ES8307825A1 - "un procedimiento para preparar un compuesto de cefem". - Google Patents

"un procedimiento para preparar un compuesto de cefem".

Info

Publication number
ES8307825A1
ES8307825A1 ES514654A ES514654A ES8307825A1 ES 8307825 A1 ES8307825 A1 ES 8307825A1 ES 514654 A ES514654 A ES 514654A ES 514654 A ES514654 A ES 514654A ES 8307825 A1 ES8307825 A1 ES 8307825A1
Authority
ES
Spain
Prior art keywords
processes
preparation
cephem compounds
compound
new cephem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES514654A
Other languages
English (en)
Other versions
ES514654A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES8307825A1 publication Critical patent/ES8307825A1/es
Publication of ES514654A0 publication Critical patent/ES514654A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE CEFEM Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R>1 ES AMINO O AMINO PROTEGIDO; R>2 ES UN GRUPO HETEROMONOCICLICO DE 4-8 MIEMBROS QUE TIENE UN ATOMO DE AZUFRE; R>3 ES CARBOXI O CARBOXI PROTEGIDO; Y R>4>C PUEDE SER VARIOS RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), O UNA DE SUS SALES, CON UN COMPUESTO DE FORMULA R>4>B, O UN DERIVADO REACTIVO DEL MISMO, FORMULAS EN LAS QUE Y ES UN GRUPO QUE PUEDE ESTAR SUSTITUIDO CON R>4>C, R>4>B ES UN TIOL HETEROCICLICO O PIRIDINA SUSTITUIDA O SIN SUSTITUIR, Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, A LA TEMPERATURA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS ACTIVIDADES ANTIMICROBIANAS.
ES514654A 1980-09-08 1982-08-02 "un procedimiento para preparar un compuesto de cefem". Granted ES514654A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8028933 1980-09-08

Publications (2)

Publication Number Publication Date
ES8307825A1 true ES8307825A1 (es) 1983-07-01
ES514654A0 ES514654A0 (es) 1983-07-01

Family

ID=10515925

Family Applications (2)

Application Number Title Priority Date Filing Date
ES505257A Expired ES8303423A1 (es) 1980-09-08 1981-09-07 Un procedimiento para preparar compuestos de cefem
ES514654A Granted ES514654A0 (es) 1980-09-08 1982-08-02 "un procedimiento para preparar un compuesto de cefem".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES505257A Expired ES8303423A1 (es) 1980-09-08 1981-09-07 Un procedimiento para preparar compuestos de cefem

Country Status (6)

Country Link
US (2) US4416879A (es)
EP (2) EP0184227B1 (es)
JP (2) JPS5777689A (es)
AT (2) ATE27956T1 (es)
DE (2) DE3176274D1 (es)
ES (2) ES8303423A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405617A (en) * 1980-02-11 1983-09-20 Fujisawa Pharmaceutical Co., Ltd. 3-(Propynyltetrazol)thiomethyl-3-cephems
US4416879A (en) * 1980-09-08 1983-11-22 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
IL69246A (en) * 1982-08-07 1986-07-31 Tanabe Seiyaku Co 7-((2-aminothiazolyl-2-pyrrolidonyl or(piperidonyl)-oxyimino)acetamido)cephem carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
JPS5946292A (ja) * 1982-09-09 1984-03-15 Otsuka Chem Co Ltd ２−置換セフエム誘導体の製造法
US4608373A (en) * 1982-12-13 1986-08-26 Yamanouchi Pharmaceutical Co., Ltd. Cephem compounds
DE3585434D1 (de) * 1984-12-27 1992-04-02 Banyu Pharma Co Ltd Cephalosporinverbindungen.
US4814328A (en) * 1986-03-19 1989-03-21 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, and antibacterial agents
US6559430B2 (en) 2001-01-04 2003-05-06 General Mills, Inc. Foil edge control for microwave heating
US20130065874A1 (en) 2011-09-09 2013-03-14 Cubist Pharmaceuticals, Inc. Methods for treating intrapulmonary infections
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US20140274997A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Cephalosporin pharmaceutical compositions
CA2906151A1 (en) 2013-03-15 2014-09-18 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
WO2015035376A2 (en) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
DE2716677C2 (de) 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
DE2967356D1 (en) * 1978-07-17 1985-02-28 Fujisawa Pharmaceutical Co Cephalosporin derivatives, process for their preparation and pharmaceutical compositions containing them
US4284631A (en) * 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
GB2028305A (en) * 1978-08-03 1980-03-05 Hoechst Ag Cephem derivatives and processes for their manufacture
HU183006B (en) * 1978-12-29 1984-04-28 Fujisawa Pharmaceutical Co Process for producing 7-substituted-3-cepheme- and cephame-4-carboxylic acid derivatives
US4416879A (en) * 1980-09-08 1983-11-22 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds

Also Published As

Publication number Publication date
EP0184227A1 (en) 1986-06-11
DE3176274D1 (en) 1987-07-30
EP0047491A2 (en) 1982-03-17
ES505257A0 (es) 1983-02-01
ES8303423A1 (es) 1983-02-01
DE3177159D1 (de) 1990-04-05
US4533738A (en) 1985-08-06
ATE50575T1 (de) 1990-03-15
ATE27956T1 (de) 1987-07-15
JPS5777689A (en) 1982-05-15
ES514654A0 (es) 1983-07-01
EP0047491B1 (en) 1987-06-24
JPH0327552B2 (es) 1991-04-16
JPS6393781A (ja) 1988-04-25
US4416879A (en) 1983-11-22
EP0184227B1 (en) 1990-02-28
JPH0158191B2 (es) 1989-12-11
EP0047491A3 (en) 1983-03-16

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