EP2669000A1 - Dispositif de mélange doté d'un stockage pour un dispositif de réception - Google Patents

Dispositif de mélange doté d'un stockage pour un dispositif de réception Download PDF

Info

Publication number
EP2669000A1
EP2669000A1 EP13004188.2A EP13004188A EP2669000A1 EP 2669000 A1 EP2669000 A1 EP 2669000A1 EP 13004188 A EP13004188 A EP 13004188A EP 2669000 A1 EP2669000 A1 EP 2669000A1
Authority
EP
European Patent Office
Prior art keywords
supports
receiving device
mixing
joint
chassis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13004188.2A
Other languages
German (de)
English (en)
Other versions
EP2669000B1 (fr
Inventor
Arne Schafrinski
Judith Jacobs
Florian Dürr
Martin Stranzinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eppendorf SE filed Critical Eppendorf SE
Priority to EP13004188.2A priority Critical patent/EP2669000B1/fr
Publication of EP2669000A1 publication Critical patent/EP2669000A1/fr
Application granted granted Critical
Publication of EP2669000B1 publication Critical patent/EP2669000B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L99/00—Subject matter not provided for in other groups of this subclass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/22—Mixing the contents of independent containers, e.g. test tubes with supporting means moving in a horizontal plane, e.g. describing an orbital path for moving the containers about an axis which intersects the receptacle axis at an angle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/70—Drives therefor, e.g. crank mechanisms

Definitions

  • the present invention relates to a mixing device, in particular for mixing laboratory vessel contents with a receiving device for receiving mixed material and having a drive, by means of which the receiving device relative to a normal stationary chassis in a mixing movement can put, in which the receiving device on a closed Path, recurring periodically to a certain position in a certain orientation in space moves, preferably in a horizontal plane of movement only translationally and cyclically, in particular on a circular path, and with a storage that guides the receiving device in the mixing movement.
  • mixing devices in which laboratory vessel contents are mixed are well known.
  • mixing devices are known to have receiving devices for a wide variety of mix containers.
  • Such receptacles may also consist of a pedestal structure on which a holder for the mix containers is kept interchangeable in order to make the mixer useful for various vessels.
  • mixers that can mix even small amounts of liquid, that small containers in suitable holders, so-called “exchange blocks” are also summarized in very large groups of two, three or even four-digit number.
  • exchangeable blocks and also the reaction vessels can be standardized. For example, there are 0.2 ml, 0.5 ml, 1.5 ml and 2.0 ml tubes - and suitable replacement blocks for this purpose.
  • such mixers are driven at a rotational frequency of 200 rpm to 1,500 rpm.
  • the frequency of the mixing movement is known to be adjustable.
  • the present invention has for its object to provide a mixing device which avoids the problems of said previous solutions mentioned or at least reduced.
  • the present invention has for its object to provide a mixer with spherical bearings, in which the risk of unwanted rotation and / or tilting of the receiving device is reduced.
  • a mixing device has in particular for mixing laboratory vessel contents a receiving device for receiving mixed material and a drive and a storage.
  • the drive can be the recording device guided relative to a designated stationary chassis led by the storage in a mixing movement.
  • the mixing movement is a translational movement of the entire recording device (driven by the drive and guided by the forced guidance of the bearing) on a path in the space which extends substantially in the horizontal plane, ie in the x and y direction in a three-dimensional coordinate system.
  • the maximum deviations of the web in a vertical (ie perpendicular to the horizontal plane) direction (z-direction) is preferably 5% of the height (in the vertical direction) of the smallest used Mischgut vessels, more preferably 1% and particularly preferably 0, 2% of the height of the smallest used mix container.
  • Deviations from the horizontal plane in the vertical are preferably not more than 0.2 mm, more preferably not more than 0.05 mm, and particularly preferably not more than 0.02 mm.
  • acceleration sensors which measure the acceleration of the recording device in all three spatial directions (x, y, z) are preferably used.
  • the magnitude of the acceleration vectors should always be constant for a given rotational frequency, with the z component being as low as possible, and the x and z components being out of phase with each other.
  • the effective value for the acceleration vector in the z-direction is less than or equal to 50 m / s 2 , preferably less than or equal to 20 m / s 2 and particularly preferably less than or equal to 10 m / s 2 , this being Value also depends on the weight load of the mixing device.
  • the RMS value is 10 m / s 2 when the mixing device as a receiving device carries an exchangeable block weighing 500 g.
  • a uniaxial sensor M352C65, M353B15
  • a triaxial sensor (356A22) from PCP Piezoelectronics Inc was used to determine the quality, ie uniformity, of the concentricity.
  • the mixing movement is a movement of the receiving device on a closed, so to speak annular and somehow spatially three-dimensionally extending path which at least predominantly translational, but can also perform rolling movements when it only periodically returns to at least one particular position in a particular orientation in space.
  • the pick-up device reverts to each point of the web in space, and is a periodic movement so that each point of the web in space is reached again and again at equal intervals - or in other words, so that the pick-up device interrupts periodically same place.
  • the preferred circular or elliptical planar path is also referred to as the orbital path.
  • the preferred circular path of movement of the mixing device according to the invention is predominantly on the x-axis (abscissa) and y-axis (ordinate) spanned horizontal plane. Movements in the direction of the z-axis (applicate) are preferably less pronounced and show up in the mixing device as a kind of up and down movement of the receiving device and thus also the vessels located therein with content. The movement in the direction of the z-axis is called a z-stroke.
  • the storage according to the invention holds and guides the receiving device during this mixing movement so that the dynamic up and down movement of the receiving device is preferably reduced as much as possible.
  • This dynamic up and down movement is known in the art as the already mentioned z-stroke.
  • a z-stroke during the mixing movement is disadvantageous in most applications, and therefore undesirable, since it can lead to wetting and thus contamination of the vessel lid, or squirts the sample out of the vessel in open vessels.
  • the storage has at least two supports.
  • the at least two supports can either be of equal length or alternatively have different lengths. For columns of different lengths, a leveling over the other components, such as the receiving device or the chassis must be done to align the recording device again in a horizontal plane.
  • Each of these supports according to the invention has at least two spaced storage areas (spherical plain bearings), which - at least substantially - no translational and at least two (linearly independent) have rotational degrees of freedom.
  • Bearing areas are the areas of the support that are in direct contact with a bearing or parts of a bearing.
  • a support can be both one-piece and multi-part. In a multi-part support at least two parts each have at least one storage area.
  • the at least two storage areas of a support can be located at different positions of the support. Preference is given to the terminal arrangement, in which a bearing is located at both ends of the support, since this simplifies the assembly of the mixing device according to the invention.
  • the storage area is a short elastic bar section where its flexural elasticity accounts for the two rotational degrees of freedom (which, however, are then limited in their range of motion, for example, by the plastic deformation limit or breaking strength of the bar).
  • the bearing areas may comprise sliding bearings each having at least one rotational degree of freedom about an axis deviating from the extension direction of the support (approximately the vertical as intended).
  • the axes of rotation are perpendicular to the direction of extension.
  • the storage area has only one warehouse.
  • This can realize all three rotational degrees of freedom (x, y and z), preferably even with axes crossing in one point (fulcrum) (eg as a ball joint).
  • the directions of one rotational degree of freedom of both bearings of the respective storage area are perpendicular to each other - possibly even crossing at a point (pivot point) (cross or "gimbal" joint).
  • the directions of the one rotational degree of freedom of both bearings are horizontal.
  • the bearings have, at least essentially, no translational degrees of freedom, ie a person skilled in the art understands a bearing without translational degrees of freedom, wherein he accepts deviations in the usual tolerance range. These unwanted deviations can happen For example, resulting from the elastic and / or plastic or deformation of the elements of the bearing, but due to the choice of materials - elastic and / or plastic deformation are not wanted, unless explicitly elastic bearing elements are used - should be negligible.
  • the bearing area is a short elastic rod section in which its bending elasticity makes up the two rotational degrees of freedom, possibly a universal joint (also known as a cardan joint) or a ball and socket joint (ball joint).
  • a provided with the ball joints support is here called ball support.
  • the storage according to the invention has a guide device, which during the mixing movement, the rotation of the receiving device relative to the chassis.
  • this guide device which is preferably form-fitting, an unwanted, in particular chaotic, rotation of the receiving device relative to the chassis can be effectively prevented.
  • the drive of the mixing device according to the invention is initially able to set the receiving device in a mixing movement, which, as mentioned, preferably runs in a circular translatory cyclical manner in a plane.
  • a mixing movement which, as mentioned, preferably runs in a circular translatory cyclical manner in a plane.
  • “circular translationally cyclical” can be described by the fact that in such a mixing movement according to the invention all points of the receiving device perform a repetitive circular motion with essentially the same radius, angular velocity and angular position about a respective center in plane-parallel planes.
  • the mixing movement preferably proceeds in substantially horizontal planes, so that exchange blocks accommodated in receiving adapters of the receiving device, for example, are reliably mixed with reaction vessels held vertically in them, ie, without spilling the vessel contents during conventional filling.
  • the drive is preferably via an eccentric, which is rotatably mounted in the receiving device.
  • the offset between the axis of the drive shaft and the parallel to it axis of the eccentric determines the orbit radius of the mixing movement.
  • This offset the Also referred to as the amplitude of the eccentric determined at constant column length, the inclination of the columns and thus the distance between the receiving device and chassis.
  • the storage of the receiving device according to the invention allows a positive guidance of the receiving device, wherein the storage is easy to assemble and yet the axial forces emanating from the receiving device, are absorbed by the storage. Furthermore, the storage according to the invention enables the construction of mixers with a small overall height. The advantages of the storage according to the invention are thus simple assembly and very strong reduction of the load of the drive in the axial direction. The latter point increases occupational safety and the life of the drive. Thus, the storage according to the invention is particularly suitable for use in mixing devices which have to carry high loads, such as large filled laboratory vessels (eg Erlenmeyer flasks (2000 ml).) Since space in a laboratory is always limited, the low overall height of the invention is Mixers also beneficial.
  • large filled laboratory vessels eg Erlenmeyer flasks (2000 ml).
  • this storage already in principle allows to set the radius of this circular path by establishing geometry parameters such as the support length or even on the device by the user to make adjustable.
  • the circular path radius is preferably between 0.5 mm and 5 mm and particularly preferably between 1 mm and 2 mm.
  • the circular path frequency can be reduced due to the new storage to values up to 50 rev / min. But it can also (especially at high loading weight of the vessels) frequencies of 2,000 rev / min, preferably 2,500 rev / min, and even 3,000 rev / min and to be driven more.
  • the storage has two, three or four of the supports, which, for example, like stool legs or table legs in principle store the receiving device as a tabletop on the chassis as a base.
  • the joint bearings in particular the pivot points of the joint bearing a support equidistant from each other as the joint bearings, in particular the pivot points of the joint bearings of all other supports, this results in a mobility of the recording device always in a plane-parallel alignment over the chassis (Movement of the plane through the cradle pivot bearings against the plane through the chassis pivot bearings). Since the supports carry the axial / vertical loads, a mixer is all the more resilient, the more supports it has.
  • this translational mobility exists, for example, for equally long, parallel supports only on a circular path with a fixed radius. This is essential to achieve a smooth mixing motion on a circular planar path, i. a stable mixing movement without tilting and with reduced z-stroke.
  • the angle of inclination of each individual support relative to the chassis remains constant over the entire revolution of the mixing movement, since the supports can not twist against each other.
  • the distance remains the same between one of these points and one of the respective equivalent points a during the mixing process ', b', c, 'd' etc., on one of the other supports. Without these features, there would be an unwanted twisting of the two levels against each other.
  • this distance is a first example of a guide device according to the invention, which leads during the mixing movement, the rotation of the receiving device relative to the chassis.
  • the distance (and thus the radius of the circular path) is ultimately determined by the amplitude with which the eccentric moves the receiving device relative to the chassis, wherein the eccentric is mounted on the chassis. If the distance of the plane of movement of the receiving device from the chassis even configured adjustable, for example, in this way, the radius of the circular path of the mixing movement can be set on the mixing device according to the invention
  • the distance between the chassis level and the recording device at the remaining points remains unchanged.
  • the distance remains unchanged at all points, since the angle of inclination of each individual support relative to the chassis is kept constant over the entire circulation of the mixing movement, and the supports can not twist against each other.
  • This feature the inclination angle of each support relative to the chassis remains the same - thus eliminates unwanted twisting of the two planes, namely the plane of movement of the cradle (the plane through the cradle pivot bearings relative to the chassis plane (plane through the chassis pivot bearings) is unwanted, and it is in the present invention to minimize them, as this leads to an uncontrolled mixing movement, which is disadvantageous (z-stroke).
  • the guide device according to the invention leads during the mixing movement, the rotation of the receiving device relative to the chassis, wherein reducing / preventing this unwanted twist falls under this inventive guiding the rotation.
  • the guide device according to the invention preferably performs such that the unintentional rotation is equal to zero. Shown as projecting into the x, y planes, it can be seen that the guide means causes the supports to always be deflected in the same direction, i. the guide device synchronizes the column movement.
  • the guide device according to the invention includes, for example, bearings, rods, cams, rails, webs, links and combinations thereof.
  • the guide device according to the invention can likewise consist of a magnetic field.
  • both the receiving device and the chassis each carry at least one compatible magnetic element, ie, in attracting interaction elements selected from the group of magnets, magnetizable elements, permanent magnets, electromagnets and current-carrying Coils or a combination thereof.
  • Examples of permanent magnets are those of a ferromagnetic material such as iron, nickel, cobalt, neodymium-iron-boron, samarium-cobalt.
  • An adjustable embodiment is possible, for example by regulating the currents in a current-carrying coil by means of a control device.
  • the control device regulates the current flow and thus the strength of the magnetic field or regulates the polarity on the basis of received signals (for example: manual inputs with respect to the current density, the weight and / or the viscosity of the vessel contents, sensor signal with respect to the detected weight and / or viscosity) the coil and thus the direction of the magnetic field.
  • vessel and / or vessel contents a directed movement in the vertical direction, i. to achieve a shaking motion (up and down motion, vibration) of the pickup device that continues to move on its orbit.
  • the guide means has at least one web of two of the supports of the invention with each other. It stores a bearing that has no translational and only one rotational degree of freedom (hinge joint) the web on one support, and a second hinge joint supports the bridge on the other support.
  • the two hinge joints are rotatable about mutually parallel axes.
  • a skewed twisting (twisting) of the supports against each other is a prerequisite for the unwanted twisting of the two supported on the supports levels (as already indicated above: when twisting the two levels against each other changes the concomitant inclination of the columns at the same time the distance between the planes).
  • the unintentional rotation of the planes relative to one another is consequently significantly reduced by the guide device according to the invention, the web attaching to the supports in interaction with the hinge joints. It is known to the person skilled in the art that compressions and expansions of the supports and webs can not be completely ruled out, which also cause unwanted twisting.
  • the axes of the hinge joints are each mounted centrally between the respective joint bearings of the two supports connected by the web.
  • the following distances to the device according to the invention are the same size: between two supports, the distance between the pivot points of the joint bearing on the chassis from each other and the distance between the pivot points of the pivot bearing on the receiving device from each other.
  • the pivot points on one support and the pivot points on the other support ie in columns of the same length, can result in the storage according to the invention a parallelogram arrangement of these fulcrums.
  • the pivot points of the joint bearings of two supports on the chassis and the pivot points of the joint bearings of the same two supports on the receiving device equidistant from each other and if all pivot points on the chassis have the same arrangement as all pivot points on the receiving device, results on each two supports to each other always a parallelogram-shaped arrangement of the fulcrums - and form-fitting guided a storage of the mixing movement according to the invention. This is even forced, if, for example, as already described above, the movement plane of the receiving device is set at a certain distance from the chassis by suitable additional storage.
  • the supports according to the invention have a length between 700 mm and 5 mm; more preferably a length of 300 mm to 10 mm; and more preferably a length of 150 mm to 20 mm.
  • the supports have a length of 35 mm, measured from the pivot point / center of the ball of the ball and socket joint.
  • the spherical plain bearings designed as a ball and socket joint, a ball diameter between 60 mm and 3 mm; more preferably a ball diameter between 30 mm and 5 mm; and more preferably a ball diameter between 20 mm and 7 mm.
  • the ball diameter is 13 mm.
  • a preferred sliding speed in the joint of between 0 and 0.2 m / s in the pairing metal / plastic and also in the reverse choice of material - advantageous in particular if the ball at least its articulated surface made of polished metal such as VA steel or aluminum ( anodised) or ceramic and the pan has at least its plastic articulation surface such as abrasion-resistant, slip-modified thermoset or thermoset.
  • the preferred sliding speed can also be achieved by reversing the choice of material, ie the ball consists at least on its surface of a plastic, in particular an abrasion-resistant sliding-modified thermoplastics or thermosets and the pan, at least their Articulated surface made of a polished metal such as stainless steel or aluminum (anodized) or ceramic.
  • the ball is rigidly connected to the support, and the pan is only indirectly over the ball in conjunction with the support.
  • the arrangement is reversed, i.
  • the pan is rigidly connected to the support and the ball is only indirectly above the pan in conjunction with the support.
  • the depending on the variant with the support only indirectly connected part of the ball and socket joint is in rigid contact with the chassis or recording device.
  • the second variant is preferred since a mixing device according to the invention with this arrangement of the bearing is particularly easy to assemble.
  • the mixing device may comprise, in addition to the receiving device, the drive and the bearing according to the invention, at least one heating element, preferably a controllable heating element.
  • a controllable heating element This is preferably embodied by a Peltier element or a resistance heating element, e.g. a heating foil.
  • the mixing device further comprises a cooling device, e.g. a Peltier element.
  • a cooling device e.g. a Peltier element.
  • different tempering devices e.g. when using a Peltier element, the complementary use of heat sinks and fans makes sense.
  • the heating or cooling element tempered the laboratory vessel and thus also the contents therein.
  • a method for mixing laboratory vessel contents can be operated.
  • a laboratory vessel with content is placed on the mixing device and then put the mixing device into operation.
  • it is also possible to temper the contents of the laboratory vessels ie to set by controlled heating and cooling to a temperature.
  • a simultaneous mixing and tempering is possible with the device according to the invention.
  • the mixing device according to the invention has various uses: first, it can be used as a freestanding mixing device, i. be used as a single independent laboratory device in the laboratory. Another use is their use in a laboratory machine, e.g. from the preparation of the sample through the mixing to the final analysis. Another use is the use in an incubator in which samples, especially living cells, a controlled atmosphere (temperature, humidity, gas) are exposed, wherein the mixing device according to the invention provides for the uniform movement of the sample to be incubated.
  • the following brief description of the device according to the invention provides the following advantages: simple mountability of the bearing and reduction of the load on the drive in the axial / vertical direction.
  • Another advantage that results from both the high load capacity of the storage as well as wide range of possible speeds (50 rpm - 3000 U / min) is the suitability of storage for both small light laboratory vessels, eg. B Eppendorf tubes Microtiter plates, slides that can be filled with very small volumes (maximum volumes: 0.1 ml, 0.2 ml, 0.5 ml, 1.5 ml and 2.0 ml) as well as large, heavily filled laboratory tubes , Falcon tubes, glass jars, Erlenmeyer flasks (eg up to 2000 ml), beakers etc.
  • a mixing device with a receiving device for receiving mixed material and with a drive by which the recording device can move relative to a chassis in a mixing movement, in which the recording device on a closed path, periodically to a certain location in a recurring, moved, and with a storage, which leads the receiving device in the mixing movement, wherein the storage at least two supports each having two spaced joint bearings, each having no translational and at least two rotational degrees of freedom, of which a joint bearing supports the support on the chassis and the other joint bearing the receiving device on the support, wherein the bearing has a guide device which guides the rotation of the receiving device relative to the chassis during the mixing movement.
  • a device according to the invention may be characterized in that at least one of the joint bearings is a universal joint or a ball joint or joint region with two bearings spaced apart from one another, each with only one rotational degree of freedom.
  • a device may be characterized in that the guide device has at least one web which connects two of the supports with each other, wherein a hinge joint, which has no translational and only one rotational degree of freedom, supports the web on one support and another hinge joint Bridge on the other support and wherein the two hinge joints are rotatable about mutually parallel axes.
  • the axes of the hinge joints are mounted centrally on the chassis and on the receiving device between the respective pivot bearings of the two supports connected by the web.
  • the web it is preferred for the web to embrace the support on which it is mounted, or for the support to embrace the web at the hinge joint.
  • a device according to the invention may be characterized in that the pivot points of the joint bearings of a support are equidistant from each other as the pivot points of the joint bearings of another support.
  • pivot points of the pivot bearings of a support are equidistant from each other as are the pivot points of the pivot bearings of all the other supports.
  • a device may be characterized in that the pivot points and / or axes of rotation of the spherical plain bearings of two supports on the chassis and the pivot points and / or axes of rotation of the spherical plain bearings of the same supports on the receiving device are equidistant from each other.
  • pivot points and / or axes of rotation of the spherical plain bearings of all supports on the chassis and the pivot points and / or axes of rotation of the spherical plain bearings of the same supports on the receiving device are equidistantly spaced from one another.
  • a device according to the invention may be characterized in that only the supports and / or the drive do not transmit a weight force acting on the receiving device into the chassis.
  • a device according to the invention may be characterized in that the device comprises a controllable heating element selected from the group of Peltier elements and resistance heating elements and heating foils.
  • the invention also provides a method for mixing laboratory vessel contents, wherein a laboratory vessel with contents is placed on the device according to one of claims 1 to 9 and then the mixing device is put into operation.
  • the content of the laboratory vessel can be tempered.
  • the use of the device according to the invention as a freestanding mixing device or as part of a laboratory machine or incubator.
  • FIG. 1 is a mixing device 2 recognizable with a chassis 4 and a receiving device 6, which are each shown schematically only as rectangular plates.
  • the receiving device 6 is supported on four supports 8, 10, 12, 14.
  • the supports have a (not shown here) circular cylindrical basic shape each with a joint ball 16 each of a hinge bearing at both ends of the respective support.
  • Each of the joint balls 16 is arranged in a ball socket in the bottom of the receiving device 6 or in the top of the chassis 4.
  • the pivot points (centers) of the bearing balls are equidistant from each other on all supports (distance a).
  • FIG. 1 results, the four pivot points (centers) of the bearing balls 16 at the upper ends of the four supports on a (horizontal) plane 6 are arranged and the four pivot points (centers) of the bearing balls 16 at the respective lower ends of the four supports on a (horizontal) Level 4 plane parallel to it.
  • This inventive storage allows a mixing movement of the receiving device 6 along the arrow 18 in a circular translational recurring.
  • the recording device 6 is driven in this mixing movement 18 by an eccentric 20, which sits on a vertical, rotationally driven shaft 22.
  • the eccentric 20 is slidably mounted in a through hole 24 in the receiving device 6 and sets with its eccentricity E between the eccentric axis and the shaft axis, the radius of rotation 18 fixed. This determined by the positive engagement of the joint bearing 16 - as long as clearance and tolerances are disregarded, so in principle - then the distance between the chassis 4 and the receiving device 6 (perpendicular to the plane of movement of the mixing movement 18).
  • pivot bearings 16 allow such a swivel angle S of the support (for example 10) relative to the receiving device 6 (and thus also relative to the chassis 4) that in the mixing movement 18, the circular path of the pivot points of the pivot bearing 16, the receiving device stored on the support (for example, 10), in plan view of the plane of movement 18 (top view not shown) are approximately equal.
  • FIG. 1 It can also be seen that the supports 8 and 10 are connected by a web 28 and the supports 12 and 14 by a web 30 together.
  • a hinge joint 32 supports the respective web on one of the supports 8, 10, 12 or 14.
  • the hinge joints 32 so store the respective web 28, 30 on the respective support rotatable about mutually parallel axes 34 Example, the axis of rotation of the hinge joint 32 at the left end of the web 28 in FIG. 1 parallel to the axis of rotation of the hinge joint 32 a right end of the web 28 in FIG. 1 ,
  • Each about the two parallel axes at its two ends rotatably hinged to the ball supports 8 to 14 webs 28, 32 is a guide device which during the mixing movement 18, the rotation of the receiving device 6 relative to the chassis 4 so that this rotation during the entire period a recurrence - that is, during the entire mixing movement 18 - equal to zero (in other words always translational).
  • FIG. 2 shows an alternative embodiment of a mixing device 2 according to the invention
  • FIG. 2 the corresponding construction elements of the device 2 are numbered identically as in FIG FIG. 1 even if it is not identical, but only functionally appropriate construction elements.
  • the device 2 according to FIG. 2 In contrast to the device 2 according to FIG. 1 has the device 2 according to FIG. 2 only two supports 10, 12. Here is the (vertical) distance of the receiving device 6 (not shown) fixed by the chassis 4 by a horizontal collar 36 at the lower end of the eccentric 20.
  • FIG. 3 a and b show a possible embodiment of a storage according to the invention, as they are in principle in FIG. 2 is shown.
  • the supports 10, 12 (each as a plastic molding - see FIG. 3 b) carry lateral bearing balls 16, which protrude into bearings 38 and thus each form a joint stock.
  • This lateral orientation of the joint bearing allows for easy mounting by simultaneous snap both bearing balls of a ball support into the respective bearing shell.
  • the web 28 is (also as a plastic molding - see FIG. 3 b) mounted on the two hinge joints 32, which here, however, include the respective ball support fork-shaped.
  • the pins of the hinge joints 32 penetrate vertically through plane-parallel, flat outer surfaces 40 on the supports 10 and 12 therethrough.
  • the flat outer surfaces 40 on the support 10 and the support 12 abut against the flat inner sides 42 of the forked ends of the web 28.
  • the bearing shells 38 into which the bearing balls 16 protrude at the upper end of the supports 10, 12 are according to FIG. 3b arranged in a plastic molded part 44 and also the bearing shells 38, in which the bearing balls 16 protrude at the lower end of the two supports 10 and 12.
  • the (same) distance between the respective bearing shells 38 and between the hinge joints 16 constructively accurate and tightly tolerated namely specify in each case only one component.
  • Figure 3 c and d show an assembly ( Figure 3c schematically and 3d figure the physical embodiment), the according to FIG. 3 a and b essentially completely correspond to the reversal of the effective area on the one hand in the spherical plain bearings and on the other hand in the bifurcation: in FIG. 3c and d at the hinge joint, the ball-stud engages around the bridge in a bifurcated manner and not vice versa, and the pans (and not the balls) of the ball-and-socket joints are arranged on the ball-support.
  • FIG. 6 shows in a physical embodiment of two modules according to FIG. 3b with the supports 8, 10, 12, 14 and the webs 28, as they store a receiving device 6 on a chassis 4. Rotationally driven on this device 2, the receiving device 6 on the chassis 4 by a motor 46 via an eccentric 20 in a through hole 24 in the receiving device 6. With a housing 47, this device 2 in FIG. 7 shown.
  • FIG. 4 shows an embodiment of the joint bearings, of the bearing balls 16 and the bearing shells 38, such as in FIG. 3 to be formed.
  • the bearing shell 38 has three slots 48 which are uniform on the circumference of the Edge 50 of the ball opening 52 of the bearing shell 38 are distributed.
  • a spring ring 54 on the outside about the bearing shell 38 biases the walls of the bearing shell 38 inwardly against the bearing ball 16.
  • Figure 5 a, b and c show several schematic spatial views of alternative arrangements of the ball supports according to the invention of a device for mixing FIG. 1 , in which the ball supports are connected in pairs differently by webs with each other.
  • the ball supports are in FIG. 5 shown most schematically without pan, the chassis 4 and the receiving device 6 only highly schematically each dashed as planes.
  • Fig. 5 a repeats the mutually rectangular arrangement of the four ball supports 8 to 14 - although, however, the ball supports 10 and 12 and 8 and 14 are connected by hinge-webs 56 and 58 with each other.
  • Fig. 5b shows a mutually triangular arrangement of three ball supports 8, 10 and 60 - wherein only the ball supports 8 and 10 are connected by the hinge joint web 28 with each other.
  • the third ball support 60 stands alone and thus supports the receiving device 6 on the chassis 4 as three legs a stool.
  • Fig. 5c Finally, a mutually hexagonal arrangement of six ball supports 8 to 14 and 62 and 64 - wherein (as in FIG. 1 ) Each two ball supports 8 and 10 by a hinge joint web (28, 30 and 66) are connected to each other.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Accessories For Mixers (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Pivots And Pivotal Connections (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP13004188.2A 2010-11-03 2010-11-03 Dispositif de mélange doté d'un palier pour un dispositif de réception, procédé de mélange associé, et l'utilisation d'un tel dispositif de mélange Active EP2669000B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP13004188.2A EP2669000B1 (fr) 2010-11-03 2010-11-03 Dispositif de mélange doté d'un palier pour un dispositif de réception, procédé de mélange associé, et l'utilisation d'un tel dispositif de mélange

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10014237.1A EP2450099B1 (fr) 2010-11-03 2010-11-03 Dispositif de mélange doté d'un stockage pour un dispositif de réception, et procédé de son utilisation
EP13004188.2A EP2669000B1 (fr) 2010-11-03 2010-11-03 Dispositif de mélange doté d'un palier pour un dispositif de réception, procédé de mélange associé, et l'utilisation d'un tel dispositif de mélange

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP10014237.1 Division 2010-11-03
EP10014237.1A Division EP2450099B1 (fr) 2010-11-03 2010-11-03 Dispositif de mélange doté d'un stockage pour un dispositif de réception, et procédé de son utilisation

Publications (2)

Publication Number Publication Date
EP2669000A1 true EP2669000A1 (fr) 2013-12-04
EP2669000B1 EP2669000B1 (fr) 2019-05-01

Family

ID=43743458

Family Applications (2)

Application Number Title Priority Date Filing Date
EP13004188.2A Active EP2669000B1 (fr) 2010-11-03 2010-11-03 Dispositif de mélange doté d'un palier pour un dispositif de réception, procédé de mélange associé, et l'utilisation d'un tel dispositif de mélange
EP10014237.1A Active EP2450099B1 (fr) 2010-11-03 2010-11-03 Dispositif de mélange doté d'un stockage pour un dispositif de réception, et procédé de son utilisation

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP10014237.1A Active EP2450099B1 (fr) 2010-11-03 2010-11-03 Dispositif de mélange doté d'un stockage pour un dispositif de réception, et procédé de son utilisation

Country Status (5)

Country Link
US (1) US8827540B2 (fr)
EP (2) EP2669000B1 (fr)
JP (1) JP5815724B2 (fr)
CN (1) CN103153449B (fr)
WO (1) WO2012059229A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2950541B1 (fr) * 2009-09-25 2011-10-21 Biomerieux Sa Procede et dispositif de melange d'une solution heterogene en solution homogene
USD731237S1 (en) 2012-08-27 2015-06-09 Eppendorf Ag Thermomixer
CN104280286A (zh) * 2013-07-12 2015-01-14 四川省新成生物科技有限责任公司 一种用于痰标本混匀的振荡器及其运行方法
DE102014111236B3 (de) * 2014-08-07 2015-10-08 Adolf Kühner Ag Orbitalschüttler mit Auswuchtvorrichtung
US9759263B1 (en) * 2014-11-13 2017-09-12 National Technology & Engineering Solutions Of Sandia, Llc Rotation flexure with temperature controlled modal frequency
CN106345356A (zh) * 2016-10-30 2017-01-25 吴波 一种畜牧业用农药高效配制设备
DE102018116093A1 (de) * 2018-07-03 2020-01-09 Mühlbauer Technology Gmbh Vorrichtung zur Homogenisierung von Harzformulierungen
RU2713808C1 (ru) * 2018-09-04 2020-02-07 Федеральное государственное бюджетное учреждение науки "Федеральный исследовательский центр "Пущинский научный центр биологических исследований Российской академии наук" (ФИЦ ПНЦБИ РАН) Способ охлаждения и нагрева с постоянной скоростью протяженных калориметрических камер изотермического капиллярного дифференциального титрационного нанокалориметра, предназначенного для работы с короткоживущими объектами
DE102020133424A1 (de) * 2020-12-14 2022-06-15 Qinstruments Gmbh Laborgerät mit mischmechanismus zum mischen von medium eines objektträgers
US11808354B2 (en) 2021-03-11 2023-11-07 Sartorius Bioanalytical Instruments, Inc. Sample shaker system with sealed airflow
DE102022205325A1 (de) * 2022-05-27 2023-11-30 Hs-Tumbler Gmbh Vorrichtung zum Schwenken entlang einer Bahnkurve

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1816710A1 (de) * 1968-12-10 1970-06-25 New Brunswick Scientific Co Schuettelvorrichtung
JPS51114767A (en) * 1975-03-31 1976-10-08 Fujirebio Inc Vibrator
US4109319A (en) * 1975-12-18 1978-08-22 Spectroderm International Agitator for laboratory tubes and flasks and the like
US4305668A (en) * 1980-04-08 1981-12-15 Scientific Manufacturing Industries, Inc. Vortexer
JPS6279838A (ja) * 1985-10-02 1987-04-13 Puranteku:Kk 植，動物の組織培養に用いる振とう機
US4702610A (en) * 1985-04-18 1987-10-27 Reynolds Jr Albert B Undulating mixing device
US5655836A (en) 1995-09-01 1997-08-12 Preston Industries, Inc. Dual action shaker table using parallelogram linkages
DE20018633U1 (de) 2000-10-31 2001-01-18 Herz, Helmut, Dr.-Ing., 85764 Oberschleißheim Schüttelgeräte für Probengefäße
DE10232202A1 (de) 2002-07-16 2004-02-05 Herz, Helmut, Dr.-Ing. Probenbehandlungsstation
DE102004021665A1 (de) * 2004-05-03 2005-12-15 H+P Labortechnik Ag Schüttelgerät für Probengefäße
DE202006001514U1 (de) * 2006-02-01 2006-04-06 Berthold Technologies Gmbh & Co. Kg Mischvorrichtung
DE102007010616A1 (de) * 2007-03-02 2008-09-04 Eppendorf Ag Mehrplatz-Vorrichtung zum Mischen von Laborgefäß-Inhalten

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2192233A (en) * 1939-05-06 1940-03-05 Oscar B Mack Graining machine
US3706443A (en) * 1970-08-19 1972-12-19 Dynatech Corp Agitation method and means
GB1425924A (en) * 1972-05-18 1976-02-25 Russel Finex Vibratory apparatus
JPS5523628Y2 (fr) * 1977-01-14 1980-06-05
JPS54102660A (en) * 1978-01-30 1979-08-13 Daito Kikai Kk Mixer
JPH0661438B2 (ja) * 1986-02-19 1994-08-17 タイテック株式会社 振とう機
DE3616600A1 (de) * 1986-05-16 1987-11-26 Elastogran Masch Bau Vorrichtung zum vermischen von mehrkomponentenkunststoffen, insbesondere polyurethan
US5171539A (en) * 1986-06-26 1992-12-15 Coombs David H Apparatus for forming a continuous solution gradient
DE3807658A1 (de) * 1988-03-09 1989-09-21 Zimmermann Wolfgang Der sto-mischer
US5066135A (en) * 1988-08-09 1991-11-19 Beckman Instruments, Inc. Rotatable vortexing turntable
US5372425A (en) * 1992-08-31 1994-12-13 New Brunswick Scientific Co., Inc. Cushioned restraining device for shaker apparatus
GB2277043B (en) * 1993-04-13 1996-10-30 David John Fletcher Orbital shaking attachment
JP3353189B2 (ja) * 1995-03-15 2002-12-03 株式会社サイニクス 波動形に旋回揺動する振盪機
US5921676A (en) * 1998-01-26 1999-07-13 Stovall Life Science, Inc. Undulating mixing device with adjustable tilt and method
US6190032B1 (en) * 1998-04-21 2001-02-20 Eyela-Chino Inc. Shaking machine with rotation regulating coupling
US7878699B2 (en) * 2004-08-07 2011-02-01 Zf Friedrichshafen Ag Drive for mixing drum with elastic element arranged between bearing incorporating drive system and base
JP3117540U (ja) * 2005-10-13 2006-01-05 株式会社日伸理化 振盪装置
DE102006062714B4 (de) * 2006-03-09 2013-02-21 Eppendorf Ag Vorrichtung zum Mischen von Laborgefäß-Inhalten
US20090040866A1 (en) * 2007-08-09 2009-02-12 Rollin Iii William A Orbital and reciprocal water bath

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1816710A1 (de) * 1968-12-10 1970-06-25 New Brunswick Scientific Co Schuettelvorrichtung
JPS51114767A (en) * 1975-03-31 1976-10-08 Fujirebio Inc Vibrator
US4109319A (en) * 1975-12-18 1978-08-22 Spectroderm International Agitator for laboratory tubes and flasks and the like
US4305668A (en) * 1980-04-08 1981-12-15 Scientific Manufacturing Industries, Inc. Vortexer
US4702610A (en) * 1985-04-18 1987-10-27 Reynolds Jr Albert B Undulating mixing device
JPS6279838A (ja) * 1985-10-02 1987-04-13 Puranteku:Kk 植，動物の組織培養に用いる振とう機
US5655836A (en) 1995-09-01 1997-08-12 Preston Industries, Inc. Dual action shaker table using parallelogram linkages
DE20018633U1 (de) 2000-10-31 2001-01-18 Herz, Helmut, Dr.-Ing., 85764 Oberschleißheim Schüttelgeräte für Probengefäße
DE10232202A1 (de) 2002-07-16 2004-02-05 Herz, Helmut, Dr.-Ing. Probenbehandlungsstation
DE102004021665A1 (de) * 2004-05-03 2005-12-15 H+P Labortechnik Ag Schüttelgerät für Probengefäße
DE202006001514U1 (de) * 2006-02-01 2006-04-06 Berthold Technologies Gmbh & Co. Kg Mischvorrichtung
DE102007010616A1 (de) * 2007-03-02 2008-09-04 Eppendorf Ag Mehrplatz-Vorrichtung zum Mischen von Laborgefäß-Inhalten

Also Published As

Publication number Publication date
US8827540B2 (en) 2014-09-09
WO2012059229A1 (fr) 2012-05-10
EP2450099B1 (fr) 2014-01-01
CN103153449A (zh) 2013-06-12
EP2450099A1 (fr) 2012-05-09
US20120140589A1 (en) 2012-06-07
EP2669000B1 (fr) 2019-05-01
JP2014501605A (ja) 2014-01-23
CN103153449B (zh) 2016-01-20
JP5815724B2 (ja) 2015-11-17

Similar Documents

Publication Publication Date Title
EP2450099B1 (fr) Dispositif de mélange doté d'un stockage pour un dispositif de réception, et procédé de son utilisation
EP1721964B1 (fr) Dispositif de stockage d'échantillons de laboratoire avec des tours de stockage et dispositif de vibration
DE102014111236B3 (de) Orbitalschüttler mit Auswuchtvorrichtung
EP1201297B1 (fr) Agitateur pour recipients d'echantillonnage
EP0626194B1 (fr) Mélangeur à entraínement vibratoire
CA2689653C (fr) Dispositif multiposte pour melanger des contenus de recipients de laboratoire
EP1815905A2 (fr) Appareil mélangeur
EP1393797A2 (fr) Appareil pour agiter et pour mélanger
EP1877170B1 (fr) Dispositif et procede de deplacement de reservoirs a liquides
EP2547431A1 (fr) Dispositif de positionnement pour un dispositif fonctionnel
EP2446959A1 (fr) Dispositif de mélange d'échantillons
WO2022128809A2 (fr) Appareil de laboratoire pourvu d'un mécanisme de mélange pour mélanger un milieu situé dans un porte-objet
DE102009007822A1 (de) Vorrichtung zur Erzeugung von Strömungsunruhe in einer Probe
DE202022105879U1 (de) Modulares Laborgerät
AT397042B (de) Eluiergerät
DE202020101027U1 (de) Dekantiervorrichtung
DE102009048317A1 (de) Schüttelrahmen
DE10209767A1 (de) Doppelkugel-Stützelement für Werkstücke
EP1935840A1 (fr) Entraînement magnétique sans contact pour un dispositif de stockage de boisson et procédé de travail associé
DE19700580A1 (de) Kippspiegel
DE202015007544U1 (de) Lager und Mischvorrichtung mit Lager
DE1644023B2 (de) Vorrichtung zum tiegelfreien Zonenschmelzen eines stabförmigen Körpers

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AC Divisional application: reference to earlier application

Ref document number: 2450099

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RBV Designated contracting states (corrected)

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

17P Request for examination filed

Effective date: 20140328

17Q First examination report despatched

Effective date: 20150306

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20181129

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AC Divisional application: reference to earlier application

Ref document number: 2450099

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Free format text: NOT ENGLISH

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

Ref country code: AT

Ref legal event code: REF

Ref document number: 1126172

Country of ref document: AT

Kind code of ref document: T

Effective date: 20190515

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 502010015977

Country of ref document: DE

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: LANGUAGE OF EP DOCUMENT: GERMAN

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20190501

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190801

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190901

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190802

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190801

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190901

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 502010015977

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

26N No opposition filed

Effective date: 20200204

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191130

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191130

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191103

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191103

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 1126172

Country of ref document: AT

Kind code of ref document: T

Effective date: 20191103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20191103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20101103

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

REG Reference to a national code

Ref country code: DE

Ref legal event code: R079

Ref document number: 502010015977

Country of ref document: DE

Free format text: PREVIOUS MAIN CLASS: B01F0011000000

Ipc: B01F0031000000

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20190501

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 13

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 502010015977

Country of ref document: DE

Owner name: EPPENDORF SE, DE

Free format text: FORMER OWNER: EPPENDORF AG, 22339 HAMBURG, DE

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230527

REG Reference to a national code

Ref country code: BE

Ref legal event code: PD

Owner name: EPPENDORF SE; DE

Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), CHANGE OF LEGAL ENTITY

Effective date: 20230222

REG Reference to a national code

Ref country code: BE

Ref legal event code: PD

Owner name: EPPENDORF SE; DE

Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), CHANGE OF LEGAL ENTITY; FORMER OWNER NAME: EPPENDORF AG

Effective date: 20230731

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20231123

Year of fee payment: 14

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LV

Payment date: 20231115

Year of fee payment: 14

Ref country code: IT

Payment date: 20231121

Year of fee payment: 14

Ref country code: FR

Payment date: 20231120

Year of fee payment: 14

Ref country code: DE

Payment date: 20231121

Year of fee payment: 14

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20231120

Year of fee payment: 14