ES407867A1 - Phenothiazine derivatives - Google Patents

Phenothiazine derivatives

Info

Publication number
ES407867A1
ES407867A1 ES407867A ES407867A ES407867A1 ES 407867 A1 ES407867 A1 ES 407867A1 ES 407867 A ES407867 A ES 407867A ES 407867 A ES407867 A ES 407867A ES 407867 A1 ES407867 A1 ES 407867A1
Authority
ES
Spain
Prior art keywords
radical
carbon atoms
general formula
radical containing
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES407867A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of ES407867A1 publication Critical patent/ES407867A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedure for obtaining phenothiazine derivatives of general formula: **(See formula)** in which: X represents a methylsulfonyl radical or a dimethylsulfamoyl radical, A represents a radical - (CH2) 3- or -CH2-CH (CH3) -CH2-, R1 represents a hydrogen atom or an alkyl radical containing from 1 to 4 carbon atoms, R represents an alkanoyl radical whose alkyl part contains from 4 to 16 carbon atoms, alkenoyl whose alkenyl part contains from 4 to 16 carbon atoms, and B represents a straight or branched alkylene radical containing from 2 to 5 carbon atoms, as well as its addition salts with acids, characterized in that a phenothiazine of general formula (I) for which R represents an atom is reacted hydrogen with a product of general formula: R4- CO- Z wherein R4 represents an alkyl or alkenyl radical containing from 4 to 16 carbon atoms and Z represents a reactive moiety such as a halogen atom, the hydroxyl radical, a lower alkyloxy radical containing from 1 to 4 carbon atoms, an imidazolyl residue or an alkanoyloxy residue which can be such that the compound R4-CO-Z represents the acid anhydride R4-CO-O-CO-R4; and then the product obtained is optionally transformed into an addition salt with an acid. (Machine-translation by Google Translate, not legally binding)
ES407867A 1971-07-21 1972-10-23 Phenothiazine derivatives Expired ES407867A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7126709A FR2146150B1 (en) 1971-07-21 1971-07-21

Publications (1)

Publication Number Publication Date
ES407867A1 true ES407867A1 (en) 1975-11-16

Family

ID=9080680

Family Applications (2)

Application Number Title Priority Date Filing Date
ES405048A Expired ES405048A1 (en) 1971-07-21 1972-07-21 Phenothiazine derivatives
ES407867A Expired ES407867A1 (en) 1971-07-21 1972-10-23 Phenothiazine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES405048A Expired ES405048A1 (en) 1971-07-21 1972-07-21 Phenothiazine derivatives

Country Status (11)

Country Link
JP (1) JPS5619349B1 (en)
AR (2) AR193118A1 (en)
AT (1) AT317234B (en)
AU (1) AU458571B2 (en)
BE (1) BE786583A (en)
CH (1) CH541578A (en)
DE (1) DE2235998C3 (en)
ES (2) ES405048A1 (en)
FR (1) FR2146150B1 (en)
GB (1) GB1333700A (en)
NL (1) NL7209698A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014105655A1 (en) 2012-12-24 2014-07-03 Neurogastrx, Inc. Methods for treating gi tract disorders
US9844554B2 (en) * 2014-06-24 2017-12-19 Neurogastrx, Inc. Prodrugs of metopimazine
US10836757B1 (en) 2020-04-02 2020-11-17 Neurogastrx, Inc. Polymorphic forms of metopimazine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL99690C (en) * 1956-11-15
DE1092476B (en) * 1958-04-24 1960-11-10 Rhone Poulenc Sa Process for the preparation of phenthiazine derivatives

Also Published As

Publication number Publication date
AR193181A1 (en) 1973-03-30
FR2146150B1 (en) 1974-09-06
GB1333700A (en) 1973-10-10
DE2235998A1 (en) 1973-02-01
DE2235998B2 (en) 1981-04-02
AU458571B2 (en) 1975-02-27
FR2146150A1 (en) 1973-03-02
AT317234B (en) 1974-08-26
AU4474172A (en) 1974-01-24
CH541578A (en) 1973-09-15
AR193118A1 (en) 1973-03-30
BE786583A (en) 1973-01-22
DE2235998C3 (en) 1982-01-07
ES405048A1 (en) 1975-07-16
NL7209698A (en) 1973-01-23
JPS5619349B1 (en) 1981-05-07

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