EP2446959A1 - Dispositif de mélange d'échantillons - Google Patents

Dispositif de mélange d'échantillons Download PDF

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Publication number
EP2446959A1
EP2446959A1 EP10405207A EP10405207A EP2446959A1 EP 2446959 A1 EP2446959 A1 EP 2446959A1 EP 10405207 A EP10405207 A EP 10405207A EP 10405207 A EP10405207 A EP 10405207A EP 2446959 A1 EP2446959 A1 EP 2446959A1
Authority
EP
European Patent Office
Prior art keywords
container
sample
base body
sample container
receptacle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP10405207A
Other languages
German (de)
English (en)
Other versions
EP2446959B1 (fr
Inventor
Beat Lüthi
Kai Schüler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CTC Analytics AG
Original Assignee
CTC Analytics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CTC Analytics AG filed Critical CTC Analytics AG
Priority to EP10405207.1A priority Critical patent/EP2446959B1/fr
Priority to US13/283,709 priority patent/US9517440B2/en
Publication of EP2446959A1 publication Critical patent/EP2446959A1/fr
Application granted granted Critical
Publication of EP2446959B1 publication Critical patent/EP2446959B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/201—Holders therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20—Mixing the contents of independent containers, e.g. test tubes
    • B01F31/26—Mixing the contents of independent containers, e.g. test tubes the containers being submitted to a wobbling movement

Definitions

  • the invention relates to a device for mixing a sample, comprising a receiving device with at least a first and a second container receptacle, wherein each container receptacle comprises a support area for receiving a sample container and a guide device for laterally guiding the sample container.
  • Sample material mixing devices are used, for example, in the laboratory for sample preparation prior to analysis and are known in many variants:
  • EP 0 853 493 B1 (Dade Behring Inc.) a device for mixing liquids, in particular for an analyzer.
  • a lower part of a container is guided in a circular path while the container is kept stationary or vice versa.
  • a centrifugal force is applied to a horizontal cam so that it pivots outwardly and deflects the centerline of the container from its original vertical orientation.
  • a chemical analyzer includes a carousel with sample containers and a cuvette carousel with cuvettes and multiple cartridges. A sample is moved by means of an arm between the various containers, in particular to the vortex mixer.
  • the EP 1 393 797 B1 (Hans Heidolph) relates to a shaker with a driven eccentric, which is set in rotation.
  • the eccentric unit comprises receptacles for vessels.
  • the receptacles are designed essentially as through openings in support elements, in which the vessels can be introduced.
  • the vessel holder can be designed so that vessels of any shape can be added and arranged in particular circular.
  • the support elements are provided interchangeable.
  • the mixing devices known from the prior art have the disadvantage that they are only conditionally suitable for optimal mixing of different sample volumes. Typically, however, different volumes are needed for the analysis, depending on various factors, in particular the concentration of the substance to be investigated in the sample. Often, although a concentration of the substance can be reduced by means of a dilution series. However, due to the changing matrix concentration, the analysis result may change. Concentrating the samples can also be problematic. When concentrated, for example, due to too low solubility, certain Substances, especially the substances to be tested fail. Concentrations of suspensions are not only difficult to detect but can also damage sensitive analyzers.
  • the object of the invention is to provide a device for mixing a sample which belongs to the technical field mentioned above and which is suitable for efficient mixing of different sample volumes.
  • a distance between the support region and the guide device of the first container receptacle is different from a distance between the support region and the guide device of the second container receptacle.
  • sample containers are held by the guide device in each case proportional to the length of the sample container at about the same height above the support area.
  • sample containers are held by the guide device so far up that they can not fall out of the guide device during mixing.
  • the guide device preferably contacts the sample container over a small area, so that the sample container can not tilt during the mixing.
  • the contact surface of the guide device is annular, wherein the sample container during the mixing process at any time in each case only touches a circular arc piece of the ring.
  • the guide device can also have, for example, three suitably arranged contact surfaces which can each contact the sample container at the same height. These may be formed, for example, as radially oriented pins.
  • the bearing areas of the container receptacles are preferably arranged at vertically different heights with respect to a horizontal plane and contact the same at the bottom, typically at a vertically lowest point of the sample container, or slightly higher, for example in the form of a lateral support in the outside bottom area of the sample container.
  • the automatic chemical analyzer may comprise a transport device which selects a corresponding container receptacle depending on the sample container size and can insert the sample container into it.
  • the heights of the bearing areas of the two container receptacles are selected such that an upper edge area of the sample containers comes to lie in each case at the same height.
  • the transport device When positioning in the receiving device, the transport device guides the sample container via the corresponding container receptacle.
  • the transport device can be connected to a computing unit, which can choose the appropriate sample taking due to the size of the sample container. This can be done, for example, by manual input or automatically.
  • the transport device can grip the sample container on the circumference and determine its size on the basis of the diameter of the sample container so that the transport device itself can determine which container receptacle has to be actuated.
  • the arithmetic unit to control the movement, in particular the way of gripper jaws of a gripping device, to derive the diameter of the To determine sample container.
  • this requires that over the diameter of the sample container, the size of the same clearly determinable.
  • sample containers of known sizes are used by means of the device, whereby detection of the same by the gripper can be dispensed with.
  • the sample container is guided over the corresponding container receptacle, lowered into this and then released.
  • the release can take place in a vertical position in which the sample container does not touch, in particular just barely, the support region of the container receptacle. This prevents the transport device from damaging the sample container due to positioning inaccuracies.
  • the support area can also be equipped with a resilient material, which can be compressed when parking the sample container. This tolerances of positioning inaccuracy can be added.
  • the support region has a concave shape, so that the sample container can be stably held.
  • the automatic analyzer can be embodied as a chromatograph, in particular as a gas (GC) or liquid chromatograph (LC, HPLC), ion chromatograph (IC, EC) or as another measuring device known to the person skilled in the art of instrumental analysis.
  • the transport device can be designed as an autosampler.
  • the receiving device comprises four container receptacles, but also three or more than four container receptacles can be provided.
  • the sample is typically liquid or the main component of the sample is liquid. Since the sample is mixed, suspensions or emulsions, which may possibly be converted into solutions by mixing, can also be mixed by means of the device.
  • the device can also be used independently of an automatic chemical analyzer.
  • the transfer of the sample container between the device and the analyzer can also be done by hand respectively.
  • the device can also be used for applications other than sample preparation for chemical analysis.
  • anyone skilled in the art is familiar with any number of fields of application in which a sample must be mixed.
  • a relative movement between the container receptacles and the guide device is executable in an operating state.
  • the receptacles of the sample containers move substantially in a horizontal plane, while the guide devices remain stationary.
  • the receptacles have a fixed position relative to one another, so that during operation the two receptacles each have the same distance from one another and the same orientation in the horizontal plane.
  • a sample container inserted into the container receptacle in particular a vertically lower region of the sample container, can be set in motion.
  • the movement is preferably cyclical and forms a closed path, so that a mixing of the sample material in the sample container is achieved by the non-constant accelerations, which inter alia act on the sample material.
  • the movement of the support areas can also take place in a non-horizontal plane; in particular, a movement path on an inclined plane or as a free spatial movement path (similar to a roller coaster) is also conceivable.
  • the receiving device preferably comprises a movable base body on which at least two container receptacles are formed as recesses in the base body.
  • the recesses may be arranged at different heights.
  • the base body can be formed in one piece. It is also possible to provide inserts with which the height of the support surfaces can be varied (see below).
  • the base body preferably comprises at least one pedestal forming a container receptacle. This can be used in the production in a simple manner
  • Sample containers corresponding individual receiving device are prepared by one or more different pedestals are assembled in appropriate combination with the base body. This is particularly advantageous when, for example, two or more different sample container sizes are used in a laboratory.
  • the base body is preferably guided against rotation, so that it can not perform any rotational movement during the mixing process.
  • the container receptacles in the operation of the device in the horizontal plane in each case the same orientation (for example, direction north).
  • the base body is preferably forcibly guided via a cam control.
  • the base body itself can take over the function of container receptacles.
  • the pedestal can be dispensed with.
  • the device may be such that a largest sample container can be used without the use of a pedestal.
  • the pedestal is replaceable formed and in particular in a recess of the base body can be arranged.
  • This ensures that the user, depending on the sample containers used, the or the pedestals can replace themselves.
  • the recesses in the base body are suitable both as a container receptacle, as well as a receptacle for the pedestals.
  • a vendor may provide a set of different pedestals with the device or offer them as accessories so that the user can quickly and inexpensively adapt the device to the respective sample containers.
  • the pedestals on a circular cylindrical shape, of course, other forms are conceivable.
  • the pedestals preferably have an external thread in a lower region, which can interact with an internal thread of the base body.
  • the thread axially has a slightly conical shape, so that a pedestal is positively and non-positively held in the base body and thus does not dissolve in a mixing process from the base body.
  • a bayonet lock can be provided for fixing.
  • a variety of other suitable techniques for fixing the pedestals on the base body are familiar to those skilled in the art.
  • the pedestals can also be dispensed with.
  • the base body may be equipped with the corresponding container receptacles.
  • the container receptacles are preferably displaceable in an eccentric translational orbital movement.
  • the container receptacles are displaceable in a circular eccentric translational orbital movement, but also an elliptical or other orbital movements would be conceivable.
  • a circular path is technically the easiest to implement and during the mixing process, the sample containers are better managed.
  • the movement of the container receptacles are thus guided substantially on a circular path, wherein the orientation of the container receptacles is in each case constant, that is, the container receptacles preferably do not perform rotation about its own axis as a partial movement during the mixing process. This ensures that a centrifugal force on the sample in the sample container during the mixing process is not constant, but steadily changes. Thus, a largely optimal mixing of the sample is achieved.
  • the container receptacles can also be arranged radially on an eccentrically rotating disk.
  • the receiving device comprises a diaphragm (50) with openings forming the guide devices for holding the sample containers (41-44) in a region lying over the support areas.
  • the diaphragm is arranged stationary over the support areas.
  • the aperture is preferably formed as a horizontally oriented plate with circular openings.
  • the sample containers are guided during insertion through the openings on the support area. When inserted, the containers are guided from the edge region of the openings at an upper region of the sample containers.
  • the openings may for this purpose have a diameter in the region of the diameter of the sample container, but preferably a diameter of the openings is slightly larger than a diameter of the sample container.
  • the openings have the Sample containers corresponding diameter, that is, the openings do not all have the same diameter. Accordingly, the aperture can also be made interchangeable, so that it can be adapted to the sample container sizes.
  • the sample container is now offset by the container receptacle in an eccentric translational orbital movement, wherein an upper portion of the sample container is held by the opening of the aperture substantially stationary.
  • an axis of the sample container describes a conical shell during the mixing process, whereby the mixing of the sample can be further optimized.
  • the bearing areas of the container receptacles preferably have a concave shape, so that the bottom of the sample container remains in contact with the support area during the mixing process.
  • the concave shape of the contact region has, for example, a spherical cap shape with a slightly larger radius, the spherical cap representing at most one hemisphere.
  • the sample containers may have at the bottom a central, axially downwardly projecting pin, which can be inserted in a passport-shaped manner into an opening in the support area.
  • a force and / or positive connection of the pin may be provided with the opening. This ensures that the sample container is held during the mixing process in the support area.
  • the bearing areas of the container receptacles may have a shape in which the sample containers are received to a substantial extent and can not get out of the container receptacle during the mixing process.
  • an axis of a sample container would essentially describe a cylinder jacket during the mixing process.
  • a relative position between a support region and an aperture of the diaphragm is determined.
  • the rest position is now as a unique position of a support area defined to an opening of the aperture. This ensures that the transport device can each lead a sample container in the same orientation in the device respectively refer to the device.
  • a relative position between the opening of the panel and the corresponding support is unique, so that when inserting the sample container through the opening of the support area is also taken.
  • the determinate rest position can also be dispensed with.
  • the support area can be correspondingly larger.
  • a center of one of the plurality of openings is preferably arranged in each case perpendicularly above a center of a corresponding support area.
  • an axis of a sample container thereby describes a shape of an oblique cone with a generatrix line substantially perpendicular to the plane of rotation.
  • the support region may have a conical shape and size, which allows a vertical insertion of the sample container on the support area in each position of the recordings.
  • a pedestal having a support area which is at least partially perpendicular in any position below a center of the corresponding opening of the panel.
  • the base body is in the rest position on the orbit.
  • a particularly simple embodiment of the device is achieved, since the position on the orbit to a certain extent represents a "natural" position of the base body.
  • the base body can also assume a centered rest position, from which it is deflected during the mixing process.
  • the device includes a sensor to determine the rest position.
  • the transport device can preferably pick up the signals of the sensor, whereby the coordination of a gripper can be controlled.
  • the sensor may be formed in a manner known to those skilled in the art.
  • the rest position with respect to the eccentric movement as a central position in the plane of rotation, that is, if the rest position is clear, can also be dispensed with the sensor.
  • the device preferably comprises a drive unit.
  • the drive unit can be designed in a conventional manner.
  • the base body can centrally have at the bottom a recess into which a cam, which is rotatably mounted eccentrically in a horizontal plane, can intervene.
  • the nubs can be arranged eccentrically on a rotatably mounted plate.
  • the rotation of the nubs can be done by means of an electric motor via a belt or a gear transmission.
  • the drive via a belt, since a belt drive is robust against vibrations due to the possibility of bias.
  • the skilled person is also known to further suitable drive options.
  • the device may be driven by an external drive unit.
  • the drive unit is controllable by means of the sensor so that the rest position can be approached.
  • the gripping of the sample container by a transport device is further simplified.
  • the device preferably comprises a control unit for controlling the drive unit.
  • the drive unit can be controlled differently depending on the sample material to be mixed.
  • the rotational frequency of the images of the sample container is controlled or adjusted. Typically, this is a constant rotational frequency set, but it is also conceivable to provide a non-constant rotational frequency, whereby the mixing could be further improved.
  • the drive unit could be controlled so that the rotational frequency continuously changes, performs a vibration overlay to the rotational movement and / or alternately changes the direction of rotation.
  • a single constant adjustment of the drive unit can be provided.
  • the FIG. 1 shows a device according to the invention for mixing a sample 1.
  • This comprises a base body 10 with a drive unit, not shown.
  • a base body 20 is movably mounted on the base body 10.
  • the mounting allows a translatory orbital movement of the base body 20 relative to the stationary base body 10.
  • the base body 20 is thus guided on a circular path without rotation.
  • the base body 20 has four circular cylindrical recesses 21 - 24 on its upper side, wherein the recess 24 in the FIG. 1 is not apparent.
  • the circular cylindrical axes of the recesses 21-24 are arranged in a square.
  • the recess 21 In the recess 21 is a circular cylindrical pedestal 31, which has an external thread in a lower region, whereby this is screwed into the correspondingly shaped internal thread having recess 21 (not shown).
  • the pedestal 31 in turn has a pedestal axially oriented cylindrical recess 31.1, in which a sample container 41 is used.
  • the sample container 41 has an outer diameter, which is smaller than the recess 31.1 of the pedestal 31, so that the sample container 41 can be pivoted in the recess 31.1 in a certain angular range (see below).
  • the recess 22 does not include a pedestal.
  • the sample container 42 is sufficiently high, whereby the recess 22 itself can serve as a support region for the sample container 42.
  • the containers 41 and 42 are arranged flush with each other by means of the pedestal 31 to each other above. Also in the recess 23 no pedestal is provided, since the sample container 43 also has a sufficient height. The sample container 43 protrudes above the sample containers 41 and 42.
  • the sample container 44 is in turn arranged on a pedestal, which is not visible, however, and is also arranged flush with the sample containers 41 and 42 via a top edge.
  • the pedestal corresponds structurally substantially to the pedestal 31 of the sample container 41, wherein the diameter is smaller and it has a greater height than the pedestal 31, since the sample container 44 is smaller than the sample container 41.
  • the pedestals are provided interchangeable, so that the user adapt it to a specific application. As already noted, the recesses in the base body 20 may each have different diameters, so that these are suitable for different diameter sample container 41-44.
  • the device 1 further comprises an aperture 50, with four openings 51-54.
  • the aperture 50 is held interchangeably in a diaphragm holder 60 and fastened, for example, by means of screws, not shown.
  • the visor holder 60 comprises a rectangular frame 61 as a receptacle for the panel 50, a base plate 62 to which the base 10 is connected, and four abutment 63, which projecting over an upper end respectively perpendicularly downwardly with the corner regions of the frame 61 and a lower end to the base plate 62 are connected.
  • the openings 51-54 are arranged vertically above the recesses 21-24 of the base body 20 and have the diameters of the recesses 21-24 in approximately proportional diameter.
  • the sample containers 41-44 each protrude at least partially through the corresponding openings 51-54 and are thus kept substantially stationary during a mixing operation in the upper region.
  • the base body 20 is located in the FIG. 1 in the so-called rest position, whereby the sample container 41-44 are each oriented vertically.
  • a support area which is formed either as a recess 21-24 of the base body 20 or as a recess 31.1 of a pedestal 31, is formed so that a sample container 41-44 is pivotable in a certain angular range.
  • This angular range depends on the diameter of a sample container 41-44, the dimension of the recess 21-24 or 31.1, the height between the support area to the panel 50 and the maximum deflection of the base body 20 relative to the base body 10.
  • the skilled person can easily determine the dimension (height and diameter) of the recess so that the sample containers 41 - 44 can not tilt during the mixing process.
  • FIG. 2a shows a side view of the device 1 according to FIG. 1 , but in a different configuration.
  • the base body 20 In contrast to FIG. 1 is used in the base body 20 only a pedestal 31, which carries the sample container 41.
  • the FIG. 2a show the FIG. 2a additionally an eccentric drive 70 and a guide element 71, which between the Base body 20 and the main body 10 are arranged.
  • the eccentric drive 70 can set the base body 20 in an eccentric translatory orbital movement, that is, the base body 20 oscillates at a constant orientation on a circular path.
  • the eccentric drive 70 is driven via a belt, not shown, by an electric motor and additionally comprises a sensor for determining the current position.
  • FIG. 2a shows the device 1 in the rest position, the (single) sample container 41, on the pedestal 31, is oriented vertically and held laterally in the unillustrated opening 51 in an upper region.
  • a sample container 41-44 is inserted or removed.
  • the transfer of the sample containers 41-44 takes place with a transport device, not shown, in particular with a transport arm, which can introduce the sample containers 41-44 vertically through the openings 51-54.
  • the mixing operation may begin, whereby the base body 20 guides the lower regions of the sample containers 41-44 in a circular path, while the upper regions of the sample containers 41-44 are held substantially stationary in the openings 51-54.
  • FIG. 2b essentially corresponds to the FIG. 2a , but wherein the eccentric 70 has completed half a turn.
  • the sample container 41 which is held over the opening 51 (not shown), is in an inclined position, in particular in the maximum inclined position and is finally returned to the vertical position according to the continuing movement of the base body 20 FIG. 2a recycled.
  • a device for mixing a sample is created, which is suitable for differently dimensioned sample containers and permits optimal mixing of the sample.
EP10405207.1A 2010-11-01 2010-11-01 Dispositif de mélange d'échantillons Active EP2446959B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP10405207.1A EP2446959B1 (fr) 2010-11-01 2010-11-01 Dispositif de mélange d'échantillons
US13/283,709 US9517440B2 (en) 2010-11-01 2011-10-28 Sample mixing device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10405207.1A EP2446959B1 (fr) 2010-11-01 2010-11-01 Dispositif de mélange d'échantillons

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EP2446959A1 true EP2446959A1 (fr) 2012-05-02
EP2446959B1 EP2446959B1 (fr) 2013-12-18

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Cited By (3)

* Cited by examiner, † Cited by third party
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CN105056819A (zh) * 2015-08-31 2015-11-18 成都欧林生物科技股份有限公司 具有固定带结构的混匀装置
EP3002056A1 (fr) * 2014-10-03 2016-04-06 CTC Analytics AG Appareil de mélange d'un échantillon au cours d'un procédé d'extraction SPME
CN111289343A (zh) * 2020-04-04 2020-06-16 太原理工大学 一种用于离线油样的自动摇匀装置

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JP6205122B2 (ja) * 2012-09-21 2017-09-27 あおい精機株式会社 検体処理装置
CN109991049B (zh) * 2017-12-29 2024-03-01 同方威视技术股份有限公司 用于食品安全检测的前处理装置以及前处理方法
US10787024B2 (en) * 2018-08-22 2020-09-29 Isaac Reyes Ventura Writing utensil stand
CN109883800B (zh) * 2019-02-18 2021-12-24 深圳唯公生物科技有限公司 样本混匀与移动机构及其方法
CN111721949B (zh) * 2019-03-22 2024-03-29 深圳迈瑞生物医疗电子股份有限公司 样本分析仪、样本检测方法以及计算机可读存储介质
CN110420588A (zh) * 2019-08-28 2019-11-08 广东中科康仪生物技术有限公司 一种医学检测用工作台及其使用方法

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US5417922A (en) * 1993-05-14 1995-05-23 Board Of Regents - University Of Nebraska Specimen carrier
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EP0853493B1 (fr) 1996-07-03 2002-10-23 Dade Behring Inc. Procede et appareil de melange par tourbillons sous l'effet d'une force centrifuge
EP1393797B1 (fr) 2002-08-29 2006-07-12 Hans Heidolph GmbH & Co. KG Appareil pour agiter et pour mélanger
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US4124122A (en) * 1976-04-21 1978-11-07 Emmitt Ronald W Test tube rack
US4453639A (en) * 1980-05-30 1984-06-12 Yash Sharma Rack or holder for test tubes
US5036989A (en) * 1989-06-22 1991-08-06 Carilli Brian D Test tube support system
US5417922A (en) * 1993-05-14 1995-05-23 Board Of Regents - University Of Nebraska Specimen carrier
EP0853493B1 (fr) 1996-07-03 2002-10-23 Dade Behring Inc. Procede et appareil de melange par tourbillons sous l'effet d'une force centrifuge
DE20018633U1 (de) * 2000-10-31 2001-01-18 Herz Helmut Schüttelgeräte für Probengefäße
EP1393797B1 (fr) 2002-08-29 2006-07-12 Hans Heidolph GmbH & Co. KG Appareil pour agiter et pour mélanger
US20070163973A1 (en) * 2005-12-23 2007-07-19 Smokowicz Nicole M Rotatable holder
GB2451491A (en) * 2007-08-02 2009-02-04 Barloworld Scient Ltd Laboratory accessory and magnetic device

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3002056A1 (fr) * 2014-10-03 2016-04-06 CTC Analytics AG Appareil de mélange d'un échantillon au cours d'un procédé d'extraction SPME
CN105056819A (zh) * 2015-08-31 2015-11-18 成都欧林生物科技股份有限公司 具有固定带结构的混匀装置
CN111289343A (zh) * 2020-04-04 2020-06-16 太原理工大学 一种用于离线油样的自动摇匀装置

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EP2446959B1 (fr) 2013-12-18
US9517440B2 (en) 2016-12-13
US20120107197A1 (en) 2012-05-03

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