ES2010568A6 - Procedimiento para la obtencion de derivados 2,5-disustituidos de tetrahidrofurano. - Google Patents

Procedimiento para la obtencion de derivados 2,5-disustituidos de tetrahidrofurano.

Info

Publication number
ES2010568A6
ES2010568A6 ES8802446A ES8802446A ES2010568A6 ES 2010568 A6 ES2010568 A6 ES 2010568A6 ES 8802446 A ES8802446 A ES 8802446A ES 8802446 A ES8802446 A ES 8802446A ES 2010568 A6 ES2010568 A6 ES 2010568A6
Authority
ES
Spain
Prior art keywords
new
tetrahydrofuran derivatives
paf
relates
disubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8802446A
Other languages
English (en)
Inventor
Javier Bartroli
Manuel Anguita
Elena Carcewler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES8802446A priority Critical patent/ES2010568A6/es
Priority to EP19890114482 priority patent/EP0353777A3/en
Publication of ES2010568A6 publication Critical patent/ES2010568A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS 2,5-DISISTITUIDOS DE TETRAHIDROFURANO, DE FORMULA (I), EN DONDE R1 ES UN ALQUILO DE CADENA LARGA; Z ES ENLACE COVALENTE, UN OXIGENO O UN GRUPO AMINOCARBONILOXI; Y ES ENLACE COVALENTE, UN GRUPO CARBONILO O GRUPO CARBONILAMINO; N ES NUMERO ENTERO ENTRE 0 Y 10; M VALE CERO O NUMERO ENTERO ENTRE 2 Y 8; P VALE 0 O 1; Q ES UN HETEROCICLO NITROGENADO; Q ES 1 O 0, Y A ES UN ANION FARMACEUTICAMENTE ACEPTABLE. EL PROCEDIMIENTO CONSISTE EN QUE UN MONOALCOHOL DE FORMULA (II) SE HACE REACCIONAR CON UN REACTIVO EQUIVALENTE-A-FOSFENO EN PRESENCIA DE UN DISOLVENTE Y UNA BASE CAPTADORA DE PROTONES, A 0-50GC, DURANTE 30 MINUTOS-24 HORAS. EL PRODUCTO DE REACCION SE TRATA CON UNA AMINA H2N-(CH2)-Q, Y SI SE DESEA, TRAS UNA TRANSFORMACION DE LA FUNCION CARBAMATO, SE CUATERNIZA EL NITROGENO NO CUATERNARIO PARA DAR EL PRODUCTO IONICO I. ESTOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES EN LAS QUE EL PAF (FACTOR ACTIVANTE DE LAS PLAQUETAS) SE HALLA INVOLUCRADO.
ES8802446A 1988-08-04 1988-08-04 Procedimiento para la obtencion de derivados 2,5-disustituidos de tetrahidrofurano. Expired ES2010568A6 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES8802446A ES2010568A6 (es) 1988-08-04 1988-08-04 Procedimiento para la obtencion de derivados 2,5-disustituidos de tetrahidrofurano.
EP19890114482 EP0353777A3 (en) 1988-08-04 1989-08-04 New 2,5-disubstituted tetrahydrofuran derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8802446A ES2010568A6 (es) 1988-08-04 1988-08-04 Procedimiento para la obtencion de derivados 2,5-disustituidos de tetrahidrofurano.

Publications (1)

Publication Number Publication Date
ES2010568A6 true ES2010568A6 (es) 1989-11-16

Family

ID=8257616

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8802446A Expired ES2010568A6 (es) 1988-08-04 1988-08-04 Procedimiento para la obtencion de derivados 2,5-disustituidos de tetrahidrofurano.

Country Status (2)

Country Link
EP (1) EP0353777A3 (es)
ES (1) ES2010568A6 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9009469D0 (en) * 1990-04-27 1990-06-20 British Bio Technology Compounds
FR2662606A1 (fr) * 1990-06-01 1991-12-06 Rhone Poulenc Sante Compositions pharmaceutiques pour le traitement de la fibrillation ventriculaire, du syndrome de menace de l'infarctus du myocarde et de l'angine de poitrine contenant le n-(benzoyl-3 phenyl) (pyridyl-3)-3 1h,3h-pyrrolo[1,2-c]thiazolecarboxamide-7.
GB9114337D0 (en) * 1991-07-03 1991-08-21 British Bio Technology Compounds
EP2128226A1 (en) * 2008-05-19 2009-12-02 Furanix Technologies B.V Fuel component
MX2015016958A (es) * 2013-06-12 2016-04-25 Archer Daniels Midland Co Sintesis de dicarbamatos de isohexida y derivados de estos.
EP3083576A4 (en) * 2013-12-19 2017-08-02 Archer Daniels Midland Co. Mono- and dialkyl ethers of furan-2,5-dimethanol and (tetra-hydrofuran-2,5-diyl)dimethanol and amphiphilic derivatives thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539332A (en) * 1983-11-14 1985-09-03 Merck & Co., Inc. 2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists
EP0178261A3 (en) * 1984-10-10 1986-12-30 Sandoz Ag Substituted 2-furanyl or 5-oxo-2-furanyl-alkoxy phosphoryl alkyl cyclimmonium salts
GB8712694D0 (en) * 1987-05-29 1987-07-01 Scras Tetrahydrofurans etc
GB8712693D0 (en) * 1987-05-29 1987-07-01 Scras Tetrahydrofurans etc
US4997843A (en) * 1987-10-13 1991-03-05 J Uriach & Cia S.A. 2,4-disubstituted derivatives of tetrahydrofuran useful for the treatment of PAF mediated illnesses

Also Published As

Publication number Publication date
EP0353777A3 (en) 1991-04-03
EP0353777A2 (en) 1990-02-07

Similar Documents

Publication Publication Date Title
FI954130A0 (fi) Heterosykliset yhdisteet ja niiden valmistus ja käyttö
ZA916579B (en) Heterocyclic compounds and their preparation and use
MY108119A (en) Imidazoylalkyl substutited with a six or seven membered heterocyclic ring containing two nitrogen atoms
CA2126086A1 (en) Imidazoylalkyl Substituted with a Six Membered Nitrogen Containing Heterocyclic Ring
ZA916580B (en) Heterocyclic compounds and their preparation and use
ES2036926A1 (es) "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina".
CA2157792A1 (en) N-(3-piperidinyl-carbonyl)-beta-alanine derivatives as paf antagonists
EP0229444A3 (en) Medicaments for the treatment of anxiety
ES2010568A6 (es) Procedimiento para la obtencion de derivados 2,5-disustituidos de tetrahidrofurano.
IE881086L (en) Aliphatic carboxamides
DE69217511D1 (de) Pyridazindionderivate, ihre Herstellung und Verwendung als Arzneimittel
CA2078869A1 (en) Pharmaceutical compositions containing ipriflavone, process for the preparation thereof and relative therapeutic use
AU581855B2 (en) 1-(4'-alkylsulphonylphenyl)-2-amino-1, 3-propanediol n-substituted derivatives
MY103289A (en) New 5-(w-ammonio acyloxy methylene) tetrahydrofurans and tetrahydrothiophenes
RU95109891A (ru) 19,11-перекрытые мостиками 4-эстрены, способ их получения, содержащая их фармацевтическая композиция и промежуточные соединения для их получения
AU581856B2 (en) 1-(4'-alkylthiophenyl)-2-amino-1, 3-propanediol N-substituted derivatives
FR2672888B1 (fr) Nouvelles urees et thiourees, leur preparation et leur application en therapeutique.
EP0090552A3 (en) Pentacyclic compounds
ES8307711A1 (es) "procedimiento para la preparacion de un nuevo derivado de alquilenodiamina".
CA2157579A1 (en) Heterocyclic compounds, their use and preparation
ATE63552T1 (de) Pyrimido(4,5-g)chinoline, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen.
RU93049414A (ru) Производные бенз(е)индена

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001009