TW200519076A - Preparation of lipoic acid and dihydrolipoic acid - Google Patents
Preparation of lipoic acid and dihydrolipoic acidInfo
- Publication number
- TW200519076A TW200519076A TW094102573A TW94102573A TW200519076A TW 200519076 A TW200519076 A TW 200519076A TW 094102573 A TW094102573 A TW 094102573A TW 94102573 A TW94102573 A TW 94102573A TW 200519076 A TW200519076 A TW 200519076A
- Authority
- TW
- Taiwan
- Prior art keywords
- acid
- preparation
- dihydrolipoic
- dihydrolipoic acid
- lipoic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/18—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by addition of thiols to unsaturated compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/02—Thiols having mercapto groups bound to acyclic carbon atoms
- C07C321/04—Thiols having mercapto groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2000138038 DE10038038A1 (de) | 2000-08-02 | 2000-08-02 | Verfahren zur Herstellung von Liponsäure und Dihydroliponsäure |
DE2000144000 DE10044000A1 (de) | 2000-09-05 | 2000-09-05 | Verfahren zur Herstellung von Liponsäure und Dihydroliponsäure |
Publications (1)
Publication Number | Publication Date |
---|---|
TW200519076A true TW200519076A (en) | 2005-06-16 |
Family
ID=26006609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW094102573A TW200519076A (en) | 2000-08-02 | 2001-08-02 | Preparation of lipoic acid and dihydrolipoic acid |
Country Status (10)
Country | Link |
---|---|
US (1) | US6906210B2 (zh) |
EP (1) | EP1307442A2 (zh) |
JP (1) | JP2004509856A (zh) |
CN (2) | CN1218945C (zh) |
AR (1) | AR030108A1 (zh) |
AU (1) | AU2001291677A1 (zh) |
BR (1) | BR0112848A (zh) |
CA (1) | CA2417842A1 (zh) |
TW (1) | TW200519076A (zh) |
WO (1) | WO2002010151A2 (zh) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7914815B2 (en) * | 2000-08-16 | 2011-03-29 | Encore Health, Llc | Method for delivery of pharmaceuticals for treating or preventing presbyopia |
US8697109B2 (en) * | 2000-08-16 | 2014-04-15 | Encore Health, Llc | Caged mercaptan and seleno-mercaptan compounds and methods of using them |
US20050112113A1 (en) * | 2000-08-16 | 2005-05-26 | Till Jonathan S. | Presbyopia treatment by lens alteration |
US8647612B2 (en) * | 2008-03-05 | 2014-02-11 | Encore Health, Llc | Dithiol compounds, derivatives, and treatment of presbyopia |
US7935332B2 (en) | 2000-08-16 | 2011-05-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
ES2266299T3 (es) * | 2000-11-30 | 2007-03-01 | Basf Aktiengesellschaft | Procedimiento para la obtencion acido lipoico y de acido dihidrolipoico. |
CN100387593C (zh) * | 2006-01-26 | 2008-05-14 | 南京师范大学 | 连续逆流液液萃取分离二硫辛酸与乙醇及碱水溶液的方法 |
WO2007093433A1 (de) | 2006-02-17 | 2007-08-23 | Carl Zeiss Smt Ag | Beleuchtungssystem für die mikro-lithographie, projektionsbelichtungsanlage mit einem derartigen beleuchtungssystem |
WO2008067403A2 (en) * | 2006-11-28 | 2008-06-05 | Encore Health Llc | Presbyopia treatment by lens alteration |
US20090078581A1 (en) * | 2007-09-24 | 2009-03-26 | Applied Intellectual Capital | Configurations and Methods of Reduction of Lipoic Acid |
US9044439B2 (en) * | 2008-03-05 | 2015-06-02 | Encore Health, Llc | Low dose lipoic and pharmaceutical compositions and methods |
WO2009111635A2 (en) | 2008-03-05 | 2009-09-11 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
WO2010065069A2 (en) * | 2008-12-01 | 2010-06-10 | In Vasc Therapeutics, Inc. | Compositions comprising renin-angiotensin aldosterone system inhibitors and lipoic acid compounds, and the use thereof for the treatment of renin-angiotensin aldosterone system related disorders |
PT2821405E (pt) | 2009-06-15 | 2016-06-14 | Encore Health Llc | Ésteres de colina para tratar a presbiopia e a catarata |
WO2010147957A2 (en) | 2009-06-15 | 2010-12-23 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
WO2015134510A1 (en) | 2014-03-03 | 2015-09-11 | Encore Vision Inc. | Lipoic acid choline ester compositions and methods of use |
US9944960B2 (en) * | 2015-11-17 | 2018-04-17 | Premier Research Labs, Lp | Process for microbial production of dihydrolipoic acid and extraction of dihydrolipoic acid with edible oils |
DE102017000811A1 (de) | 2017-01-28 | 2018-08-02 | Alzchem Trostberg Gmbh | Verfahren zur Herstellung von Dihydroliponsäure |
CN111377840A (zh) * | 2018-12-29 | 2020-07-07 | 江苏同禾药业有限公司 | 一种r-(+)-二氢硫辛酸的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2788355A (en) * | 1953-10-19 | 1957-04-09 | American Cyanamid Co | 6, 8-dithioloctanoic acid, salts and esters thereof |
US3132152A (en) * | 1958-10-04 | 1964-05-05 | Fujisawa Pharmaceutical Co | Production of dithiofatty acid derivatives and intermediates thereof |
US3223712A (en) | 1960-07-18 | 1965-12-14 | Yamanouchi Pharma Co Ltd | Synthesis of thioctic acid and thioctic acid amide |
DE4037440A1 (de) | 1990-11-24 | 1992-05-27 | Basf Ag | Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern |
DE4137773A1 (de) * | 1991-11-16 | 1993-05-19 | Degussa | Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure |
DE4229914A1 (de) | 1992-09-08 | 1994-03-10 | Basf Ag | Verbessertes Verfahren zur Herstellung von R/S-Ï-Liponsäure oder R/S-â-Liponsäure |
DE19533881A1 (de) * | 1995-09-13 | 1997-03-20 | Dresden Arzneimittel | Herstellung und Verwendung der reinen Enantiomere der 8-Chlor-6-sulfonyloxy-octansäuren und ihrer Alkylester und der reinen Enantiomere der 6,8-Dichlor-octansäure und ihrer Alkylester |
DE19834608A1 (de) | 1998-07-31 | 2000-02-03 | Basf Ag | Kristallmodifikation der Liponsäure |
-
2001
- 2001-07-24 WO PCT/EP2001/008523 patent/WO2002010151A2/de not_active Application Discontinuation
- 2001-07-24 US US10/343,034 patent/US6906210B2/en not_active Expired - Fee Related
- 2001-07-24 JP JP2002515882A patent/JP2004509856A/ja not_active Withdrawn
- 2001-07-24 CN CNB018135781A patent/CN1218945C/zh not_active Expired - Fee Related
- 2001-07-24 EP EP01971775A patent/EP1307442A2/de not_active Withdrawn
- 2001-07-24 AU AU2001291677A patent/AU2001291677A1/en not_active Abandoned
- 2001-07-24 CN CNA2005100088649A patent/CN1680364A/zh active Pending
- 2001-07-24 BR BR0112848-5A patent/BR0112848A/pt not_active IP Right Cessation
- 2001-07-24 CA CA002417842A patent/CA2417842A1/en not_active Abandoned
- 2001-08-02 TW TW094102573A patent/TW200519076A/zh unknown
- 2001-08-02 AR ARP010103687A patent/AR030108A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR0112848A (pt) | 2003-06-24 |
WO2002010151A3 (de) | 2002-11-14 |
US6906210B2 (en) | 2005-06-14 |
CN1218945C (zh) | 2005-09-14 |
CA2417842A1 (en) | 2003-01-30 |
WO2002010151A2 (de) | 2002-02-07 |
AR030108A1 (es) | 2003-08-13 |
US20040044227A1 (en) | 2004-03-04 |
CN1444580A (zh) | 2003-09-24 |
CN1680364A (zh) | 2005-10-12 |
JP2004509856A (ja) | 2004-04-02 |
AU2001291677A1 (en) | 2002-02-13 |
EP1307442A2 (de) | 2003-05-07 |
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