DK171470B1 - Fremgangsmåde til industriel syntese af det tertiære butylaminsalt af (2S,3aS,7aS)-1-(2-[1-(ethoxycarbonyl)-(S)-butylamino]-(S)-propionyl)octahydroindol-2-carboxylsyre - Google Patents

Fremgangsmåde til industriel syntese af det tertiære butylaminsalt af (2S,3aS,7aS)-1-(2-[1-(ethoxycarbonyl)-(S)-butylamino]-(S)-propionyl)octahydroindol-2-carboxylsyre Download PDF

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Publication number
DK171470B1
DK171470B1 DK515188A DK515188A DK171470B1 DK 171470 B1 DK171470 B1 DK 171470B1 DK 515188 A DK515188 A DK 515188A DK 515188 A DK515188 A DK 515188A DK 171470 B1 DK171470 B1 DK 171470B1
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formula
process according
carboxyindoline
carried out
catalyst
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DK515188A
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Danish (da)
English (en)
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DK515188D0 (da
DK515188A (da
Inventor
Michel Vincent
Jean Baliarda
Bernard Marchand
Georges Remond
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Adir
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Bending Of Plates, Rods, And Pipes (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Casting Devices For Molds (AREA)
DK515188A 1987-09-17 1988-09-15 Fremgangsmåde til industriel syntese af det tertiære butylaminsalt af (2S,3aS,7aS)-1-(2-[1-(ethoxycarbonyl)-(S)-butylamino]-(S)-propionyl)octahydroindol-2-carboxylsyre DK171470B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8712896A FR2620709B1 (fr) 1987-09-17 1987-09-17 Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR8712896 1987-09-17

Publications (3)

Publication Number Publication Date
DK515188D0 DK515188D0 (da) 1988-09-15
DK515188A DK515188A (da) 1989-03-18
DK171470B1 true DK171470B1 (da) 1996-11-11

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ID=9354991

Family Applications (1)

Application Number Title Priority Date Filing Date
DK515188A DK171470B1 (da) 1987-09-17 1988-09-15 Fremgangsmåde til industriel syntese af det tertiære butylaminsalt af (2S,3aS,7aS)-1-(2-[1-(ethoxycarbonyl)-(S)-butylamino]-(S)-propionyl)octahydroindol-2-carboxylsyre

Country Status (15)

Country Link
US (1) US4914214A (pt)
EP (1) EP0308341B1 (pt)
JP (1) JPH01110696A (pt)
AT (1) ATE59047T1 (pt)
CA (1) CA1336348C (pt)
DE (1) DE3861275D1 (pt)
DK (1) DK171470B1 (pt)
ES (1) ES2019703B3 (pt)
FR (1) FR2620709B1 (pt)
GR (1) GR3001539T3 (pt)
IE (1) IE61453B1 (pt)
NZ (1) NZ226224A (pt)
OA (1) OA08915A (pt)
PT (1) PT88527B (pt)
ZA (1) ZA886932B (pt)

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FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
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FR2811319B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811320B1 (fr) * 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
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KR20060035636A (ko) * 2003-06-24 2006-04-26 르 라보레또레 쎄르비에르 신규한 결정형의 페린도프릴 에르부민
PT1362864E (pt) * 2003-06-30 2007-07-23 Servier Lab Novo processo de síntese do perindopril e dos seus sais aceitáveis do ponto de vista farmacêutico
WO2005037788A1 (en) * 2003-10-21 2005-04-28 Lupin Ltd. Novel method for preparation of crystalline perindopril erbumine
US20050171165A1 (en) * 2003-11-12 2005-08-04 Bhirud Shekhar B. Process for the preparation of perindopril
ES2282587T3 (es) * 2003-11-19 2007-10-16 Les Laboratoires Servier Procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
EP1420028B1 (fr) * 2003-11-19 2007-02-21 Les Laboratoires Servier Pocédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
EP1420030A3 (fr) * 2003-12-10 2004-05-26 Les Laboratoires Servier Procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS) - 1 - [(S)-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
SI21704A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd New crystal form of perindopril, procedure of its preparation, pharmaceutical preparations containing this form and their application in treatment of hypertensia
SI21703A (en) * 2004-01-14 2005-08-31 Lek Farmacevtska Druzba Dd Inclusion complexes of perindopril, procedure of their preparation, pharmaceutical compositions containing these complexes and their application in treatment of hypertensia
JP4948392B2 (ja) * 2004-03-29 2012-06-06 レ ラボラトア セルビエ 固形薬学的組成物を調製するためのプロセス
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
WO2005108365A1 (en) * 2004-05-07 2005-11-17 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
US20050250706A1 (en) * 2004-05-07 2005-11-10 Glenmark Pharmaceuticals Limited Processes for the preparation of alpha polymorph of perindopril erbumine
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
US20060178422A1 (en) * 2004-05-31 2006-08-10 Ashok Kumar Process for making (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl] amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid
SI21881A (sl) 2004-10-15 2006-04-30 Diagen, Smartno Pri Ljubljani, D.O.O. Nove kristalne oblike perindopril erbumin hidratov, postopek za njihovo pripravo in farmacevtske oblike, ki vsebujejo te spojine
JP4547245B2 (ja) * 2004-12-16 2010-09-22 株式会社パーマケム・アジア ペリンドプリルエルブミンのｉ型結晶、及びその製造方法
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
SI1679072T1 (sl) 2005-01-06 2009-02-28 Ipca Lab Ltd Postopek za sintezo derivatov (2S,3aS,7aS)-1-(S)-alanil-oktahidro-1H-indol-2-karboksilne kisline inuporaba v sintezi perindoprila
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DE602005015492D1 (de) * 2005-03-14 2009-08-27 Servier Lab Verbessertes verfahren zur aufreinigung von perindopril
US7291745B2 (en) * 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
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US20070032661A1 (en) * 2005-08-03 2007-02-08 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of perindopril
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
EP1815857A1 (en) 2006-02-02 2007-08-08 LEK Pharmaceuticals D.D. A pharmaceutical composition comprising perindopril
EA200600630A1 (ru) * 2006-04-20 2007-02-27 ИСМАГИЛОВ, Искандар Халиуллович ζ-ЗЕТА ФОРМА ПЕРИНДОПРИЛ ЭРБУМИНА
EP1864973A1 (en) * 2006-06-09 2007-12-12 Sochinaz SA Process for the preparation of perindopril and salts thereof
EP2137148A1 (en) * 2007-03-22 2009-12-30 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
CN101514180B (zh) * 2008-02-20 2012-08-01 上海医药工业研究院 培哚普利叔丁铵盐的ⅰ晶型及其制备方法
SI2318365T1 (sl) 2008-06-24 2016-01-29 Mylan Laboratories Limited Nove polimorfne oblike perindopril (l) - arginina in postopek za pripravo
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SI23149A (sl) 2009-09-21 2011-03-31 Silverstone Pharma Nove benzatinske soli ACE inhibitorjev, postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
PT105315B (pt) 2010-09-29 2013-01-16 Inst Superior Tecnico Uma nova forma cristalina hidratada de erbumina de perindopril, métodos para a sua preparação e sua utilização em preparações farmacêuticas
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Also Published As

Publication number Publication date
FR2620709B1 (fr) 1990-09-07
EP0308341B1 (fr) 1990-12-12
PT88527A (pt) 1988-10-01
JPH0543717B2 (pt) 1993-07-02
IE61453B1 (en) 1994-11-02
OA08915A (fr) 1989-10-31
IE882806L (en) 1989-03-17
DK515188D0 (da) 1988-09-15
JPH01110696A (ja) 1989-04-27
EP0308341A1 (fr) 1989-03-22
ATE59047T1 (de) 1990-12-15
DE3861275D1 (de) 1991-01-24
US4914214A (en) 1990-04-03
AU608363B2 (en) 1991-03-28
PT88527B (pt) 1993-03-31
DK515188A (da) 1989-03-18
ES2019703B3 (es) 1991-07-01
AU2236288A (en) 1989-03-23
GR3001539T3 (en) 1992-11-23
ZA886932B (en) 1989-05-30
CA1336348C (fr) 1995-07-18
NZ226224A (en) 1990-09-26
FR2620709A1 (fr) 1989-03-24

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B1 Patent granted (law 1993)