IE37347L - Oxazoloazepines - Google Patents
OxazoloazepinesInfo
- Publication number
- IE37347L IE37347L IE730211A IE21173A IE37347L IE 37347 L IE37347 L IE 37347L IE 730211 A IE730211 A IE 730211A IE 21173 A IE21173 A IE 21173A IE 37347 L IE37347 L IE 37347L
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- formula
- group
- feb
- prepared
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measurement Of Radiation (AREA)
Abstract
1412377 Oxazoloazepine derivatives DR KARL THOMAE GmbH 9 Feb 1973 [10 Feb 1972] 6476/73 Heading C2C [Also in Division A5] Novel compounds of Formula I: (wherein R represents a hydrogen atom, an alkyl group containing from 1 to 4 carbon atoms substituted by a hydroxy, carboxy or carbalkoxy group; a saturated or unsaturated aliphatic acyl group containing from 1 to 6 carbon atoms optionally substituted by a hydroxyl group; a benzoyl group optionally substituted by one or more methyl or methoxy groups or by one or more halogen atoms; or a pyridinecarbonyl or phenylacyl group) and acid addition salts thereof, are prepared by reacting a compound of Formula II with urea. Intermediates of Formula II are prepared by various methods for example by the following sequence : (i) for R = H, a compound of formula is cyclized and then the N-benzyl compound is debenzylated; (ii) for R = acetyl, the compound R = H is acetylated; (iii) for R = hydroxyalkyl, the ethylene glycol ketal of the compound R = H is reacted with ethylene oxide.
[GB1412377A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2206385A DE2206385C2 (en) | 1972-02-10 | 1972-02-10 | 2-Amino-4,5,7,8-tetrahydro-6H-oxazolo- [4,5-d] azepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37347L true IE37347L (en) | 1973-08-10 |
| IE37347B1 IE37347B1 (en) | 1977-07-06 |
Family
ID=5835665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE211/73A IE37347B1 (en) | 1972-02-10 | 1973-02-09 | Oxazolo (5,4-d) azepines |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS5825678B2 (en) |
| KR (1) | KR780000196B1 (en) |
| AT (1) | AT321296B (en) |
| BE (1) | BE795257A (en) |
| BG (1) | BG22826A3 (en) |
| CA (1) | CA997342A (en) |
| CH (1) | CH576476A5 (en) |
| CS (1) | CS181231B2 (en) |
| DD (1) | DD104083A5 (en) |
| DE (1) | DE2206385C2 (en) |
| DK (1) | DK137011C (en) |
| FI (1) | FI54126C (en) |
| FR (1) | FR2181718B1 (en) |
| GB (1) | GB1412377A (en) |
| HU (1) | HU165459B (en) |
| IE (1) | IE37347B1 (en) |
| IL (1) | IL41512A (en) |
| NL (1) | NL173525C (en) |
| NO (1) | NO131599C (en) |
| PL (1) | PL84740B1 (en) |
| RO (1) | RO61191A (en) |
| SE (1) | SE380805B (en) |
| SU (1) | SU474990A3 (en) |
| ZA (1) | ZA73924B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3820775A1 (en) * | 1988-06-20 | 1989-12-21 | Thomae Gmbh Dr K | NEW 4,5,7,8-TETRAHYDRO-6H-THIAZOLO (5,4, -D) AZEPINES, THEIR PREPARATION AND THEIR USE AS DRUGS |
| DE4345224C2 (en) * | 1993-12-18 | 1999-07-01 | Asta Medica Ag | Process for the preparation of acid addition salts of azelastine and flezelastin |
| CL2004000553A1 (en) | 2003-03-20 | 2005-02-04 | Actelion Pharmaceuticals Ltd | USE OF GUANIDINE DERIVATIVE COMPOUNDS AS ANTAGONISTS OF THE FF NEUROPEPTIDE RECEIVER; COMPOUNDS DERIVED FROM GUANIDINA; PREPARATION PROCEDURES; AND PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM. |
| KR20060064065A (en) | 2003-09-05 | 2006-06-12 | 액테리온 파마슈티칼 리미티드 | Guanidine derivatives |
| US20110230472A1 (en) * | 2008-08-29 | 2011-09-22 | Shionogi & Co., Ltd. | Ring-fused azole derivative having pi3k-inhibiting activity |
| US20160268611A1 (en) | 2013-11-11 | 2016-09-15 | Kabushiki Kaisha Kobe Seiko Sho (Kobe Steel, Ltd.) | Titanium separator material for fuel cells, and method for producing titanium separator material for fuel cells |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2040510C3 (en) * | 1970-08-14 | 1980-03-06 | Dr. Karl Thomae Gmbh, 7950 Biberach | Oxazole and thiazole square brackets on 5,4-d] azepine derivatives |
| BG17968A3 (en) * | 1970-08-14 | 1974-03-05 | ||
| ZA756062B (en) * | 1975-09-23 | 1977-04-27 | M Schoeman | Supplying fuel to internal combustion engines |
-
0
- BE BE795257D patent/BE795257A/en not_active IP Right Cessation
-
1972
- 1972-02-10 DE DE2206385A patent/DE2206385C2/en not_active Expired
-
1973
- 1973-01-18 NL NLAANVRAGE7300744,A patent/NL173525C/en not_active IP Right Cessation
- 1973-01-29 DD DD168504A patent/DD104083A5/xx unknown
- 1973-01-29 AT AT73473A patent/AT321296B/en not_active IP Right Cessation
- 1973-01-31 SU SU1878315A patent/SU474990A3/en active
- 1973-02-07 KR KR7300224A patent/KR780000196B1/en active
- 1973-02-08 BG BG22667A patent/BG22826A3/xx unknown
- 1973-02-08 HU HUTO898A patent/HU165459B/hu unknown
- 1973-02-08 CH CH187273A patent/CH576476A5/xx not_active IP Right Cessation
- 1973-02-08 SE SE7301773A patent/SE380805B/en unknown
- 1973-02-09 FR FR7304643A patent/FR2181718B1/fr not_active Expired
- 1973-02-09 FI FI394/73A patent/FI54126C/en active
- 1973-02-09 NO NO533/73A patent/NO131599C/no unknown
- 1973-02-09 IE IE211/73A patent/IE37347B1/en unknown
- 1973-02-09 PL PL1973160658A patent/PL84740B1/pl unknown
- 1973-02-09 IL IL41512A patent/IL41512A/en unknown
- 1973-02-09 ZA ZA730924A patent/ZA73924B/en unknown
- 1973-02-09 CS CS7300000974A patent/CS181231B2/en unknown
- 1973-02-09 CA CA163,409A patent/CA997342A/en not_active Expired
- 1973-02-09 JP JP48016407A patent/JPS5825678B2/en not_active Expired
- 1973-02-09 DK DK74573A patent/DK137011C/en not_active IP Right Cessation
- 1973-02-09 GB GB647673A patent/GB1412377A/en not_active Expired
- 1973-02-10 RO RO73806A patent/RO61191A/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DD104083A5 (en) | 1974-02-20 |
| AT321296B (en) | 1975-03-25 |
| FR2181718B1 (en) | 1976-12-31 |
| DK137011B (en) | 1978-01-02 |
| CS181231B2 (en) | 1978-03-31 |
| NL7300744A (en) | 1973-08-14 |
| FR2181718A1 (en) | 1973-12-07 |
| NO131599B (en) | 1975-03-17 |
| CA997342A (en) | 1976-09-21 |
| NL173525C (en) | 1984-02-01 |
| NO131599C (en) | 1975-06-25 |
| DE2206385A1 (en) | 1973-08-16 |
| CH576476A5 (en) | 1976-06-15 |
| DE2206385C2 (en) | 1983-04-21 |
| HU165459B (en) | 1974-08-28 |
| RO61191A (en) | 1976-10-15 |
| BG22826A3 (en) | 1977-04-20 |
| FI54126C (en) | 1978-10-10 |
| SE380805B (en) | 1975-11-17 |
| NL173525B (en) | 1983-09-01 |
| DK137011C (en) | 1978-06-05 |
| FI54126B (en) | 1978-06-30 |
| BE795257A (en) | 1973-08-09 |
| IE37347B1 (en) | 1977-07-06 |
| ZA73924B (en) | 1974-11-27 |
| SU474990A3 (en) | 1975-06-25 |
| AU5203573A (en) | 1974-08-15 |
| GB1412377A (en) | 1975-11-05 |
| PL84740B1 (en) | 1976-04-30 |
| IL41512A (en) | 1976-01-30 |
| JPS4886885A (en) | 1973-11-15 |
| JPS5825678B2 (en) | 1983-05-28 |
| KR780000196B1 (en) | 1978-05-26 |
| IL41512A0 (en) | 1973-04-30 |
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