WO1999022787A1 - Appareil a perfusion avec chambre de goutte a goutte et clamp tubulaire - Google Patents

Appareil a perfusion avec chambre de goutte a goutte et clamp tubulaire Download PDF

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Publication number
WO1999022787A1
WO1999022787A1 PCT/EP1998/006945 EP9806945W WO9922787A1 WO 1999022787 A1 WO1999022787 A1 WO 1999022787A1 EP 9806945 W EP9806945 W EP 9806945W WO 9922787 A1 WO9922787 A1 WO 9922787A1
Authority
WO
WIPO (PCT)
Prior art keywords
drip chamber
infusion
air
infusion solution
filter
Prior art date
Application number
PCT/EP1998/006945
Other languages
German (de)
English (en)
Inventor
Gerhard Kirschner
Antje Huber
Original Assignee
Becton Dickinson Medizintechnik Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson Medizintechnik Gmbh & Co. Kg filed Critical Becton Dickinson Medizintechnik Gmbh & Co. Kg
Priority to DE19881721T priority Critical patent/DE19881721B4/de
Priority to AU16658/99A priority patent/AU1665899A/en
Publication of WO1999022787A1 publication Critical patent/WO1999022787A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
    • A61M5/38—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body using hydrophilic or hydrophobic filters

Definitions

  • the invention relates to an infusion device according to the preamble of claim 1.
  • Such infusion devices are used to introduce infusion solutions directly into a patient's vein. Since many infusions often have to be administered directly in succession in many patients, there is a need to be able to use an infusion device once used for an infusion also for further subsequent infusions. The transition from one infusion to the next occurs in such a way that after the end of a first infusion, the solution for infusion is withdrawn from the spike of the drip chamber and a new bottle is placed on the spike.
  • a problem with this change is that after an infusion bottle has been emptied, and in particular after it has been removed from the spike, air can enter the tube between the patient and the drip chamber, which must be laboriously removed before the start of a subsequent infusion, if not the risk of it Air embolism in the patient should be accepted. Even if there is no air in the bottle when the infusion solution bottle is empty
  • the tube penetrates, this can happen when the pumping process is carried out after a full infusion solution bottle has been attached. Having air once entered the hose is difficult To remove this, the emptying of the infusion solution bottle should actually be observed by a supervisor so that the hose clamp, which is preferably designed as a roller clamp, can be closed inside the hose before the infusion solution has completely flowed out of the drip chamber and air enters the hose.
  • the hose clamp which is preferably designed as a roller clamp
  • the problem with the known solution is the need for a valve with a movable valve body, which must be lighter than the infusion solution, as a result of which the choice of material for the movable element is considerably restricted.
  • the systems working with a valve can be regarded as very unstable, since the lift forces during running infusion are very small compared to the flow forces and the valve body tends to get stuck when the infusion solution bottle is empty (adhesive forces), so that the movable valve body is difficult to control with regard to its opening and closing movement. Therefore, there is always an unwanted closing or opening of the valve.
  • the aim of the present invention is to provide an infusion device of the type mentioned at the outset, in which, without moving mechanisms, it is ensured that, after an infusion solution bottle has drained and during the process of exchanging the empty infusion solution bottle for a full one, there is still as much Liquid remains in the drip chamber to effectively prevent air from entering the hose.
  • the idea of the invention is therefore to be seen in the fact that the adhesive forces present in a filter having a certain porosity are used to generate a barrier for air under atmospheric pressure which normally - ie without the filter according to the invention - affects the one in the drip chamber Liquid would exert a pressure which, if the drip chamber is above the patient and the infusion solution bottle is empty, will finally also convey air into the tube.
  • the filter according to the invention which is arranged at a suitable point clearly above the bottom of the drip chamber, provides up to a certain pressure difference between see the top and bottom of the filter as a barrier to the passage of air from the top down, even if the hose clamp remains open. Only when a new infusion bottle has been put on and possibly pumped on does the liquid that runs onto the filter from above cause the lock to be lifted by liquid now entering or passing through the filter and the normal emptying process of the infusion bottle taking place.
  • a particularly important criterion for the height of the filter above the bottom of the drip chamber can be found in claim 2. Since a certain vacuum can form below the filter after the infusion solution bottle has emptied, a suitable height of the filter above the bottom of the drip chamber must ensure that the blocking effect according to the invention occurs before the infusion solution is completely removed from the lower part of the drip chamber the hose has entered.
  • the drip chamber is vented, in particular when the first infusion is initiated, according to claim 3, preferably by compressing the flexible or elastic wall of the drip chamber.
  • the process of venting by cyclically squeezing the wall of the drip chamber before the start of the first infusion is also known as pumping.
  • a preferred arrangement of the filter can be found in claims 4 and 5, the height of the filter within the drip chamber preferably being as defined in claim 6. In this way, the area between the bottom of the drip chamber and the in this arranged filter by cyclically squeezing the drip chamber below the filter and filled with liquid up to a desired height.
  • a suitable marking is preferably provided at the level of the drip chamber to which the liquid is to be pumped.
  • the filter can also be arranged according to claim 7 or 8, although care should be taken, if possible, that the filter takes up as large a cross-sectional area as possible within the infusion solution path, so that the flow resistance remains as low as possible.
  • Filters at the bottom of a drip chamber are generally known (WO 96/35465). They are used to keep latex particles and other contaminants that could enter the fluid channel of the piercing pin away from the patient when the piercing pin is inserted into the stopper of an infusion solution bottle.
  • the filter according to the invention also fulfills this function, but additionally has the function of a lock that prevents the drip chamber from completely emptying.
  • the invention can be realized in that an auxiliary drip chamber is arranged tightly between the drip chamber and the hose according to claims 9 or 10.
  • this embodiment also ensures that no air enters the hose when the infusion solution bottle runs empty. penetrates if the auxiliary drip chamber had been filled with sufficient infusion solution by pumping.
  • the average pore size of the filter according to the invention can be of the same order of magnitude as in the known filters arranged at the bottom of the drip chamber. Preferred areas can be found in claims 9 and 10.
  • the blocking effect of the filter according to the invention can be increased in a desired manner by reducing the pore size.
  • the embodiment according to claim 13 is expedient, on the one hand to facilitate the so-called pumping of the infusion device at the start of operation, but on the other hand to obtain the desired effect of air retention when idling.
  • the filter surface can be modified in the desired manner by means of a hydrophilic coating (e.g. in the plasma coating process).
  • the hydrophilic coating preferably extends over the entire cross section of the filter.
  • the guide body or the guide plate are provided according to claims 14 to 18.
  • the preferably sheet-shaped filter is applied from below to the guide plate, which surprisingly significantly reduces the resistance for pumping air from bottom to top without reducing the resistance to the passage of air from top to bottom.
  • the infusion bottle is empty, the air is kept away from the tube in the desired manner, although pumping is made considerably easier.
  • the filter is limited only at the top by the guide plate; below, on the other hand, it must at least be largely free of any components. From below, only the retaining ring for attachment attaches to the filter.
  • FIG. 1 shows a schematic, partially sectioned view of a preferred embodiment of an infusion device according to the invention
  • FIG. 2 shows a sectional view of only the drip chamber with the piercing part of a further embodiment with the liquid filter arranged in the piercing part
  • FIG. 3 shows a corresponding sectional view of a further embodiment with the liquid filter arranged in the liquid channel of the piercing mandrel
  • Figure 4 is a corresponding sectional view of a fourth embodiment, in which the drip chamber below by a
  • FIG. 5 shows a sectional view analogous to FIG. 2 of an embodiment of the infusion device according to the invention and provided with a guide plate
  • FIG. 6 shows section VI from FIG. 6 on a clearly enlarged scale.
  • an infusion device has a flexible and preferably also transparent tube 13, into which a flow controller 14 in the form of a hose clamp is switched on and which has at one end a connector 27 covered by a removable cap 28 with an outer cone for attaching a cannula, not shown and at the other end is pushed tightly onto a connection piece 29 provided at the bottom on a drip chamber 11 having a resiliently elastic wall 21, in order to bring the hose into flow connection with the drip chamber 11.
  • a piercing part 15 is placed tightly, which has a piercing mandrel 12 which contains a liquid channel 16, the upper end of which opens into the surrounding atmosphere and the lower end of which opens into the inside of the drip chamber 11.
  • an air channel 16 runs in the piercing mandrel 12, which opens at the upper tip of the piercing mandrel 12, preferably above the upper end of the liquid channel 16 and in the rear region via an air filter 17 in the surrounding atmosphere.
  • Retaining ring 23 inserted tightly, to which a liquid filter 19 is attached, which is designed as a thin plate which extends perpendicular to the longitudinal axis 22 of the drip chamber 11, which preferably has a circular cylindrical cross section.
  • a mark 24 is located between the bottom 20 of the drip chamber 11 and the filter 19 approximately in the middle of the height of the drip chamber 11.
  • the drip chamber 11 should consist of transparent or at least translucent material so that the liquid level inside the drip chamber 11 is checked from the outside can be.
  • the function of the infusion device described is as follows: After the piercing spike 12 is inserted from below into the stopper of an infusion solution bottle suspended above the head, when the hose clamp 14 is closed, the pumping first takes place in that the drip chamber 11 is vented between its base 20 and the liquid filter 19 by cyclical compression. With each compression, air is pumped through the liquid channel 16 into the interior of the infusion solution bottle, whereupon liquid is then sucked out of the infusion solution bottle through the liquid channel 16 into the drip chamber 11 when the drip chamber 11 is released. In this way, the liquid level in the drip chamber 11 rises gradually until it finally reaches the marking 24.
  • the hose 13 must be completely filled with liquid by draining off part of the infusion solution. Now the hose clamp 14 is closed again.
  • the infusion device is now operational, ie the cap 28 can be removed from the connector 27 and the connector 27 can be placed on a cannula inserted into the patient's vein.
  • the infusion solution bottle can run empty, air being sucked in through the air filter 17 and the air channel 18, so that there is always at least essentially atmospheric pressure in the infusion solution bottle above the infusion solution.
  • the surface of the filter 19 is subject to atmospheric pressure, the effect of which, however, owing to the inventive blocking action of the liquid filter 19, is reduced only to that in the lower part of the drip chamber 11 liquid can affect. Therefore, the liquid remains at least substantially at the previously set height in the drip chamber 11 and there is no air entry into the hose 13.
  • the desired liquid level in the drip chamber 1 1 is maintained even when the infusion solution bottle is removed. After fitting a new infusion solution bottle and, if necessary, pumping it again to bring the liquid level back to the desired level, infusion solution emerges from the new and full infusion solution bottle through the liquid channel 16 into the upper part of the drip chamber 1 1, where the liquid is on the filter 19 drips. As a result, the blocking effect existing in the presence of air above the filter 19 is canceled and the liquid from the new infusion solution bottle passes through the filter 19 into the lower part of the drip chamber 11 and the hose 13, via which it finally reaches the patient.
  • the liquid filter 19 is arranged in a space 30 specially provided for this in the lower area of the piercing part 15, which has an at least approximately as large a cross-section as the drip chamber 11, which benefits a low flow resistance of the liquid filter 19. Due to the arrangement of the liquid filter 19 in the piercing part 15, the entire height of the drip chamber 11 stands for the liquid absorption during pumping and subsequent work. available.
  • a holding ring 23 ′ with an annular disk bottom 23 ′′ and a central feed connector 33 is inserted tightly into the lower region of the piercing part 15 to hold the filter 19.
  • the liquid filter 19 is arranged inside the liquid channel 16 of the piercing mandrels 12, which is structurally a particularly simple measure, but leads to increased flow resistance, so that the pore size of the liquid filter 19 is not chosen too small in this case may.
  • the exemplary embodiment according to FIG. 4 shows how the invention can also be implemented with a known drip chamber 11, in which a liquid filter 19 is arranged on the bottom 20 of the drip chamber 11.
  • auxiliary drip chamber 25 In this case, one can plug the upper opening 31 of an auxiliary drip chamber 25 onto the connecting piece 29 of the drip chamber 11 from below, which has a connecting piece 29 'at the bottom, onto which the hose 13 is pushed tightly.
  • the auxiliary drip chamber 25 has an elastic wall 26, so that it can be pumped at the start of operation in an analogous manner to the drip chamber 11 itself, so that a desired liquid level 32 is reached in the auxiliary drip chamber 25.
  • the liquid filter 19 provided on the bottom 20 of the drip chamber 11 requires a corresponding blocking effect as in the previous exemplary embodiments, so that the drip chamber 11 itself, but not the auxiliary drip chamber 25, can run completely empty and thus despite the arrangement of the liquid filter 19 on the bottom 20 of the drip chamber 11, the entry of air into the hose 13 is prevented.
  • a substantially circular disk-shaped guide plate 35 with a central channel 36 and recesses 34 provided on its underside is arranged above the sheet-shaped liquid filter 19.
  • the recesses 34 can have the shape of grooves concentric or radial to the central channel 36. They must each be in flow connection with the central connecting channel 36.
  • the liquid filter 19 is in continuous contact with the lower surface of the guide plate 35 from below, so that the recesses 34, which are only open and closed at the bottom, also adjoin the upper surface of the liquid filter.
  • the edge 38 of the filter 19 is clamped between the retaining ring 23 'and the radially outer fastening edge 37 of the guide plate 35.
  • the filter material should be hydrophilic or have a hydrophilic coating. This can for example applied by the plasma coating process.
  • Feed connector Recess guide plate connecting channel mounting edge filter edge

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  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un appareil à perfusion comportant un tuyau (13) menant d'un patient à l'extrémité de sortie d'une chambre de goutte à goutte (11), ce tuyau étant obturable notamment par clamp tubulaire (14) servant au dosage et à l'obturation. L'appareil à perfusion comporte également une partie de ponction (15) placée de manière étanche à l'extrémité d'admission de la chambre de goutte à goutte (11) et présentant une aiguille de ponction (12) destinée à ponctionner dans un bouchon de flacon de solution de perfusion, cette partie de ponction (15) étant munie d'un conduit liquidien (16) s'étendant également à travers l'aiguille de ponction (12), ce conduit débouchant d'une part dans la chambre de goutte à goutte (11) et d'autre part dans la région antérieure de l'aiguille de ponction (12). Un conduit d'air (18) situé à côté du conduit liquidien (16) est pourvu de préférence d'un filtre à air (17) et débouche d'une part dans la région antérieure de l'aiguille de ponction (12) et d'autre part dans la région postérieure de la partie de ponction (15), dans l'atmosphère ambiante, et relie l'espace intérieur du flacon de solution de perfusion avec l'atmosphère ambiante lorsque l'aiguille de ponction (12) est enfichée dans le bouchon dudit flacon. Ainsi, l'air peut continuer à s'écouler depuis l'extérieur jusque dans ledit flacon lorsque du liquide pénètre par débordement dans la chambre de goutte à goutte (11), un filtre à liquide (19) à pores fins étant intercalé dans le trajet de la solution de perfusion entre l'aiguille de ponction (12) et le tuyau (13). Des moyens permettent au moins partiellement l'évacuation de l'air et le remplissage de la chambre de goutte à goutte (11) avec la solution de perfusion avant le début d'une perfusion, et d'autres mesures permettent d'empêcher l'entrée d'air dans le tuyau lorsqu'un flacon de solution de perfusion se vide et doit être remplacé par un plein. L'invention consiste en ce que le filtre à liquide (19) est situé au-dessus du fond (20) de la chambre de goutte à goutte (11) à une distance empêchant la pénétration d'air dans le tuyau (13) même lorsque celui-ci n'est pas obturé.
PCT/EP1998/006945 1997-11-03 1998-11-03 Appareil a perfusion avec chambre de goutte a goutte et clamp tubulaire WO1999022787A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19881721T DE19881721B4 (de) 1997-11-03 1998-11-03 Infusionsgerät mit Tropfkammer und Schlauchklemme
AU16658/99A AU1665899A (en) 1997-11-03 1998-11-03 Infusion apparatus with a drip-chamber and tubing clamp

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1997148497 DE19748497A1 (de) 1997-11-03 1997-11-03 Infusionsgerät mit Tropfkammer und Schlauchklemme
DE19748497.2 1997-11-03

Publications (1)

Publication Number Publication Date
WO1999022787A1 true WO1999022787A1 (fr) 1999-05-14

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PCT/EP1998/006945 WO1999022787A1 (fr) 1997-11-03 1998-11-03 Appareil a perfusion avec chambre de goutte a goutte et clamp tubulaire

Country Status (3)

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AU (1) AU1665899A (fr)
DE (2) DE19748497A1 (fr)
WO (1) WO1999022787A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102553033A (zh) * 2012-02-05 2012-07-11 戎静华 一种自动排气止液输液器
US8523829B2 (en) 2004-01-29 2013-09-03 Becton, Dickinson And Company Intravenous delivery system
US10105899B2 (en) 2015-03-26 2018-10-23 Becton, Dickinson And Company IV membrane attachment systems and methods
US10201667B2 (en) 2015-03-26 2019-02-12 Becton, Dickinson And Company IV membrane attachment systems and methods
US10232130B2 (en) 2015-03-26 2019-03-19 Becton, Dickinson And Company Anti-run dry membrane
US10646648B2 (en) 2015-04-01 2020-05-12 Becton, Dickinson And Company IV flow management systems and methods
US10702689B2 (en) 2015-03-26 2020-07-07 Becton, Dickinson And Company Auto-stop vent plug

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE29921086U1 (de) * 1999-12-01 2001-04-12 Braun Melsungen Ag Infusionsgerät
DE202004015907U1 (de) * 2004-10-14 2006-02-16 B. Braun Melsungen Ag Infusionsgerät
DE102006053219B4 (de) * 2006-11-11 2017-01-05 Fresenius Kabi Deutschland Gmbh Tropfkammer für ein Infusionsgerät und Infusionsgerät mit einer Tropfkammer sowie Anordnung bestehend aus einem Infusionsbehältnis und einem Infusionsgerät
DE102007061346A1 (de) * 2007-12-17 2009-06-18 Bayer Schering Pharma Aktiengesellschaft Spike mit zwei Dornen
DE102009022417A1 (de) * 2009-05-22 2010-12-30 Fresenius Kabi Deutschland Gmbh Tropfkammer für ein Infusionsgerät und Infusionsgerät mit einer Tropfkammer
SI2399621T1 (sl) * 2010-06-25 2017-01-31 Codan Holding Gmbh Kapljalna komora s prezračevalnim ventilom
CN103933642A (zh) * 2013-12-21 2014-07-23 山东中保康医疗器具有限公司 输液器薄膜式液流通断控制装置
US10413662B2 (en) 2015-05-14 2019-09-17 Carefusion 303, Inc. Priming apparatus and method
DE102017201755A1 (de) 2017-02-03 2018-08-09 B. Braun Melsungen Ag Einstechteil für ein medizinisches Infusionssystem, Tropfkammer und Infusionssystem
DE102017205250A1 (de) * 2017-03-28 2018-10-04 B. Braun Melsungen Ag Einstechteil für ein medizinisches Infusionssystem

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EP0001114A2 (fr) * 1977-09-07 1979-03-21 Karl Edmund Dr. Becker Dispositif de régulation de débit pour perfusion intraveineuse
US4173222A (en) * 1976-08-19 1979-11-06 Abbott Laboratories Apparatus for controllably administering a parenteral fluid
GB2044620A (en) * 1979-03-26 1980-10-22 Abbott Lab Administering parenteral fluid
US4413990A (en) * 1981-08-31 1983-11-08 Baxter Travenol Laboratories, Inc. Air bypass valve assembly for a medical fluid administration set
WO1996029104A1 (fr) * 1995-03-22 1996-09-26 Travenol Laboratories (Israel) Ltd. Chambre de goutte-a-goutte pour perfusion intraveineuse
WO1996035465A1 (fr) 1995-05-10 1996-11-14 Ohmeda Gmbh & Co. Kg Dispositif de perfusion

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DE2161828A1 (de) * 1970-12-14 1972-06-29 The Green Cross Corp., Osaka (Japan) Tropfkammer für Intravenös-Infusionsapparat
DE2264148C2 (de) * 1972-12-29 1974-08-08 The Green Cross Corp., Osaka (Japan) Tropfkammer für eine Vorrichtung zur intravenösen Infusion
DD244695A1 (de) * 1985-12-24 1987-04-15 Medizin Labortechnik Veb K Tropfkammer fuer infusionsbestecke
DE9317423U1 (de) * 1993-11-13 1994-01-20 Clinico Gmbh Infusionstech Gerät zur medizinischen Infusion oder Transfusion
DE9402983U1 (de) * 1994-02-25 1994-04-07 Meyer Frieder Zylindrische Tropfkammer eines Schwerkraftinfusionsgerätes
DE29512323U1 (de) * 1995-07-31 1996-12-05 Ohmeda Gmbh & Co Kg Infusionsgerät
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Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
US4173222A (en) * 1976-08-19 1979-11-06 Abbott Laboratories Apparatus for controllably administering a parenteral fluid
EP0001114A2 (fr) * 1977-09-07 1979-03-21 Karl Edmund Dr. Becker Dispositif de régulation de débit pour perfusion intraveineuse
GB2044620A (en) * 1979-03-26 1980-10-22 Abbott Lab Administering parenteral fluid
US4413990A (en) * 1981-08-31 1983-11-08 Baxter Travenol Laboratories, Inc. Air bypass valve assembly for a medical fluid administration set
WO1996029104A1 (fr) * 1995-03-22 1996-09-26 Travenol Laboratories (Israel) Ltd. Chambre de goutte-a-goutte pour perfusion intraveineuse
WO1996035465A1 (fr) 1995-05-10 1996-11-14 Ohmeda Gmbh & Co. Kg Dispositif de perfusion

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8523829B2 (en) 2004-01-29 2013-09-03 Becton, Dickinson And Company Intravenous delivery system
CN102553033A (zh) * 2012-02-05 2012-07-11 戎静华 一种自动排气止液输液器
US10105899B2 (en) 2015-03-26 2018-10-23 Becton, Dickinson And Company IV membrane attachment systems and methods
US10201667B2 (en) 2015-03-26 2019-02-12 Becton, Dickinson And Company IV membrane attachment systems and methods
US10232130B2 (en) 2015-03-26 2019-03-19 Becton, Dickinson And Company Anti-run dry membrane
US10702689B2 (en) 2015-03-26 2020-07-07 Becton, Dickinson And Company Auto-stop vent plug
US10926029B2 (en) 2015-03-26 2021-02-23 Becton, Dickinson And Company IV membrane attachment systems and methods
US10973993B2 (en) 2015-03-26 2021-04-13 Becton, Dickinson And Company Anti-run dry membrane
US11744941B2 (en) 2015-03-26 2023-09-05 Becton, Dickinson And Company IV membrane attachment systems and methods
US11826557B2 (en) 2015-03-26 2023-11-28 Becton, Dickinson And Company Anti-run dry membrane
US10646648B2 (en) 2015-04-01 2020-05-12 Becton, Dickinson And Company IV flow management systems and methods
US11617831B2 (en) 2015-04-01 2023-04-04 Becton, Dickinson And Company IV flow management systems and methods

Also Published As

Publication number Publication date
AU1665899A (en) 1999-05-24
DE19748497A1 (de) 1999-05-06
DE19881721D2 (de) 2001-06-13
DE19881721B4 (de) 2005-05-19

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