JPS55127353A - Gamma-rearrangement of alpha-glutamylpeptide - Google Patents

Gamma-rearrangement of alpha-glutamylpeptide

Info

Publication number
JPS55127353A
JPS55127353A JP3336079A JP3336079A JPS55127353A JP S55127353 A JPS55127353 A JP S55127353A JP 3336079 A JP3336079 A JP 3336079A JP 3336079 A JP3336079 A JP 3336079A JP S55127353 A JPS55127353 A JP S55127353A
Authority
JP
Japan
Prior art keywords
glutamylpeptide
protecting group
reaction
cooh
rearrangement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3336079A
Other languages
Japanese (ja)
Inventor
Masayoshi Misawa
Mineyuki Hayashi
Yoshikazu Isowa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd, Sagami Chemical Research Institute filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP3336079A priority Critical patent/JPS55127353A/en
Publication of JPS55127353A publication Critical patent/JPS55127353A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PURPOSE: To improve the yield of γ-rearragement of α-glutamylpeptide with alkali treatment, by carrying out the reaction in the presence of DMF or DMSO, and to prepare glutathione by using the γ-rearrangement.
CONSTITUTION: An α-glutamylpeptide such as the formula I (R-CO- is amino acid residue, peptide residue, etc. having free NH2 terminal group; NHR' is an amino acid residue or peptide residue having free COOH terminal group; R" is protecting group of COOH), is treated with an alkali in the presence of DMF or DMSO to obtain a γ-glutamylpeptide. The reaction is carried out at 10W40°C. Preferable example of the raw material is a tripeptide of formula II (B is H or SH-protecting group; X is H or NH2-protecting group; Y, D are OH or COOH-protecting group), obtained by an enzymatic synthesis. Glutathione is prepared by eliminating the protecting groups after the γ-rearragement reaction.
COPYRIGHT: (C)1980,JPO&Japio
JP3336079A 1979-03-23 1979-03-23 Gamma-rearrangement of alpha-glutamylpeptide Pending JPS55127353A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3336079A JPS55127353A (en) 1979-03-23 1979-03-23 Gamma-rearrangement of alpha-glutamylpeptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3336079A JPS55127353A (en) 1979-03-23 1979-03-23 Gamma-rearrangement of alpha-glutamylpeptide

Publications (1)

Publication Number Publication Date
JPS55127353A true JPS55127353A (en) 1980-10-02

Family

ID=12384410

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3336079A Pending JPS55127353A (en) 1979-03-23 1979-03-23 Gamma-rearrangement of alpha-glutamylpeptide

Country Status (1)

Country Link
JP (1) JPS55127353A (en)

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