processo para a sintese industrial do perindopril e de seus principais intermedios de sintese |
Country Status (15)
Country | Link |
---|---|
US (1) | US4914214A (pt) |
EP (1) | EP0308341B1 (pt) |
JP (1) | JPH01110696A (pt) |
AT (1) | ATE59047T1 (pt) |
CA (1) | CA1336348C (pt) |
DE (1) | DE3861275D1 (pt) |
DK (1) | DK171470B1 (pt) |
ES (1) | ES2019703B3 (pt) |
FR (1) | FR2620709B1 (pt) |
GR (1) | GR3001539T3 (pt) |
IE (1) | IE61453B1 (pt) |
NZ (1) | NZ226224A (pt) |
OA (1) | OA08915A (pt) |
PT (1) | PT88527B (pt) |
ZA (1) | ZA886932B (pt) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012044189A1 (en) | 2010-09-29 | 2012-04-05 | Instituto Superior Técnico | A new hydrated crystalline form of perindopril erbumine, methods for its preparation and its use in pharmaceutical preparations |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2620700B1 (fr) * | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides |
FR2620699B1 (fr) * | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides |
US5212319A (en) * | 1990-02-26 | 1993-05-18 | Eli Lilly And Company | Intermediates to 4-amino-hexahydrobenz[cd]indoles and processes therefor |
FR2807037B1 (fr) * | 2000-03-31 | 2002-05-10 | Adir | NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL |
FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
FR2807430B1 (fr) * | 2000-04-11 | 2002-05-17 | Adir | Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril |
FR2811320B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2811319B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
AU2007203451B2 (en) * | 2000-07-06 | 2010-09-02 | Les Laboratoires Servier | Pharmaceutical composition containing a crystalline form of perindopril tert-butylamine salt |
FR2811318B1 (fr) * | 2000-07-06 | 2002-08-23 | Adir | Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
AR036187A1 (es) * | 2001-07-24 | 2004-08-18 | Adir | Un proceso para la preparacion de perindopril, compuestos analogos y sus sales, compuesto intermediario 2,5-dioxo-oxazolidina y proceso para preparar un intermediario |
ES2289060T3 (es) * | 2002-01-30 | 2008-02-01 | Les Laboratoires Servier | Proceso para la preparacion de perindopril de alta pureza y de intermedios utiles en su sintesis. |
JP2005519098A (ja) * | 2002-03-01 | 2005-06-30 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 変形性関節症の治療方法 |
GB2395195A (en) * | 2002-11-18 | 2004-05-19 | Cipla Ltd | Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors |
WO2004065368A1 (ja) * | 2003-01-21 | 2004-08-05 | Ohara Chemical Industries, Ltd. | トランドラプリル合成中間体の製造方法 |
EP1338591B1 (fr) * | 2003-02-28 | 2005-10-26 | Les Laboratoires Servier | Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril |
SI1603558T1 (sl) * | 2003-02-28 | 2008-12-31 | Servier S A Lab | Postopek za pripravo perindoprila in njegovih soli |
ATE307139T1 (de) * | 2003-02-28 | 2005-11-15 | Servier Lab | Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salze |
GB0305066D0 (en) * | 2003-03-06 | 2003-04-09 | Ibm | System and method for publish/subscribe messaging |
ATE319668T1 (de) * | 2003-04-09 | 2006-03-15 | Servier Lab | Verfahren zur synthese von (2s)-indolin-2- carbonsäure, und verwendung in der synthese von perindopril |
WO2004099138A2 (en) * | 2003-05-12 | 2004-11-18 | Cipla Limited | Process for the preparation of perindopril |
SI21507A (sl) * | 2003-05-16 | 2004-12-31 | LEK farmacevtska dru�ba d.d. | Postopek za pripravo spojin z ace inhibitornim delovanjem |
WO2004113293A1 (de) * | 2003-06-24 | 2004-12-29 | Les Laboratoires Servier | Neue kristalline formen von perindopril erbumine |
DK1362864T3 (da) * | 2003-06-30 | 2007-09-17 | Servier Lab | Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf |
DK1675827T3 (da) * | 2003-10-21 | 2010-04-19 | Servier Lab | Ny fremgangsmåde til fremstilling af krystallint perindopril erbumin |
US20050171165A1 (en) * | 2003-11-12 | 2005-08-04 | Bhirud Shekhar B. | Process for the preparation of perindopril |
SI1420028T1 (sl) * | 2003-11-19 | 2007-06-30 | Servier Lab | Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli |
ATE353910T1 (de) * | 2003-11-19 | 2007-03-15 | Servier Lab | Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen |
EP1420030A3 (fr) * | 2003-12-10 | 2004-05-26 | Les Laboratoires Servier | Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril |
SI21704A (en) * | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia |
SI21703A (en) | 2004-01-14 | 2005-08-31 | Lek Farmacevtska Druzba Dd | Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia |
EA011712B1 (ru) * | 2004-03-29 | 2009-04-28 | Ле Лаборатуар Сервье | Способ производства твёрдой фармацевтической композиции |
GB2413128A (en) | 2004-04-13 | 2005-10-19 | Neopharma Ltd | Process for the preparation of perindopril |
US20050250706A1 (en) * | 2004-05-07 | 2005-11-10 | Glenmark Pharmaceuticals Limited | Processes for the preparation of alpha polymorph of perindopril erbumine |
WO2005108365A1 (en) * | 2004-05-07 | 2005-11-17 | Glenmark Pharmaceuticals Limited | Processes for the preparation of alpha polymorph of perindopril erbumine |
SI21800A (sl) * | 2004-05-14 | 2005-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek sinteze perindoprila |
US20060178422A1 (en) * | 2004-05-31 | 2006-08-10 | Ashok Kumar | Process for making (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl] amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid |
SI21881A (sl) | 2004-10-15 | 2006-04-30 | Diagen, Smartno Pri Ljubljani, D.O.O. | Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine |
JP4547245B2 (ja) * | 2004-12-16 | 2010-09-22 | 株式会社パーマケム・アジア | ペリンドプリルエルブミンのi型結晶、及びその製造方法 |
ES2255872B1 (es) * | 2004-12-31 | 2007-08-16 | Quimica Sintetica, S.A. | Procedimiento para la preparacion de perindopril erbumina. |
DE602005009918D1 (de) | 2005-01-06 | 2008-11-06 | Ipca Lab Ltd | Verfahren zur Synthese von (2S,3aS,7aS)-1-(S)-Alanyl-octahydro-1H-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril |
MY138209A (en) * | 2005-03-11 | 2009-05-29 | Servier Lab | New (y) crystalline form of perindopril tert-butylamine salt, a process for its preparation and pharmaceutical compositions containing it. |
DE602005015492D1 (de) * | 2005-03-14 | 2009-08-27 | Servier Lab | Verbessertes verfahren zur aufreinigung von perindopril |
US7291745B2 (en) * | 2005-03-21 | 2007-11-06 | Glenmark Pharmaceuticals Limited | Process for the preparation of perindopril |
JP2008545006A (ja) * | 2005-07-05 | 2008-12-11 | シプラ・リミテッド | Ace阻害剤の合成方法 |
CA2615691C (en) * | 2005-07-25 | 2015-11-10 | Lek Pharmaceuticals D.D. | Process for the preparation of crystalline perindopril |
US20070032661A1 (en) * | 2005-08-03 | 2007-02-08 | Glenmark Pharmaceuticals Limited | Process for the preparation of intermediates of perindopril |
EP1792896A1 (en) * | 2005-12-01 | 2007-06-06 | KRKA, tovarna zdravil, d.d., Novo mesto | Process for the preparation of perindopril and salts thereof |
EP1815857A1 (en) | 2006-02-02 | 2007-08-08 | LEK Pharmaceuticals D.D. | A pharmaceutical composition comprising perindopril |
EA007988B1 (ru) * | 2006-04-20 | 2007-02-27 | ИСМАГИЛОВ, Искандар Халиуллович | ξ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА |
EP1864973A1 (en) * | 2006-06-09 | 2007-12-12 | Sochinaz SA | Process for the preparation of perindopril and salts thereof |
EP2137148A1 (en) * | 2007-03-22 | 2009-12-30 | Aarti Healthcare Limited | Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof |
SI22543A (sl) | 2007-06-27 | 2008-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove soli perindoprila |
CN101514180B (zh) * | 2008-02-20 | 2012-08-01 | 上海医药工业研究院 | 培哚普利叔丁铵盐的ⅰ晶型及其制备方法 |
AU2009263737B2 (en) | 2008-06-24 | 2013-10-24 | Mylan Laboratories Ltd. | Novel polymorphic forms of Perindopril (L)-Arginine and process for the preparation thereof |
GB0910692D0 (en) | 2009-06-20 | 2009-08-05 | Teva Pharma | Compound |
SI23149A (sl) | 2009-09-21 | 2011-03-31 | Silverstone Pharma | Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni |
FR2985512B1 (fr) * | 2012-01-05 | 2014-06-20 | Servier Lab | Procede de preparation du sel de l-arginine du perindopril |
WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
FR3050380B1 (fr) | 2016-04-20 | 2020-07-10 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains. |
CN106631977A (zh) * | 2016-11-11 | 2017-05-10 | 上海雅本化学有限公司 | 一种s‑吲哚啉‑2‑羧酸合成的优化方法 |
CN108752259A (zh) * | 2018-07-04 | 2018-11-06 | 南京方生和医药科技有限公司 | 培哚普利消旋体及其中间体的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2503155A2 (fr) * | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
DE3360065D1 (en) * | 1982-03-08 | 1985-03-28 | Schering Corp | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
DE3302125A1 (de) * | 1983-01-22 | 1984-07-26 | Boehringer Ingelheim KG, 6507 Ingelheim | Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung |
DE3431541A1 (de) * | 1984-08-28 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung |
-
1987
- 1987-09-17 FR FR8712896A patent/FR2620709B1/fr not_active Expired - Lifetime
-
1988
- 1988-09-07 CA CA000577078A patent/CA1336348C/fr not_active Expired - Lifetime
- 1988-09-15 DK DK515188A patent/DK171470B1/da active IP Right Grant
- 1988-09-16 JP JP63232125A patent/JPH01110696A/ja active Granted
- 1988-09-16 PT PT88527A patent/PT88527B/pt not_active IP Right Cessation
- 1988-09-16 ES ES88402339T patent/ES2019703B3/es not_active Expired - Lifetime
- 1988-09-16 EP EP19880402339 patent/EP0308341B1/fr not_active Expired - Lifetime
- 1988-09-16 AT AT88402339T patent/ATE59047T1/de not_active IP Right Cessation
- 1988-09-16 NZ NZ226224A patent/NZ226224A/xx unknown
- 1988-09-16 ZA ZA886932A patent/ZA886932B/xx unknown
- 1988-09-16 US US07/245,446 patent/US4914214A/en not_active Expired - Lifetime
- 1988-09-16 OA OA59433A patent/OA08915A/xx unknown
- 1988-09-16 DE DE8888402339T patent/DE3861275D1/de not_active Expired - Lifetime
- 1988-09-16 IE IE280688A patent/IE61453B1/en not_active IP Right Cessation
-
1991
- 1991-03-04 GR GR91400252T patent/GR3001539T3/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012044189A1 (en) | 2010-09-29 | 2012-04-05 | Instituto Superior Técnico | A new hydrated crystalline form of perindopril erbumine, methods for its preparation and its use in pharmaceutical preparations |
Also Published As
Publication number | Publication date |
---|---|
FR2620709A1 (fr) | 1989-03-24 |
DK515188A (da) | 1989-03-18 |
DK515188D0 (da) | 1988-09-15 |
NZ226224A (en) | 1990-09-26 |
FR2620709B1 (fr) | 1990-09-07 |
CA1336348C (fr) | 1995-07-18 |
ZA886932B (en) | 1989-05-30 |
DK171470B1 (da) | 1996-11-11 |
OA08915A (fr) | 1989-10-31 |
ES2019703B3 (es) | 1991-07-01 |
AU2236288A (en) | 1989-03-23 |
EP0308341B1 (fr) | 1990-12-12 |
IE882806L (en) | 1989-03-17 |
ATE59047T1 (de) | 1990-12-15 |
AU608363B2 (en) | 1991-03-28 |
US4914214A (en) | 1990-04-03 |
EP0308341A1 (fr) | 1989-03-22 |
JPH01110696A (ja) | 1989-04-27 |
PT88527B (pt) | 1993-03-31 |
GR3001539T3 (en) | 1992-11-23 |
IE61453B1 (en) | 1994-11-02 |
DE3861275D1 (de) | 1991-01-24 |
JPH0543717B2 (pt) | 1993-07-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG3A | Patent granted, date of granting |
Effective date: 19920914 |
|
PC3A | Transfer or assignment |
Free format text: 20011105 LES LABORATOIRES SERVIER FR |
|
MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20080916 |