EP4234062A3 - Verfahren zur elektrosprayionisation von mit amphipathischen, stark basischen einheiten modifizierten glykanen - Google Patents

Verfahren zur elektrosprayionisation von mit amphipathischen, stark basischen einheiten modifizierten glykanen Download PDF

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Publication number
EP4234062A3
EP4234062A3 EP23181382.5A EP23181382A EP4234062A3 EP 4234062 A3 EP4234062 A3 EP 4234062A3 EP 23181382 A EP23181382 A EP 23181382A EP 4234062 A3 EP4234062 A3 EP 4234062A3
Authority
EP
European Patent Office
Prior art keywords
electrospray ionization
amphipathic
glycans
solutions
strongly basic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23181382.5A
Other languages
English (en)
French (fr)
Other versions
EP4234062A2 (de
Inventor
Darryl W. Brousmiche
Matthew A. Lauber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Waters Technologies Corp
Original Assignee
Waters Technologies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Waters Technologies Corp filed Critical Waters Technologies Corp
Publication of EP4234062A2 publication Critical patent/EP4234062A2/de
Publication of EP4234062A3 publication Critical patent/EP4234062A3/de
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/12—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3847—Multimodal interactions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N2030/067—Preparation by reaction, e.g. derivatising the sample
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8836—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving saccharides
EP23181382.5A 2016-06-21 2017-06-19 Verfahren zur elektrosprayionisation von mit amphipathischen, stark basischen einheiten modifizierten glykanen Pending EP4234062A3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662352755P 2016-06-21 2016-06-21
PCT/US2017/038073 WO2017222955A1 (en) 2016-06-21 2017-06-19 Methods of electrospray ionization of glycans modified with amphipathic, strongly basic moieties
EP17815988.5A EP3472621A4 (de) 2016-06-21 2017-06-19 Verfahren zur elektrosprayionisation von mit amphipathischen, stark basischen einheiten modifizierten glykanen

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP17815988.5A Division EP3472621A4 (de) 2016-06-21 2017-06-19 Verfahren zur elektrosprayionisation von mit amphipathischen, stark basischen einheiten modifizierten glykanen

Publications (2)

Publication Number Publication Date
EP4234062A2 EP4234062A2 (de) 2023-08-30
EP4234062A3 true EP4234062A3 (de) 2023-10-25

Family

ID=60784046

Family Applications (2)

Application Number Title Priority Date Filing Date
EP23181382.5A Pending EP4234062A3 (de) 2016-06-21 2017-06-19 Verfahren zur elektrosprayionisation von mit amphipathischen, stark basischen einheiten modifizierten glykanen
EP17815988.5A Withdrawn EP3472621A4 (de) 2016-06-21 2017-06-19 Verfahren zur elektrosprayionisation von mit amphipathischen, stark basischen einheiten modifizierten glykanen

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP17815988.5A Withdrawn EP3472621A4 (de) 2016-06-21 2017-06-19 Verfahren zur elektrosprayionisation von mit amphipathischen, stark basischen einheiten modifizierten glykanen

Country Status (4)

Country Link
US (1) US11035832B2 (de)
EP (2) EP4234062A3 (de)
CN (1) CN109642906A (de)
WO (1) WO2017222955A1 (de)

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Title
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MICHAEL KIMZEY ET AL: "Development of an Instant Glycan Labeling Dye for High Throughput Analysis by Mass Spectrometry", vol. V2-r2, 31 May 2015 (2015-05-31), pages 1 - 4, XP009525792, Retrieved from the Internet <URL:https://www.europa-bioproducts.com/productsheets/IPC_Glycan-Labeling-Dye-2015_handout_v3_r2.pdf> *
WATERS: "BEST PRACTICES IN THE ANALYSIS OF RAPIFLUOR-MS LABELED GLYCANS USING THE ACQUITY QDa DETECTOR (PERFORMANCE MODEL)", 1 March 2016 (2016-03-01), XP055659864, Retrieved from the Internet <URL:https://www.gimitec.com//file/720005655en.pdf> [retrieved on 20200121] *

Also Published As

Publication number Publication date
EP3472621A4 (de) 2020-03-04
US20190219548A1 (en) 2019-07-18
CN109642906A (zh) 2019-04-16
US11035832B2 (en) 2021-06-15
WO2017222955A1 (en) 2017-12-28
EP3472621A1 (de) 2019-04-24
EP4234062A2 (de) 2023-08-30

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