EP1392824B1 - Improved isoprenoid production - Google Patents
Improved isoprenoid production Download PDFInfo
- Publication number
- EP1392824B1 EP1392824B1 EP02745362A EP02745362A EP1392824B1 EP 1392824 B1 EP1392824 B1 EP 1392824B1 EP 02745362 A EP02745362 A EP 02745362A EP 02745362 A EP02745362 A EP 02745362A EP 1392824 B1 EP1392824 B1 EP 1392824B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- seq
- paracoccus
- strain
- pbbr
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1229—Phosphotransferases with a phosphate group as acceptor (2.7.4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01034—Hydroxymethylglutaryl-CoA reductase (NADPH) (1.1.1.34)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01036—Acetoacetyl-CoA reductase (1.1.1.36)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
- C12Y203/0301—Hydroxymethylglutaryl-CoA synthase (2.3.3.10)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01036—Mevalonate kinase (2.7.1.36)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/04—Phosphotransferases with a phosphate group as acceptor (2.7.4)
- C12Y207/04002—Phosphomevalonate kinase (2.7.4.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01033—Diphosphomevalonate decarboxylase (4.1.1.33), i.e. mevalonate-pyrophosphate decarboxylase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29629901P | 2001-06-06 | 2001-06-06 | |
US296299P | 2001-06-06 | ||
PCT/EP2002/006171 WO2002099095A2 (en) | 2001-06-06 | 2002-06-05 | Improved isoprenoid production |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1392824A2 EP1392824A2 (en) | 2004-03-03 |
EP1392824B1 true EP1392824B1 (en) | 2008-08-20 |
Family
ID=23141440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02745362A Expired - Lifetime EP1392824B1 (en) | 2001-06-06 | 2002-06-05 | Improved isoprenoid production |
Country Status (11)
Country | Link |
---|---|
US (2) | US6989257B2 (zh) |
EP (1) | EP1392824B1 (zh) |
JP (1) | JP4280627B2 (zh) |
KR (1) | KR100704072B1 (zh) |
CN (1) | CN1630718A (zh) |
AT (1) | ATE405638T1 (zh) |
AU (1) | AU2002316966B2 (zh) |
CA (1) | CA2449885A1 (zh) |
DE (1) | DE60228439D1 (zh) |
ES (1) | ES2311613T3 (zh) |
WO (1) | WO2002099095A2 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10017804B2 (en) | 2013-02-11 | 2018-07-10 | Evolva Sa | Efficient production of steviol glycosides in recombinant hosts |
US10662415B2 (en) | 2017-12-07 | 2020-05-26 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6E)-8-hydroxygeraniol by fermentation |
US10696991B2 (en) | 2017-12-21 | 2020-06-30 | Zymergen Inc. | Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2281890A1 (en) | 2000-07-31 | 2011-02-09 | Danisco US Inc. | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
US20040121309A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues |
US7226739B2 (en) | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
US20030027135A1 (en) | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
US7666588B2 (en) | 2001-03-02 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy |
US7217510B2 (en) | 2001-06-26 | 2007-05-15 | Isis Pharmaceuticals, Inc. | Methods for providing bacterial bioagent characterizing information |
US8073627B2 (en) | 2001-06-26 | 2011-12-06 | Ibis Biosciences, Inc. | System for indentification of pathogens |
US7192751B2 (en) | 2001-12-06 | 2007-03-20 | The Regents Of The University Of California | Biosynthesis of amorpha-4,11-diene |
US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
JP2006516193A (ja) | 2002-12-06 | 2006-06-29 | アイシス・ファーマシューティカルス・インコーポレーテッド | ヒトおよび動物における病原体の迅速な同定方法 |
AU2004206046B2 (en) * | 2003-01-21 | 2009-12-17 | Thallion Pharmaceuticals Inc. | Farnesyl dibenzodiazepinones, processes for their production and their use as pharmaceuticals |
US8057993B2 (en) | 2003-04-26 | 2011-11-15 | Ibis Biosciences, Inc. | Methods for identification of coronaviruses |
US7964343B2 (en) | 2003-05-13 | 2011-06-21 | Ibis Biosciences, Inc. | Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
US8158354B2 (en) | 2003-05-13 | 2012-04-17 | Ibis Biosciences, Inc. | Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
JP4643569B2 (ja) | 2003-06-12 | 2011-03-02 | ディーエスエム アイピー アセッツ ビー.ブイ. | フィードバック耐性メバロン酸キナーゼ |
JP4528297B2 (ja) * | 2003-07-08 | 2010-08-18 | ディーエスエム アイピー アセッツ ビー.ブイ. | コエンザイムq−10の向上した産生 |
US8097416B2 (en) | 2003-09-11 | 2012-01-17 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
US8394945B2 (en) | 2003-09-11 | 2013-03-12 | Ibis Biosciences, Inc. | Compositions for use in identification of bacteria |
US8546082B2 (en) | 2003-09-11 | 2013-10-01 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
US7927794B2 (en) * | 2003-09-29 | 2011-04-19 | The Regents Of The University Of California | Methods for identifying a biosynthetic pathway gene product |
US8163895B2 (en) | 2003-12-05 | 2012-04-24 | Ibis Biosciences, Inc. | Compositions for use in identification of orthopoxviruses |
US7666592B2 (en) | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
WO2006085899A2 (en) * | 2004-05-21 | 2006-08-17 | The Regents Of The University Of California | Method for enhancing production of isoprenoid compounds |
CA2567839C (en) | 2004-05-24 | 2011-06-28 | Isis Pharmaceuticals, Inc. | Mass spectrometry with selective ion filtration by digital thresholding |
US20050266411A1 (en) | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
US7811753B2 (en) | 2004-07-14 | 2010-10-12 | Ibis Biosciences, Inc. | Methods for repairing degraded DNA |
WO2006018211A1 (en) * | 2004-08-19 | 2006-02-23 | Dsm Ip Assets B.V. | Production of isoprenoids |
ATE500321T1 (de) * | 2004-12-14 | 2011-03-15 | Dsm Ip Assets Bv | Verbesserte mevalonatkinase |
EA012165B1 (ru) | 2005-02-11 | 2009-08-28 | ДСМ АйПи АССЕТС Б.В. | Ферментативное получение витамина с |
CA2600184A1 (en) | 2005-03-03 | 2006-09-08 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of adventitious viruses |
US8084207B2 (en) | 2005-03-03 | 2011-12-27 | Ibis Bioscience, Inc. | Compositions for use in identification of papillomavirus |
US7851199B2 (en) | 2005-03-18 | 2010-12-14 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
JP2006280297A (ja) * | 2005-04-01 | 2006-10-19 | Tosoh Corp | ゲラニルゲラニル2リン酸合成酵素及びその遺伝子等 |
CA2616281C (en) | 2005-07-21 | 2014-04-22 | Isis Pharmaceuticals, Inc. | Methods for rapid identification and quantitation of mitochondrial dna variants |
DE602006012521D1 (de) | 2005-09-08 | 2010-04-08 | Dsm Ip Assets Bv | Neues gen sms 37 |
JP5023474B2 (ja) * | 2005-10-28 | 2012-09-12 | 東ソー株式会社 | カロテノイド合成微生物の作製方法およびカロテノイドの製造方法 |
EP1942185A4 (en) | 2005-10-28 | 2009-11-25 | Tosoh Corp | PROCESS FOR PREPARING CAROTINOIDY SYNTHETIZING MICROORGANISM AND METHOD FOR CAROTINOID PRODUCTION |
JP2007151475A (ja) * | 2005-12-06 | 2007-06-21 | Tosoh Corp | 新規微生物およびそれを用いたゼアキサンチンの製造方法 |
JP4887764B2 (ja) * | 2005-12-06 | 2012-02-29 | 東ソー株式会社 | 新規微生物およびそれを用いたリコペンの製造法 |
DE102006001868B4 (de) * | 2006-01-13 | 2012-03-01 | Austriamicrosystems Ag | Schaltungsanordnung und Verfahren zur Ansteuerung einer elektrischen Last und eine Energieversorgungseinrichtung |
US8114645B2 (en) * | 2006-05-19 | 2012-02-14 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
BRPI0712508B1 (pt) * | 2006-05-26 | 2018-04-10 | Amyris, Inc. | Sistemas e métodos para produzir composto isoprenoide, sistema de produção de composição de combustível, e, método para fabricar uma composição de combustível |
CN101484584B (zh) * | 2006-05-26 | 2013-03-27 | 阿米瑞斯公司 | 类异戊二烯的生产 |
AU2012202630B2 (en) * | 2006-05-26 | 2014-01-16 | Amyris, Inc. | Production of isoprenoids |
US7659097B2 (en) * | 2006-05-26 | 2010-02-09 | Amyris Biotechnologies, Inc. | Production of isoprenoids |
WO2008008256A2 (en) * | 2006-07-07 | 2008-01-17 | The Regents Of The University Of California | Methods for enhancing production of isoprenoid compounds by host cells |
EP2064332B1 (en) | 2006-09-14 | 2012-07-18 | Ibis Biosciences, Inc. | Targeted whole genome amplification method for identification of pathogens |
WO2008042338A2 (en) | 2006-09-28 | 2008-04-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
WO2008104002A2 (en) | 2007-02-23 | 2008-08-28 | Ibis Biosciences, Inc. | Methods for rapid forensic dna analysis |
US7531980B2 (en) * | 2007-03-02 | 2009-05-12 | Honeywell International Inc. | Aircraft cabin pressure controls: duty cycle offset to compensate for asymmetric motor loading in an open-loop motor control system |
US9598724B2 (en) | 2007-06-01 | 2017-03-21 | Ibis Biosciences, Inc. | Methods and compositions for multiple displacement amplification of nucleic acids |
JP2009000046A (ja) * | 2007-06-21 | 2009-01-08 | Hitachi Zosen Corp | トチュウのメバロン酸経路の酵素をコードする遺伝子 |
WO2009005704A1 (en) * | 2007-07-03 | 2009-01-08 | The Regents Of The University Of California | Methods of increasing isoprenoid or isoprenoid precursor production |
RU2545699C2 (ru) | 2007-12-13 | 2015-04-10 | ДАНИСКО ЮЭс ИНК. | Композиции и способы получения изопрена |
ES2330602B1 (es) * | 2008-03-19 | 2010-09-30 | Vitatene, S.A | Metodo de produccion de fitoeno y/o fitoflueno, o mezclas de carotenoides con alto contenido en los mismos. |
RU2516343C2 (ru) | 2008-04-23 | 2014-05-20 | ДАНИСКО ЮЭс ИНК. | Варианты изопренсинтазы, применяемые для улучшения продуцирования изопрена микроорганизмами |
CN102083990B (zh) | 2008-07-04 | 2016-05-04 | 财富科学家股份有限公司 | 通过3-羟基烷酸的酶促脱羧制备烯 |
US9556456B2 (en) * | 2008-09-09 | 2017-01-31 | Battelle Memorial Institute | Production of bio-based materials using photobioreactors with binary cultures |
US8148163B2 (en) | 2008-09-16 | 2012-04-03 | Ibis Biosciences, Inc. | Sample processing units, systems, and related methods |
US8550694B2 (en) | 2008-09-16 | 2013-10-08 | Ibis Biosciences, Inc. | Mixing cartridges, mixing stations, and related kits, systems, and methods |
WO2010033625A1 (en) | 2008-09-16 | 2010-03-25 | Ibis Biosciences, Inc. | Microplate handling systems and related computer program products and methods |
WO2010093943A1 (en) | 2009-02-12 | 2010-08-19 | Ibis Biosciences, Inc. | Ionization probe assemblies |
EP2421966A2 (en) | 2009-04-23 | 2012-02-29 | Danisco US Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
US8950604B2 (en) | 2009-07-17 | 2015-02-10 | Ibis Biosciences, Inc. | Lift and mount apparatus |
EP2454000A4 (en) | 2009-07-17 | 2016-08-10 | Ibis Biosciences Inc | SYSTEMS FOR IDENTIFYING BIOLOGICAL SUBSTANCES |
EP2478092A4 (en) * | 2009-09-15 | 2013-04-10 | Wwcc Ltd | FOR TRITERPENOIDSYNTHASE-ENCODING NUCLEIC ACID MOLECULE |
EP2488656B1 (en) | 2009-10-15 | 2015-06-03 | Ibis Biosciences, Inc. | Multiple displacement amplification |
EP2336310A1 (en) | 2009-12-16 | 2011-06-22 | Isobionics B.V. | Valencene synthase |
CA2785101C (en) | 2009-12-22 | 2017-06-20 | Global Bioenergies Sa | Process for the production of isoprenol from mevalonate employing a diphosphomevalonate decarboxylase |
MY180803A (en) | 2010-06-02 | 2020-12-09 | Evolva Inc | Recombinant production of steviol glycosides |
BR112013009078A2 (pt) | 2010-10-19 | 2016-07-19 | Global Bioenergies | produção de alquenos por conversão enzimática combinada de ácidos 3-hidroxialcanoicos |
WO2012058494A2 (en) | 2010-10-27 | 2012-05-03 | Danisco Us Inc. | Isoprene synthase variants for improved production of isoprene |
SG10201606565XA (en) | 2011-08-08 | 2016-10-28 | Evolva Sa | Recombinant production of steviol glycosides |
US9163263B2 (en) | 2012-05-02 | 2015-10-20 | The Goodyear Tire & Rubber Company | Identification of isoprene synthase variants with improved properties for the production of isoprene |
US20130323820A1 (en) * | 2012-06-01 | 2013-12-05 | Lanzatech New Zealand Limited | Recombinant microorganisms and uses therefor |
WO2014052054A1 (en) * | 2012-09-25 | 2014-04-03 | Albert Einstein College Of Medicine Of Yeshiva University | Enzymatic platform for the synthesis of isoprenoid precursors and uses thereof |
WO2014089436A1 (en) * | 2012-12-07 | 2014-06-12 | Ginkgo Bioworks, Inc. | Methods and systems for methylotrophic production of organic compounds |
EA033724B1 (ru) * | 2012-12-20 | 2019-11-20 | Dsm Ip Assets Bv | Трансформированные микроорганизмы, обладающие ацетилтрансферазной активностью и способные продуцировать ацетилированные каротиноиды, и их применение |
JP6379112B2 (ja) | 2013-02-06 | 2018-08-22 | エヴォルヴァ エスアー.Evolva Sa. | レバウディオサイドdおよびレバウディオサイドmの改良された産生方法 |
KR102178036B1 (ko) * | 2013-03-15 | 2020-11-13 | 디에스엠 아이피 어셋츠 비.브이. | 핵산 분해를 위한 호열성 뉴클레아제의 용도 |
JP6282813B2 (ja) | 2013-07-16 | 2018-02-21 | 住友ゴム工業株式会社 | ヒドロキシメチルグルタリルCoAレダクターゼの発現をbZIP型転写因子により調整する方法、bZIP型転写因子をコードする遺伝子が導入されたイソプレノイド産生植物、及び該イソプレノイド産生植物を用いたポリイソプレノイドの製造方法 |
WO2016008885A1 (en) * | 2014-07-14 | 2016-01-21 | Photanol B.V. | Biosynthesis of sesquiterpenes in cyanobacteria |
US10421983B2 (en) | 2014-08-11 | 2019-09-24 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
CN107109358B (zh) | 2014-09-09 | 2022-08-02 | 埃沃尔瓦公司 | 在重组宿主中生产甜菊醇糖苷 |
SG11201705606PA (en) | 2015-01-30 | 2017-08-30 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
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US20170145441A1 (en) * | 2015-08-17 | 2017-05-25 | INVISTA North America S.à.r.l. | Methods, hosts, and reagents related thereto for production of unsaturated pentahydrocarbons, derivatives and intermediates thereof |
WO2017036495A1 (de) * | 2015-08-28 | 2017-03-09 | Phytowelt Greentechnologies Gmbh | Verfahren zur fermentativen alpha-ionen produktion |
JP6357186B2 (ja) * | 2016-03-31 | 2018-07-11 | Jxtgエネルギー株式会社 | カロテノイドの製造方法 |
MX2018012561A (es) | 2016-04-13 | 2019-01-17 | Evolva Sa | Produccion de glicosidos de esteviol en huespedes recombinantes. |
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US11634733B2 (en) | 2017-06-30 | 2023-04-25 | Inv Nylon Chemicals Americas, Llc | Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof |
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US11505809B2 (en) | 2017-09-28 | 2022-11-22 | Inv Nylon Chemicals Americas Llc | Organisms and biosynthetic processes for hydrocarbon synthesis |
CN108285902A (zh) * | 2017-11-03 | 2018-07-17 | 杭州爱蔻思生物科技有限公司 | 生产高价值天然产物的工程菌的构造方法 |
JP6810096B2 (ja) * | 2018-05-09 | 2021-01-06 | Eneos株式会社 | カロテノイドの製造方法 |
CN109666683B (zh) * | 2019-02-27 | 2021-10-29 | 昆明理工大学 | 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用 |
CN109880745A (zh) * | 2019-03-15 | 2019-06-14 | 江苏大学 | 一种利用腌制废水、晒盐卤水分段培养盐藻的方法 |
CN109777815B (zh) * | 2019-03-28 | 2021-10-29 | 昆明理工大学 | HMG-CoA合成酶基因RKHMGCS及其应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3891504A (en) * | 1970-07-31 | 1975-06-24 | Hoffmann La Roche | Process for the manufacture of zeaxanthin |
US5015580A (en) * | 1987-07-29 | 1991-05-14 | Agracetus | Particle-mediated transformation of soybean plants and lines |
US5328845A (en) * | 1992-03-27 | 1994-07-12 | Universal Foods Corporation | Fungal negative microorganism capable of producing high levels of beta-carotene |
US5466599A (en) * | 1993-04-19 | 1995-11-14 | Universal Foods Corporation | Astaxanthin over-producing strains of phaffia rhodozyma |
US5985623A (en) * | 1995-01-24 | 1999-11-16 | Shin-Etsu Bio, Inc. | DNA segments and methods for increasing polysaccharide production |
ATE262590T1 (de) * | 1995-06-09 | 2004-04-15 | Dsm Ip Assets Bv | Fermentative herstellung von carotenoiden |
DE69722766T2 (de) | 1996-12-02 | 2004-04-22 | Dsm Ip Assets B.V. | Verbesserte fermentative Herstellung von Carotenoide |
US5935808A (en) * | 1997-07-29 | 1999-08-10 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | Carotenoid-producing bacterial species and process for production of carotenoids using same |
US6208893B1 (en) * | 1998-01-27 | 2001-03-27 | Genetronics, Inc. | Electroporation apparatus with connective electrode template |
AU3169999A (en) * | 1998-04-14 | 1999-11-01 | Kyowa Hakko Kogyo Co. Ltd. | Process for producing isoprenoid compounds by using microorganisms and method for detecting compounds having antibacterial or herbicidal activity |
EP1095034A1 (en) | 1998-07-06 | 2001-05-02 | Eastman Chemical Company | Preparation of tocopherols |
ATE537265T1 (de) * | 1998-07-06 | 2011-12-15 | Dcv Inc | Verfahren zur vitaminherstellung |
ES2156735B1 (es) | 1999-06-09 | 2002-02-16 | Antibioticos Sau | Procedimiento de produccion de licopeno. |
US6133785A (en) | 1999-06-30 | 2000-10-17 | Harris Corporation | False carrier lock receiver and associated methods for detection |
-
2002
- 2002-06-05 EP EP02745362A patent/EP1392824B1/en not_active Expired - Lifetime
- 2002-06-05 CA CA002449885A patent/CA2449885A1/en not_active Abandoned
- 2002-06-05 ES ES02745362T patent/ES2311613T3/es not_active Expired - Lifetime
- 2002-06-05 CN CNA028113802A patent/CN1630718A/zh active Pending
- 2002-06-05 US US10/166,225 patent/US6989257B2/en not_active Expired - Lifetime
- 2002-06-05 WO PCT/EP2002/006171 patent/WO2002099095A2/en active IP Right Grant
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- 2002-06-05 AT AT02745362T patent/ATE405638T1/de not_active IP Right Cessation
- 2002-06-05 DE DE60228439T patent/DE60228439D1/de not_active Expired - Lifetime
- 2002-06-05 KR KR1020037015938A patent/KR100704072B1/ko not_active IP Right Cessation
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-
2005
- 2005-05-13 US US11/129,143 patent/US7232679B2/en not_active Expired - Lifetime
Non-Patent Citations (2)
Title |
---|
DATABASE EMBL [online] August 2000 (2000-08-01), "Streptomyces sp. CL190 genes for mevalonate kinase, diphosphomevalonate decarboxylase, phosphomevalonate kinase, hypothetical protein, 3-hydroxy-3-methylglutaryl CoA reductase, 3-hydroxy-3-methylglutaryl CoA synthase, complete cds.", Database accession no. AB037666 * |
TAKAGI M. ET AL: "A GENE CLUSTER FOR THE MEVALONATE PATHWAY FROM STREPTOMYCES SP. STRAIN CL190", JOURNAL OF BACTERIOLOGY, vol. 182, no. 15, August 2000 (2000-08-01), pages 4153 - 4157, XP002937865 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10017804B2 (en) | 2013-02-11 | 2018-07-10 | Evolva Sa | Efficient production of steviol glycosides in recombinant hosts |
US10662415B2 (en) | 2017-12-07 | 2020-05-26 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6E)-8-hydroxygeraniol by fermentation |
US10696991B2 (en) | 2017-12-21 | 2020-06-30 | Zymergen Inc. | Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone |
US11193150B2 (en) | 2017-12-21 | 2021-12-07 | Zymergen Inc. | Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone |
Also Published As
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ATE405638T1 (de) | 2008-09-15 |
US20050266518A1 (en) | 2005-12-01 |
AU2002316966B2 (en) | 2007-05-17 |
JP2004527265A (ja) | 2004-09-09 |
KR100704072B1 (ko) | 2007-04-05 |
US6989257B2 (en) | 2006-01-24 |
EP1392824A2 (en) | 2004-03-03 |
KR20040010683A (ko) | 2004-01-31 |
WO2002099095A2 (en) | 2002-12-12 |
DE60228439D1 (de) | 2008-10-02 |
US20030148416A1 (en) | 2003-08-07 |
CN1630718A (zh) | 2005-06-22 |
ES2311613T3 (es) | 2009-02-16 |
WO2002099095A3 (en) | 2003-12-18 |
CA2449885A1 (en) | 2002-12-12 |
US7232679B2 (en) | 2007-06-19 |
JP4280627B2 (ja) | 2009-06-17 |
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