EP1307442A2 - Verfahren zur herstellung von liponsäure und dihydroliponsäure - Google Patents
Verfahren zur herstellung von liponsäure und dihydroliponsäureInfo
- Publication number
- EP1307442A2 EP1307442A2 EP01971775A EP01971775A EP1307442A2 EP 1307442 A2 EP1307442 A2 EP 1307442A2 EP 01971775 A EP01971775 A EP 01971775A EP 01971775 A EP01971775 A EP 01971775A EP 1307442 A2 EP1307442 A2 EP 1307442A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- acid
- dihydroliponic acid
- dihydroliponic
- extraction
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/18—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by addition of thiols to unsaturated compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/02—Thiols having mercapto groups bound to acyclic carbon atoms
- C07C321/04—Thiols having mercapto groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
Definitions
- the invention relates to processes for the production of R- and S-lipoic acid and R- and S-dihydrolipoic acid.
- the invention relates to processes for producing pure R- or S-dihydrolipoic acid, which is either used directly or is further processed to R- and S-lipoic acid.
- Dihydrolipoic acid and lipoic acid are naturally occurring substances that are of particular importance in cell metabolism.
- R-lipoic acid plays as a coenzyme, e.g. pyruvate dehydrogenase, a central role in energy production.
- R-Lipoic acid is activated in the metabolism to fully develop its very good anti-oxidative properties to dihydrolipoic acid. Since they are converted into one another in vivo, dihydrolipoic acid and lipoic acid can be used for the same fields of application.
- R-Lipoic acid has a positive effect on age-related changes in the metabolism and is therefore also of interest in the cosmetic field.
- Lipoic acid and dihydrolipoic acid can be used as nutraceutical in the food sector.
- R-lipoic acid increases insulin sensitivity and can therefore be used as an anti-diabetic, also for the prevention and relief of late diabetic damage.
- R- and S-lipoic acid or dihydrolipoic acid are known.
- the enantiomerically pure lipoic acid and dihydrolipoic acid are produced in various ways such as chemical or enzymatic cleavage of the racemate, with the help of chiral templates, by enantioselective synthesis or microbiological transformation.
- the yields of lipoic acid with respect to (1) are 65%; the material obtained has only a purity in the GC of 98% when introducing S with KSAc, which could be problematic for human applications.
- Ms for -S0 -R 'and R and R' independently of one another represent 10 Cx-C ö alkyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkylalkyl, aryl or aralkyl, preferably methyl, with sodium sulfide and sulfur in ethanol and subsequent reaction with a complex hydride of pure dihydroliponic acid
- This reaction is preferably carried out without isolating the intermediates.
- Ms mesylate or tosylate.
- the process according to the invention achieves a higher chemical purity of R- or S-lipoic acid in comparison with the process described in EP 487 986.
- the compound (2) is e.g. prepared by reacting the corresponding 6, 8-dihydroxyoctanoic acid alkyl ester (1) with triethylamine and 30 mesyl chloride.
- the preferred alkyl esters are C 1 -C 6 -alkyl, methyl is particularly preferred.
- Aryl or Ar in aralkyl preferably denotes phenyl, naphthyl, which can each be substituted by one, two or three Ci- -t-alkyl radicals;
- "alkyl" in aralkyl or cycloalkyl-alkyl means preferably -CC 4 alkyl, particularly preferably -CH-.
- reaction of the sulfonic acid derivatives 2, e.g. of the mesylate is preferably carried out in an ethanolic NaS-S mixture with over
- the ethanolic mixture preferably contains at least equimolar amounts of NaS, S and mesylate and at most one 100% molar excess of NaS and S based on mesylate. A 25 to 35% molar excess is preferred
- the ethanolic Na -S mixture is preferably boiled beforehand.
- Complex hydrides are preferably boranates, in particular alkali boranates such as NaBH 4 .
- the reaction with complex hydrides is preferably carried out in an alkaline solution, especially in a concentrated alkali hydroxide solution.
- a borol solution (12% NaBH 4 in 14M NaOH) is particularly preferred.
- dihydroliponic acid is obtained in high yield.
- the dihydrolipoic acid obtained in this way is oxidized and crystallized to lipoic acid, very pure lipoic acid (GC> 99.5%, ee HPLC (CSP)> 99% (detection limit)) is obtained in high yield.
- the oxidation can be carried out with FeCl / air, the crystallization preferably in heptane / toluene (WO 00/08012).
- dihydrolipoic acid can be decomposed without substantial decomposition in a temperature range from 160 to 220 ° C, preferably even at 180 to 210 ° C, particularly preferably at 200 ° C ⁇ 5 ° C, at pressures of 0.5 to 5 mbar, particularly preferably at 1 to 3 mbar, distill.
- the distillation is preferably carried out continuously (Sambay, falling film or thin film evaporator). This pressure range can be realized technically without considerable effort.
- Sambay falling film or thin film evaporator
- the protic solution of dihydroliponic acid is extracted with an organic solvent at a pH of 9 to 10, preferably at 9.5, more yield of crystals is obtained after working up to lipoic acid. If the protic solution of dihydrolipoic acid is extracted into a pH of 4 to 5, preferably 4.5, in organic solvent, more yield of crystallizate is obtained after working up to lipoic acid.
- Protic solutions are solvent mixtures with at least 30% water, preferably more than 50% water, particularly preferably more than 75% water.
- the other components are polar solvents such as DMF or alcohols, especially ethanol.
- Organic solvents for extraction are preferably apolar solvents, e.g. halogenated solvents such as methylene chloride or chloroform, glycol ethers, ethers such as diethyl ether or methyl-t.
- esters such as ethyl acetate, aliphatic and aromatic hydrocarbons such as cyclohexane, hexane, heptane, toluene, or mixtures thereof, hexane, heptane, toluene and ethyl acetate being preferred as solvents.
- Pure liponic acid or pure dihydroliponic acid means chemically and in particular enantiomerically pure liponic acid or dihydroliponic acid.
- R- or S-dihydroliponic acid and R-lipoic acid or S-lipoic acid mean material which preferably has an enantiomeric purity (ee value determined by HPLC, CSP) of greater than / equal to 70%, preferably 80%, particularly preferably 90%, very particularly preferably 95%, even more preferably 97% or 98%, most preferably 99% and larger, ie lying on the detection line.
- enantiomeric purity ee value determined by HPLC, CSP
- R- or S-dihydroliponic acid material is preferably with a purity greater than or equal to 80%, particularly preferably greater than or equal to 90%, very particularly preferably greater than or equal to 95% or 97%.
- material is preferably greater than 99%, particularly preferably greater than 99.5%, very particularly preferably greater than 99.9%. This corresponds to the detection limit of the methods used.
- the invention relates to the further processing of R-lipoic acid or S-lipoic acid obtained by the processes according to the invention in pharmacologically acceptable derivatives such as esters or amides of lipoic acid.
- pharmacologically acceptable derivatives such as esters or amides of lipoic acid.
- the implementation and derivatives are known from the literature.
- the invention also relates to the further processing of the R- or S-lipoic acid prepared according to the invention into pharmacologically acceptable salts, such as alkali and alkaline earth metal salts or, for example, the trometamol salt of R-lipoic acid.
- pharmacologically acceptable salts such as alkali and alkaline earth metal salts or, for example, the trometamol salt of R-lipoic acid.
- the invention further relates to a new optically active trithiol of the formula
- the 1, 6, 8-octanetrithiol results from the 1, 6, 8-octanetriol during the introduction of sulfur.
- the triol is a minor component of the diol (1). It is enriched during extraction with pH 9 in the organic phase and can be isolated from it.
- the octanetrithiol can be used as an optically active synthetic building block and as a selective catalyst poison.
- the reaction mixture is mixed with 0.5 mol of the mesylate. It is diluted with demineralized water and 174 g (0.55 mol) of borol solution are added. The mixture is adjusted to pH 9 with sulfuric acid and extracted with toluene. The toluene phase is discarded. The mixture is then adjusted to pH 4 and extracted with toluene. The organic phase is freed from the solvent. The remaining oil is distilled in a falling film evaporator (1 to 3 mbar, 200 ° C). Yield: 95.2 g (97%, 88% with respect to diol 1).
- Air is gassed until the conversion is complete.
- the solution is adjusted to pH 2 and extracted with toluene.
- the phases are separated and the organic phase is concentrated.
- Technical heptane is added to the residue and pressed through a filter loaded with 5 g of silica gel.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2000138038 DE10038038A1 (de) | 2000-08-02 | 2000-08-02 | Verfahren zur Herstellung von Liponsäure und Dihydroliponsäure |
DE10038038 | 2000-08-02 | ||
DE10044000 | 2000-09-05 | ||
DE2000144000 DE10044000A1 (de) | 2000-09-05 | 2000-09-05 | Verfahren zur Herstellung von Liponsäure und Dihydroliponsäure |
PCT/EP2001/008523 WO2002010151A2 (de) | 2000-08-02 | 2001-07-24 | Verfahren zur herstellung von liponsäure und dihydroliponsäure |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1307442A2 true EP1307442A2 (de) | 2003-05-07 |
Family
ID=26006609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01971775A Withdrawn EP1307442A2 (de) | 2000-08-02 | 2001-07-24 | Verfahren zur herstellung von liponsäure und dihydroliponsäure |
Country Status (10)
Country | Link |
---|---|
US (1) | US6906210B2 (zh) |
EP (1) | EP1307442A2 (zh) |
JP (1) | JP2004509856A (zh) |
CN (2) | CN1218945C (zh) |
AR (1) | AR030108A1 (zh) |
AU (1) | AU2001291677A1 (zh) |
BR (1) | BR0112848A (zh) |
CA (1) | CA2417842A1 (zh) |
TW (1) | TW200519076A (zh) |
WO (1) | WO2002010151A2 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007093433A1 (de) | 2006-02-17 | 2007-08-23 | Carl Zeiss Smt Ag | Beleuchtungssystem für die mikro-lithographie, projektionsbelichtungsanlage mit einem derartigen beleuchtungssystem |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7914815B2 (en) * | 2000-08-16 | 2011-03-29 | Encore Health, Llc | Method for delivery of pharmaceuticals for treating or preventing presbyopia |
US8697109B2 (en) * | 2000-08-16 | 2014-04-15 | Encore Health, Llc | Caged mercaptan and seleno-mercaptan compounds and methods of using them |
US20050112113A1 (en) * | 2000-08-16 | 2005-05-26 | Till Jonathan S. | Presbyopia treatment by lens alteration |
US8647612B2 (en) * | 2008-03-05 | 2014-02-11 | Encore Health, Llc | Dithiol compounds, derivatives, and treatment of presbyopia |
US7935332B2 (en) | 2000-08-16 | 2011-05-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
ES2266299T3 (es) * | 2000-11-30 | 2007-03-01 | Basf Aktiengesellschaft | Procedimiento para la obtencion acido lipoico y de acido dihidrolipoico. |
CN100387593C (zh) * | 2006-01-26 | 2008-05-14 | 南京师范大学 | 连续逆流液液萃取分离二硫辛酸与乙醇及碱水溶液的方法 |
WO2008067403A2 (en) * | 2006-11-28 | 2008-06-05 | Encore Health Llc | Presbyopia treatment by lens alteration |
US20090078581A1 (en) * | 2007-09-24 | 2009-03-26 | Applied Intellectual Capital | Configurations and Methods of Reduction of Lipoic Acid |
US9044439B2 (en) * | 2008-03-05 | 2015-06-02 | Encore Health, Llc | Low dose lipoic and pharmaceutical compositions and methods |
WO2009111635A2 (en) | 2008-03-05 | 2009-09-11 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
WO2010065069A2 (en) * | 2008-12-01 | 2010-06-10 | In Vasc Therapeutics, Inc. | Compositions comprising renin-angiotensin aldosterone system inhibitors and lipoic acid compounds, and the use thereof for the treatment of renin-angiotensin aldosterone system related disorders |
PT2821405E (pt) | 2009-06-15 | 2016-06-14 | Encore Health Llc | Ésteres de colina para tratar a presbiopia e a catarata |
WO2010147957A2 (en) | 2009-06-15 | 2010-12-23 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
WO2015134510A1 (en) | 2014-03-03 | 2015-09-11 | Encore Vision Inc. | Lipoic acid choline ester compositions and methods of use |
US9944960B2 (en) * | 2015-11-17 | 2018-04-17 | Premier Research Labs, Lp | Process for microbial production of dihydrolipoic acid and extraction of dihydrolipoic acid with edible oils |
DE102017000811A1 (de) | 2017-01-28 | 2018-08-02 | Alzchem Trostberg Gmbh | Verfahren zur Herstellung von Dihydroliponsäure |
CN111377840A (zh) * | 2018-12-29 | 2020-07-07 | 江苏同禾药业有限公司 | 一种r-(+)-二氢硫辛酸的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2788355A (en) * | 1953-10-19 | 1957-04-09 | American Cyanamid Co | 6, 8-dithioloctanoic acid, salts and esters thereof |
US3132152A (en) * | 1958-10-04 | 1964-05-05 | Fujisawa Pharmaceutical Co | Production of dithiofatty acid derivatives and intermediates thereof |
US3223712A (en) | 1960-07-18 | 1965-12-14 | Yamanouchi Pharma Co Ltd | Synthesis of thioctic acid and thioctic acid amide |
DE4037440A1 (de) | 1990-11-24 | 1992-05-27 | Basf Ag | Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern |
DE4137773A1 (de) * | 1991-11-16 | 1993-05-19 | Degussa | Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure |
DE4229914A1 (de) | 1992-09-08 | 1994-03-10 | Basf Ag | Verbessertes Verfahren zur Herstellung von R/S-Ï-Liponsäure oder R/S-â-Liponsäure |
DE19533881A1 (de) * | 1995-09-13 | 1997-03-20 | Dresden Arzneimittel | Herstellung und Verwendung der reinen Enantiomere der 8-Chlor-6-sulfonyloxy-octansäuren und ihrer Alkylester und der reinen Enantiomere der 6,8-Dichlor-octansäure und ihrer Alkylester |
DE19834608A1 (de) | 1998-07-31 | 2000-02-03 | Basf Ag | Kristallmodifikation der Liponsäure |
-
2001
- 2001-07-24 WO PCT/EP2001/008523 patent/WO2002010151A2/de not_active Application Discontinuation
- 2001-07-24 US US10/343,034 patent/US6906210B2/en not_active Expired - Fee Related
- 2001-07-24 JP JP2002515882A patent/JP2004509856A/ja not_active Withdrawn
- 2001-07-24 CN CNB018135781A patent/CN1218945C/zh not_active Expired - Fee Related
- 2001-07-24 EP EP01971775A patent/EP1307442A2/de not_active Withdrawn
- 2001-07-24 AU AU2001291677A patent/AU2001291677A1/en not_active Abandoned
- 2001-07-24 CN CNA2005100088649A patent/CN1680364A/zh active Pending
- 2001-07-24 BR BR0112848-5A patent/BR0112848A/pt not_active IP Right Cessation
- 2001-07-24 CA CA002417842A patent/CA2417842A1/en not_active Abandoned
- 2001-08-02 TW TW094102573A patent/TW200519076A/zh unknown
- 2001-08-02 AR ARP010103687A patent/AR030108A1/es unknown
Non-Patent Citations (1)
Title |
---|
See references of WO0210151A2 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007093433A1 (de) | 2006-02-17 | 2007-08-23 | Carl Zeiss Smt Ag | Beleuchtungssystem für die mikro-lithographie, projektionsbelichtungsanlage mit einem derartigen beleuchtungssystem |
Also Published As
Publication number | Publication date |
---|---|
BR0112848A (pt) | 2003-06-24 |
WO2002010151A3 (de) | 2002-11-14 |
US6906210B2 (en) | 2005-06-14 |
CN1218945C (zh) | 2005-09-14 |
CA2417842A1 (en) | 2003-01-30 |
WO2002010151A2 (de) | 2002-02-07 |
AR030108A1 (es) | 2003-08-13 |
TW200519076A (en) | 2005-06-16 |
US20040044227A1 (en) | 2004-03-04 |
CN1444580A (zh) | 2003-09-24 |
CN1680364A (zh) | 2005-10-12 |
JP2004509856A (ja) | 2004-04-02 |
AU2001291677A1 (en) | 2002-02-13 |
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