ES483377A1 - Procedimiento para preparar gamma-lactonas de esteroides - Google Patents

Procedimiento para preparar gamma-lactonas de esteroides

Info

Publication number
ES483377A1
ES483377A1 ES483377A ES483377A ES483377A1 ES 483377 A1 ES483377 A1 ES 483377A1 ES 483377 A ES483377 A ES 483377A ES 483377 A ES483377 A ES 483377A ES 483377 A1 ES483377 A1 ES 483377A1
Authority
ES
Spain
Prior art keywords
oxo
beta
alpha
hydroxy
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES483377A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gist Brocades NV
Original Assignee
Gist Brocades NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades NV filed Critical Gist Brocades NV
Publication of ES483377A1 publication Critical patent/ES483377A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17

Abstract

Gama-lactonas de esteroides, a partir de materiales facialmente disponibles, por ejemplo dehidroepiandrosterona (abreviado a continuacion como DHA) o androst-4-eno-3, 17-diona (abreviado a continuación como AD), DHA se hace reaccionar con etino para dar el derivado 17alfa-17beta-etino, el cual, después de reacción con un compuesto de Grignard para formar el correspondiente derivado de Grignard, seguido por adición de dióxido de carbono, se convierte en el correspondiente compuesto 17alfa-hidroxi-17beta-(ácido 3-propinóico) el cual, después de la hidrogena de 17alfa-hidroxi-17beta-(ácido 3-propenóico la cual, a su vez, se hidrogena cataliticamente a la gamma-lactona de 17alfa-hidroxi-17beta-(ácido 3-propanóido).
ES483377A 1978-08-15 1979-08-14 Procedimiento para preparar gamma-lactonas de esteroides Expired ES483377A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7833384 1978-08-15

Publications (1)

Publication Number Publication Date
ES483377A1 true ES483377A1 (es) 1980-05-16

Family

ID=10499063

Family Applications (1)

Application Number Title Priority Date Filing Date
ES483377A Expired ES483377A1 (es) 1978-08-15 1979-08-14 Procedimiento para preparar gamma-lactonas de esteroides

Country Status (23)

Country Link
US (1) US4267106A (es)
JP (1) JPS5536490A (es)
AT (1) AT374486B (es)
AU (1) AU531717B2 (es)
BE (1) BE878259A (es)
CA (1) CA1138432A (es)
CH (1) CH649304A5 (es)
DE (1) DE2932925A1 (es)
DK (1) DK162448C (es)
ES (1) ES483377A1 (es)
FI (1) FI70720C (es)
FR (1) FR2433541A1 (es)
GR (1) GR72269B (es)
HU (1) HU179479B (es)
IE (1) IE48803B1 (es)
IT (1) IT1118831B (es)
LU (1) LU81604A1 (es)
NL (1) NL190897C (es)
NO (1) NO153853C (es)
NZ (1) NZ191288A (es)
PT (1) PT70065A (es)
SE (1) SE445225B (es)
YU (1) YU41412B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4501695A (en) * 1983-05-16 1985-02-26 The Upjohn Company Spironalactone process
FR2559156B1 (fr) * 1984-02-03 1989-03-24 Roussel Uclaf Procede de preparation de derives de la prednisone et produits intermediaires de ce procede
PT973791E (pt) 1995-12-11 2007-09-26 Searle Llc Processo para a preparação de um composto epoxi
ATE225367T1 (de) 1996-12-11 2002-10-15 Searle & Co Verfahren zur herstellung von 3-keto-7alpha- alkoxycarbonyl- delta4,5-steroiden sowie zwischenprodukte
US6887991B1 (en) 1996-12-11 2005-05-03 G. D. Searle & Company Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein
FR2811563B1 (fr) * 2000-07-13 2003-06-20 Oreal Composition, notamment cosmetique, comprenant la dhea et/ou un precurseur ou derive, et au moins un compose augmentant la synthese des glycosaminoglycanes
FR2811561B1 (fr) * 2000-07-13 2003-03-21 Oreal Composition, notamment cosmetique, renfermant la dhea et/ou un precurseur ou derive chimique ou biologique de celle-ci, et un inhibiteur de metalloproteinase
US7235655B2 (en) 2002-03-22 2007-06-26 Pharmacia & Upjohn Company Processes to prepare eplerenone
US7354956B2 (en) 2002-04-12 2008-04-08 L'oreal Composition containing a sapogenin and use thereof
CN109879908A (zh) * 2019-01-10 2019-06-14 安徽昊帆生物有限公司 烯丙基n,n,n`,n`-四乙基磷二酰胺的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1087071A (en) * 1963-07-03 1967-10-11 Res Inst Medicine Chem Preparation of lactones
US3632576A (en) * 1968-03-11 1972-01-04 Schering Ag Steroid butenolides
DE2237143A1 (de) * 1972-07-28 1974-02-14 Hoechst Ag Verfahren zur herstellung von beta(3-keto-7alpha-acetylthio-17beta-hydroxy4-androsten-17alpha-yl)-propionsaeuregamma-lacton und dessen 1-dehydro-derivat
DE2251476A1 (de) * 1972-10-20 1974-05-02 Hoechst Ag Verfahren zur herstellung von beta(3-keto-7 alpha-thioacyl-17 beta-hydroxy4-androsten-17 alpha -yl)-propionsaeuregamma -lactonen

Also Published As

Publication number Publication date
FI70720C (fi) 1986-10-06
NL190897C (nl) 1994-10-17
HU179479B (en) 1982-10-28
IE48803B1 (en) 1985-05-15
AT374486B (de) 1984-04-25
ATA548779A (de) 1983-09-15
US4267106A (en) 1981-05-12
NL7906158A (nl) 1980-02-19
GR72269B (es) 1983-11-11
JPS6254317B2 (es) 1987-11-13
CH649304A5 (de) 1985-05-15
DE2932925A1 (de) 1980-02-28
NO153853B (no) 1986-02-24
NL190897B (nl) 1994-05-16
CA1138432A (en) 1982-12-28
SE7906785L (sv) 1980-02-16
JPS5536490A (en) 1980-03-14
NO792651L (no) 1980-02-18
YU195779A (en) 1983-02-28
DK162448B (da) 1991-10-28
AU531717B2 (en) 1983-09-01
DE2932925C2 (es) 1989-12-21
IT1118831B (it) 1986-03-03
IT7968666A0 (it) 1979-08-13
PT70065A (en) 1979-09-01
SE445225B (sv) 1986-06-09
LU81604A1 (fr) 1979-12-07
DK340179A (da) 1980-02-16
BE878259A (fr) 1980-02-14
IE791558L (en) 1980-02-15
FI70720B (fi) 1986-06-26
AU4983179A (en) 1980-02-21
FR2433541B1 (es) 1983-01-21
FR2433541A1 (fr) 1980-03-14
DK162448C (da) 1992-03-23
NO153853C (no) 1986-06-11
YU41412B (en) 1987-04-30
FI792516A (fi) 1980-02-16
NZ191288A (en) 1981-07-13

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