ES8206509A1 - Procedimiento de fabricacion y de aplicacion de derivados iridoides reactivos - Google Patents
Procedimiento de fabricacion y de aplicacion de derivados iridoides reactivosInfo
- Publication number
- ES8206509A1 ES8206509A1 ES504702A ES504702A ES8206509A1 ES 8206509 A1 ES8206509 A1 ES 8206509A1 ES 504702 A ES504702 A ES 504702A ES 504702 A ES504702 A ES 504702A ES 8206509 A1 ES8206509 A1 ES 8206509A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- atoms
- oxa
- bicyclo
- ene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- ZIWPQHNMPZBHOU-UHFFFAOYSA-N 4,4a,5,6-tetrahydro-3h-cyclopenta[c]pyran-7-one Chemical class C1COC=C2C(=O)CCC21 ZIWPQHNMPZBHOU-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- -1 benzoyl- Chemical group 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- LHDWRKICQLTVDL-PZYDOOQISA-N catalpol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@@H]2[C@@]3(CO)O[C@H]3[C@@H](O)[C@@H]2C=CO1 LHDWRKICQLTVDL-PZYDOOQISA-N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- LHDWRKICQLTVDL-UHFFFAOYSA-N methyl iridoid glycoside Natural products OC1C(O)C(O)C(CO)OC1OC1C2C3(CO)OC3C(O)C2C=CO1 LHDWRKICQLTVDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005445 natural material Substances 0.000 abstract 1
- 229940127293 prostanoid Drugs 0.000 abstract 1
- 150000003814 prostanoids Chemical class 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 125000005147 toluenesulfonyl group Chemical group C=1(C(=CC=CC1)S(=O)(=O)*)C 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
Abstract
PROCEDIMENTO PARA LA OBTENCION DE DERIVADOS IRIDOIDES DE FORMULA (I), EN LA QUE R PUEDE SER UNO DE VARIOS TIPOS DE RADICALES. CONSISTE EN LA ACILACION DE CATALPOL, EXTRAIDO DE LA PICRORHIZA KURREA, CON ANHIDRIDO DE UN ACIDO CARBONICO C2-6, EN UN DISOLVENTE INERTE, TAL COMO PIRIDINA ANHIDRA; SEGUIDA DE HIDROGENACION CATALITICA Y TRANSFORMACION EN 6-8-DIHIDROXI-8-HIDROXIMETIL-1-IRIDANIL-1''-B-D-GLUCOPIRANOSIDO POR DIVISION DE EPOXIDOS ZONALMENTE SELECTIVA MEDIANTE REDUCCION CON ALANATO DE LITIO; OXIDACION DEL PRODUCTO OBTENIDO CON ACIDO PERYODICO A SUS SALES, O TETRACETATO DE PLOMO, Y SATURACION DE LA DISOLUCION CON UNA BASE DEBIL, TAL COMO BICARBONATO. ESTOS COMPUESTOS TIENE APLICACIONES COMO PRODUCTOS INTERMEDIOS PARA LA SINTESIS DE SUSTANCIAS NATURALES, TALES COMO PROSTANOIDES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3030477A DE3030477C2 (de) | 1980-08-12 | 1980-08-12 | Iridoid-Derivate, Verfahren zu ihrer Herstellung und deren Verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8206509A1 true ES8206509A1 (es) | 1982-08-16 |
| ES504702A0 ES504702A0 (es) | 1982-08-16 |
Family
ID=6109452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES504702A Granted ES504702A0 (es) | 1980-08-12 | 1981-08-12 | Procedimiento de fabricacion y de aplicacion de derivados iridoides reactivos |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4401825A (es) |
| EP (1) | EP0045837B1 (es) |
| JP (1) | JPS6056715B2 (es) |
| AT (1) | ATE9469T1 (es) |
| CA (1) | CA1185252A (es) |
| DE (1) | DE3030477C2 (es) |
| ES (1) | ES504702A0 (es) |
| IE (1) | IE51532B1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0144459A1 (de) * | 1983-12-09 | 1985-06-19 | Dr. Willmar Schwabe GmbH & Co. | Prostaglandine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| US4912235A (en) * | 1983-12-22 | 1990-03-27 | Syntex (U.S.A.) Inc. | Processes and intermediates for making 16-phenoxy- and 16-substituted phenoxy-prostatrienoic acid derivatives and their stereoisomers |
| US4600785A (en) * | 1983-12-22 | 1986-07-15 | Syntex (U.S.A.) Inc. | Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
| US4804787A (en) * | 1983-12-22 | 1989-02-14 | Syntex (U.S.A.) Inc. | Processes and intermediates for making 16-phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives |
| EP0159695B1 (en) * | 1984-04-23 | 1989-12-27 | Kyowa Hakko Kogyo Co., Ltd. | Cyclopentenone compound and process for production thereof |
| JPS60224684A (ja) * | 1984-04-23 | 1985-11-09 | Kyowa Hakko Kogyo Co Ltd | シクロペンテノン化合物及びその製造法 |
| JPH02107162A (ja) * | 1988-10-15 | 1990-04-19 | Suntory Ltd | 乳化物のゲル化方法 |
| US5270446A (en) * | 1989-04-04 | 1993-12-14 | Suntory Limited | Decolorized crosslinked products and method for decolorization of crosslinked products |
| CN1020794C (zh) * | 1990-09-15 | 1993-05-19 | 浙江瑞安永久机电研究所 | 反冲过滤阀 |
| US5145955A (en) * | 1991-10-28 | 1992-09-08 | Council Of Scientific & Industrial Research | Process for the preparation and composition of a fraction containing picroside I and kutkoside |
| US20050222053A1 (en) * | 2003-10-31 | 2005-10-06 | Health Research, Inc. | Iridoid-saccharide compound and method of using same |
| US20080032939A1 (en) * | 2004-10-28 | 2008-02-07 | Health Research, Inc. | Iridoid-saccharide compound and method of using same |
| BR102017003318A2 (pt) * | 2017-02-17 | 2018-10-30 | Aché Laboratórios Farmacêuticos S.A. | compostos, processo de produção de compostos, extrato enriquecido, frações ativas de extrato enriquecido, processo de produção de extrato enriquecido, método de seleção de biomassa vegetal para produção de extrato enriquecido, composição e uso para tratamento de desordens imunológicas |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE579766A (es) * | 1958-06-18 | |||
| DE1768069A1 (de) * | 1968-03-28 | 1971-07-29 | Kali Chemie Ag | Cyclopenta(c)pyrane |
-
1980
- 1980-08-12 DE DE3030477A patent/DE3030477C2/de not_active Expired
-
1981
- 1981-06-03 EP EP81104248A patent/EP0045837B1/de not_active Expired
- 1981-06-03 AT AT81104248T patent/ATE9469T1/de not_active IP Right Cessation
- 1981-07-08 CA CA000381345A patent/CA1185252A/en not_active Expired
- 1981-07-23 US US06/285,989 patent/US4401825A/en not_active Expired - Fee Related
- 1981-08-11 IE IE1827/81A patent/IE51532B1/en unknown
- 1981-08-12 ES ES504702A patent/ES504702A0/es active Granted
- 1981-08-12 JP JP56125399A patent/JPS6056715B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6056715B2 (ja) | 1985-12-11 |
| ATE9469T1 (de) | 1984-10-15 |
| DE3030477C2 (de) | 1986-10-16 |
| CA1185252A (en) | 1985-04-09 |
| IE811827L (en) | 1982-02-12 |
| EP0045837A1 (de) | 1982-02-17 |
| US4401825A (en) | 1983-08-30 |
| JPS5754183A (es) | 1982-03-31 |
| DE3030477A1 (de) | 1982-04-01 |
| EP0045837B1 (de) | 1984-09-19 |
| ES504702A0 (es) | 1982-08-16 |
| IE51532B1 (en) | 1987-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000301 |