EP1877170B1 - Dispositif et procede de deplacement de reservoirs a liquides - Google Patents

Dispositif et procede de deplacement de reservoirs a liquides Download PDF

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Publication number
EP1877170B1
EP1877170B1 EP06721945A EP06721945A EP1877170B1 EP 1877170 B1 EP1877170 B1 EP 1877170B1 EP 06721945 A EP06721945 A EP 06721945A EP 06721945 A EP06721945 A EP 06721945A EP 1877170 B1 EP1877170 B1 EP 1877170B1
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EP
European Patent Office
Prior art keywords
movement
support
support unit
support element
unit
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Active
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EP06721945A
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German (de)
English (en)
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EP1877170A1 (fr
Inventor
Adi Zuppiger
Roland Fuchs
Urs Knecht
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Tecan Trading AG
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Tecan Trading AG
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Publication of EP1877170A1 publication Critical patent/EP1877170A1/fr
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/22—Mixing the contents of independent containers, e.g. test tubes with supporting means moving in a horizontal plane, e.g. describing an orbital path for moving the containers about an axis which intersects the receptacle axis at an angle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/24—Mixing the contents of independent containers, e.g. test tubes the containers being submitted to a rectilinear movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/27—Mixing the contents of independent containers, e.g. test tubes the vibrations being caused by electromagnets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials

Definitions

  • the invention relates to a device for moving liquid containers, which comprises a carrying unit designed to receive liquid containers; a base unit, against which the support unit is mounted substantially horizontally freely swinging by means of connecting elements; and moving means for moving the support unit relative to the base unit.
  • Automated plants typically include a single pipetting device or multiple pipetting devices that are used on liquid containers located on the workstation of a workstation. Such workstations are often able to perform a wide variety of work on these fluid samples, such as optical measurements, pipetting, washing, centrifuging, incubating and filtering.
  • One or more robots now operating on Cartesian or polar coordinates, can be used to process samples at such a workstation. Such robots can be liquid containers, such as. eg carry sample tubes or microplates and reposition.
  • Such robots can also be used as a so-called “robotic sample processor” (RSP), such as a pipetting device for aspirating and dispensing, or as a dispenser for distributing liquid samples.
  • RSP robottic sample processor
  • a pipetting device for aspirating and dispensing
  • a dispenser for distributing liquid samples.
  • RSP robot sample processor
  • shakers move the liquid container itself.
  • Such shakers which move the liquid containers in a thermostatically controlled bath, are, for example US 3,601,372 known:
  • the support device of this shaker is not free swinging special firm, but still connected via three crankshaft movably connected to a resting intermediate floor and can perform a corresponding deflection of the crankshaft circular motion.
  • On one of these crankshaft downwardly directed permanent magnets are fixed, which produce a magnetic coupling to a outside of the water bath and driven by a stuck motor driven permanent magnet.
  • the motor drive and at least mechanically decoupled the wing from each other.
  • shakers perform a rapid circular motion with a hollow rubber dome in which a test tube or sample tube is held by hand.
  • shakers which move a platform in a horizontal plane linear or circular; For example, baths for dyeing polyacrylamide gels, for example, are applied to these platforms.
  • rocking platforms are known.
  • the U.S. Patent 5,409,312 discloses a device with which a magnetic stirrer can be converted into a magnetically driven orbital shaker.
  • This device consists of a horizontally arranged, quadrangular base plate and a likewise quadrangular, arranged parallel thereto support plate.
  • Arranged in the corners and opposite each other are four ball bearings which allow the support plate for receiving a liquid vessel to perform a free or circular orbital motion.
  • the support plate has a circular magnet in the center on its underside, and is thus magnetic coupled with the rotatable magnet of the magnetic stirrer.
  • such magnetic stirrers are known to give off strong vibrations to their environment, especially to the table on which they stand.
  • the U.S. Patent 6,508,582 discloses an electromagnetically driven microplate in-line shaker which vibrates a support plate connected to a base plate via leaf springs to frequencies of 120 Hz (7,200 reciprocal movements per minute).
  • the microplates be it a single standard plate, a single "deep-well micropattern" or entire stacks thereof, are fixed on the support plate by means of tensioning devices.
  • these fixtures are not suitable for automated or robotic loading of the support plate with such microplates.
  • the delivery of strong vibrations to the base must be feared here as well, because the direct movement of the support plate and all liquid container disposed thereon requires a correspondingly strong electromagnet.
  • the published patent application US 2003/0081499 A1 discloses an electromagnetically or mechanically driven multi-directional shaker for microplates or sample tubes.
  • a first support plate is suspended from leaf springs, so that they can swing in a certain first direction substantially horizontally and freely.
  • a second support plate is suspended from leaf springs so that they can swing in a direction perpendicular to the first direction, the second direction substantially horizontally and freely.
  • the vibrations are generated by two electromagnets oriented in the respective vibration direction by providing, for each support plate, a core fixed to the respective support plate, which is partially inserted in each of the electromagnets.
  • the support plates are generated by two aligned perpendicular to the respective vibration direction electric motors with directly acting on the edge of the respective support plate ExzenterTriebraten; In this case, springs counteract the eccentric drive wheels.
  • the delivery of strong vibrations to the pad must be feared because the direct movement of the support plate and all arranged thereon Liquid container requires a correspondingly strong electromagnet or a correspondingly strong electric motor.
  • the present invention is based on the object to propose an alternative device for moving liquid containers, which eliminates or at least minimizes the disadvantages of the prior art.
  • liquid containers are accommodated with a carrying unit - which is mounted substantially horizontally and freely swinging by means of connecting elements relative to a base unit - and this carrying unit is moved relative to the base unit with moving means.
  • the inventive method is characterized in that at least one support element of this support unit, on which at least one moving mass is movably mounted, with a - on the same Carrying element attached - moving means, which is in interaction with this at least one moving mass, is moved so that the movements of these at least one moving mass offset the same supporting support member and the liquid container received with the support unit in corresponding countermovements.
  • FIGS. 1, 2 and 3 represent the side, bottom and elevation of a daily unit of a device 1 for moving liquid containers 2.
  • the carrying unit 3 is designed to receive liquid containers 2.
  • Such liquid containers in the form of sample tubes can be placed on the support unit in suitable racks or racks (not shown).
  • Liquid container in the form of microplates with eg 96 or 384 or more or fewer wells (cf. Figures 3 and 5 ) can also be parked on the support unit 3.
  • Retaining springs 4 or other suitable, attached to the support unit means (not shown) prevent that put on the support unit 3 or placed liquid container 2 to slide around when moving the support unit or otherwise move uncontrollably.
  • Such means also include clamping levers, which can be opened by robotic grippers, so that a fully automatic loading of the support unit 3 with liquid containers 2 and a secure holding these liquid containers on the surface of the support unit 3 is possible.
  • the carrying unit 3 is opposite a base unit 5 (not shown here; Fig. 4 ) By means of connecting elements 7 substantially horizontally swinging freely.
  • FIG. 1 shows a side view of an inventive, horizontally freely oscillating support unit 3 for receiving liquid containers 2.
  • a moving mass 8 is movably arranged, which is movable by a moving means 6.
  • This movement mass 8 comprises a so-called oscillator formed, movable magnet 9, which by a moving means 6 in the form of an electromagnetic coil in the direction of the axis of symmetry 11 (see. Fig. 2 ) can be moved back and forth.
  • the magnet is connected to a plate 10, which is preferably made of iron and forms a closed circle with the magnet 9.
  • the plate 10 thus also belongs to the movement mass. 8
  • the electromagnetic coil 6 is fixedly mounted on the support unit 3.
  • the oscillator 9 or "moving magnet” is movably mounted on the support unit 3.
  • This storage comprises two slide rods 12, which are slidably mounted in a pair of sleeves 13.
  • Two stop plates 14 limit the horizontal mobility of the vibrator 9 and the movement mass 8. So that the transverse flanges 15 of the vibrator 9 does not strike the stop plates 14, are on the transverse flanges 15 and also directed against these stop surfaces 16 of the stop plates 14 strong, against arranged each other equal-pole permanent magnets 17.
  • the support unit 3 consisting of a single support element 20 can perform a rotating pendulum movement which is opposite to the rotational movement of a circulating movement mass 8.
  • This alternative, circular movement of the moving mass 8 can be effected by an electric motor, to whose drive shaft the moving mass 8 is eccentrically mounted (not shown).
  • the support unit 3 is to perform a rotational movement without using rotating electric motors and eccentrically arranged movement masses 8, the support unit 3 preferably comprises two support elements 20, 21.
  • FIG. 4 is a particularly preferred first embodiment of the inventive device for moving liquid containers with a first and second support member 20,21 shown.
  • these two support members 20,21 which are suspended on leaf springs 22, swing substantially at right angles to each other.
  • the support unit 3 moves freely in any substantially horizontal direction.
  • the base unit 5 comprises bent-up support members 23 which carry at least one leaf spring 22 on each side of the base unit 4.
  • the additional leaf springs enhance the spring action, but they also reduce the achievable with the movement of the moving mass 8 deflection.
  • the number and / or spring strength of the leaf springs 22 adapted to the requirements become.
  • leaf springs 22 and connecting elements 7 are clamped here hanging and wear upturned hanging parts 24 of the first support member 20.
  • This first support member 20 includes bent-up support members 25 on which also formed as leaf springs 22 connecting elements 7 are in turn suspended hanging. These leaf springs 22 are also clamped clamped down on the support member 21. Again, three leaf springs are preferably provided, which connect the first and second support members 20,21 together.
  • the horizontal portion 27 of the raised portion 26 of the second support member 21 forms the effective support surface 28 of the support unit 3, which comprises the first and second support member 20,21.
  • the corresponding axis of symmetry 11 "(and movement direction) is in FIG. 4 located.
  • the symmetry axis 11 '(and the direction of movement) of the first support element 20 is at right angles to the illustrated axis of symmetry 11 "and is also indicated here
  • the movement masses or oscillators 8 are preferably linearly movable on friction-minimized plain bearings and laterally supported at least approximately free of play By overlaying the movements of the first and second support elements 20, 21, the support surface 28 moves freely swinging in all directions in a substantially horizontal plane.
  • substantially torsion-resistant leaf springs made of steel generally applies that two support elements 20,21 must be used.
  • This arrangement successfully prevents or minimizes unwanted and uncontrollable swinging of the liquid container bearing support surface 28 of the support member 3 into a pendulum motion about a Z-axis.
  • Such a swinging may occur, in particular, with wings 28 suspended from cords or wires which carry a microplate with asymmetrically only partially filled and partially empty wells.
  • FIG. 4 shown embodiment of a device for moving liquid containers is completely insensitive to unilateral loading. Even several, one-sided filled, stacked microplates are moved without problems and controlled. Thus, solid particles can be kept in suspension in virtually any liquid containers, emulsified unstable emulsions and mixing processes can be supported.
  • a shock-free shaking or mixing of cell cultures is made possible by the device according to the invention. Due to the free-swinging movement of the support surface 28 even a vortex effect in the liquid containers can be achieved without the device emitting vibrations to the immediate environment. Due to the free-swinging suspension of all supporting elements 20,21 and by these free-swinging support elements inherent motion means 6 and masses of movement 8, no radial forces on the device, so that it does not "emigrate". The preferred suspension of the support members 20,21 on leaf springs causes no signs of fatigue in the attachment and also small uncontrolled loosening of screws by vibration.
  • the actual movement of the support plate and thus also the liquid container 2 is determined for each direction of movement in the X- and Y-axis by means of a Hall sensor.
  • This real motion detection is used as a manipulated variable in the control of the movement means 6 and movement masses 8.
  • the driving of the movement means 6 with 2 frequencies and 2 deflections.
  • the deflection of the support surface 28 of the height and the diameter of the liquid container 2, in particular the wells of a microplate can be adjusted. The smaller the deflection, the higher the frequency can be selected.
  • the preferred deflection is about 1/3 to 1/2 of the well diameter, which corresponds to a preferred deflection of about 3 mm, for example, in deep-well microplates.
  • the Frequency of an individually controlled, inventive device 0.1 to over 4000 Hz.
  • any, preferably cyclic movement patterns are generated by the movement means 6 and movement masses inherent in these free-swinging support elements.
  • These can be serrated stars, circles, rotating figure-eight figures and complex circular or elliptical movements, which correspond to the course of a freeform, in particular a Lissajous figure.
  • motion sensors preferably Hall sensors, enable the sensing of the effective movements of the support plate or reservoir 2 in both the X and Y directions of a substantially horizontal plane.
  • the support surface 28 is provided with a non-slip coating, such as a rubber mat or the like and / or with retaining springs 4 or other holding means.
  • a device 1 preferably comprises a blocking device with which the carrying unit 3 and the liquid container 2 accommodated therewith are fixed in a predetermined position. Depending on the selected spring constant and / or number of leaf springs, the support surface 28 is kept so quiet that even such a blocking device can be dispensed with.
  • devices 1 which comprise a housing 31 having on its upper side an opening through which a liquid container 2, in particular a microplate, can be placed on the support unit 3, wherein the support unit 3 a fixing mechanism 4 for holding the liquid container 2 includes. So that this storage robotized or automated can take place, the fixing mechanism 4 for holding the liquid container 2 on the support unit 3 is preferably detachably formed by a microplate handling robot.
  • such a housing 31 may also include a bottom 34, a lid 35 and side walls 36 (bottom and lid removed for clarity) and a movably mounted in this housing 31 slider 37.
  • the housing 31 on at least one side of an opening 38 through which the slide 37 is extendable to receive a liquid container 2, in particular a microplate, to pull into the housing 31 and store on the support unit 3.
  • a support unit comprises a fixing device 4 (not shown) for holding the liquid container 2.
  • FIG. 5 Devices shown are preferably formed as a stackable module, wherein the bottom 34 and the lid 35 are formed as lower and upper stacking surfaces by having complementary to each other formed relief structures, such as ribs and troughs and the like.
  • all the devices or groups thereof may be individually formed as incubators, cold rooms, or merely as shakers.
  • Such stackable devices can be used as modules for populating a workstation or a so-called “robotic sample processor” (RSP).
  • RSP robottic sample processor
  • such devices 1 are preferably designed as incubators by comprising a temperature-controlled heating plate and arranged on the bottom 34 and cover 35 and on all sides 36 heat insulation, which also closes all the openings 33,38.
  • preferred devices 1 are designed as a cooling space by comprising a temperature-controlled cooling plate and arranged on the bottom 34 and cover 35 and on all sides 36 heat insulation, which also closes all openings 38.
  • Peltier elements or so-called "heat pipes" are used for the incubators or cold rooms.
  • Devices for moving liquid containers differing from the shown or described devices form part of the present invention, if one or more moving means 6 and one or more moving masses 8 are movably arranged on their carrying unit, which are movable by these moving means and whose movement causes the carrying unit and put the liquid container thus received in corresponding countermovements.
  • the designated as the support surface 28 part of the support unit 3 may also be formed as a contiguous support frame or as a separate multi-surface.
  • each rotatable movement mass 8 is magnetically connected to a rotating part of a movement means 6.
  • the moving means 6 is an electric motor, which is attached to the base unit 5 and on the drive axle, a permanent or permanent magnet is mounted eccentrically.
  • the corresponding movement masses 8 are then connected via a rotation axis to the support elements 20, 21 or to the support unit 3.
  • the axis of rotation of the moving means 6 is arranged substantially in the geometric axis of the corresponding moving mass 8.
  • the movement masses 8 also have an eccentrically mounted permanent magnet, which represents the opposite pole to the permanent magnet of the corresponding movement means 6.
  • This arrangement is particularly suitable for automated multiple arrangements of fermenters or incubators in biotechnology, which at one of their Have outer walls or at its lid or bottom rotatable movement masses 8 with at least one permanent magnet.
  • These fermenters are then preferably equipped with stirring devices, which are operatively connected to the movement masses 8.
  • This active compound may be mechanical or magnetic in nature. If these fermenters are transported (preferably remotely controlled) from one stirring station to the next, the movement means 6 of the next stirring station, which are arranged identically or differently, interact with one or more of the moving masses 8 of the fermenter, so that one of the stirring stations receives appropriate movement in the fermenter available liquid can be provided.
  • Stirring stations may also differ in temperature and in other physical or chemical parameters. Alternatively, the entire fermenter can be suspended free-swinging and be brought by the masses of movement 8 in corresponding countermovements.
  • the support unit 3 of the device according to the invention comprises a first and second support element 20, 21 with at least two rotatable movement masses 8 fastened to this second support element 21 and the associated movement means 6.
  • the symmetrical arrangement of four electric motors 40 is particularly preferred under the second one Support member 21, wherein the axes of rotation 41 of these electric motors 40 are arranged in the corners of a square. It is particularly preferred to select the direction of rotation of the electric motors (and thus also the direction of rotation of the wheels 43, which are preferably driven by toothed belts 42 and arranged in the center of this square, which are located diagonally opposite one another) in the same direction.
  • each of these two engine pairs controlled synchronously.
  • Fig. 7 For the sake of clarity, only two of the total four wheels are drawn, with only one movement mass 8 being visible.
  • the timing belt 42 dampening against a possible rocking of vibrations.
  • the very close positioning of the wheels 43 with their eccentrically arranged masses of movement on a common central axis 44 additionally helps to minimize the occurrence of undesirable torques.
  • the two support elements 20, 21 of the support unit 3 are preferably arranged the same and formed, as already in connection with the FIGS. 4 and 5 was shown and explained.
  • Such an eddy current brake with a permanent magnet 45 has, inter alia, the advantage that it represents a completely passive system which does not require any control.
  • each such individual eddy current brake is provided for each of the support elements 20,21 . Even a system with leaf spring suspensions can be improved by the use of such eddy current brakes.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)

Claims (21)

  1. Dispositif (1) permettant de déplacer des réservoirs de fluide (2), comportant :
    - une unité de support (3) conçue pour recevoir des réservoirs de fluide (2),
    - une unité de base (5) vis à vis de laquelle l'unité de support (3) est logée de façon à osciller librement sur un plan essentiellement horizontal, au moyen d'éléments de liaison (7), et
    - des moyens de déplacement (6) permettant de déplacer l'unité de support (3) vis à vis de l'unité de base (5),
    dans lequel l'unité de support (3) comporte au moins un élément porteur (20,21), caractérisé en ce qu'au niveau de l'élément porteur est fixée de façon mobile au moins une masse de déplacement (8), cette masse de déplacement (8), au moins au nombre de une, se trouvant en interaction avec un moyen de déplacement (6) - fixé à ce même élément porteur (20,21) - et pouvant être déplacée par celui-ci, les déplacements de cette masse de déplacement (8), au moins au nombre de une, déplaçant l'élément porteur (20,21) portant celle-ci et les réservoirs de fluide (2) logés par l'unité de support (3) selon des contre-mouvements correspondants.
  2. Dispositif selon la revendication 1, caractérisé en ce que l'unité de support (3) comporte un élément porteur (20) unique avec au moins une masse de déplacement (8) fixée au niveau de cet élément porteur (20) et mobile de façon linéaire ou en rotation.
  3. Dispositif selon la revendication 1, caractérisé en ce que l'unité de support (3) comporte un premier et un second élément porteur (20,21) avec au moins deux masses de déplacement (8), fixées à ce second élément porteur (21) et mobiles de façon linéaire ou par rotation.
  4. Dispositif selon la revendication 1, caractérisé en ce que l'unité de support comporte un premier et un second élément porteur (20,21) avec au moins respectivement une masse de déplacement (8), fixée au niveau de ce premier et de ce second éléments porteurs (21) et mobile de façon linéaire ou par rotation.
  5. Dispositif selon l'une des revendications précédentes, caractérisé en ce que les moyens de déplacement (6) sont entraînés par voie électrique, les masses de déplacement (8) mobiles de façon linéaire étant conçues en tant que partie de ces moyens de déplacement (6), en particulier en tant qu'aimant mobile (9).
  6. Dispositif selon l'une des revendications 1 à 4, caractérisé en ce que les moyens de déplacement (6) sont entraînés par voie électrique, chaque masse de déplacement (8) qui peut se déplacer en rotation étant reliée par voie magnétique ou mécanique à un élément en rotation d'un de ces moyens de déplacement (6).
  7. Dispositif selon l'une des revendications précédentes, caractérisé en ce que les éléments de liaison (7) pour loger un premier et/ou un second élément(s) porteur(s) (20,21) vis à vis de l'unité de base (5) sont conçus en suspension ou debout.
  8. Dispositif selon l'une des revendications 3 à 6, caractérisé en ce que les éléments de liaison (7) pour loger le premier élément porteur (20) vis à vis de l'unité de base (5) et les éléments de liaison (7) pour loger le second élément porteur (21) vis à vis du premier élément porteur (20) sont des ressorts à lames suspendus (22).
  9. Dispositif selon l'une des revendications précédentes, caractérisé en ce qu'il comporte un dispositif de blocage au moyen duquel l'unité de support (3), et par conséquent les réservoirs de fluide (2) supportés, peut être fixée dans une position prédéfinie.
  10. Dispositif selon l'une des revendications précédentes, caractérisé en ce qu'il comporte un boîtier (31) qui présente au niveau de sa face supérieure (32) une ouverture (33) par le biais de laquelle il est possible de déposer sur l'unité de support (3) un réservoir de fluide (2), en particulier une plaque de microtitration, l'unité de support (3) comportant un mécanisme de fixation (4) permettant de retenir le réservoir de fluide (2).
  11. Dispositif selon la revendication 10, caractérisé en ce que le mécanisme de fixation (4) permettant de retenir le réservoir de fluide (2) sur l'unité de support (3) est exécuté de façon amovible, par le biais d'un robot de manipulation de plaques de microtitration.
  12. Dispositif selon l'une des revendications 1 à 9, caractérisé en ce qu'il comporte un boîtier (31) équipé d'un fond (34), d'un couvercle (35) et de parois latérales (36), ainsi qu'un tiroir (37) logé de façon mobile dans ce boîtier (31), le boîtier (31) présentant au niveau d'au moins un côté (36) une ouverture (38) par laquelle le tiroir (37) est extractible, afin de recevoir un réservoir de fluide (2), en particulier une plaque de microtitration, de le tirer dans le boîtier (31) et de le déposer sur l'unité de support (3), et dans lequel l'unité de support (3) comporte un dispositif de fixation (4) permettant de retenir le réservoir de fluide (2).
  13. Dispositif selon la revendication 12, caractérisé en ce qu'il est exécuté en tant que module gerbable, le fond (34) et le couvercle (35) étant exécutés en tant que surfaces d'empilage inférieure et supérieure, en ce qu'elles présentent des structures en relief exécutées de façon complémentaire les unes aux autres.
  14. Dispositif selon la revendication 12 ou 13, caractérisé en ce qu'il est exécuté en tant qu'incubateur à agitation, en ce qu'il comporte un plateau chauffant commandé en température et une isolation thermique (39) disposée au niveau du fond (34) et du couvercle (35), ainsi que de tous les côtés (36), et qui ferme également toutes les ouvertures (33,38).
  15. Dispositif selon l'une des revendications précédentes, caractérisé en ce qu'il comporte au moins un frein à courant de Foucault avec un aimant permanent (45).
  16. Dispositif selon la revendication 12 ou 13, caractérisé en ce qu'il est exécuté en tant que chambre froide à agitation, en ce qu'il comporte une plaque de refroidissement commandée en température et une isolation thermique (39) disposée au niveau du fond (34) et du couvercle (35), ainsi que de tous les côtés (36), et qui ferme également toutes les ouvertures (33,38).
  17. Dispositif selon l'une des revendications précédentes, caractérisé en ce que, pour détecter les déplacements actuels d'un élément porteur (20,21) de l'unité de support (3) portant au moins un réservoir de fluide (2), il comporte des capteurs de mouvement, en particulier des capteurs à effet Hall.
  18. Dispositif selon l'une des revendications précédentes, caractérisé en ce qu'il comporte des suspensions de butée pour les éléments porteurs (20,21), logés de façon à osciller librement sur un plan essentiellement horizontal, sous la forme d'aimants permanents (17) orientés en opposition l'un à l'autre par le même pole.
  19. Procédé de déplacement de réservoirs de fluide (2), en particulier avec un dispositif (1) selon l'une des revendications 1 à 17, dans lequel des réservoirs de fluide (2) sont logés par une unité de support (3), qui est logée pour osciller librement sur un plan essentiellement horizontal vis à vis d'une unité de base (5) au moyen d'éléments de liaison (7), et dans lequel cette unité de support (3) est déplacée vis à vis de l'unité de base (5) par des moyens de déplacement (6), caractérisé en ce qu'au moins un élément porteur (20,21) de cette unité de support (3), au niveau duquel est fixée de façon mobile au moins une masse de déplacement (8), est déplacé avec un moyen de déplacement (6) - fixé au niveau de ce même élément porteur (20, 21) - qui se trouve en interaction avec cette masse mobile (8), au moins au nombre de une, de façon telle que les déplacements de cette masse mobile (8), au moins au nombre de une, déplacent l'élément porteur (20,21) portant celle-ci et les réservoirs de fluide (2) logés par l'unité de support (3) selon des contre-mouvements correspondants.
  20. Procédé selon la revendication 19, caractérisé en ce que ces contre-mouvements sont un déplacement linéaire d'aller et venue, un déplacement circulaire ou elliptique, ou un déplacement qui correspond au tracé d'une forme libre, en particulier une figure de Lissajous.
  21. Utilisation d'un dispositif selon l'une des revendications 1 à 18 ou d'un procédé selon l'une des revendications 19 ou 20 pour obtenir ou maintenir des mélanges de composés essentiellement homogènes dans ces réservoirs de fluide (2).
EP06721945A 2005-05-04 2006-05-04 Dispositif et procede de deplacement de reservoirs a liquides Active EP1877170B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH7872005 2005-05-04
PCT/CH2006/000243 WO2006116892A1 (fr) 2005-05-04 2006-05-04 Dispositif et procede de deplacement de reservoirs a liquides

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EP1877170A1 EP1877170A1 (fr) 2008-01-16
EP1877170B1 true EP1877170B1 (fr) 2010-06-16

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US (1) US8215826B2 (fr)
EP (1) EP1877170B1 (fr)
JP (1) JP4964229B2 (fr)
CN (1) CN101213012B (fr)
DE (1) DE502006007232D1 (fr)
WO (1) WO2006116892A1 (fr)

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CA3033195A1 (fr) * 2018-02-09 2019-08-09 Ecolab Usa Inc. Systemes de test d'ecoulement et methodes
CN108441402A (zh) * 2018-03-16 2018-08-24 梁多彬 一种医药生物培养装置
DE102018215084A1 (de) * 2018-09-05 2020-04-23 Bernhard Hukelmann Misch- und Knetverfahren
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JP4964229B2 (ja) 2012-06-27
DE502006007232D1 (de) 2010-07-29
US8215826B2 (en) 2012-07-10
JP2008540071A (ja) 2008-11-20
WO2006116892A1 (fr) 2006-11-09
CN101213012B (zh) 2012-02-15
US20090097948A1 (en) 2009-04-16
EP1877170A1 (fr) 2008-01-16
WO2006116892B1 (fr) 2007-02-08
CN101213012A (zh) 2008-07-02

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