ES2009925A6 - Procedimiento para preparar nuevos tetrahidrofuranos y tetrahidrotiofenos. - Google Patents

Procedimiento para preparar nuevos tetrahidrofuranos y tetrahidrotiofenos.

Info

Publication number
ES2009925A6
ES2009925A6 ES8801675A ES8801675A ES2009925A6 ES 2009925 A6 ES2009925 A6 ES 2009925A6 ES 8801675 A ES8801675 A ES 8801675A ES 8801675 A ES8801675 A ES 8801675A ES 2009925 A6 ES2009925 A6 ES 2009925A6
Authority
ES
Spain
Prior art keywords
tetrahydrothiophenes
tetrahydrofurans
alkyl ammonium
methoxy alkyl
paf agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8801675A
Other languages
English (en)
Inventor
Jean-Jacques Godfroid
Pierre Braquet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CONSEILS DE RECH ET D APLICATT
Ipsen Pharma SAS
Original Assignee
CONSEILS DE RECH ET D APLICATT
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CONSEILS DE RECH ET D APLICATT, Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical CONSEILS DE RECH ET D APLICATT
Publication of ES2009925A6 publication Critical patent/ES2009925A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVAS TETRAHIDROFURANOS Y TETRAHIDROTIOFENOS DE FORMULA GENERAL: DONDE X REPRESENTA O O S, M ES UN NUMERO ENTERO DE 1 A 11 Y A ES UNA SAL DE PIRIDINIO O AMONIO. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA: CON UN COMPUESTO DE FORMULA NAOB, DONDE B REPRESENTE A O EL PRECURSOR DE A QUE CONTIENE UN GRUPO AMINO, EFECTUANDOSE LA REACCION EN UN DISOLVENTE, TAL COMO DIMETILFORMAMIDA, A UNA TEMPERATURA DE 60 A 80GC. LOS COMPUESTOS OBTENIDOS SON UTILES COMO ANTI-ANAFILACTICOS, ANTI-TROMBOTICOS, ANTI-ISQUEMICOS E INMUNODEPRESORES, ACTUANDO TAMBIEN CONTRA INMUNOALTERACIONES DEL RIÑON, ALERGIAS DE LA PIEL Y ULCERAS INTESTINALES.
ES8801675A 1987-05-29 1988-05-27 Procedimiento para preparar nuevos tetrahidrofuranos y tetrahidrotiofenos. Expired ES2009925A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878712694A GB8712694D0 (en) 1987-05-29 1987-05-29 Tetrahydrofurans etc

Publications (1)

Publication Number Publication Date
ES2009925A6 true ES2009925A6 (es) 1989-10-16

Family

ID=10618140

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8801675A Expired ES2009925A6 (es) 1987-05-29 1988-05-27 Procedimiento para preparar nuevos tetrahidrofuranos y tetrahidrotiofenos.

Country Status (32)

Country Link
US (1) US4888338A (es)
JP (1) JPS63310880A (es)
KR (1) KR960012371B1 (es)
AR (1) AR244223A1 (es)
AT (1) AT396471B (es)
AU (1) AU605717B2 (es)
BE (1) BE1002145A3 (es)
CA (1) CA1318673C (es)
CH (1) CH675123A5 (es)
DE (1) DE3818122C2 (es)
DK (1) DK167678B1 (es)
ES (1) ES2009925A6 (es)
FI (1) FI89354C (es)
FR (2) FR2615855B1 (es)
GB (2) GB8712694D0 (es)
GR (1) GR1000146B (es)
HK (1) HK100490A (es)
IE (1) IE61385B1 (es)
IN (1) IN169649B (es)
IT (1) IT1219697B (es)
LU (1) LU87230A1 (es)
MA (1) MA21288A1 (es)
MY (1) MY103731A (es)
NL (1) NL192573C (es)
NO (1) NO168247C (es)
NZ (1) NZ224776A (es)
OA (1) OA08740A (es)
PT (1) PT87586B (es)
SE (1) SE466448B (es)
SG (1) SG83090G (es)
TN (1) TNSN88050A1 (es)
ZA (1) ZA883732B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8701727D0 (en) * 1987-01-27 1987-03-04 Scras Tetrahydrofuran derivatives
GB8712693D0 (en) * 1987-05-29 1987-07-01 Scras Tetrahydrofurans etc
ES2010568A6 (es) * 1988-08-04 1989-11-16 Uriach & Cia Sa J Procedimiento para la obtencion de derivados 2,5-disustituidos de tetrahidrofurano.
JP2805006B2 (ja) * 1991-08-29 1998-09-30 財団法人 工業技術研究院 チオフェン系化合物及びその薬理的に許容できる塩類よりなる医薬
KR100836547B1 (ko) * 2002-01-11 2008-06-10 상꾜 가부시키가이샤 아미노 알코올 유도체 또는 포스폰산 유도체 및 이들을함유하는 의약 조성물
WO2005079788A1 (ja) 2004-02-24 2005-09-01 Sankyo Company, Limited アミノアルコール化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1088880A (en) * 1964-11-18 1967-10-25 Vantorex Ltd ª‡-cycloalkyleneimino-substituted esters
US4289884A (en) * 1979-01-08 1981-09-15 Shell Oil Company Herbicidal tetrahydrofuran derivatives
DK162882A (da) * 1981-04-13 1982-10-14 Searle & Co Imidazolderivater eller syreadditionssalte deraf,deres fremstilling og anvendelse
DE3408879A1 (de) * 1984-03-10 1985-09-12 Basf Ag, 6700 Ludwigshafen Pyridiniumsalze und diese enthaltende fungizide und bakterizide
GB8701727D0 (en) * 1987-01-27 1987-03-04 Scras Tetrahydrofuran derivatives
GB8712693D0 (en) * 1987-05-29 1987-07-01 Scras Tetrahydrofurans etc
NZ227287A (en) * 1987-12-21 1992-01-29 Merck & Co Inc 2,5-diaryl tetrahydrofurans and medicaments

Also Published As

Publication number Publication date
US4888338A (en) 1989-12-19
BE1002145A3 (fr) 1990-07-31
IT8820772A0 (it) 1988-05-27
NO882336D0 (no) 1988-05-27
FR2615855B1 (fr) 1990-12-28
GB2205315B (en) 1990-08-15
FR2615855A1 (fr) 1988-12-02
NO168247B (no) 1991-10-21
NL192573B (nl) 1997-06-02
FR2615736B1 (fr) 1990-12-28
DK167678B1 (da) 1993-12-06
AU605717B2 (en) 1991-01-17
ATA140688A (de) 1993-01-15
AR244223A1 (es) 1993-10-29
DE3818122A1 (de) 1988-12-15
PT87586B (pt) 1992-09-30
KR960012371B1 (ko) 1996-09-20
SE466448B (sv) 1992-02-17
IE61385B1 (en) 1994-11-02
OA08740A (fr) 1989-03-31
MA21288A1 (fr) 1988-12-31
NL192573C (nl) 1997-10-03
AU1672188A (en) 1988-12-01
GR1000146B (el) 1991-09-27
ZA883732B (en) 1989-02-22
DE3818122C2 (de) 1994-03-03
NL8801314A (nl) 1988-12-16
HK100490A (en) 1990-12-07
LU87230A1 (fr) 1988-12-13
SE8801945L (sv) 1988-11-30
FR2615736A1 (fr) 1988-12-02
DK291188D0 (da) 1988-05-27
NO882336L (no) 1988-11-30
SG83090G (en) 1991-01-18
CA1318673C (en) 1993-06-01
DK291188A (da) 1988-11-30
KR880013929A (ko) 1988-12-22
JPH0561271B2 (es) 1993-09-06
NO168247C (no) 1992-01-29
GR880100341A (en) 1989-02-23
MY103731A (en) 1993-09-30
FI89354B (fi) 1993-06-15
JPS63310880A (ja) 1988-12-19
TNSN88050A1 (fr) 1990-07-10
GB8712694D0 (en) 1987-07-01
NZ224776A (en) 1990-04-26
AT396471B (de) 1993-09-27
CH675123A5 (es) 1990-08-31
FI882476A0 (fi) 1988-05-26
IT1219697B (it) 1990-05-24
GB2205315A (en) 1988-12-07
GB8812487D0 (en) 1988-06-29
FI89354C (fi) 1993-09-27
PT87586A (pt) 1989-05-31
SE8801945D0 (sv) 1988-05-25
IE881600L (en) 1988-11-29
IN169649B (es) 1991-11-30
FI882476A (fi) 1988-11-30

Similar Documents

Publication Publication Date Title
GR3005315T3 (es)
ES2001341A6 (es) Un procedimiento de producir un derivado de acido guanidinometilbenzoico.
ES8307825A1 (es) "un procedimiento para preparar un compuesto de cefem".
MY105538A (en) Derivatives of thieno-triazolo-diazepine, a preparation process of the same and therapeutic compositions containing them.
JPS55115892A (en) 3-phosphonocephalosporanic acid derivative, its preparation, and medicine containing the same
ES8504682A1 (es) Un procedimiento para la preparacion de compuestos nitro alifaticos
PH18498A (en) Novel cephalosporin compounds,pharmaceutical compositions containing same and method of treatment thereof
ES2009925A6 (es) Procedimiento para preparar nuevos tetrahidrofuranos y tetrahidrotiofenos.
ES484718A1 (es) Un procedimiento para la preparacion de benzopiranos.
GR3007401T3 (es)
ES2005504A6 (es) Un procedimiento para preparar nuevos derivados de tetrahidrofurano.
ES8702433A1 (es) Un procedimiento para la preparacion de un compuesto heterociclico sustituido con peptidos.
ES2009924A6 (es) Procedimiento para preparar nuevos tetrahidrofuranos y tetrahidrotiofenos.
GR3030506T3 (en) 1-azaadamantane derivatives as 5-ht agonists or antagonists.
DE3277971D1 (en) Acylamino-4-aza-1-adamantanes, process for their preparation and their therapeutic use
GR3007219T3 (es)
ES8200689A1 (es) Un procedimiento para la produccion de analogos de cefalosporina.
ES2023607A6 (es) Procedimiento de preparacion de derivados de 3-(n-metil-n-alquil)-amino-2-metoximetilen-propan-1-ol".
ES8600636A1 (es) Procedimiento de preparacion de derivados de piperacina
ES8302702A1 (es) Procedimiento para la produccion de nuevos compuestos de lactama.
GB2021588A (en) Bibenzyl Derivatives, the Preparation thereof and Pharmaceutical Compositions Containing them
GB2175584A (en) Kojic acid derivatives and whitening cosmetics containing same
JPS53127443A (en) Organosilicon compounds
ES8101578A1 (es) Procedimiento para la obtencion de un derivado del aldehido 3,4-dihidroxicinamico
ES8602744A1 (es) Procedimiento de obtencion de nuevos derivados -(alquilamino-propionil)-tiofeno sustituidos en el anillo tiofenico

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20041102