EP1998180A1 - Réservoir à liquides doté d'un cheminée variable - Google Patents

Réservoir à liquides doté d'un cheminée variable Download PDF

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Publication number
EP1998180A1
EP1998180A1 EP07010826A EP07010826A EP1998180A1 EP 1998180 A1 EP1998180 A1 EP 1998180A1 EP 07010826 A EP07010826 A EP 07010826A EP 07010826 A EP07010826 A EP 07010826A EP 1998180 A1 EP1998180 A1 EP 1998180A1
Authority
EP
European Patent Office
Prior art keywords
liquid
chimney
container
permeable zone
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP07010826A
Other languages
German (de)
English (en)
Inventor
Gottfried Senftner
Markus Winkenbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Roche Diagnostics GmbH filed Critical F Hoffmann La Roche AG
Priority to EP07010826A priority Critical patent/EP1998180A1/fr
Priority to EP08009646.4A priority patent/EP1998181B8/fr
Priority to ES08009646T priority patent/ES2742511T3/es
Priority to US12/127,880 priority patent/US8003053B2/en
Priority to CA2632622A priority patent/CA2632622C/fr
Priority to JP2008142443A priority patent/JP5075018B2/ja
Priority to CN2008100987323A priority patent/CN101314142B/zh
Publication of EP1998180A1 publication Critical patent/EP1998180A1/fr
Priority to HK09104709.5A priority patent/HK1126157A1/xx
Priority to US13/176,139 priority patent/US8153086B2/en
Withdrawn legal-status Critical Current

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Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/08Flasks
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52Containers specially adapted for storing or dispensing a reagent
    • B01L3/523Containers specially adapted for storing or dispensing a reagent with means for closing or opening
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3216Rigid containers disposed one within the other
    • B65D81/3222Rigid containers disposed one within the other with additional means facilitating admixture
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16Reagents, handling or storing thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/046Function or devices integrated in the closure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/046Function or devices integrated in the closure
    • B01L2300/049Valves integrated in closure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0644Valves, specific forms thereof with moving parts rotary valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/065Valves, specific forms thereof with moving parts sliding valves
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation

Definitions

  • the invention relates to a liquid container having an upper opening and with a running into alignment with the upper opening in the container, tubular discharge chimney having a liquid-permeable zone in its lower, the container bottom adjacent end portion.
  • the invention relates to liquid containers used as reagent liquid containers in automatic analyzers.
  • reagent liquid is taken from the liquid containers by automatic pipetting. This is done in a faster cycle in more modern systems to allow high throughput of relevant analysis operations.
  • the liquid container by means of a transport device, for example in the form of a rotor quickly supplied to the pipetting and braked there, whereupon the automatic pipette or suction needle through the upper opening of the liquid container passes into the extraction chimney to suck liquid.
  • a transport device for example in the form of a rotor quickly supplied to the pipetting and braked there, whereupon the automatic pipette or suction needle through the upper opening of the liquid container passes into the extraction chimney to suck liquid.
  • each individual pipetting operation including the positioning of the liquid container in the pipetting zone, has extremely short single-second cycle times.
  • the pipette tip during pipetting should also dip only slightly into the liquid to be pipetted and the level in the liquid container should be as calm as possible. It should also be avoided that the pipette draws air due to a fluctuating liquid level. Furthermore, foaming in the extraction chimney should be suppressed.
  • the state of the art of reaction liquid containers with removal chimney can, for example, on the WO 97/12677 A1 , on the US 5,102,631 or on the DE 38 38 278 C1 to get expelled.
  • the tubular discharge chimney is provided at its upper end with a radially outwardly projecting flange, with which it is suspended from a spout of the container opening.
  • the completely open lower end of the removal chimney extends into the vicinity of the bottom of the liquid container, so that liquid communication between the removal chimney and the surrounding interior region of the liquid container can only take place via a narrow bottom gap through the lower opening of the removal chimney.
  • slit-like wall thickness reductions are provided in the upper region of the extraction chimney, which are intended to allow an influx of air between the mouth of the liquid container and the mantle of the extraction chimney.
  • a liquid container with removal chimney is known in which the cross section of the removal chimney is substantially smaller than the cross section of the upper container opening, wherein this Extraction chimney a screwed with the grommet screw cap penetrated and fixed to this. A through hole in the screw cap allows pressure equalization between the container interior and the external environment.
  • the removal chimney extends into the vicinity of the container bottom, so that liquid exchange between the discharge chimney and the surrounding interior of the container can take place through the open underside of the removal chimney.
  • the outer circumference of the removal chimney at its upper end and the inner circumference of the discharge chimney surrounding at its upper end spout are only slightly different, so that between the outside of the extraction chimney and the inner surface of the spout not sufficiently large ventilation path for pressure equalization between the container interior and the environment remains.
  • a through hole in the jacket of the extraction chimney is provided at its upper end.
  • the removal chimney is substantially completely open at its lower end, with spacer webs being provided at the lower end of the withdrawal chimney.
  • the from the US 5,102,631 known liquid container is similar to the last-mentioned embodiment of the DE 38 38 278 C1 constructed and thus also has a through hole in the jacket of the discharge chimney at the upper end.
  • the extraction chimney extends to the bottom of the liquid container, but large lateral openings are provided in the jacket of the extraction chimney at the lower end.
  • the removal chimney According to the operating principle of the removal chimney, it is provided in the known examples that between the lower end of the removal chimney and the opposite container bottom only a small distance and thus only a narrow flow gap to form a large flow resistance is given, so that fluctuations in the container volume outside the withdrawal chimney as damp as possible in the extraction chimney can affect.
  • the known extraction chimneys thus have at their end adjacent the container bottom end a liquid-permeable zone with a low fluid permeability.
  • the invention has for its object to provide a liquid container of the type mentioned, which can be filled quickly through the upper opening and through the removal chimney and yet in the liquid removal operation, the desired properties of calming the liquid level within the extraction chimney against the fluctuations in the container area outside of the Removal chimney has.
  • the liquid-permeable zone may be e.g. be set so that their fluid permeability is relatively large. After the filling process, the liquid-permeable zone can then be set back into a state with low liquid permeability, so that the removal chimney can fulfill its desired function in the liquid-removal operation of the liquid container.
  • the liquid-permeable zone comprises at least one opening in the lower end region of the extraction chimney, the effective opening cross-section is adjustable, this preferably by a movement, in particular rotational movement and / or lifting movement of the extraction chimney or a part thereof can take place relative to the liquid container bottom.
  • the discharge chimney has a tube section extending downwardly from the upper container opening and a tube receiving the tube section, wherein the tube section and the tube holder are inserted into one another and are adjustable relative to each other to the effective opening cross section of the liquid-permeable Change zone.
  • the liquid-permeable zone lateral openings in the pipe section and lateral openings in the pipe receiving in the lower end of the extraction chimney, wherein lateral openings of the pipe section and lateral openings of the pipe receiving relative to each other in common alignment are aligned to the effective opening cross-section of the liquid-permeable zone.
  • the change in the transmission capacity of the liquid-permeable zone is effected simply by bringing a pipe section of the extraction chimney extending from the upper container opening close to the container bottom closer to the container bottom, so that only a small flow gap between container bottom and lower end of the pipe section remains. This is then the condition of the lower fluid permeability of the liquid-permeable zone.
  • the liquid permeability of the liquid-permeable zone is then increased.
  • the vertical longitudinal section runs centrally through the discharge chimney 3 or 3a.
  • the liquid container 1 is a reagent liquid container which is used in the manner described in the beginning in automatic analyzers.
  • the liquid container 1 has at its upper end a screw cap opening 5, starting from which a pipe section 7 of the discharge chute 3 extends vertically into the container interior.
  • the container bottom 9 has a tube receptacle 11, which has a pot-like shape with two, for example, rectangular, open at the top incisions 13.
  • the incisions 13 are in the direction of the Fig. 1 a and 1b in flight one behind the other on diametrically opposite sides of the tube receptacles eleventh
  • the pipe section 7 is received with its lower end in the pipe receptacle 11, in such a way that it lies with its outer circumference the inner periphery of the pipe receptacle 11 closely adjacent and preferably touching.
  • the pipe receptacle 11 thus forms a pivot bearing for the pipe section 7 of the removal chimney 3, so that the pipe section 7 is rotatable about the vertical axis of rotation 15.
  • lateral cuts 17, which are provided at diametrically opposite regions of the pipe section 7 and do not extend beyond the uppermost edge of the pipe receptacle 11 also upward, are rotated relative to the notches 13 of the pipe receiving.
  • the cuts 17 and 13 represent lateral openings in the pipe section 7 and in the pipe receptacle 11 and together form a liquid-permeable zone 18 of the discharge chimney 3, whose effective opening cross-section depends on the extent to which the lateral openings 17 of the pipe section 7 in common alignment with the lateral openings 13 of the pipe receiving 11 are.
  • Fig. 1a the lateral openings 17 of the pipe section 7 are completely aligned in alignment with the lateral openings 13, so that the openings 13, 17 show a maximum overlap.
  • This is the position of the maximum effective opening cross-section of Liquid-permeable zone 18 of the removal chimney 3. It can take place in this situation, relatively good fluid exchange between the interior of the discharge chimney 3 and the container volume outside the discharge chimney 3, which is important for filling the liquid container 1 through the opening 5 and the discharge chimney 3 therethrough.
  • the liquid passage capacity of the liquid-permeable zone 18 is varied by a lifting movement of the pipe section 7a relative to the vessel bottom 9.
  • the liquid-permeable zone is defined by the annular gap 19, while the discharge chimney pipe section 7a is raised Fig. 2a larger than when lowered extraction chimney pipe section 7a according to Fig. 2b and defined by the crenelated spaces 21.
  • Slings 20 and 22 ensure that defined end positions for the stroke adjustment of the pipe section 7a are possible, as this in the Fig. 2a and 2b can be seen.
  • Fig. 2a shows a provided for filling the container 1 setting the removal chimney 3a.
  • Fig. 2b shows the favorable for the liquid removal operation position of the removal chimney 3a.
  • a variant of the second embodiment with a modification of the lower end of the pipe section 7a is in the Fig. 3a and 3b shown.
  • Fig. 3a and 3b has the pipe section 7a at its lower end four spacer webs 22, which ensure that in the lowered state of the pipe section 7a according to Fig. 3b this is not occlusive with its lower edge on the bottom 9 and also a circumferential portion of the pipe circumference collar 24 maintains a distance from the bottom of the vessel 9, so that the liquid-permeable zone 18 in Fig. 3b with reduced fluid transmission capacity, fluid communication between the interior of the withdrawal chimney 3a. and the container volume can take place outside of the withdrawal chimney.
  • Fig. 3a shows an intended for filling the container 1 setting the. Ent Spotifykamins 3a.
  • Fig. 3b shows the favorable for the liquid removal operation position of the removal chimney 3a.
  • the extraction chimney can e.g. be adjustable by a combined lifting and turning movement. This may in particular be a screwing movement of the removal chimney.
  • the extraction chimney can already be mounted in it before filling the liquid container.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
EP07010826A 2007-05-31 2007-05-31 Réservoir à liquides doté d'un cheminée variable Withdrawn EP1998180A1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP07010826A EP1998180A1 (fr) 2007-05-31 2007-05-31 Réservoir à liquides doté d'un cheminée variable
EP08009646.4A EP1998181B8 (fr) 2007-05-31 2008-05-27 Réservoir à liquides doté d'une cheminée variable
ES08009646T ES2742511T3 (es) 2007-05-31 2008-05-27 Recipiente de líquidos con chimenea variable
US12/127,880 US8003053B2 (en) 2007-05-31 2008-05-28 Liquid container with variable extraction chimney
CA2632622A CA2632622C (fr) 2007-05-31 2008-05-29 Recipient avec cheminee a extraction variable
JP2008142443A JP5075018B2 (ja) 2007-05-31 2008-05-30 可変抽出筒を有する液体容器
CN2008100987323A CN101314142B (zh) 2007-05-31 2008-05-30 带有可变抽取井道的液体容器
HK09104709.5A HK1126157A1 (en) 2007-05-31 2009-05-25 Fluid container with variable extraction chimney
US13/176,139 US8153086B2 (en) 2007-05-31 2011-07-05 Liquid container with variable extraction chimney

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07010826A EP1998180A1 (fr) 2007-05-31 2007-05-31 Réservoir à liquides doté d'un cheminée variable

Publications (1)

Publication Number Publication Date
EP1998180A1 true EP1998180A1 (fr) 2008-12-03

Family

ID=38657241

Family Applications (2)

Application Number Title Priority Date Filing Date
EP07010826A Withdrawn EP1998180A1 (fr) 2007-05-31 2007-05-31 Réservoir à liquides doté d'un cheminée variable
EP08009646.4A Active EP1998181B8 (fr) 2007-05-31 2008-05-27 Réservoir à liquides doté d'une cheminée variable

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP08009646.4A Active EP1998181B8 (fr) 2007-05-31 2008-05-27 Réservoir à liquides doté d'une cheminée variable

Country Status (7)

Country Link
US (2) US8003053B2 (fr)
EP (2) EP1998180A1 (fr)
JP (1) JP5075018B2 (fr)
CN (1) CN101314142B (fr)
CA (1) CA2632622C (fr)
ES (1) ES2742511T3 (fr)
HK (1) HK1126157A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015183977A3 (fr) * 2014-05-27 2016-01-21 Beckman Coulter, Inc. Bouteille de réactif à tuyau d'aspiration
EP3097978B1 (fr) * 2015-05-27 2018-03-28 Siemens Healthcare Diagnostics Products GmbH Récipient de liquide doté d'un dispositif anticlapotis

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2434932A2 (fr) * 2009-05-27 2012-04-04 Kids-kit Cooperative Society Ltd. Tasse pour enfant
JP5242537B2 (ja) * 2009-11-06 2013-07-24 株式会社日立ハイテクノロジーズ 試薬容器、および試薬容器用管体
JP5292325B2 (ja) * 2010-01-28 2013-09-18 株式会社日立ハイテクノロジーズ 試薬容器
AU2013202778A1 (en) 2013-03-14 2014-10-02 Gen-Probe Incorporated Systems, methods, and apparatuses for performing automated reagent-based assays
WO2015069549A1 (fr) 2013-11-05 2015-05-14 Siemens Healthcare Diagnostics Inc. Tube anti-évaporation de récipient de réactif
US9783358B2 (en) * 2015-01-08 2017-10-10 Rajiv Dhand Segmented yogurt container

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE533852A (fr) *
US3139121A (en) * 1961-03-29 1964-06-30 Dosamatic Dropper Corp Liquid dispensing container
DE19536789A1 (de) * 1995-10-02 1997-04-03 Boehringer Mannheim Gmbh Gefäß für Flüssigkeiten
WO2003106292A1 (fr) * 2002-06-12 2003-12-24 Adam Smith Reservoir pour boisson servant a combiner une poudre a un liquide

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JPH0535099Y2 (fr) * 1986-07-04 1993-09-06
DE3838278C1 (en) 1988-11-11 1990-01-18 Eppendorf - Netheler - Hinz Gmbh, 2000 Hamburg, De Reagent dispensing vessel
US5102631A (en) 1989-12-18 1992-04-07 Abbott Laboratories Evaporation chimney
JPH09297146A (ja) * 1996-05-02 1997-11-18 Toa Medical Electronics Co Ltd 液体吸引装置
US5980834A (en) * 1996-07-25 1999-11-09 The United States Of America As Represented By The Secretary Of Commerce Sample storage devices
US6435383B1 (en) * 1998-07-15 2002-08-20 Jung-Min Lee Spout assembly for liquid container
US6959615B2 (en) * 1999-03-05 2005-11-01 Gamble Kimberly R Sample collection and processing device
JP2001322660A (ja) * 2000-05-17 2001-11-20 Yoshida Industry Co Ltd 吐出量調整用中栓
JP2002019855A (ja) * 2000-07-04 2002-01-23 Olympus Optical Co Ltd アダプターおよびアダプター付き容器
US6890484B2 (en) * 2001-05-18 2005-05-10 Acon Laboratories, Inc. In line test device and methods of use
US6726879B2 (en) * 2001-05-21 2004-04-27 Ameditech, Inc. Dual chambered fluid specimen testing device and method
JP4020843B2 (ja) * 2003-09-05 2007-12-12 株式会社日立ハイテクノロジーズ 分析装置及び試薬容器
US20060286004A1 (en) * 2005-06-15 2006-12-21 Jacobs Merrit N Containers for reducing or eliminating foaming

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE533852A (fr) *
US3139121A (en) * 1961-03-29 1964-06-30 Dosamatic Dropper Corp Liquid dispensing container
DE19536789A1 (de) * 1995-10-02 1997-04-03 Boehringer Mannheim Gmbh Gefäß für Flüssigkeiten
WO2003106292A1 (fr) * 2002-06-12 2003-12-24 Adam Smith Reservoir pour boisson servant a combiner une poudre a un liquide

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015183977A3 (fr) * 2014-05-27 2016-01-21 Beckman Coulter, Inc. Bouteille de réactif à tuyau d'aspiration
EA032016B1 (ru) * 2014-05-27 2019-03-29 Бекман Каултер, Инк. Флакон для реактивов со всасывающей трубкой
US10625266B2 (en) 2014-05-27 2020-04-21 Beckman Coulter, Inc. Reagent bottle with aspiration pipe
EP3097978B1 (fr) * 2015-05-27 2018-03-28 Siemens Healthcare Diagnostics Products GmbH Récipient de liquide doté d'un dispositif anticlapotis

Also Published As

Publication number Publication date
US8153086B2 (en) 2012-04-10
EP1998181B8 (fr) 2019-09-11
HK1126157A1 (en) 2009-08-28
CA2632622C (fr) 2011-04-26
CA2632622A1 (fr) 2008-11-30
JP2008298779A (ja) 2008-12-11
JP5075018B2 (ja) 2012-11-14
EP1998181B1 (fr) 2019-06-19
US20080299011A1 (en) 2008-12-04
EP1998181A3 (fr) 2011-02-23
CN101314142B (zh) 2011-04-06
US8003053B2 (en) 2011-08-23
ES2742511T3 (es) 2020-02-14
US20110263039A1 (en) 2011-10-27
CN101314142A (zh) 2008-12-03
EP1998181A2 (fr) 2008-12-03

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