EP0650370A4 - Procedes et compositions permettant de cibler des tissus specifiques. - Google Patents

Procedes et compositions permettant de cibler des tissus specifiques.

Info

Publication number
EP0650370A4
EP0650370A4 EP93914334A EP93914334A EP0650370A4 EP 0650370 A4 EP0650370 A4 EP 0650370A4 EP 93914334 A EP93914334 A EP 93914334A EP 93914334 A EP93914334 A EP 93914334A EP 0650370 A4 EP0650370 A4 EP 0650370A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
specific tissue
targeting specific
targeting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93914334A
Other languages
German (de)
English (en)
Other versions
EP0650370A1 (fr
Inventor
Yuet Wai Kan
Noriyuki Kasahara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of EP0650370A1 publication Critical patent/EP0650370A1/fr
Publication of EP0650370A4 publication Critical patent/EP0650370A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
EP93914334A 1992-06-08 1993-06-03 Procedes et compositions permettant de cibler des tissus specifiques. Withdrawn EP0650370A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90609292A 1992-06-08 1992-06-08
US906092 1992-06-08
PCT/US1993/005260 WO1993025234A1 (fr) 1992-06-08 1993-06-03 Procedes et compositions permettant de cibler des tissus specifiques

Publications (2)

Publication Number Publication Date
EP0650370A1 EP0650370A1 (fr) 1995-05-03
EP0650370A4 true EP0650370A4 (fr) 1995-11-22

Family

ID=25421920

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93914334A Withdrawn EP0650370A4 (fr) 1992-06-08 1993-06-03 Procedes et compositions permettant de cibler des tissus specifiques.

Country Status (3)

Country Link
EP (1) EP0650370A4 (fr)
JP (1) JPH07507689A (fr)
WO (1) WO1993025234A1 (fr)

Families Citing this family (259)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE263252T1 (de) 1992-11-09 2004-04-15 Us Health Erzielbare vektorenpartikel
GB9402857D0 (en) * 1994-02-15 1994-04-06 Isis Innovation Targeting gene therapy
US6150137A (en) 1994-05-27 2000-11-21 Ariad Pharmaceuticals, Inc. Immunosuppressant target proteins
GB9412844D0 (en) * 1994-06-27 1994-08-17 Medical Res Council Improvements in or relating to therapeutic methods
US6465253B1 (en) 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US6127525A (en) * 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
US5770442A (en) 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
EP0840797B1 (fr) * 1995-07-25 2014-09-03 Crucell Holland B.V. Procedes et moyens d'apport cible de genes
GB9519776D0 (en) * 1995-09-28 1995-11-29 Casimir Colin Materials and methods relating to the transfer of nucleic acid into stem cells
WO1997024453A1 (fr) * 1995-12-28 1997-07-10 Chiron Corporation Polypeptides chimeres de surface virale, specifiques d'un recepteur, pour l'incorporation et l'interiorisation d'une particule et d'un virus dans des cellules cibles
DE19605279A1 (de) * 1996-02-13 1997-08-14 Hoechst Ag Zielzellspezifische Vektoren für die Einschleusung von Genen in Zellen, Arzneimittel enthaltend derartige Vektoren und deren Verwendung
EP1860192A1 (fr) 1996-09-17 2007-11-28 Novartis Vaccines and Diagnostics, Inc. Compositions et procédés de traitement de maladies intracellulaires
US6544523B1 (en) 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
EP0973538B1 (fr) 1997-04-10 2008-03-12 University of Southern California Proteines modifiees se fixant a des composants de matrice extracellulaires
US6004798A (en) * 1997-05-14 1999-12-21 University Of Southern California Retroviral envelopes having modified hypervariable polyproline regions
US6162641A (en) * 1997-06-06 2000-12-19 The Regents Of The University Of Michigan Neuregulin response element and uses therefor
DE69838584T2 (de) 1997-08-04 2008-06-26 Cell Genesys, Inc., Foster City Enhancer des menschlichen glandulären kallikreingens, vektoren die ihn enthalten und methoden für seine verwendung
ATE374247T1 (de) 1997-10-14 2007-10-15 Darwin Molecular Corp Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten
CN1263854C (zh) 1997-11-06 2006-07-12 启龙股份公司 奈瑟球菌抗原
WO1999036544A2 (fr) 1998-01-14 1999-07-22 Chiron S.P.A. Antigenes du $i(neisseria meningitidis)
US7078483B2 (en) 1998-04-29 2006-07-18 University Of Southern California Retroviral vectors including modified envelope escort proteins
EP1645631B1 (fr) 1998-05-01 2007-10-24 Novartis Vaccines and Diagnostics, Inc. Antigènes de Neisseria meningitidis et compositions
EP0972841A1 (fr) * 1998-05-20 2000-01-19 Introgene B.V. Présentation de protéines virales comme ligands de récepteur cellulaire de surface
EP0959136A1 (fr) * 1998-05-20 1999-11-24 Introgene B.V. Délivrance ciblée via un transporteur d' acides aminés cationiques
EP0960942A3 (fr) * 1998-05-20 2000-01-12 Introgene B.V. Délivrance ciblée via un transporteur d'acide aminé
EP0959135A1 (fr) * 1998-05-20 1999-11-24 Introgene B.V. Présentation de protéines virales et délivrance ciblée au récepteur cellulaire
JP2002527066A (ja) 1998-10-15 2002-08-27 カイロン コーポレイション 転移性乳癌および結腸癌調節遺伝子
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
WO2000032773A1 (fr) 1998-11-27 2000-06-08 Darwin Discovery Ltd. Compositions et methodes d'augmentation de la mineralisation de la substance osseuse
ATE408695T1 (de) 1998-12-16 2008-10-15 Novartis Vaccines & Diagnostic Menschliche cyclin-abhängige kinase (hpnqalre)
US7063850B1 (en) 1998-12-22 2006-06-20 University Of Tennessee Research Foundation Protective antigen of group A Streptococci
US7935805B1 (en) 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
WO2000039302A2 (fr) 1998-12-31 2000-07-06 Chiron Corporation Expression amelioree de polypeptides hiv et production de particules de type viral
US6864235B1 (en) 1999-04-01 2005-03-08 Eva A. Turley Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US6911429B2 (en) 1999-04-01 2005-06-28 Transition Therapeutics Inc. Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
WO2000066741A2 (fr) 1999-04-30 2000-11-09 Chiron S.P.A. Antigenes de neisseria conserves
GB9911683D0 (en) 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
US7396905B1 (en) 1999-05-21 2008-07-08 Mckeon Frank Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
GB9916529D0 (en) 1999-07-14 1999-09-15 Chiron Spa Antigenic peptides
PT2275551E (pt) 1999-10-29 2015-06-29 Novartis Vaccines & Diagnostic Péptidos antigénicos de neisseria
JP2003516731A (ja) 1999-11-18 2003-05-20 カイロン コーポレイション ヒトｆｇｆ−２１遺伝子および遺伝子発現産物
US8168178B2 (en) 1999-11-30 2012-05-01 Curis, Inc. Methods and compositions for regulating lymphocyte activity
US6951839B1 (en) 1999-11-30 2005-10-04 Curis, Inc. Methods and compositions for regulating lymphocyte activity
MXPA02006962A (es) 2000-01-17 2002-12-13 Chiron Spa Vacuna de vesicula de membrana exterior que comprende proteinas de membrana exterior de neisseria meningitidis serogrupo b.
EP1854476A3 (fr) 2000-02-09 2008-05-07 Bas Medical, Inc. Utilisation de la relaxine pour traiter des maladies associées à la vasoconstriction
EP2075255A1 (fr) 2000-03-08 2009-07-01 Novartis Vaccines and Diagnostics, Inc. Gène FGF-23 humain et produits d'expression de gènes
EP1950297A2 (fr) 2000-05-31 2008-07-30 Novartis Vaccines and Diagnostics, Inc. Compositions et procédés de traitement de maladie néoplastique utilisant la chimiothérapie et des sensibilisateurs à rayonnement
US7700359B2 (en) 2000-06-02 2010-04-20 Novartis Vaccines And Diagnostics, Inc. Gene products differentially expressed in cancerous cells
EP1370684B1 (fr) 2000-06-15 2008-05-28 Novartis Vaccines and Diagnostics, Inc. Polynucleotides lies au cancer du colon
CA2881568C (fr) 2000-10-27 2019-09-24 Novartis Vaccines And Diagnostics, Inc. Acides nucleiques et proteines derives des groupes de streptocoques a et b
US7776523B2 (en) 2000-12-07 2010-08-17 Novartis Vaccines And Diagnostics, Inc. Endogenous retroviruses up-regulated in prostate cancer
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
EP2706116A1 (fr) 2001-01-17 2014-03-12 Emergent Product Development Seattle, LLC Proteines de fusion d'immunoglobuline de domaine de liaison
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
US7541512B2 (en) 2001-03-30 2009-06-02 Synageva Biopharma Corp. Avians containing a lysozyme promoter transgene
US7176300B2 (en) 2001-03-30 2007-02-13 Avigenics, Inc. Avian lysozyme promoter
EP1478751A4 (fr) 2001-03-30 2005-10-19 Avigenics Inc Promoteur de lysozymes aviaires
WO2002081641A2 (fr) 2001-04-06 2002-10-17 Georgetown University Gene scc-112 et utilisations diagnostique et therapeutique de ce gene
WO2002081639A2 (fr) 2001-04-06 2002-10-17 Georgetown University Gene brcc2 et ses utilisations diagnostiques et therapeutiques
AU2002258728A1 (en) 2001-04-06 2002-10-21 Georgetown University Gene brcc-3 and diagnostic and therapeutic uses thereof
JP4353701B2 (ja) 2001-05-08 2009-10-28 ダーウィン モレキュラー コーポレイション Ｆｏｘｐ３蛋白質を用いた霊長類における免疫機能の調節方法
JP5033303B2 (ja) 2001-07-05 2012-09-26 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 抗原性ｃ型ｈｉｖポリペプチドをコードするポリヌクレオチド、ポリペプチドおよびそれらの使用
EP2292772A1 (fr) 2001-07-05 2011-03-09 Novartis Vaccines and Diagnostics, Inc. Vaccination VIH avec un ADN codant un polypeptide VIH et un polypeptide VIH
US6867189B2 (en) 2001-07-26 2005-03-15 Genset S.A. Use of adipsin/complement factor D in the treatment of metabolic related disorders
US7550650B2 (en) 2001-09-18 2009-06-23 Synageva Biopharma Corp. Production of a transgenic avian by cytoplasmic injection
WO2003060143A2 (fr) 2001-10-26 2003-07-24 Id Biomedical Corporation Of Washington Systeme d'expression de proteine efficace
CA2465953A1 (fr) 2001-11-09 2003-05-15 Georgetown University Nouveaux isoformes de l'inhibiteur de la croissance de cellules endotheliales vasculaires
US7335761B2 (en) 2001-11-30 2008-02-26 Avigenics, Inc. Avian gene expression controlling regions
US6875588B2 (en) 2001-11-30 2005-04-05 Avigenics, Inc. Ovomucoid promoter and methods of use
US7294507B2 (en) 2001-11-30 2007-11-13 Avigenics, Inc. Ovomucoid promoters and methods of use
EP2335724A1 (fr) 2001-12-12 2011-06-22 Novartis Vaccines and Diagnostics S.r.l. Immunisation contre la Chlamydia trachomatis
SG148035A1 (en) 2002-01-08 2008-12-31 Novartis Vaccines & Diagnostic Gene products differentially expressed in cancerous breast cells and their methods of use
US7135562B2 (en) 2002-03-14 2006-11-14 University Of Cincinnati Avian iFABP gene expression controlling region
CN100593544C (zh) 2002-03-15 2010-03-10 惠氏控股有限公司 酶活性减少的非典型流感嗜血杆菌的p4蛋白突变体
JP2005520543A (ja) 2002-03-21 2005-07-14 サイグレス ディスカバリー， インコーポレイテッド 癌における新規組成物および方法
US7244565B2 (en) 2002-04-10 2007-07-17 Georgetown University Gene shinc-3 and diagnostic and therapeutic uses thereof
AU2003276679A1 (en) 2002-06-13 2003-12-31 Chiron Corporation Vectors for expression of hml-2 polypeptides
CA2421269A1 (fr) 2002-08-09 2004-02-09 President And Fellows Of Harvard College Methodes et compositions pour prolonger la duree de vie et accroitre la resistance au stress de cellules et d'organismes
UA80447C2 (en) 2002-10-08 2007-09-25 Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic
US7569364B2 (en) 2002-12-24 2009-08-04 Pfizer Inc. Anti-NGF antibodies and methods using same
US9498530B2 (en) 2002-12-24 2016-11-22 Rinat Neuroscience Corp. Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
EP1575517B1 (fr) 2002-12-24 2012-04-11 Rinat Neuroscience Corp. Anticorps anti-ngf et procedes d'utilisation de ces anticorps
WO2004074321A2 (fr) 2003-02-14 2004-09-02 Sagres Discovery, Inc. Nouveaux cibles therapeutiques du recepteur de couplage a la proteine g dans le cancer
US7767387B2 (en) 2003-06-13 2010-08-03 Sagres Discovery, Inc. Therapeutic targets in cancer
US20040170982A1 (en) 2003-02-14 2004-09-02 Morris David W. Novel therapeutic targets in cancer
DE602004030535D1 (de) 2003-02-19 2011-01-27 Rinat Neuroscience Corp Verfahren zur behandlung von schmerzen durch verabreichung eines nervenwachstumsfaktor-antagonisten und eines nsaid und diese enthaltende zusammensetzung
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
ATE513471T1 (de) 2003-04-21 2011-07-15 Epeius Biotechnologies Corp Verfahren und zusammensetzungen zur behandlung von erkrankungen
US20070178066A1 (en) 2003-04-21 2007-08-02 Hall Frederick L Pathotropic targeted gene delivery system for cancer and other disorders
US20060025337A1 (en) 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
US9532994B2 (en) 2003-08-29 2017-01-03 The Regents Of The University Of California Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
WO2005062955A2 (fr) 2003-12-23 2005-07-14 Rinat Neuroscience Corp. Anticorps anti-trkc agonistes et procedes d'utilisation
KR101222281B1 (ko) 2004-03-29 2013-01-28 가르파마 컴퍼니 리미티드 신규 갈렉틴 9 개변체 단백질 및 그 용도
ES2338344T3 (es) 2004-04-07 2010-05-06 Rinat Neuroscience Corporation Procedimiento de tratamiento del dolor de cancer de hueso mediante la administracion de una antagonista del factor de crecimiento neuronal.
US7875275B2 (en) 2004-06-16 2011-01-25 The General Hospital Corporation Use of Bridge-1 and activators and inhibitors thereof in the treatment of insulin deficiency and diabetes
EP1789593B1 (fr) 2004-07-09 2017-03-15 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Formes solubles de glycoproteine g des virus hendra
EP1773375A1 (fr) 2004-07-14 2007-04-18 University of Utah Research Foundation Compositions et utilisations liees a des netrines
US20060024677A1 (en) 2004-07-20 2006-02-02 Morris David W Novel therapeutic targets in cancer
US7807165B2 (en) 2004-07-30 2010-10-05 Rinat Neuroscience Corp. Antibodies directed against amyloid-beta peptide and methods using same
ES2385045T3 (es) 2005-02-18 2012-07-17 Novartis Vaccines And Diagnostics, Inc. Inmunógenos de Escherichia coli uropatogénica
EP1865981A2 (fr) 2005-04-07 2007-12-19 Chiron Corporation Cacna1e dans le diagnostic, la detection et le traitement du cancer
US20090220495A1 (en) 2005-04-07 2009-09-03 Abdallah Fanidi Cancer Related Genes (PRLR)
CA2615615A1 (fr) 2005-07-22 2007-02-01 Y's Therapeutics Co., Ltd. Anticorps anti-cd26 et methodes d'utilisation de ces derniers
ES2460517T3 (es) 2005-07-25 2014-05-13 Emergent Product Development Seattle, Llc Reducción de células b mediante el uso de moléculas de unión específica a cd37 y de unión específica a cd20
AP2008004467A0 (en) 2005-11-14 2008-06-30 Rinat Neurosciene Corp Antagonist antibodies directed against calcitonin generelated peptide anf methods using same
US7935342B2 (en) 2006-02-02 2011-05-03 Rinat Neuroscience Corp. Methods for treating obesity by administering a trkB antagonist
EP1993558B1 (fr) 2006-02-27 2014-07-30 The Regents of The University of California Composés oxystérols et hedgehog voie
RU2461572C2 (ru) 2006-06-07 2012-09-20 Биоэллаенс К.В. Антитела, распознающие содержащий углеводы эпитоп на cd-43 и сеа, экспрессируемых на злокачественных клетках, и способы их применения
EP2035035A2 (fr) 2006-06-09 2009-03-18 Novartis AG Compositions immunogenes pour streptococcus agalactiae
AU2007257692B2 (en) 2006-06-12 2013-11-14 Aptevo Research And Development Llc Single-chain multivalent binding proteins with effector function
JP2010500399A (ja) 2006-08-16 2010-01-07 ノバルティス アーゲー 尿路病原性大腸菌由来の免疫原
PL2484375T3 (pl) 2006-09-26 2018-09-28 Infectious Disease Research Institute Kompozycja szczepionki zawierająca syntetyczny adiuwant
US20090181078A1 (en) 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
EP2629094A1 (fr) 2007-01-24 2013-08-21 Carnegie Mellon University Biocapteurs optiques
WO2008116116A2 (fr) 2007-03-20 2008-09-25 Harold Brem Compositions gm-csf cosméceuticales et leurs procédés d'utilisation
EP2155777A2 (fr) 2007-04-10 2010-02-24 The Administrators of the Tulane Educational Fund Formes solubles et ancrées sur membrane de protéines de sous-unité du virus lassa
GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
US9526737B2 (en) 2007-12-03 2016-12-27 The Regents Of The University Of California Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
CN102216329A (zh) 2007-12-17 2011-10-12 辉瑞有限公司 间质性膀胱炎的治疗
EP2245063B1 (fr) 2007-12-18 2015-08-26 BioAlliance C.V. Anticorps reconnaissant un épitope contenant des glucides sur cd-43 et cea exprimés sur des cellules cancéreuses et leurs procédés d'utilisation
WO2009126306A2 (fr) 2008-04-10 2009-10-15 Cell Signaling Technology, Inc. Compositions et procédés pour la détection des mutations d’egfr en cas de cancer
DK2132228T3 (da) 2008-04-11 2011-10-10 Emergent Product Dev Seattle CD37-immunterapeutisk middel og kombination med bifunktionelt kemoterapeutisk middel deraf
US7928189B2 (en) 2008-05-05 2011-04-19 Ottawa Health Research Institute PCSK9 polypeptide fragment
WO2009150623A1 (fr) 2008-06-13 2009-12-17 Pfizer Inc Traitement de la prostatite chronique
TWI516501B (zh) 2008-09-12 2016-01-11 禮納特神經系統科學公司 Ｐｃｓｋ９拮抗劑類
WO2010039536A2 (fr) 2008-09-23 2010-04-08 President And Fellows Of Harvard College Sirt4 et utilisations de celui-ci
WO2010080985A1 (fr) 2009-01-08 2010-07-15 Dana-Farber Cancer Institute, Inc. Compositions et procédés pour induire la différenciation du tissu adipeux brun
JP2012515532A (ja) 2009-01-20 2012-07-12 ラモット アット テル アビブ ユニバーシティ， リミテッド Ｍｉｒ−２１プロモーター駆動性標的がん治療
US9719069B2 (en) 2009-01-27 2017-08-01 University Of Utah Research Foundation Methods and compositions relating to viral latency
WO2010086828A2 (fr) 2009-02-02 2010-08-05 Rinat Neuroscience Corporation Anticorps monoclonaux agonistes anti-trkb
EP2403526B1 (fr) 2009-03-06 2019-05-15 GlaxoSmithKline Biologicals SA Antigènes de chlamydia
CA2755870C (fr) 2009-03-20 2019-04-09 Angioblast Systems, Inc. Production de cellules pluripotentes reprogrammees
WO2010118243A2 (fr) 2009-04-08 2010-10-14 Genentech, Inc. Utilisation d'antagonistes de il-27 pour traiter le lupus
BRPI1013780B8 (pt) 2009-04-14 2022-10-04 Novartis Ag Composição imunogênica útil para imunização contra staphylococcus aureus, seu método de preparação e composição farmacêutica
WO2010124365A1 (fr) 2009-04-27 2010-11-04 Ottawa Hospital Research Institute Compositions et méthodes permettant de moduler les cellules souches et leurs utilisations
TWI549688B (zh) 2009-06-05 2016-09-21 美國疾病傳染研究機構 合成的葡萄吡喃糖基脂質佐劑
WO2010146511A1 (fr) 2009-06-17 2010-12-23 Pfizer Limited Traitement d'une vessie hyperactive
PL2464658T3 (pl) 2009-07-16 2015-03-31 Novartis Ag Immunogeny z Escherichia coli o zniesionej toksyczności
US8563261B2 (en) 2009-09-28 2013-10-22 The Trustees Of The University Of Pennsylvania Method of diagnosing and treating interstitial cystitis
GB0919690D0 (en) 2009-11-10 2009-12-23 Guy S And St Thomas S Nhs Foun compositions for immunising against staphylococcus aureus
JP2013517772A (ja) 2010-01-21 2013-05-20 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 遺伝子発見および標的確認を補助するための状況特異的遺伝子スクリーニングプラットフォーム
TWI552760B (zh) 2010-02-24 2016-10-11 雷那特神經科學股份有限公司 拮抗劑抗－ｉｌ－７受體抗體及方法
GB201003333D0 (en) 2010-02-26 2010-04-14 Novartis Ag Immunogenic proteins and compositions
CN102844332B (zh) 2010-03-11 2015-08-19 瑞纳神经科学公司 呈pH依赖性抗原结合的抗体
GB201005625D0 (en) 2010-04-01 2010-05-19 Novartis Ag Immunogenic proteins and compositions
WO2011133931A1 (fr) 2010-04-22 2011-10-27 Genentech, Inc. Utilisation d'antagonistes d'il-27 pour traiter une maladie intestinale inflammatoire
WO2012015758A2 (fr) 2010-07-30 2012-02-02 Saint Louis University Méthodes de traitement de la douleur
US9539427B2 (en) 2010-11-08 2017-01-10 The Johns Hopkins University Methods for improving heart function
WO2012075243A2 (fr) 2010-12-01 2012-06-07 The University Of North Carolina At Chapel Hill Procédés et compositions destinés à cibler des sites de croissance néovasculaire
WO2012072769A1 (fr) 2010-12-01 2012-06-07 Novartis Ag Epitopes rrgb de pneumocoque et combinaisons de variantes
EP3026432A3 (fr) 2010-12-27 2016-07-27 Brown University Procédé de prévision de la réponse du patient au traitement avec biglycan
EA027236B1 (ru) 2011-04-08 2017-07-31 Иммьюн Дизайн Корп. Иммуногенные композиции и способы применения таких композиций для индукции гуморального и клеточного иммунного ответа
US20130071375A1 (en) 2011-08-22 2013-03-21 Saint Louis University Compositions and methods for treating inflammation
WO2013028527A1 (fr) 2011-08-23 2013-02-28 Indiana University Research And Technology Corporation Compositions et procédés pour traiter le cancer
US10093705B2 (en) 2011-09-13 2018-10-09 Dana-Farber Cancer Institute, Inc. Compositions and methods for brown fat induction and activity using FNDC5
US10378060B2 (en) 2011-10-14 2019-08-13 Dana-Farber Cancer Institute, Inc. ZNF365/ZFP365 biomarker predictive of anti-cancer response
CN104053672A (zh) 2011-11-11 2014-09-17 瑞纳神经科学公司 Trop-2特异性抗体及其用途
RU2014123030A (ru) 2011-12-22 2016-02-20 Ринат Ньюросайенс Корп. Антагонистические антитела против человеческого рецептора гормона роста и способы их применения
WO2013093693A1 (fr) 2011-12-22 2013-06-27 Rinat Neuroscience Corp. Anticorps spécifiques de staphylococcus aureus et leurs utilisations
HUE044841T2 (hu) 2012-02-07 2019-11-28 Infectious Disease Res Inst TLR4 agonistákat tartalmazó javított adjuváns készítmények és azok alkalmazási eljárásai
WO2013164754A2 (fr) 2012-05-04 2013-11-07 Pfizer Inc. Régimes immunothérapeutiques basés sur des antigènes associés à la prostate et un vaccin
WO2013169399A1 (fr) 2012-05-07 2013-11-14 The Regents Of The University Of California Oxy133, un analogue de l'oxystérol, induisant l'ostéo-genèse et la signalisation hedgehog et inhibant l'adipogenèse
SI2850431T1 (en) 2012-05-16 2018-08-31 Immune Design Corp. Vaccine against HSV-2
US8603470B1 (en) 2012-08-07 2013-12-10 National Cheng Kung University Use of IL-20 antagonists for treating liver diseases
BR112015010722A2 (pt) 2012-11-09 2017-08-22 Pfizer Anticorpos específicos de fator de crescimento derivado de plaquetas de isoforma b e composições e usos dos mesmos
AU2014236086B2 (en) 2013-03-14 2020-03-05 Genvivo, Inc. Improved thymidine kinase gene
CA2906624A1 (fr) 2013-03-15 2014-09-25 Dyax Corp. Anticorps anti-kallicreine plasmatique
JP6426706B2 (ja) 2013-04-18 2018-11-21 イミューン デザイン コーポレイション がん処置で使用するためのｇｌａ単剤療法
WO2014179756A1 (fr) 2013-05-02 2014-11-06 The Regents Of The University Of California Agents de ciblage osseux à base d'oxystérol ostéogène à sélectivité osseuse
JP2016520058A (ja) 2013-05-07 2016-07-11 ライナット ニューロサイエンス コーポレイション 抗グルカゴン受容体抗体およびその使用方法
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
EP3008043A2 (fr) 2013-06-14 2016-04-20 University Of Utah Research Foundation Analogues triazol-1-ol médicaments de latence antirétroviral
WO2015006641A2 (fr) 2013-07-12 2015-01-15 Georgia State University Research Foundation, Inc. Procédés et compositions d'interférence pour polymérase d'adn et synthèse d'adn
US10208125B2 (en) 2013-07-15 2019-02-19 University of Pittsburgh—of the Commonwealth System of Higher Education Anti-mucin 1 binding agents and uses thereof
BR112016002008B1 (pt) 2013-08-02 2021-06-22 Pfizer Inc. Anticorpos anti-cxcr4, seu uso, conjugado anticorpo-fármaco e composição farmacêutica
US9683998B2 (en) 2013-11-13 2017-06-20 Pfizer Inc. Tumor necrosis factor-like ligand 1A specific antibodies and compositions and uses thereof
WO2015087187A1 (fr) 2013-12-10 2015-06-18 Rinat Neuroscience Corp. Anticorps anti-sclérostine
WO2015109212A1 (fr) 2014-01-17 2015-07-23 Pfizer Inc. Anticorps anti-il-2 et compositions et utilisations de ceux-ci
MX2016012188A (es) 2014-03-21 2017-04-27 Teva Pharmaceuticals Int Gmbh Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos.
WO2015164743A2 (fr) 2014-04-24 2015-10-29 Dana-Farber Cancer Institute, Inc. Suppresseur de tumeur et biomarqueurs oncogènes prédictifs de réponse à un inhibiteur de point de contrôle anti-immunitaire
WO2015168474A1 (fr) 2014-04-30 2015-11-05 President And Fellows Of Harvard College Protéines de fusion pour le traitement du cancer et procédés associés
EP3143138B1 (fr) 2014-05-13 2022-03-23 BioAtla, Inc. Protéines biologiques conditionnellement actives
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
EP3186284B1 (fr) 2014-08-28 2022-04-06 BioAtla, Inc. Récepteurs d'antigènes chimères conditionnellement actifs pour cellules t modifiées
US11111288B2 (en) 2014-08-28 2021-09-07 Bioatla, Inc. Conditionally active chimeric antigen receptors for modified t-cells
KR20170044115A (ko) 2014-09-03 2017-04-24 바이오아트라, 엘엘씨 동일한 진핵생물 세포 생산 숙주 내 조건부 활성 생체 단백질의 발견 및 제조
US20180133252A9 (en) 2014-09-09 2018-05-17 Unum Therapeutics Inc. Chimeric receptors and uses thereof in immune therapy
CA2963091A1 (fr) 2014-10-06 2016-04-14 Dana-Farber Cancer Institute, Inc. Biomarqueurs a base d'angiopoietine -2 utilises pour la prediction de la reponse de point de controle anti-immunitaire
CN113230384A (zh) 2014-10-09 2021-08-10 丹娜法伯癌症研究院 用于治疗免疫失调的多次-可变il-2剂量方案
TWI595006B (zh) 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗ｐｄ－１抗體類和使用彼等之方法
US10948492B2 (en) 2015-03-06 2021-03-16 Dana-Farber Cancer Institute, Inc. PD-L2 biomarkers predictive of PD-1 pathway inhibitor responses in esophagogastric cancers
EP3735982A1 (fr) 2015-03-10 2020-11-11 The University of Massachusetts Ciblage de gdf6 et de la signalisation médiée par les bmp pour une thérapie contre le mélanome
US9758575B2 (en) 2015-04-06 2017-09-12 Yung Shin Pharmaceutical Industrial Co. Ltd. Antibodies which specifically bind to canine vascular endothelial growth factor and uses thereof
MY196625A (en) 2015-04-13 2023-04-23 Pfizer Therapeutic Antibodies and Their Uses
CA2993026A1 (fr) 2015-07-21 2017-01-26 Dyax Corp. Inhibiteur d'anticorps monoclonal du facteur xiia
WO2017015334A1 (fr) 2015-07-21 2017-01-26 Saint Louis University Compositions et méthodes pour diagnostiquer et traiter l'infertilité associée à l'endométriose
EP3325010B1 (fr) 2015-07-23 2023-06-21 The Regents of The University of California Anticorps anti-facteur de coagulation xia et leurs utilisations
NZ739871A (en) 2015-08-19 2022-05-27 Pfizer Tissue factor pathway inhibitor antibodies and uses thereof
CN113896789A (zh) 2015-09-15 2022-01-07 供石公司 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其用途
UA126278C2 (uk) 2015-09-21 2022-09-14 Аптево Рісьорч Енд Девелопмент Ллс Поліпептиди, які зв'язують cd3
US11207393B2 (en) 2015-10-16 2021-12-28 President And Fellows Of Harvard College Regulatory T cell PD-1 modulation for regulating T cell effector immune responses
CA3001859A1 (fr) 2015-10-16 2017-04-20 The Trustees Of Columbia University In The City Of New York Compositions et methodes d'inhibition d'antigenes specifiques a une lignee
CA2946113A1 (fr) 2015-10-23 2017-04-23 Pfizer Inc. Anticorps anti-il-2 et leurs compositions et methodes d'utilisation
WO2017075037A1 (fr) 2015-10-27 2017-05-04 Scholar Rock, Inc. Facteurs de croissance amorcés et leurs utilisations
US20210106661A1 (en) 2015-10-29 2021-04-15 Dana-Farber Cancer Institute, Inc. Methods for identification, assessment, prevention, and treatment of metabolic disorders using pm20d1 and n-lipidated amino acids
CN106699889A (zh) 2015-11-18 2017-05-24 礼进生物医药科技（上海）有限公司 抗pd-1抗体及其治疗用途
RU2744860C2 (ru) 2015-12-30 2021-03-16 Кодиак Сайенсиз Инк. Антитела и их конъюгаты
TW201936640A (zh) 2016-01-21 2019-09-16 美商輝瑞股份有限公司 對表皮生長因子受體變異體ｉｉｉ具特異性之抗體類及彼等之用途
AU2017238054B2 (en) 2016-03-21 2023-10-19 Dana-Farber Cancer Institute, Inc. T-cell exhaustion state-specific gene expression regulators and uses thereof
ES2930255T3 (es) 2016-05-13 2022-12-09 Bioatla Inc Anticuerpos anti-Ror2, fragmentos de anticuerpos, sus inmunoconjugados y usos de los mismos
EP3458475B1 (fr) 2016-05-16 2022-07-27 Access to Advanced Health Institute Formulation contenant un agoniste de tlr et procédés d'utilisation
KR102472026B1 (ko) 2016-06-01 2022-11-30 액세스 투 어드밴스드 헬스 인스티튜트 사이징제를 함유하는 나노명반 입자
JP7099967B2 (ja) 2016-07-01 2022-07-12 リサーチ ディベロップメント ファウンデーション 幹細胞由来移植片からの増殖性細胞の排除
WO2018057618A1 (fr) 2016-09-20 2018-03-29 Dana-Farber Cancer Institute, Inc. Compositions et méthodes pour l'identification, l'évaluation, la prévention et le traitement de la lma au moyen de biomarqueurs usp10 et de modulateurs
US20180119141A1 (en) 2016-10-28 2018-05-03 Massachusetts Institute Of Technology Crispr/cas global regulator screening platform
US20190345501A1 (en) 2017-02-07 2019-11-14 Massachusetts Institute Of Technology Methods and compositions for rna-guided genetic circuits
KR20190124753A (ko) 2017-03-03 2019-11-05 리나트 뉴로사이언스 코프. 항-gitr 항체 및 이의 사용 방법
JP7177076B2 (ja) 2017-03-16 2022-11-22 ファイザー・インク チロシン原栄養性
CA3059938A1 (fr) 2017-04-14 2018-10-18 Kodiak Sciences Inc. Anticorps antagonistes du facteur d du complement et leurs conjugues
WO2018220584A1 (fr) 2017-06-02 2018-12-06 Pfizer Inc. Anticorps spécifiques à la flt3 et leurs utilisations
EP3634496A4 (fr) 2017-06-06 2021-09-08 Dana-Farber Cancer Institute, Inc. Procédés de sensibilisation de cellules cancéreuses à une destruction médiée par des lymphocytes t par modulation de voies moléculaires
JP7034183B2 (ja) 2017-06-13 2022-03-11 ボストンジーン コーポレイション 免疫チェックポイント遮断療法に対するレスポンダー及び非レスポンダーを特定するためのシステム及び方法
WO2019016784A1 (fr) 2017-07-21 2019-01-24 Universidade De Coimbra Anticorps anti-nucléoline
EP3692370A2 (fr) 2017-10-04 2020-08-12 OPKO Pharmaceuticals, LLC Articles et procédés destinés à la thérapie personnalisée du cancer
CN112020518A (zh) 2018-02-01 2020-12-01 辉瑞公司 靶向cd70的嵌合抗原受体
US11377500B2 (en) 2018-02-01 2022-07-05 Pfizer Inc. Antibodies specific for CD70 and their uses
KR20200128116A (ko) 2018-02-28 2020-11-11 화이자 인코포레이티드 Il-15 변이체 및 이의 용도
MX2020012539A (es) 2018-05-23 2021-02-16 Pfizer Anticuerpos especificos para cd3 y sus usos.
MX2020012607A (es) 2018-05-23 2021-01-29 Pfizer Anticuerpos especificos para gucy2c y sus usos.
KR20220036908A (ko) 2018-08-28 2022-03-23 보르 바이오파마 인크. 유전자 조작된 조혈 줄기 세포 및 그의 용도
EP3721896B1 (fr) 2019-04-08 2023-11-29 Giuseppe Scalabrino Facteur de croissance épidermique (egf) et ses variantes pour le traitement ou la prévention de troubles inflammatoires de demyelinisation
US20210005284A1 (en) 2019-07-03 2021-01-07 Bostongene Corporation Techniques for nucleic acid data quality control
AU2020363372A1 (en) 2019-10-07 2022-05-19 University Of Virginia Patent Foundation Modulating lymphatic vessels in neurological disease
CN114786731A (zh) 2019-10-10 2022-07-22 科达制药股份有限公司 治疗眼部病症的方法
CA3152623A1 (fr) 2019-10-11 2021-04-15 Richard D. Cummings Anticorps anti-tn et leurs utilisations
US20230067811A1 (en) 2020-01-24 2023-03-02 University Of Virginia Patent Foundation Modulating lymphatic vessels in neurological disease
WO2021205325A1 (fr) 2020-04-08 2021-10-14 Pfizer Inc. Anticorps anti-gucy2c et leurs utilisations
WO2021224850A1 (fr) 2020-05-06 2021-11-11 Crispr Therapeutics Ag Peptides masques et anticorps anti-ptk7 masqués les comprenant
EP4182346A1 (fr) 2020-07-17 2023-05-24 Pfizer Inc. Anticorps thérapeutiques et leurs utilisations
US20230287455A1 (en) 2020-07-30 2023-09-14 Pfizer Inc. Cells Having Gene Duplications and Uses Thereof
EP4229222A2 (fr) 2020-10-19 2023-08-23 Dana-Farber Cancer Institute, Inc. Biomarqueurs germinaux de la réponse clinique et du bénéfice d'un traitement par inhibiteur de points de contrôle immunitaire
WO2022104104A2 (fr) 2020-11-13 2022-05-19 Dana-Farber Cancer Institute, Inc. Vaccins à cellules de fusion personnalisés
US20220180972A1 (en) 2020-12-04 2022-06-09 Bostongene Corporation Hierarchical machine learning techniques for identifying molecular categories from expression data
WO2022159793A2 (fr) 2021-01-25 2022-07-28 Dana-Farber Cancer Institute, Inc. Procédés et compositions pour identifier un cancer de la prostate neuroendocrinien
WO2022232615A1 (fr) 2021-04-29 2022-11-03 Bostongene Corporation Techniques d'apprentissage machine pour estimer une expression de cellules tumorales dans un tissu tumoral complexe
WO2022261183A2 (fr) 2021-06-08 2022-12-15 Dana-Farber Cancer Institute, Inc. Compositions et procédés de traitement et/ou d'identification d'un agent pour le traitement de cancers intestinaux
WO2023012627A1 (fr) 2021-08-02 2023-02-09 Pfizer Inc. Vecteurs d'expression améliorés et leurs utilisations
CA3232833A1 (fr) 2021-09-27 2023-03-30 Kathleen Mcginness Polypeptides recepteurs chimeriques en combinaison avec des molecules de metabolisme trans qui reorientent des metabolites de glucose hors de la voie de glycolyse et leurs utilisations therapeutique
WO2023091909A1 (fr) 2021-11-16 2023-05-25 Sotio Biotech Inc. Traitement de patients atteints de liposarcome myxoïde/à cellules rondes
WO2023097119A2 (fr) 2021-11-29 2023-06-01 Dana-Farber Cancer Institute, Inc. Méthodes et compositions pour moduler riok2
WO2023147177A1 (fr) 2022-01-31 2023-08-03 Bostongene Corporation Techniques d'apprentissage automatique pour cytométrie
WO2023148598A1 (fr) 2022-02-02 2023-08-10 Pfizer Inc. Prototrophie cystéinique
WO2023158732A1 (fr) 2022-02-16 2023-08-24 Dana-Farber Cancer Institute, Inc. Procédés de diminution de l'alpha-synucléine pathologique à l'aide d'agents qui modulent fndc5 ou des fragments biologiquement actifs de celui-ci
WO2024015561A1 (fr) 2022-07-15 2024-01-18 Bostongene Corporation Techniques de détection d'une déficience de recombinaison homologue (hrd)
WO2024040207A1 (fr) 2022-08-19 2024-02-22 Sotio Biotech Inc. Cellules tueuses naturelles (nk) génétiquement modifiées avec des polypeptides récepteurs chimériques en combinaison avec des molécules de trans-métabolisme et leurs utilisations thérapeutiques
WO2024040208A1 (fr) 2022-08-19 2024-02-22 Sotio Biotech Inc. Cellules immunitaires génétiquement modifiées avec des polypeptides récepteurs chimériques en combinaison avec de multiples molécules du métabolisme trans et leurs utilisations thérapeutiques

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000103A1 (fr) * 1991-06-21 1993-01-07 The Wistar Institute Of Anatomy And Biology Proteines d'enveloppe chimeriques pour le ciblage de virus
WO1993022433A2 (fr) * 1992-04-28 1993-11-11 Frank Andreas Harald Meyer Medicament permettant de traiter l'homme, les animaux et les plantes par therapie genetique, dans le but notamment de bloquer la proliferation de virus et les carcinogenes et procede de fabrication dudit medicament

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000103A1 (fr) * 1991-06-21 1993-01-07 The Wistar Institute Of Anatomy And Biology Proteines d'enveloppe chimeriques pour le ciblage de virus
WO1993022433A2 (fr) * 1992-04-28 1993-11-11 Frank Andreas Harald Meyer Medicament permettant de traiter l'homme, les animaux et les plantes par therapie genetique, dans le but notamment de bloquer la proliferation de virus et les carcinogenes et procede de fabrication dudit medicament

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
ADV. EXP. MED. BIOL. (1988), 241(MOL. BIOL. HEMOPOIESIS), 19-27 CODEN: AEMBAP;ISSN: 0065-2598 *
CHEMICAL ABSTRACTS, vol. 111, no. 13, 25 September 1989, Columbus, Ohio, US; abstract no. 110248, EGLITIS, MARTIN A. ET AL: "Retroviral-mediated gene transfer into hemopoietic cells" *
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; *
KASAHARA N. ET AL.: "TARGETED GENE DELIVERY BY RETROVIRUSES WITH PEPTIDE HORMONE SEQUENCES INCORPORATED INTO THE ENVELOPE.", J. CELL BIOCHEM. SUPPL., vol. 0, pages 237 *
LI, JING PO ET AL: "Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor", NATURE (LONDON) (1990), 343(6260), 762-4 CODEN: NATUAS;ISSN: 0028-0836 *
RANDY A. HOCK ET AL.: "RETROVIRUS-MEDIATED TRANSFER AND EXPRESSION OF DRUG RESISTANCE GENES IN HUMAN HAEMATOPOIETIC PROGENITOR CELLS.", NATURE, vol. 320, 20 March 1986 (1986-03-20), LONDON GB, pages 275 - 277 *
See also references of WO9325234A1 *
YOSHIMURA, AKIHIKO ET AL: "Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism", PROC. NATL. ACAD. SCI. U. S. A. (1990), 87(11), 4139-43 CODEN: PNASA6;ISSN: 0027-8424 *

Also Published As

Publication number Publication date
EP0650370A1 (fr) 1995-05-03
WO1993025234A1 (fr) 1993-12-23
JPH07507689A (ja) 1995-08-31

Similar Documents

Publication Publication Date Title
EP0650370A4 (fr) Procedes et compositions permettant de cibler des tissus specifiques.
PH31081A (en) Methods and compositions for mineralizing and fluoridating calcified tissues.
EP0634459A3 (fr) Formulations.
ZA932646B (en) Cosmetic composition.
ZA936704B (en) Cosmetic composition.
ZA945653B (en) Therapeutic compositions
EP0640097A4 (fr) Compositions et procedes de vaccination contre les coronavirus.
EP0604748A3 (fr) Manchon de trocart.
ZA932586B (en) Cosmetic composition.
GB2271059B (en) Pharmaceutical compositions comprising aconitane derivatives and tetrahydroprotoberberine derivatives.
ZA942814B (en) Agricultural formulations
EP0596962A4 (en) Therapeutic compositions and methods.
PH31211A (en) Cosmetic composition.
EP0656791A4 (fr) Compositions et methodes therapeutiques a base de 2,7,9-tricarboxy-pyrroloquinoleine (pqq).
HK1001286A1 (en) Benzopyrans and their use as therapeutic agents.
ZA966063B (en) Synergistic herbicidal composition and method of use thereof.
GB2294213B (en) Pulverizer
AU3674595A (en) Antianemic agent containing iron and difructose
AU663832B2 (en) Easy chess-like game
EP0586848A3 (fr) Implant.
EP0673640A4 (fr) Composition de traitement intermediaire pour la permanente.
EP0868430A4 (fr) Compositions therapeutiques
AU3423397A (en) Therapeutic methods and compositions for use therein
ZA93662B (en) Sterilising composition
PL303352A1 (en) Symmetrical plough

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19941124

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19951006

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

RHK1 Main classification (correction)

Ipc: A61K 39/12

17Q First examination report despatched

Effective date: 19980605

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19991125