EP2714073B1 - Vaccin anticancéreux de génération d'antigène in situ - Google Patents
Vaccin anticancéreux de génération d'antigène in situ Download PDFInfo
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- EP2714073B1 EP2714073B1 EP12792161.7A EP12792161A EP2714073B1 EP 2714073 B1 EP2714073 B1 EP 2714073B1 EP 12792161 A EP12792161 A EP 12792161A EP 2714073 B1 EP2714073 B1 EP 2714073B1
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Claims (15)
- Composition comprenant(a) un chimioattractant de cellules cancéreuses et une composition induisant une cytotoxicité, et(b) une composition de recrutement de cellules dentritiques,pour une utilisation dans le traitement de cancer,
dans laquelle le chimioattractant de cellules cancéreuses et la composition induisant une cytotoxicité sont compris dans une première zone d'un échafaudage tridimensionnel poreux, et la composition de recrutement de cellules dendritiques est comprise dans une deuxième zone, dans laquelle ledit échafaudage est administré à un sujet chez lequel un cancer a été diagnostiqué et maintenu in situ pendant une période de temps suffisante pour accumuler une cellule cancéreuse circulante pour obtenir un échafaudage contenant une cellule cancéreuse ; dans laquelle
ledit échafaudage contenant une cellule cancéreuse est mis en contact avec un élément cytotoxique ou cytolytique pour la disruption de ladite cellule cancéreuse résidant dans la première zone, ce qui permet de produire un antigène tumoral traité sans nécessité d'une biopsie ; et dans laquelle
ledit échafaudage fournit une résidence temporaire pour charger une cellule dendritique recrutée dans l'échafaudage avec ledit antigène tumoral traité. - Composition pour une utilisation selon la revendication 1, dans laquelle ledit échafaudage contenant une cellule est mis en contact avec une chaleur externe, un ultrason, un rayonnement laser ou un rayonnement gamma.
- Composition pour une utilisation selon la revendication 1, dans laquelle ladite composition induisant une cytotoxicité comprend une composition induisant une hyperthermie.
- Composition pour une utilisation selon la revendication 3, dans laquelle(a) ladite composition induisant une hyperthermie comprend une nanoparticule magnétique, et dans laquelle ledit élément cytotoxique ou cytolytique comprend un champ alternativement magnétique qui induit une hyperthermie locale in situ, ce qui permet la disruption de ladite cellule cancéreuse et la production d'un antigène tumoral traité, ou(b) ladite composition induisant une hyperthermie comprend une nanoparticule proche infrarouge (NIR) sélectionnée dans le groupe constitué d'une nanotige d'or, une nanocoquille d'or, une nanocage d'or, une nanoparticule de métal noble, un nanotube de carbone, une nanoparticule de carbone et une nanoparticule de graphite, et dans laquelle ledit élément cytotoxique ou cytolytique comprend un rayonnement NIR qui induit une hyperthermie locale in situ, ce qui permet la disruption de ladite cellule cancéreuse et la production d'un antigène tumoral traité.
- Composition pour une utilisation selon la revendication 1, dans laquelle ledit chimioattractant de cellules cancéreuses comprend une chimiokine sélectionnée dans le groupe constitué de CCL-21, CCL-19, SDF-1, VEGF et IL-4.
- Composition pour une utilisation selon l'une quelconque des revendications précédentes, dans laquelle ledit cancer est caractérisé par des cellules tumorales circulantes.
- Composition pour une utilisation selon l'une quelconque des revendications précédentes, dans laquelle(i) ledit cancer est un état cancéreux métastatique, un cancer hématologique ou un cancer du système cardiovasculaire ; ou(ii) ladite cellule cancéreuse comprend une cellule de cancer hématologique, une leucémie, une cellule cancéreuse primaire circulante ou une cellule cancéreuse métastatique.
- Composition pour une utilisation selon la revendication 7, dans laquelle ledit cancer est un cancer hématologique ou un cancer du système cardiovasculaire, et dans laquelle le cancer hématologique ou le cancer du système cardiovasculaire est une leucémie.
- Composition pour une utilisation selon la revendication 1, dans laquelle ladite deuxième zone ne comprend pas de composition induisant une cytotoxicité.
- Dispositif de traitement d'un antigène tumoral comprenant un échafaudage polymère tridimensionnel poreux, ledit échafaudage comprenant :(a) une première zone comprenant un chimioattractant pour cellules cancéreuses et une composition induisant une cytotoxicité, et(b) une deuxième zone comprenant une composition de recrutement de cellules dendritiques,dans lequel ladite première zone fournit un compartiment pour tuer des cellules cancéreuses résidant dans ladite première zone ; et
dans lequel ledit échafaudage fournit une résidence temporaire pour charger une cellule dendritique recrutée dans l'échafaudage avec un antigène tumoral traité dérivé de cellules cancéreuses tuées. - Dispositif selon la revendication 10, dans lequel ladite composition induisant une cytotoxicité comprend une particule induisant une hyperthermie.
- Dispositif selon la revendication 10, dans lequel ladite composition de recrutement de cellules dendritiques comprend un facteur stimulant les colonies de granulocytes et de macrophages.
- Dispositif selon la revendication 10, dans lequel ladite deuxième zone ne comprend pas la composition induisant une cytotoxicité.
- Dispositif selon la revendication 10, dans lequel ladite première zone est configurée sous la forme d'un noyau et ladite deuxième zone est configurée sous la forme d'une enveloppe.
- Dispositif selon la revendication 11, dans lequel ladite composition induisant une hyperthermie(a) comprend une nanoparticule magnétique ; ou(b) comprend une nanoparticule absorbant le proche infrarouge (NIR) sélectionnée dans le groupe constitué d'une nanotige d'or, une nanocoquille d'or, une nanocage d'or, une nanoparticule de métal noble, un nanotube de carbone, une nanoparticule de carbone et une nanoparticule de graphite.
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| US201161493398P | 2011-06-03 | 2011-06-03 | |
| PCT/US2012/040687 WO2012167230A1 (fr) | 2011-06-03 | 2012-06-04 | Vaccin anticancéreux de génération d'antigène in situ |
Publications (3)
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| EP2714073A1 EP2714073A1 (fr) | 2014-04-09 |
| EP2714073A4 EP2714073A4 (fr) | 2014-12-31 |
| EP2714073B1 true EP2714073B1 (fr) | 2021-03-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| EP12792161.7A Active EP2714073B1 (fr) | 2011-06-03 | 2012-06-04 | Vaccin anticancéreux de génération d'antigène in situ |
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| US (2) | US9486512B2 (fr) |
| EP (1) | EP2714073B1 (fr) |
| JP (2) | JP6062426B2 (fr) |
| AU (1) | AU2012261848B2 (fr) |
| CA (1) | CA2838125A1 (fr) |
| WO (1) | WO2012167230A1 (fr) |
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| AU2012261848B2 (en) | 2017-06-15 |
| JP2014518893A (ja) | 2014-08-07 |
| JP6062426B2 (ja) | 2017-01-18 |
| US20140193488A1 (en) | 2014-07-10 |
| US20170182138A1 (en) | 2017-06-29 |
| CA2838125A1 (fr) | 2012-12-06 |
| US9486512B2 (en) | 2016-11-08 |
| AU2012261848A1 (en) | 2013-12-19 |
| WO2012167230A1 (fr) | 2012-12-06 |
| EP2714073A1 (fr) | 2014-04-09 |
| JP2017071638A (ja) | 2017-04-13 |
| US10406216B2 (en) | 2019-09-10 |
| EP2714073A4 (fr) | 2014-12-31 |
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