BR0112848A - Processos para a preparação de ácido r-lipóico ou de ácido s-lipóico, de ácido r-dihidrolipóico ou de ácido s-dihidrolipóico puros, e de sais farmacologicamente aceitáveis ou de derivados de ácido r-lipóico ou de ácido s-lipóico, e, composto - Google Patents

Processos para a preparação de ácido r-lipóico ou de ácido s-lipóico, de ácido r-dihidrolipóico ou de ácido s-dihidrolipóico puros, e de sais farmacologicamente aceitáveis ou de derivados de ácido r-lipóico ou de ácido s-lipóico, e, composto

Info

Publication number
BR0112848A
BR0112848A BR0112848-5A BR0112848A BR0112848A BR 0112848 A BR0112848 A BR 0112848A BR 0112848 A BR0112848 A BR 0112848A BR 0112848 A BR0112848 A BR 0112848A
Authority
BR
Brazil
Prior art keywords
acid
lipoic acid
dihydrolipoic
dihydrolipoic acid
lipoic
Prior art date
Application number
BR0112848-5A
Other languages
English (en)
Inventor
Martin Jochen Klatt
Markus Niebel
Joachim Paust
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2000138038 external-priority patent/DE10038038A1/de
Priority claimed from DE2000144000 external-priority patent/DE10044000A1/de
Application filed by Basf Ag filed Critical Basf Ag
Publication of BR0112848A publication Critical patent/BR0112848A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/18—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by addition of thiols to unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/02—Thiols having mercapto groups bound to acyclic carbon atoms
    • C07C321/04—Thiols having mercapto groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"PROCESSOS PARA A PREPARAçãO DE áCIDO R-LIPóICO OU DE áCIDO S-LIPóICO, DE áCIDO R-DIHIDROLIPóICO OU DE áCIDO S-DIHIDROLIPóICO PUROS, E DE SAIS FARMACOLOGICAMENTE ACEITáVEIS OU DE DERIVADOS DE áCIDO R-LIPóICO OU DE áCIDO S-LIPóICO, E, COMPOSTO". A invenção refere-se a um processo para a produção de ácido R- e S-lipóico e de ácido R- e S-dihidrolipóico que compreende uma etapa selecionada entre as seguintes: (a) destilação do ácido dihidrolipóico, (b) reação de (2) ou do estereoisómero do mesmo, em que Ms representa -SO~ 2~-R' e R e R' independentemente significam C~ 1~-C~ 6~-alquila, C~ 3~-C~ 8~-cicloalquila, C~ 3~C~ 8~-cicloalquilalquila, arila ou aralquila, com sulfeto de sódio e enxofre em etanol e reação com um hidreto complexo, (c) extração de uma solução prótica de ácido R-dihidrolipóico ou de ácido S-dihidrolipóico com um solvente orgânico de uma solução prótica a um valor de pH de 9 - 10 ou (d) extração de ácido R-dihidrolipóico ou de ácido S-dihidrolipóico com um solvente orgânico de uma solução prótica a um valor de pH de 4 - 5, ou uma combinação de uma etapa individual ou de diversas etapas (a) a (d). A invenção também se refere a um processo para a produção de ácido dihidrolipóico e do composto 1,6,8-octano triol.
BR0112848-5A 2000-08-02 2001-07-24 Processos para a preparação de ácido r-lipóico ou de ácido s-lipóico, de ácido r-dihidrolipóico ou de ácido s-dihidrolipóico puros, e de sais farmacologicamente aceitáveis ou de derivados de ácido r-lipóico ou de ácido s-lipóico, e, composto BR0112848A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2000138038 DE10038038A1 (de) 2000-08-02 2000-08-02 Verfahren zur Herstellung von Liponsäure und Dihydroliponsäure
DE2000144000 DE10044000A1 (de) 2000-09-05 2000-09-05 Verfahren zur Herstellung von Liponsäure und Dihydroliponsäure
PCT/EP2001/008523 WO2002010151A2 (de) 2000-08-02 2001-07-24 Verfahren zur herstellung von liponsäure und dihydroliponsäure

Publications (1)

Publication Number Publication Date
BR0112848A true BR0112848A (pt) 2003-06-24

Family

ID=26006609

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0112848-5A BR0112848A (pt) 2000-08-02 2001-07-24 Processos para a preparação de ácido r-lipóico ou de ácido s-lipóico, de ácido r-dihidrolipóico ou de ácido s-dihidrolipóico puros, e de sais farmacologicamente aceitáveis ou de derivados de ácido r-lipóico ou de ácido s-lipóico, e, composto

Country Status (10)

Country Link
US (1) US6906210B2 (pt)
EP (1) EP1307442A2 (pt)
JP (1) JP2004509856A (pt)
CN (2) CN1680364A (pt)
AR (1) AR030108A1 (pt)
AU (1) AU2001291677A1 (pt)
BR (1) BR0112848A (pt)
CA (1) CA2417842A1 (pt)
TW (1) TW200519076A (pt)
WO (1) WO2002010151A2 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8147816B2 (en) * 2000-08-16 2012-04-03 Encore Health, Llc Presbyopia treatment by lens alteration
US7935332B2 (en) * 2000-08-16 2011-05-03 Encore Health, Llc Presbyopia treatment by lens alteration
US7914815B2 (en) * 2000-08-16 2011-03-29 Encore Health, Llc Method for delivery of pharmaceuticals for treating or preventing presbyopia
US8697109B2 (en) * 2000-08-16 2014-04-15 Encore Health, Llc Caged mercaptan and seleno-mercaptan compounds and methods of using them
US20050112113A1 (en) * 2000-08-16 2005-05-26 Till Jonathan S. Presbyopia treatment by lens alteration
US8647612B2 (en) * 2008-03-05 2014-02-11 Encore Health, Llc Dithiol compounds, derivatives, and treatment of presbyopia
EP1339705B1 (de) * 2000-11-30 2006-06-07 Basf Aktiengesellschaft Verfahren zur herstellung von liponsäure und dihydroliponsaüre
CN100387593C (zh) * 2006-01-26 2008-05-14 南京师范大学 连续逆流液液萃取分离二硫辛酸与乙醇及碱水溶液的方法
KR101314974B1 (ko) 2006-02-17 2013-10-04 칼 짜이스 에스엠티 게엠베하 마이크로리소그래픽 조명 시스템 및 이를 구비한 투사 노출장치
US20090078581A1 (en) * 2007-09-24 2009-03-26 Applied Intellectual Capital Configurations and Methods of Reduction of Lipoic Acid
US9044439B2 (en) * 2008-03-05 2015-06-02 Encore Health, Llc Low dose lipoic and pharmaceutical compositions and methods
WO2009111635A2 (en) 2008-03-05 2009-09-11 Encore Health, Llc Dithiol compounds, derivatives, and uses therefor
KR20110103987A (ko) * 2008-12-01 2011-09-21 인베이스크 테라퓨틱, 인크. 레닌-안지오텐신 알도스테론계 억제제 및 리포산 화합물을 포함하는 조성물, 및 레닌-안지오텐신 알도스테론계 관련 질환의 치료를 위한 이의 용도
ES2579173T3 (es) 2009-06-15 2016-08-05 Encore Health, Llc Ésteres de colina para tratar presbicia y cataratas
EP4082542A1 (en) * 2009-06-15 2022-11-02 Encore Health, LLC Dithiol compounds, derivatives, and uses therefor
CN112641720A (zh) 2014-03-03 2021-04-13 诺华股份有限公司 硫辛酸胆碱酯组合物及使用方法
US9944960B2 (en) 2015-11-17 2018-04-17 Premier Research Labs, Lp Process for microbial production of dihydrolipoic acid and extraction of dihydrolipoic acid with edible oils
DE102017000811A1 (de) 2017-01-28 2018-08-02 Alzchem Trostberg Gmbh Verfahren zur Herstellung von Dihydroliponsäure
CN111377840A (zh) * 2018-12-29 2020-07-07 江苏同禾药业有限公司 一种r-(+)-二氢硫辛酸的制备方法
CN116102532A (zh) * 2023-01-09 2023-05-12 国药集团威奇达药业有限公司 从硫辛酸结晶母液中回收硫辛酸的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2788355A (en) * 1953-10-19 1957-04-09 American Cyanamid Co 6, 8-dithioloctanoic acid, salts and esters thereof
US3132152A (en) * 1958-10-04 1964-05-05 Fujisawa Pharmaceutical Co Production of dithiofatty acid derivatives and intermediates thereof
US3223712A (en) * 1960-07-18 1965-12-14 Yamanouchi Pharma Co Ltd Synthesis of thioctic acid and thioctic acid amide
DE4037440A1 (de) 1990-11-24 1992-05-27 Basf Ag Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern
DE4137773A1 (de) * 1991-11-16 1993-05-19 Degussa Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure
DE4229914A1 (de) * 1992-09-08 1994-03-10 Basf Ag Verbessertes Verfahren zur Herstellung von R/S-Ï-Liponsäure oder R/S-â-Liponsäure
DE19533881A1 (de) * 1995-09-13 1997-03-20 Dresden Arzneimittel Herstellung und Verwendung der reinen Enantiomere der 8-Chlor-6-sulfonyloxy-octansäuren und ihrer Alkylester und der reinen Enantiomere der 6,8-Dichlor-octansäure und ihrer Alkylester
DE19834608A1 (de) 1998-07-31 2000-02-03 Basf Ag Kristallmodifikation der Liponsäure

Also Published As

Publication number Publication date
CN1218945C (zh) 2005-09-14
EP1307442A2 (de) 2003-05-07
CN1680364A (zh) 2005-10-12
CA2417842A1 (en) 2003-01-30
TW200519076A (en) 2005-06-16
JP2004509856A (ja) 2004-04-02
AR030108A1 (es) 2003-08-13
AU2001291677A1 (en) 2002-02-13
US6906210B2 (en) 2005-06-14
CN1444580A (zh) 2003-09-24
WO2002010151A2 (de) 2002-02-07
US20040044227A1 (en) 2004-03-04
WO2002010151A3 (de) 2002-11-14

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2021 DE 29/09/2009.