ES8608478A1 - Un metodo de preparar bestatinas - Google Patents

Un metodo de preparar bestatinas

Info

Publication number
ES8608478A1
ES8608478A1 ES541544A ES541544A ES8608478A1 ES 8608478 A1 ES8608478 A1 ES 8608478A1 ES 541544 A ES541544 A ES 541544A ES 541544 A ES541544 A ES 541544A ES 8608478 A1 ES8608478 A1 ES 8608478A1
Authority
ES
Spain
Prior art keywords
bestatin
derivatives
intermediates
preparation
novel process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541544A
Other languages
English (en)
Other versions
ES541544A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES8608478A1 publication Critical patent/ES8608478A1/es
Publication of ES541544A0 publication Critical patent/ES541544A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

METODO PARA PREPARAR BESTATINAS. COMPRENDE: A) HIDROLIZAR A (A) D.F. (II) CON UN ACIDO (CLH O SO4H2), EN AGUA Y ENTRE 0 Y 160JC, PARA ABRIR EL ANILLO DE OXAZOLIDINA Y ELIMINAR (R) DEL C.D.F (II) Y OBTENER A (B); B) TRATAR A (B) CON (C) EN PRESENCIA DE UN ALCALI, PARA PROTEGER EL GRUPO AMINO DE (B); C) CONDENSAR AL (B) PROTEGIDO CON UNA L-LEUCINA QUE TIENE UN GRUPO CARBOXILO PROTEGIDO PARA FORMAR UNA UNION IMIDA DEL ACIDO; Y D) SEPARAR LOS GRUPOS PROTECTORES DE CONDENSACION, MEDIANTE REDUCCION CATALITICA CON PT, PARA OBTENER UN C.D.F. (I). SIENDO: (A), (4R,5S)-4-BENCIL-5-ALCOXICARBONIL-OXAZOLIDINA-2-ONA; (B), ACIDO (2S,5R)-3-AMINO-2-HIDROXI-4-FENILBUTIRICO; (C), CLORURO DE BENCILOXICARBONILO; PH, FENILO; R, GRUPO ALQUILO INFERIOR; D.F., DE FORMULA; Y C.D.F., COMPUESTO D.F. SE UTILIZAN COMO ANTI-TUMORALES.
ES541544A 1984-03-26 1985-03-25 Un metodo de preparar bestatinas Expired ES8608478A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59056137A JPS60199884A (ja) 1984-03-26 1984-03-26 ベスタチン類の新規製造法

Publications (2)

Publication Number Publication Date
ES8608478A1 true ES8608478A1 (es) 1986-06-16
ES541544A0 ES541544A0 (es) 1986-06-16

Family

ID=13018682

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541544A Expired ES8608478A1 (es) 1984-03-26 1985-03-25 Un metodo de preparar bestatinas

Country Status (10)

Country Link
EP (1) EP0156279B1 (es)
JP (1) JPS60199884A (es)
AT (1) ATE46322T1 (es)
DE (1) DE3572969D1 (es)
DK (1) DK133285A (es)
ES (1) ES8608478A1 (es)
GR (1) GR850734B (es)
HU (1) HU197586B (es)
PT (1) PT80158B (es)
ZA (1) ZA852216B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8605573D0 (sv) * 1986-12-29 1986-12-29 Haessle Ab Novel compounds
US5455353A (en) * 1993-03-24 1995-10-03 Hoffmann-La Roche Inc. 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides
US5630958A (en) * 1995-01-27 1997-05-20 Stewart, Jr.; John B. Side entry coil induction heater with flux concentrator
JP2002080435A (ja) * 2000-06-26 2002-03-19 Kanegafuchi Chem Ind Co Ltd ３−アミノ−２−ヒドロキシプロピオン酸誘導体の製造法
JP2002371044A (ja) 2001-04-11 2002-12-26 Ajinomoto Co Inc β−アミノ−α−ヒドロキシカルボン酸の製造方法
CN103333089A (zh) * 2013-06-20 2013-10-02 深圳万乐药业有限公司 N-[(2s,3r)-4-苯基-3-苄基-3-苄氧甲酰氨基-2-羟基丁酰]-l-亮氨酸苄酯的晶型及其制备方法
CN107141232A (zh) * 2017-07-07 2017-09-08 国药集团川抗制药有限公司 一种乌苯美司的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5116660A (en) * 1974-08-02 1976-02-10 Sagami Chem Res 55 karubokishi 22 okisazorijinonno seizoho

Also Published As

Publication number Publication date
DK133285A (da) 1985-09-27
ZA852216B (en) 1985-11-27
JPH0534348B2 (es) 1993-05-21
PT80158B (en) 1987-01-16
EP0156279B1 (en) 1989-09-13
ATE46322T1 (de) 1989-09-15
DK133285D0 (da) 1985-03-25
HUT37444A (en) 1985-12-28
EP0156279A2 (en) 1985-10-02
DE3572969D1 (en) 1989-10-19
JPS60199884A (ja) 1985-10-09
PT80158A (en) 1985-04-01
HU197586B (en) 1989-04-28
GR850734B (es) 1985-07-19
ES541544A0 (es) 1986-06-16
EP0156279A3 (en) 1987-01-28

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