EP2669000B1 - Dispositif de mélange doté d'un palier pour un dispositif de réception, procédé de mélange associé, et l'utilisation d'un tel dispositif de mélange - Google Patents

Dispositif de mélange doté d'un palier pour un dispositif de réception, procédé de mélange associé, et l'utilisation d'un tel dispositif de mélange Download PDF

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Publication number
EP2669000B1
EP2669000B1 EP13004188.2A EP13004188A EP2669000B1 EP 2669000 B1 EP2669000 B1 EP 2669000B1 EP 13004188 A EP13004188 A EP 13004188A EP 2669000 B1 EP2669000 B1 EP 2669000B1
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EP
European Patent Office
Prior art keywords
mixing
bearing
rotation
chassis
joints
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
EP13004188.2A
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German (de)
English (en)
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EP2669000A1 (fr
Inventor
Arne Schafrinski
Judith Jacobs
Florian Dürr
Martin Stranzinger
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Eppendorf SE
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Eppendorf SE
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Priority to EP13004188.2A priority Critical patent/EP2669000B1/fr
Publication of EP2669000A1 publication Critical patent/EP2669000A1/fr
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L99/00—Subject matter not provided for in other groups of this subclass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/22—Mixing the contents of independent containers, e.g. test tubes with supporting means moving in a horizontal plane, e.g. describing an orbital path for moving the containers about an axis which intersects the receptacle axis at an angle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/70—Drives therefor, e.g. crank mechanisms

Definitions

  • the present invention relates to a mixing device, in particular for mixing laboratory vessel contents with a receiving device for receiving mixed material and having a drive, by means of which the receiving device relative to a normal stationary chassis in a mixing movement can put, in which the receiving device on a closed Path, recurring periodically to a certain position in a certain orientation in space moves, preferably in a horizontal plane of movement only translationally and cyclically, in particular on a circular path, and with a storage that guides the receiving device in the mixing movement.
  • mixing devices in which laboratory vessel contents are mixed are well known.
  • mixing devices are known to have receiving devices for a wide variety of mix containers.
  • Such receptacles may also consist of a pedestal structure on which a holder for the mix containers is kept interchangeable in order to make the mixer useful for various vessels.
  • mixers that can mix even small amounts of liquid, that small containers in suitable holders, so-called “exchange blocks” are also summarized in very large groups of two, three or even four-digit number.
  • exchangeable blocks and also the reaction vessels can be standardized. For example, there are 0.2 ml, 0.5 ml, 1.5 ml and 2.0 ml tubes - and suitable replacement blocks for this purpose.
  • such mixers are driven at a rotational frequency of 200 rpm to 1,500 rpm.
  • the frequency of the mixing movement is known to be adjustable.
  • the present invention has for its object to provide a mixing device which avoids the problems of said previous solutions mentioned or at least reduced.
  • the present invention has for its object to provide a mixer with spherical bearings, in which the risk of unwanted rotation and / or tilting of the receiving device is reduced.
  • a mixing device has in particular for mixing laboratory vessel contents a receiving device for receiving mixed material and a drive and a storage.
  • the drive can be the recording device guided relative to a designated stationary chassis led by the storage in a mixing movement.
  • the mixing movement is a translational movement of the entire recording device (driven by the drive and guided by the forced guidance of the bearing) on a path in the space which extends substantially in the horizontal plane, ie in the x and y direction in a three-dimensional coordinate system.
  • the maximum deviations of the web in a vertical (ie perpendicular to the horizontal plane) direction (z-direction) is preferably 5% of the height (in the vertical direction) of the smallest used Mischgut vessels, more preferably 1% and particularly preferably 0, 2% of the height of the smallest used mix container.
  • Deviations from the horizontal plane in the vertical are preferably not more than 0.2 mm, more preferably not more than 0.05 mm, and particularly preferably not more than 0.02 mm.
  • acceleration sensors which measure the acceleration of the recording device in all three spatial directions (x, y, z) are preferably used.
  • the magnitude of the acceleration vectors should always be constant for a given rotational frequency, with the z component being as low as possible, and the x and z components being out of phase with each other.
  • the effective value for the acceleration vector in the z-direction is less than or equal to 50 m / s 2 , preferably less than or equal to 20 m / s 2 and particularly preferably less than or equal to 10 m / s 2 , this being Value also depends on the weight load of the mixing device.
  • the RMS value is 10 m / s 2 when the mixing device as a receiving device carries an exchangeable block weighing 500 g.
  • a uniaxial sensor M352C65, M353B15
  • a triaxial sensor (356A22) from PCP Piezoelectronics Inc was used to determine the quality, ie uniformity, of the concentricity.
  • the mixing movement is a movement of the receiving device on a closed, so to speak annular and somehow spatially three-dimensionally extending path which at least predominantly translational, but can also perform rolling movements when it only periodically returns to at least one particular position in a particular orientation in space.
  • the pick-up device reverts to each point of the web in space, and is a periodic movement so that each point of the web in space is reached again and again at equal intervals - or in other words, so that the pick-up device interrupts periodically same place.
  • the preferred circular or elliptical planar path is also referred to as the orbital path.
  • the preferred circular path of movement of the mixing device according to the invention is predominantly on the x-axis (abscissa) and y-axis (ordinate) spanned horizontal plane. Movements in the direction of the z-axis (applicate) are preferably less pronounced and show up in the mixing device as a kind of up and down movement of the receiving device and thus also the vessels located therein with content. The movement in the direction of the z-axis is called a z-stroke.
  • the storage according to the invention holds and guides the receiving device during this mixing movement so that the dynamic up and down movement of the receiving device is reduced as much as possible.
  • This dynamic up and down movement is known in the art as the already mentioned z-stroke.
  • a z-stroke during the mixing movement is disadvantageous in most applications, and therefore undesirable, since it can lead to wetting and thus contamination of the vessel lid, or squirts the sample out of the vessel in open vessels.
  • the storage has at least two supports.
  • the at least two supports can either be of equal length or alternatively have different lengths. For columns of different lengths, a leveling over the other components, such as the receiving device or the chassis must be done to align the recording device again in a horizontal plane.
  • Each of these supports according to the invention has at least two spaced storage areas (spherical plain bearings), which - at least substantially - no translational and at least two (linearly independent) have rotational degrees of freedom.
  • Bearing areas are the
  • a support can be both one-piece and multi-part. In a multi-part support at least two parts each have at least one storage area. The at least two storage areas of a support can be located at different positions of the support. Preference is given to the terminal arrangement, in which a bearing is located at both ends of the support, since this simplifies the assembly of the mixing device according to the invention.
  • the storage area is a short elastic bar section where its flexural elasticity accounts for the two rotational degrees of freedom (which, however, are then limited in their range of motion, for example, by the plastic deformation limit or breaking strength of the bar).
  • the (at least) two rotational degrees of freedom are realized by at least two separate bearings.
  • the bearings have at least substantially no translational degrees of freedom, ie, a person skilled in the art understands a bearing without translational degrees of freedom, wherein he accepts deviations in the usual tolerance range. These unwanted deviations can happen For example, resulting from the elastic and / or plastic or deformation of the elements of the bearing, but due to the choice of materials - elastic and / or plastic deformation are not wanted, unless explicitly elastic bearing elements are used - should be negligible.
  • the bearing area is a short elastic rod section in which its bending elasticity makes up the two rotational degrees of freedom.
  • the storage according to the invention has a Guiding device, which leads during the mixing movement, the rotation of the receiving device relative to the chassis.
  • this guide device which is preferably form-fitting, an unwanted, in particular chaotic, rotation of the receiving device relative to the chassis can be effectively prevented.
  • the drive of the mixing device according to the invention is initially able to set the receiving device in a mixing movement, which, as mentioned, preferably runs in a circular translatory cyclical manner in a plane.
  • a mixing movement which, as mentioned, preferably runs in a circular translatory cyclical manner in a plane.
  • “circular translationally cyclical” can be described by the fact that in such a mixing movement according to the invention all points of the receiving device perform a repetitive circular motion with essentially the same radius, angular velocity and angular position about a respective center in plane-parallel planes.
  • the mixing movement preferably proceeds in substantially horizontal planes, so that exchange blocks accommodated in receiving adapters of the receiving device, for example, are reliably mixed with reaction vessels held vertically in them, ie, without spilling the vessel contents during conventional filling.
  • the drive is preferably via an eccentric, which is rotatably mounted in the receiving device.
  • the offset between the axis of the drive shaft and the parallel to it axis of the eccentric determines the orbit radius of the mixing movement.
  • This offset the Also referred to as the amplitude of the eccentric determined at constant column length, the inclination of the columns and thus the distance between the receiving device and chassis.
  • the storage of the receiving device according to the invention allows a positive guidance of the receiving device, wherein the storage is easy to assemble and yet the axial forces emanating from the receiving device, are absorbed by the storage. Furthermore, the storage according to the invention enables the construction of mixers with a small overall height. The advantages of the storage according to the invention are thus simple assembly and very strong reduction of the load of the drive in the axial direction. The latter point increases occupational safety and the life of the drive. Thus, the storage according to the invention is particularly suitable for use in mixing devices which have to carry high loads, such as large filled laboratory vessels (eg Erlenmeyer flasks (2000 ml).) Since space in a laboratory is always limited, the low overall height of the invention is Mixers also beneficial.
  • large filled laboratory vessels eg Erlenmeyer flasks (2000 ml).
  • this storage already in principle allows to set the radius of this circular path by establishing geometry parameters such as the support length or even on the device by the user to make adjustable.
  • the circular path radius is preferably between 0.5 mm and 5 mm and particularly preferably between 1 mm and 2 mm.
  • the circular path frequency can be reduced due to the new storage to values up to 50 rev / min. But it can also (especially at high loading weight of the vessels) frequencies of 2,000 rev / min, preferably 2,500 rev / min, and even 3,000 rev / min and to be driven more.
  • the storage has three or four of the supports, which, for example, like stool legs or table legs in principle store the receiving device as a tabletop on the chassis as a base.
  • the joint bearings in particular the pivot points of the joint bearing a support equidistant from each other as the joint bearings, in particular the pivot points of the joint bearings of all other supports, this results in a mobility of the recording device always in a plane-parallel alignment over the chassis (Movement of the plane through the cradle pivot bearings against the plane through the chassis pivot bearings). Since the supports carry the axial / vertical loads, a mixer is all the more resilient, the more supports it has.
  • this translational mobility exists, for example, for equally long, parallel supports only on a circular path with a fixed radius. This is essential to achieve a smooth mixing motion on a circular planar path, i. a stable mixing movement without tilting and with reduced z-stroke.
  • the angle of inclination of each individual support relative to the chassis remains constant over the entire revolution of the mixing movement, since the supports can not twist against each other.
  • the distance remains the same between one of these points and one of the respective equivalent points a during the mixing process ', b', c, 'd' etc., on one of the other supports. Without these features, there would be an unwanted twisting of the two levels against each other.
  • this distance is a first example of a guide device according to the invention, which leads during the mixing movement, the rotation of the receiving device relative to the chassis.
  • the distance (and thus the radius of the circular path) is ultimately determined by the amplitude with which the eccentric moves the receiving device relative to the chassis, wherein the eccentric is mounted on the chassis. If the distance of the plane of movement of the receiving device from the chassis even configured adjustable, for example, in this way, the radius of the circular path of the mixing movement can be set on the mixing device according to the invention
  • the distance between the chassis level and the recording device at the remaining points remains unchanged.
  • the distance remains unchanged at all points, since the angle of inclination of each individual support relative to the chassis is kept constant over the entire circulation of the mixing movement, and the supports can not twist against each other.
  • This feature the inclination angle of each support relative to the chassis remains the same - thus eliminates unwanted twisting of the two planes, namely the plane of movement of the cradle (the plane through the cradle pivot bearings relative to the chassis plane (plane through the chassis pivot bearings) is unwanted, and it is in the present invention to minimize them, as this leads to an uncontrolled mixing movement, which is disadvantageous (z-stroke).
  • the guide device according to the invention leads during the mixing movement, the rotation of the receiving device relative to the chassis, wherein reducing / preventing this unwanted twist falls under this inventive guiding the rotation.
  • the guide device according to the invention preferably performs such that the unintentional rotation is equal to zero. Shown as projecting into the x, y planes, it can be seen that the guide means causes the supports to always be deflected in the same direction, i. the guide device synchronizes the column movement.
  • the guide device according to the invention includes, for example, bearings, rods, cams, rails, webs, links and combinations thereof.
  • the guide device according to the invention can likewise consist of a magnetic field.
  • both the receiving device and the chassis each carry at least one compatible magnetic element, ie, in attracting interaction elements selected from the group of magnets, magnetizable elements, permanent magnets, electromagnets and current-carrying Coils or a combination thereof.
  • Examples of permanent magnets are those of a ferromagnetic material such as iron, nickel, cobalt, neodymium-iron-boron, samarium-cobalt.
  • An adjustable embodiment is possible, for example by regulating the currents in a current-carrying coil by means of a control device.
  • the control device regulates the current flow and thus the strength of the magnetic field or regulates the polarity on the basis of received signals (for example: manual inputs with respect to the current density, the weight and / or the viscosity of the vessel contents, sensor signal with respect to the detected weight and / or viscosity) the coil and thus the direction of the magnetic field.
  • the guide device has at least one web which connects two of the supports according to the invention with each other. It stores a bearing that has no translational and only one rotational degree of freedom (hinge joint) the web on one support, and a second hinge joint supports the bridge on the other support.
  • the two hinge joints are rotatable about mutually parallel axes.
  • the unintentional rotation of the planes relative to one another is consequently significantly reduced by the guide device according to the invention, the web attaching to the supports in interaction with the hinge joints. It is known to the person skilled in the art that compressions and expansions of the supports and webs can not be completely ruled out, which also cause unwanted twisting.
  • the axes of the hinge joints are each mounted centrally between the respective joint bearings of the two supports connected by the web. This is especially true for two different length supports that are connected by a bridge and hinge joints.
  • the following distances to the device according to the invention are the same size: between two supports, the distance between the pivot points of the joint bearing on the chassis from each other and the distance between the pivot points of the pivot bearing on the receiving device from each other.
  • the pivot points on one support and the pivot points on the other support ie in columns of the same length, can result in the storage according to the invention a parallelogram arrangement of these fulcrums.
  • the pivot points of the joint bearings of two supports on the chassis and the pivot points of the joint bearings of the same two supports on the receiving device equidistant from each other and if all pivot points on the chassis have the same arrangement as all pivot points on the receiving device, results on each two supports to each other always a parallelogram-shaped arrangement of the fulcrums - and form-fitting guided a storage of the mixing movement according to the invention. This is even forced, if, for example, as already described above, the movement plane of the receiving device is set at a certain distance from the chassis by suitable additional storage.
  • the supports according to the invention have a length between 700 mm and 5 mm; more preferably a length of 300 mm to 10 mm; and more preferably a length of 150 mm to 20 mm.
  • the mixing device may comprise, in addition to the receiving device, the drive and the bearing according to the invention, at least one heating element, preferably a controllable heating element.
  • a controllable heating element This is preferably embodied by a Peltier element or a resistance heating element, e.g. a heating foil.
  • the mixing device further comprises a cooling device, e.g. a Peltier element.
  • a cooling device e.g. a Peltier element.
  • different tempering devices e.g. when using a Peltier element, the complementary use of heat sinks and fans makes sense.
  • the heating or cooling element tempered the laboratory vessel and thus also the contents therein.
  • a method for mixing laboratory vessel contents can be operated.
  • a laboratory vessel with content is placed on the mixing device and then put the mixing device into operation.
  • it is also possible to temper the contents of the laboratory vessels ie to set by controlled heating and cooling to a temperature.
  • a simultaneous mixing and tempering is possible with the device according to the invention.
  • the mixing device according to the invention has various uses: first, it can be used as a freestanding mixing device, i. be used as a single independent laboratory device in the laboratory. Another use is their use in a laboratory machine, e.g. from the preparation of the sample through the mixing to the final analysis. Another use is the use in an incubator in which samples, especially living cells, a controlled atmosphere (temperature, humidity, gas) are exposed, wherein the mixing device according to the invention provides for the uniform movement of the sample to be incubated.
  • the following description of the device according to the invention provides the following advantages: simple mountability of the bearing and reduction of the load on the drive in the axial / vertical direction.
  • Another advantage that results from both the high load capacity of the storage as well as wide range of possible speeds (50 rpm - 3000 U / min) is the suitability of storage for both small light laboratory vessels, such as Eppendorf microplate wells, slides which can all be filled with very small volumes (maximum filling volumes: 0.1 ml, 0.2 ml, 0.5 ml, 1.5 ml and 2.0 ml) as well as for large, heavily filled laboratory vessels, Falcon tubes, glass vessels, Erlenmeyer flasks (eg up to 2000 ml), beakers etc ..
  • a mixing device with a receiving device for receiving mixed material and with a drive by which the recording device can move relative to a chassis in a mixing movement, in which the recording device on a closed path, periodically to a certain location in a recurring, moved, and with a storage, which leads the receiving device in the mixing movement, wherein the storage at least two supports each having two spaced joint bearings, each having no translational and at least two rotational degrees of freedom, of which a joint bearing supports the support on the chassis and the other joint bearing the receiving device on the support, wherein the bearing has a guide device which guides the rotation of the receiving device relative to the chassis during the mixing movement.
  • a device is characterized in that the guide means comprises at least one web which connects two of the supports with each other, wherein a S hinge joint, which has no translational and only one rotational degree of freedom, supports the web on one support and another hinge joint the Bridge on the other support and wherein the two hinge joints are rotatable about mutually parallel axes.
  • the axes of the hinge joints are mounted centrally on the chassis and on the receiving device between the respective pivot bearings of the two supports connected by the web.
  • it is preferred for the web to embrace the support on which it is mounted, or for the support to embrace the web at the hinge joint.
  • a device according to the invention may be characterized in that the pivot points of the joint bearings of a support are equidistant from each other as the pivot points of the joint bearings of another support.
  • pivot points of the pivot bearings of a support are equidistant from each other as are the pivot points of the pivot bearings of all the other supports.
  • a device may be characterized in that the pivot points and / or axes of rotation of the spherical plain bearings of two supports on the chassis and the pivot points and / or axes of rotation of the spherical plain bearings of the same supports on the receiving device are equidistant from each other.
  • pivot points and / or axes of rotation of the spherical plain bearings of all supports on the chassis and the pivot points and / or axes of rotation of the spherical plain bearings of the same supports on the receiving device are equidistantly spaced from one another.
  • a device according to the invention may be characterized in that only the supports and not the drive transmit a weight force acting on the receiving device into the chassis.
  • a device according to the invention may be characterized in that the device comprises a controllable heating element selected from the group of Peltier elements and resistance heating elements and heating foils.
  • Also according to the invention is a method according to claim 10 for mixing laboratory vessel contents, wherein a laboratory vessel with contents is placed on the device according to one of claims 1 to 9 and then the mixing device is put into operation.
  • the content of the laboratory vessel can be tempered.
  • FIG. 1 is a mixing device 2 recognizable with a chassis 4 and a receiving device 6, which are each shown schematically only as rectangular plates.
  • the receiving device 6 is supported on four supports 8, 10, 12, 14.
  • the supports have a (not shown here) circular cylindrical basic shape each with a schematic joint ball 16 as a schematic representation of a respective joint bearing with only two (rotational) degrees of freedom at both ends of the respective support.
  • Each of the joint balls 16 is arranged in a (schematic) ball socket in the underside of the receiving device 6 or in the top of the chassis 4.
  • the pivot points (centers) of the bearing balls are equidistant from each other on all supports (distance a).
  • FIG. 1 results, the four pivot points (centers) of the bearing balls 16 at the upper ends of the four supports on a (horizontal) plane 6 are arranged and the four pivot points (centers) of the bearing balls 16 at the respective lower ends of the four supports on a (horizontal) Level 4 plane parallel to it.
  • This inventive storage allows a mixing movement of the receiving device 6 along the arrow 18 in a circular translational recurring.
  • the recording device 6 is driven in this mixing movement 18 by an eccentric 20, which sits on a vertical, rotationally driven shaft 22.
  • the eccentric 20 is slidably mounted in a through hole 24 in the receiving device 6 and sets with its eccentricity E between the eccentric axis and the shaft axis, the radius of rotation 18 fixed. This determined by the positive engagement of the joint bearing 16 - as long as clearance and tolerances are disregarded, so in principle - then the distance between the chassis 4 and the receiving device 6 (perpendicular to the plane of movement of the mixing movement 18).
  • pivot bearings 16 allow such a swivel angle S of the support (for example 10) relative to the receiving device 6 (and thus also relative to the chassis 4) that in the mixing movement 18, the circular path of the pivot points of the pivot bearing 16, the receiving device stored on the support (for example, 10), in plan view of the plane of movement 18 (top view not shown) are approximately equal.
  • FIG. 1 It can also be seen that the supports 8 and 10 are connected by a web 28 and the supports 12 and 14 by a web 30 together.
  • a hinge joint 32 supports the respective web on one of the supports 8, 10, 12 or 14.
  • the hinge joints 32 so store the respective web 28, 30 on the respective support rotatable about mutually parallel axes 34 Example, the axis of rotation of the hinge joint 32 at the left end of the web 28 in FIG. 1 parallel to the axis of rotation of the hinge joint 32 a right end of the web 28 in FIG. 1 ,
  • FIG. 2 shows an alternative embodiment of a mixing device 2 according to the invention
  • FIG. 2 the corresponding construction elements of the device 2 are numbered identically as in FIG FIG. 1 even if it is not identical, but only functionally appropriate construction elements.
  • the device 2 according to FIG. 2 In contrast to the device 2 according to FIG. 1 has the device 2 according to FIG. 2 only two supports 10, 12. Here is the (vertical) distance of the receiving device 6 (not shown) fixed by the chassis 4 by a horizontal collar 36 at the lower end of the eccentric 20.
  • FIG. 3 shows a possible embodiment of a storage according to the invention, as they are in principle in FIG. 2 is shown.
  • the web 28 is mounted on the two hinge joints 32, which here, however, include the respective ball support fork-shaped.
  • the pins of the hinge joints 32 penetrate vertically through plane-parallel, flat outer surfaces 40 on the supports 10 and 12 therethrough.
  • the flat outer surfaces 40 on the support 10 and the support 12 abut against the flat inner sides 42 of the forked ends of the web 28.
  • FIG. 3 c shows an assembly schematically, the according to FIG. 3 a substantially completely corresponds to the effective surface reversal in the crotch: in FIG. 3 c
  • the ball support engages the web fork-shaped at the hinge joint and not vice versa.
  • housing 47 With a housing 47 is a device 2 according to the invention in FIG. 7 shown.
  • Figure 5 a, b and c show several schematic spatial views of alternative arrangements of the ball supports according to the invention of a device for mixing FIG. 1 , in which the ball supports are connected in pairs differently by webs with each other.
  • the ball supports are in FIG. 5 shown most schematically without pan, the chassis 4 and the receiving device 6 only highly schematically each dashed as planes.
  • Fig. 5 a repeats the mutually rectangular arrangement of the four ball supports 8 to 14 - although, however, the ball supports 10 and 12 and 8 and 14 are connected by hinge-webs 56 and 58 with each other.
  • Fig 5 b shows a mutually triangular arrangement of three ball supports 8, 10 and 60 - wherein only the ball supports 8 and 10 are connected by the hinge joint web 28 with each other.
  • the third ball support 60 stands alone and thus supports the receiving device 6 on the chassis 4 as three legs a stool.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Accessories For Mixers (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Pivots And Pivotal Connections (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Claims (12)

  1. Dispositif de mélange avec
    - un dispositif de réception (6) pour recevoir un mélange et avec
    - un entraînement (20, 22), grâce auquel le dispositif de réception (6) peut être déplacé par rapport à un châssis (4) au cours d'un mouvement de mélange (18), au sein duquel le dispositif de réception (6) se déplace sur un trajet fermé, en retournant périodiquement à un emplacement déterminé avec une orientation déterminée dans l'espace, et avec
    - une suspension, qui guide le dispositif de réception (6) lors du mouvement de mélange,
    - dans lequel la suspension présente au moins deux jambes (8, 10, 12, 14, 60, 62, 64), munies respectivement de deux paliers articulés (16) espacés l'un de l'autre, se présentant sous la forme de sections de barre élastiques courtes qui ne présentent respectivement pas de degré de liberté de translation et au moins deux degrés de liberté de rotation, parmi lesquels le premier palier articulé (16) permet l'installation des jambes (8, 10, 12, 14, 60, 62, 64) au niveau du châssis (4) et l'autre palier articulé (16) permet l'installation du dispositif de réception (6) au niveau des jambes (8, 10, 12, 14, 60, 62, 64),
    caractérisé en ce que
    - la suspension présente un dispositif de guidage (28, 30, 32), qui guide le dispositif de réception (6) par rapport au châssis (4) au cours du mouvement de mélange (18), dans lequel le dispositif de guidage (28, 30, 32) présente au moins une réglette (28, 30), qui relie deux des jambes (8, 12, 62) l'une à l'autre, dans lequel une articulation de charnière (32), ne présentant pas de degré de liberté de translation et seulement un degré de liberté de rotation permet l'installation de la réglette (28, 30) au niveau de l'une première jambe (10, 14, 64) et une autre articulation de charnière (32) permet l'installation de la réglette (28, 30) au niveau de l'autre jambe (8, 10, 12, 14, 62, 64) et dans lequel les deux articulations de charnière (32) peuvent tourner autour d'axes parallèles l'un à l'autre.
  2. Appareil selon la revendication 1, caractérisé en ce que les axes des articulations de charnière (32) sont centrés au niveau du châssis (4) et au niveau du dispositif de réception (6) entre les paliers articulés (16) respectifs des deux jambes (8, 10, 12, 14, 62, 64) reliées par la réglette (28, 30).
  3. Dispositif selon la revendication 2, caractérisé en ce que la réglette (42) entoure la jambe (40) au niveau duquel elle est installée, ou la jambe entoure la réglette au niveau de l'articulation de charnière en adoptant une forme de fourche.
  4. Dispositif selon l'une quelconque des revendications 1 à 3, caractérisé en ce que les points de rotation des paliers articulés (16) d'une jambe (8, 10, 12, 14, 60, 62, 64) sont équidistants les uns des autres, tout comme les points de rotation des paliers articulés (16) d'une autre jambe (8, 10, 12, 14, 60, 62, 64).
  5. Dispositif selon la revendication précédente, caractérisé en ce que les points de rotation des paliers articulés (16) d'une jambe (8, 10, 12, 14, 60, 62, 64) sont équidistants les uns des autres, tout comme les points de rotation des paliers articulés (16) de toutes les autres jambes (8,10, 12, 14, 60, 62, 64).
  6. Dispositif selon l'une quelconque des revendications 1 à 4, caractérisé en ce que les points de rotation et/ou les axes de rotation des paliers articulés (16) d'une paire de jambes (8, 10, 12, 14, 60, 62, 64) au niveau du châssis (4) et les points de rotation et/ou les axes de rotation des paliers articulés (16) de ces mêmes jambes (8, 10, 12, 14, 60, 62, 64) au niveau du dispositif de réception (6) sont équidistants les uns des autres.
  7. Dispositif selon la revendication précédente, caractérisé en ce que les points de rotation et/ou les axes de rotation des paliers articulés (16) de toutes les jambes (8, 10, 12, 14, 60, 62, 64) au niveau du châssis (4) et les points de rotation et/ou les axes de rotation des paliers articulés (16) de ces mêmes jambes (8, 10, 12, 14, 60, 62, 64) au niveau du dispositif de réception (6) sont équidistants les uns des autres.
  8. Dispositif selon l'une quelconque des revendications 1 à 5, caractérisé en ce que seules les jambes (8, 10, 12, 14, 60, 62, 64), et non l'entraînement (20, 22), transmettent au châssis (4) une force s'exerçant sur le dispositif de réception (6).
  9. Dispositif selon l'une quelconque des revendications 1 à 7, dans lequel le dispositif (2) comprend un élément chauffant réglable choisi dans le groupe des éléments à effet Peltier et des éléments chauffants à résistance et des films chauffants.
  10. Procédé de mélange de contenu de récipient de laboratoire, dans lequel un récipient de laboratoire est placé avec son contenu sur le dispositif (2) selon l'une quelconque des revendications 1 à 9, et le dispositif de mélange (2) est ensuite mis en marche.
  11. Procédé selon la revendication 10, dans lequel le contenu du récipient de laboratoire est mis à température.
  12. Utilisation du dispositif selon l'une quelconque des revendications 1 à 9 en tant que dispositif de mélange autonome (2) ou en tant que partie d'un automate de laboratoire ou d'un incubateur.
EP13004188.2A 2010-11-03 2010-11-03 Dispositif de mélange doté d'un palier pour un dispositif de réception, procédé de mélange associé, et l'utilisation d'un tel dispositif de mélange Active EP2669000B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP13004188.2A EP2669000B1 (fr) 2010-11-03 2010-11-03 Dispositif de mélange doté d'un palier pour un dispositif de réception, procédé de mélange associé, et l'utilisation d'un tel dispositif de mélange

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13004188.2A EP2669000B1 (fr) 2010-11-03 2010-11-03 Dispositif de mélange doté d'un palier pour un dispositif de réception, procédé de mélange associé, et l'utilisation d'un tel dispositif de mélange
EP10014237.1A EP2450099B1 (fr) 2010-11-03 2010-11-03 Dispositif de mélange doté d'un stockage pour un dispositif de réception, et procédé de son utilisation

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP10014237.1A Division EP2450099B1 (fr) 2010-11-03 2010-11-03 Dispositif de mélange doté d'un stockage pour un dispositif de réception, et procédé de son utilisation
EP10014237.1 Division 2010-11-03

Publications (2)

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EP2669000A1 EP2669000A1 (fr) 2013-12-04
EP2669000B1 true EP2669000B1 (fr) 2019-05-01

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EP10014237.1A Active EP2450099B1 (fr) 2010-11-03 2010-11-03 Dispositif de mélange doté d'un stockage pour un dispositif de réception, et procédé de son utilisation
EP13004188.2A Active EP2669000B1 (fr) 2010-11-03 2010-11-03 Dispositif de mélange doté d'un palier pour un dispositif de réception, procédé de mélange associé, et l'utilisation d'un tel dispositif de mélange

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US (1) US8827540B2 (fr)
EP (2) EP2450099B1 (fr)
JP (1) JP5815724B2 (fr)
CN (1) CN103153449B (fr)
WO (1) WO2012059229A1 (fr)

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Also Published As

Publication number Publication date
US20120140589A1 (en) 2012-06-07
WO2012059229A1 (fr) 2012-05-10
EP2450099B1 (fr) 2014-01-01
EP2450099A1 (fr) 2012-05-09
CN103153449A (zh) 2013-06-12
CN103153449B (zh) 2016-01-20
JP2014501605A (ja) 2014-01-23
US8827540B2 (en) 2014-09-09
JP5815724B2 (ja) 2015-11-17
EP2669000A1 (fr) 2013-12-04

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