EP0382526B1 - Substituted -1,3-oxathiolanes with antiviral properties - Google Patents
Substituted -1,3-oxathiolanes with antiviral properties Download PDFInfo
- Publication number
- EP0382526B1 EP0382526B1 EP90301335A EP90301335A EP0382526B1 EP 0382526 B1 EP0382526 B1 EP 0382526B1 EP 90301335 A EP90301335 A EP 90301335A EP 90301335 A EP90301335 A EP 90301335A EP 0382526 B1 EP0382526 B1 EP 0382526B1
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- EP
- European Patent Office
- Prior art keywords
- compound
- formula
- group
- cis
- oxathiolane
- Prior art date
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- 0 CC(C(*)=CN(C(C1)OC(CO)C1F)C(C)=O)=O Chemical compound CC(C(*)=CN(C(C1)OC(CO)C1F)C(C)=O)=O 0.000 description 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Definitions
- the present invention relates to novel substituted 1,3-oxathiolane cyclic compounds having pharmacological activity, to processes for and intermediates of use in their preparation, to pharmaceutical compositions containing them, and to the use of these compounds in the antiviral treatment of mammals.
- Retroviral infections are a serious cause of disease, most notably, the acquired immunodeficiency syndrome (AIDS).
- AIDS acquired immunodeficiency syndrome
- the human immunodeficiency virus (HIV) has been recognized as the etiologic agent of AIDS and compounds having an inhibitory effect against HIV multiplication have been actively sought.
- Balzarini et al. "Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine", Biochem. Biophys. Res. Comm. , 140, pp. 735-42 (1986), refer to an unsaturated analogue of these nucleosides--2'3'-dideoxy-cytidine, shown in formula (C)--as being characterized by antiretroviral activity.
- European publication EP A-337,713 is directed to 1,3-dioxolane nucleoside analogues of formula (E') with antiviral properties.
- the present invention provides novel 2-substituted-5-substituted-1,3-oxathiolanes which have antiretroviral activity.
- these compounds have been found to act as non-toxic inhibitors of the replication of HIV-1 in T-lymphocytes over prolonged periods of time.
- Cis -2-hydroxymethyl-5-(cytosin-1'-yl)-1,3-oxathiolane may be represented by the formula
- formula (I) contains two chiral centers (shown as * in formula (I)) and thus includes two pairs of optical isomers (i.e. enantiomers) and mixtures thereof including racemic mixtures. Both cis -isomers and mixtures thereof, including racemic mixtures, are included within the scope of the invention.
- the cis -isomers may also be represented by formula (II), and similarly, the trans -isomers may be represented by formula (III)
- a pharmaceutically acceptable derivative means any pharmaceutically acceptable salt of a compound of formulae (I) or (II), and the following esters thereof : a C1 ⁇ 16 alkanoyl ester, an unsubstituted benzoyl ester or a benzoyl ester substituted by at least one halogen (bromine, chlorine, fluorine or iodine), C1 ⁇ 6 alkyl, C1 ⁇ 6 alkoxy, nitro or trifluoromethyl groups.
- halogen bromine, chlorine, fluorine or iodine
- Preferred esters of the compounds of formulae (I) or (II) include the compounds in which H is replaced by a carboxyl function in which the non-carbonyl moiety R of the ester grouping is selected from hydrogen, straight or branched chain alkyl (e.g., methyl, ethyl, n-propyl, t-butyl, n-butyl), phenyl optionally substituted by halogen, C1 ⁇ 4 alkyl or C1 ⁇ 4 alkoxy.
- any alkyl moiety present advantageously contains 1 to 16 carbon atoms, preferably 1 to 4 carbon atoms.
- Pharmaceutically acceptable salts of the compounds of formulae (I) or (II) include those derived from pharmaceutically acceptable inorganic and organic acids and bases.
- suitable acids include hydrochloric, hydrobromic, sulfuric, nitric, perchloric, fumaric, maleic, phosphoric, glycollic, lactic, salicylic, succinic, toluene-p-sulfonic, tartaric, acetic, citric, methanesulfonic, formic, benzoic, malonic, naphthalene-2-sulfonic and benzenesulfonic acids.
- Other acids such as oxalic, while not in themselves pharmaceutically acceptable, may be useful in the preparation of salts useful as intermediates in obtaining the compounds of the invention and their pharmaceutically acceptable acid addition salts.
- Salts derived from appropriate bases include alkali metal (e.g., sodium), alkaline earth metal (e.g., magnesium), ammonium and NR4+ (where R is C1 ⁇ 4 alkyl) salts.
- alkali metal e.g., sodium
- alkaline earth metal e.g., magnesium
- ammonium e.g., ammonium
- NR4+ where R is C1 ⁇ 4 alkyl
- references hereinafter to a compound according to the invention includes both compounds of formulae (I) or (II) and their pharmaceutically acceptable derivatives.
- the compounds of the invention either themselves possess antiviral activity and/or are metabolizable to such compounds.
- these compounds are effective in inhibiting the replication of retroviruses, including human retroviruses such as human immunodeficiency viruses (HIV's), the causative agents of AIDS.
- retroviruses including human retroviruses such as human immunodeficiency viruses (HIV's), the causative agents of AIDS.
- HIV's human immunodeficiency viruses
- a compound formula (I) or a pharmaceutically acceptable derivative thereof for use as an active therapeutic agent in particular as an antiviral agent, for example in the treatment of retroviral infections.
- a method for the treatment of a viral infection in particular an infection caused by a retrovirus such as HIV, in a mammal, including man, comprising administration of an effective amount of an antiviral compound of formula (I) or a pharmaceutically acceptable derivative thereof.
- the compounds of the invention are also useful in the treatment of AIDS related conditions such as AIDS-related complex (ARC), persistent generalized lymphadenopathy (PGL), AIDS-related neurological conditions (such as dementia), anti-HIV antibody positive and HIV- positive conditions, Kaposi's sarcoma, thrombocytopenia purpurea and opportunistic infections.
- AIDS related conditions such as AIDS-related complex (ARC), persistent generalized lymphadenopathy (PGL), AIDS-related neurological conditions (such as dementia), anti-HIV antibody positive and HIV- positive conditions, Kaposi's sarcoma, thrombocytopenia purpurea and opportunistic infections.
- the compounds of the invention are also useful in the prevention or progression to clinical illness of individuals who are anti-HIV antibody or HIV-antigen positive and in prophylaxis following exposure to HIV.
- the compounds of formula (I) or the pharmaceutically acceptable derivatives thereof may also be used for the prevention of viral contamination of biological fluids such as blood or semen in vitro .
- references herein to treatment extends to prophylaxis as well as the treatment of established infections or symptoms.
- a suitable dose will be in the range from about 1 to about 750 mg/kg of bodyweight per day, such as 3 to about 120 mg per kilogram body weight of the recipient per day, preferably in the range of 6 to 90 mg/kg/day, most preferably in the range of 15 to 60 mg/kg/day.
- the desired dose may conveniently be presented in a single dose or as divided doses administered at appropriate intervals, for example as two, three, four or more sub-doses per day.
- the compound is conveniently administered in unit dosage form; for example containing lo to 1500 mg, conveniently 20 to 1000 mg, most conveniently 50 to 700 mg of active ingredient per unit dosage form.
- the active ingredient should be administered to achieve peak plasma concentrations of the active compound of from about 1 to 75 ⁇ M, preferably about 2 to 50 ⁇ M, most preferably about 3 to about 30 ⁇ M. This may be achieved, for example, by the intravenous injection of a 0.1 to 5% solution of the active ingredient, optionally in saline, or administered as a bolus containing about 0.1 to about 110 mg/kg of the active ingredient. Desirable blood levels may be maintained by a continuous infusion to provide about 0.01 to about 5.0 mg/kg/hour or by intermittent infusions containing about 0.4 to about 15 mg/kg of the active ingredient.
- a compound of the invention may be administered as the raw chemical it is preferable to present the active ingredient as a pharmaceutical formulation.
- the invention thus further provides a pharmaceutical formulation comprising a compound of formula (I) or a pharmaceutically acceptable derivative thereof together with one or more pharmaceutically acceptable carriers therefor and, optionally, other therapeutic and/or prophylactic ingredients.
- the carrier(s) must be 'acceptable' in the sense of being compatible with the other ingredients of the formulation and not deleterious to the recipient therefor.
- compositions include those suitable for oral, rectal, nasal, topical (including buccal and sub-lingual), vaginal or parenteral (including intramuscular, sub-cutaneous and intravenous) administration or in a form suitable for administration by inhalation or insufflation.
- the formulations may, where appropriate, be conveniently presented in discrete dosage units and may be prepared by any of the methods well known in the art of pharmacy. All methods include the step cf bringing into association the active compound with liquid carriers or finely divided solid carriers or both and then, if necessary, shaping the product into the desired formulation.
- compositions suitable for oral administration may conveniently be presented as discrete units such as capsules, cachets or tablets each containing a predetermined amount of the active ingredient; as a powder or granules; as a solution; as a suspension; or as an emulsion.
- the active ingredient may also be presented as a bolus, electuary or paste.
- Tablets and capsules for oral administration may contain conventional excipients such as binding agents, fillers, lubricants, disintegrants, or wetting agents.
- the tablets may be coated according to methods well known in the art.
- Oral liquid preparations may be in the form of, for example, aqueous or oily suspensions, solutions, emulsions, syrups or elixirs, or may be presented as a dry product for constitution with water or other suitable vehicle before use.
- Such liquid preparations may contain conventional additives such as suspending agents, emulsifying agents, non-aqueous vehicles (which may include edible oils) or preservatives.
- the compounds according to the invention may also be formulated for parenteral administration (e.g., by injection, for example bolus injection or continuous infusion) and may be presented in unit dose form in ampoules, pre-filled syringes, small volume infusion or in multi-dose containers with an added preservative.
- the compositions may take such forms as suspensions, solutions, or emulsions in oily or aqueous vehicles, and may contain formulatory agents such as suspending, stabilizing and/or dispersing agents.
- the active ingredient may be in powder form, obtained by aseptic isolation of sterile solid or by lyophilization from solution, for constitution with a suitable vehicle, e.g., sterile, pyrogen-free water, before use.
- the compounds according to the invention may be formulated as ointments, creams or lotions, or as a transdermal patch.
- Ointments and creams may, for example, be formulated with an aqueous or oily base with the addition of suitable thickening and/or gelling agents.
- Lotions may be formulated with an aqueous or oily base and will in general also contain one or more emulsifying agents, stabilizing agents, dispersing agents, suspending agents, thickening agents, or coloring agents.
- Formulations suitable for topical administration in the mouth include lozenges comprising active ingredient in a flavored based, usually sucrose and acacia or tragacanth; pastilles comprising the active ingredient in an inert base such as gelatin and glycerin or sucrose and acacia; and mouthwashes comprising the active ingredient in a suitable liquid carrier.
- compositions suitable for rectal administration wherein the carrier is a solid are most preferably represented as unit dose suppositories.
- Suitable carriers include cocoa butter and other materials commonly used in the art, and the suppositories may be conveniently formed by admixture of the active compound with the softened or melted carrier(s) followed by chilling and shaping in molds.
- Formulations suitable for vaginal administration may be presented as pessaries, tampons, creams, gels, pastes, foams or sprays containing in addition to the active ingredient, such carriers as are known in the art to be appropriate.
- the compounds of the invention may be used as a liquid spray or dispersible powder or in the form of drops.
- Drops may be formulated with an aqueous or non-aqueous base also comprising one or more dispersing agents, solubilizing agents or suspending agents. Liquid sprays are conveniently delivered from pressurized packs.
- the compounds according to the invention are conveniently delivered from an insufflator, nebulizer or a pressurized pack or other convenient means of delivering an aerosol spray.
- Pressurized packs may comprise a suitable propellant such as dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas.
- the dosage unit may be determined by providing a valve to deliver a metered amount.
- the compounds according to the invention may take the form of a dry powder composition, for example a powder mix of the compound and a suitable powder base such as lactose or starch.
- the powder composition may be presented in unit dosage form in, for example, capsules or cartridges or e.g., gelatin or blister packs from which the powder may be administered with the aid of an inhalator or insufflator.
- compositions according to the invention may also contain other active ingredients such as antimicrobial agents, or preservatives.
- the compounds of the invention may also be used in combination with other therapeutic agents, for example, other antiinfective agents.
- other therapeutic agents for example, other antiinfective agents.
- the compounds of the invention may be employed together with known antiviral agents.
- the invention thus provides, in a further aspect, a combination comprising a compound of formula (I) or a physiologically acceptable derivative thereof together with another therapeutically active agent, in particular, an antiviral agent.
- compositions comprising a combination as defined above together with a pharmaceutically acceptable carrier therefor comprise a further aspect of the invention.
- Suitable therapeutic agents for use in such combinations include acyclic nucleosides such as aciclovir, ganciclovir, interferons such as alpha-, beta-and gamma-interferon; glucuronation inhibitors such as probenicid; nucleoside transport inhibitors such as dipyridamole; nucleoside analogues such as 3'-azido-2',3'-dideoxythymidine, 2',3'-dideoxycytidine, 2',3'-dideoxyadenosine, 2',3'-dideoxyinosine, 2',3'-dideoxythymidine, 2',3'-dideoxy-2',3'-didehydrothymidine, and 2',3'-dideoxy-2',3'-didehydrocytidine and ribavirin; immunomodulators such as interleukin II (IL2) and granulocyte macrophage colony stimulating factor (GM-C
- the dose of each compound may be either the same or differ from that when the compound is used alone. Appropriate doses will be readily appreciated by those skilled in the art.
- the compounds of formula (I) and their pharmaceutically acceptable derivatives may be prepared by any method known in the art for the preparation of compounds of analogous structure.
- Suitable groups L include alkoxy carbonyl groups such as ethoxy carbonyl or halogens, for example, iodine, bromine or chlorine or -OR where R is a substituted or unsubstituted, saturated or unsaturated alkyl group, e.g., a C1 ⁇ 6 alkyl group such as methyl, or R is a substituted or unsubstituted aliphatic or aromatic acyl group, e.g., a C1 ⁇ 6 aliphatic acyl group such as acetyl and an aromatic acyl group such as benzoyl.
- alkoxy carbonyl groups such as ethoxy carbonyl or halogens, for example, iodine, bromine or chlorine or -OR
- R is a substituted or unsubstituted, saturated or unsaturated alkyl group, e.g., a C1 ⁇ 6 alkyl group such as methyl, or R is a substituted or unsub
- the compound of formula (VIII) is conveniently reacted with the appropriate purine or pyrimidine base R2-H (previously silylated with a silylating agent such as hexamethyldisilazane) in a compatible solvent such as methylene chloride using a Lewis acid (such as titanium tetrachloride or stannic chloride) or trimethylsilytriflate.
- a silylating agent such as hexamethyldisilazane
- a compatible solvent such as methylene chloride using a Lewis acid (such as titanium tetrachloride or stannic chloride) or trimethylsilytriflate.
- the 1,3-oxathiolanes of formula (VIII) may be prepared, for example, by reaction of an aldehyde of formula (VII) with a mercaptoacetal of formula (VI) in a compatible organic solvent, such an toluene, in the presence of an acid catalyst such an a para-toluene sulfonic acid or a Lewis acid, e.g., zinc chloride.
- a compatible organic solvent such an toluene
- an acid catalyst such an a para-toluene sulfonic acid or a Lewis acid, e.g., zinc chloride.
- the mercaptoacetals of formula (VI) may be prepared by methods known in the art, for example, G. Hesse and I. Jorder, "Mercaptoacetaldehyde and dioxy-1, 4-dithiane", Chem. Ber 85, pp. 924-932 (1952).
- aldehydes of formula (VII) may be prepared by methods known in the art, for example, E.G. Halloquist and H. Hibbert, "Studies on reactions relating to carbohydrates and polysaccharides. Part XLIV: Synthesis of isomeric bicyclic acetal ethers", Can. J. Research, 8, pp. 129-136 (1933).
- a compound of formula (I') wherein R2 is a purine or pyrimidine base other than cytosine is converted to a compound of formula (I) by base interconversion.
- interconversion may be effected either by simple chemical transformation (e.g., the conversion of uracil base to cytosine) or by an enzymatic conversion using, for example, a deoxyribosyl transferase.
- Such methods and conditions for base interconversions are well known in the art of nucleoside chemistry.
- the compounds of formula (I) may be prepared by the reaction of a compound of formula (IX) with a compound of formula (X) where P is a protecting group, followed by removal of the protecting group.
- the compounds of formula (IX) may be prepared for reaction by a suitable epoxide (XI). with an appropriate sulphur-containing compound, e.g., sodium thioacetate.
- a suitable epoxide (XI) with an appropriate sulphur-containing compound, e.g., sodium thioacetate.
- Compounds of formula (XI) are either known in the art or may be obtained by analogous processes.
- a compound of formula (XII) may be converted to a compound of formulae (I) or (II) by conversion of the anomeric NH2 group to the required base by methods well known in the art of nucleoside chemistry.
- hydroxyl protecting groups include groups selected from alkyl (e.g., methyl, t-butyl or methoxymethyl), aralkyl (e.g., benzyl, diphenylmethyl or triphenylmethyl), heterocyclic groups such as tetrahydropyranyl, acyl, (e.g., acetyl or benzoyl) and silyl groups such as trialkylsilyl (e.g., t-butyldimethylsilyl).
- alkyl e.g., methyl, t-butyl or methoxymethyl
- aralkyl e.g., benzyl, diphenylmethyl or triphenylmethyl
- heterocyclic groups such as tetrahydropyranyl
- acyl e.g., acetyl or benzoyl
- silyl groups such as trialkylsilyl (e.g., t-butyldimethylsilyl
- alkyl, silyl, acyl and heterocyclic groups may be removed by solvolysis, e.g., by hydrolysis under acidic or basic conditions.
- Aralkyl groups such as triphenylmethyl may similarly be removed by solvolysis, e.g., by hydrolysis under acidic conditions.
- Aralkyl groups such as benzyl may be cleaved, for example, by treatment with Bf3/etherate and acetic anhydride followed by removal of acetate groups so formed at an appropriate stage in the synthesis.
- Silyl groups may also conveniently be removed using a source of fluoride ions such as tetra-n-butylammonium fluoride.
- isomers may be separated, for example, by acetylation, e.g., with acetic anhydride followed by separation by physical means, e.g., chromatography on silica gel and deacetylation, e.g., with methanolic ammonia or by fractional crystallization.
- acetylation e.g., with acetic anhydride
- separation by physical means, e.g., chromatography on silica gel and deacetylation, e.g., with methanolic ammonia or by fractional crystallization.
- compositions of the compounds of the invention may be prepared as described in United States Patent No. 4,383,114, the disclosure of which is incorporated by reference herein.
- an acid addition salt of a compound of formula (I) the product of any of the above procedures may be converted into a salt by treatment of the resulting free base with a suitable acid using conventional methods.
- Pharmaceutically acceptable acid addition salts may be prepared by reacting the free base with an appropriate acid optionally in the presence of a suitable solvent such as an ester (e.g., ethyl acetate) or an alcohol (e.g., methanol, ethanol or isopropanol).
- Inorganic basic salts may be prepared by reacting the free base with a suitable base such as an alkoxide (e.g., sodium methoxide) optionally in the presence of a solvent such as an alcohol (e.g., methanol).
- a suitable base such as an alkoxide (e.g., sodium methoxide) optionally in the presence of a solvent such as an alcohol (e.g., methanol).
- Pharmaceutically acceptable salts may also be prepared from other salts, including other pharmaceutically acceptable salts, of the compounds of formula (I) using conventional methods.
- a compound of formula (I) may be converted into a pharmaceutically acceptable phosphate or other ester by reaction-with a phosphorylating agent, such as Pocl3, or a suitable esterifying agent, such as an acid halide or anhydride, as appropriate.
- a phosphorylating agent such as Pocl3
- a suitable esterifying agent such as an acid halide or anhydride, as appropriate.
- An ester or salt of a compound of formula (I) may be converted to the parent compound, for example, by hydrolysis.
- Resolution of the final product, or an intermediate or starting material therefore may be effected by any suitable method known in the art: see for example, stereochemistry of Carbon Compounds , by E.L. Eliel (McGraw Hill, 1962) and Tables of Resolvina Agents, by S.H. Wilen.
- This known intermediate was prepared by a previously unreported method from the known 1-benzoyl glycerol.
- 50 g of the latter in a mixture of 500 ml of CH2Cl2 and 25 ml of H2O was treated portionwise with 80 g of NaIO under vigorous stirring at room temperature. After addition, stirring was continued for 2 h after which time 100 g of MgSO4 was added and stirring continued for 30 min.
- the mixture was filtered, the filtrate evaporated in vacuo and the residue distilled in vacuo to yield 26 g of pure (VII) b.p. 92-94°/0.25 mm.
- 1H NMR (200 MH z ; TMS as internal reference) ⁇ (ppm in CDCl3,):
- trans-(XV) m.p. 158-160°; R f : 0.48 EtOAc:CH3OH 95:5 U.V.: (CH3OH) Lambda max: 297 nm 1H NMR ⁇ (ppm in CDCl3):
- the following formulation is prepared by wet granulation of the ingredients with a solution of povidone in water, drying and screening, followed by addition of magnesium stearate and compression.
- mg/tablet (a) Active ingredient 250 (b) Lactose B.P. 210 (c) Povidone B.P. 15 (d) Sodium Starch Glycolate 20 (e) Magnesium Stearate 5 500 ⁇ B.
- the following formulation is prepared by direct compression; the lactose is of the direct compression type.
- Controlled Release Formulation The formulation is prepared by wet granulation of the ingredients (below) with a solution of povidone in water, drying and screening followed by the addition of magnesium stearate and compression.
- mg/tablet (a) Active ingredient 500 (b) Hydroxypropylemethylcellulose (Methocel K4M Premium) 112 (c) Lactose B.P. 53 (d) Povidone B.P. 28 (e) Magnesium Stearate 7 700 ⁇
- a capsule formulation is prepared by admixing the ingredients below and filling into a two-part hard gelatin capsule.
- mg/capsule Active ingredient 125 Lactose 72.5 Avicel 50 Magnesium Stearate 2.5 250 ⁇
- Active ingredient 0.200 g Sodium hydroxide solution, 0.1M q.s. to a pH of about 11. Sterile water q.s. to 10 ml.
- the active ingredient is suspended in some of the water (which may be warmed) and the pH adjusted to about 11 with a solution of sodium hydroxide.
- the batch is then made up to volume and filtered through a sterilizing grade membrane filter into a sterile 10 ml glass vial and sealed with sterile closures and overseas.
- One-fifth of the hard fat is melted in a steam-jacketed pan at 45°C maximum.
- the active ingredient is sifted through a 200 ⁇ m sieve and added to the molten base with mixing, using a high shear stirrer, until a smooth dispersion is achieved. Maintaining the mixture at 45°C, the remaining hard fat is added to the suspension and stirred to ensure a homogenous mix.
- the entire suspension is passed through a 250 ⁇ m stainless steel screen and, with continuous stirring, is allowed to cool to 40°C. At a temperature of 38°C to 40°C, 2.02 g of the mixture is filled into suitable, 2 ml plastic molds. The suppositories are allowed to cool to room temperature.
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- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
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- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
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Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95120531A EP0711771B1 (en) | 1989-02-08 | 1990-02-08 | Substituted-1,3-oxathiolanes with antiviral properties |
US09/163,374 US6350753B1 (en) | 1988-04-11 | 1998-09-30 | 2-Substituted-4-substituted-1,3-dioxolanes and use thereof |
US10/887,182 US7122693B2 (en) | 1988-04-11 | 2004-07-09 | Acetaldehyde acetal compounds, their synthesis, and uses thereof |
US11/502,602 US20070037977A1 (en) | 1988-04-11 | 2006-08-11 | Substituted-1, 3-oxathiolanes and substituted-1, 3-dioxolanes with antiviral properties |
US11/580,866 US20070037975A1 (en) | 1988-04-11 | 2006-10-16 | Substituted-1,3-oxathiolanes and substituted-1, 3-dioxolanes with antiviral properties |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/308,101 US5047407A (en) | 1989-02-08 | 1989-02-08 | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
US308101 | 1989-02-08 | ||
CA002152269A CA2152269C (en) | 1989-02-08 | 1992-12-21 | Process for preparing substituted 1,3-oxathiolanes with antiviral properties |
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EP95120531A Division EP0711771B1 (en) | 1989-02-08 | 1990-02-08 | Substituted-1,3-oxathiolanes with antiviral properties |
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EP90301335A Expired - Lifetime EP0382526B1 (en) | 1988-04-11 | 1990-02-08 | Substituted -1,3-oxathiolanes with antiviral properties |
EP95120531A Expired - Lifetime EP0711771B1 (en) | 1989-02-08 | 1990-02-08 | Substituted-1,3-oxathiolanes with antiviral properties |
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Publication number | Priority date | Publication date | Assignee | Title |
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WO1991017159A1 (en) * | 1990-05-02 | 1991-11-14 | Iaf Biochem International Inc. | 1,3-oxathiolane nucleoside analogues |
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Families Citing this family (108)
Publication number | Priority date | Publication date | Assignee | Title |
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CA2351049C (en) | 2001-06-18 | 2007-03-13 | Brantford Chemicals Inc. | Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers |
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RS53167B (en) | 2009-03-31 | 2014-06-30 | Boehringer Ingelheim International Gmbh | 1-HETEROCYCLYL-1,5-DIHYDRO-PYRAZOLO [3,4-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR APPLICATIONS AS A PDE9A MODULATOR |
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991011186A1 (en) * | 1990-02-01 | 1991-08-08 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4000137A (en) * | 1975-06-10 | 1976-12-28 | American Home Products Corporation | Antitumor derivatives of periodate-oxidized nucleosides |
JPS5259171A (en) * | 1975-11-10 | 1977-05-16 | Asahi Chem Ind Co Ltd | Preparation of uracil derivatives |
JPS6045196B2 (ja) * | 1976-08-09 | 1985-10-08 | 株式会社興人 | 1−(2−テトラヒドロフリル)ウラシル類の製造方法 |
JPS5668674A (en) * | 1979-11-08 | 1981-06-09 | Shionogi & Co Ltd | 5-fluorouracil derivative |
JPS56167685A (en) * | 1980-05-28 | 1981-12-23 | Taiho Yakuhin Kogyo Kk | 1- 2-tetrahydrothiophene-1,1-dioxide -5-fluorouracil and its preparation |
JPS56169689A (en) * | 1980-06-02 | 1981-12-26 | Taiho Yakuhin Kogyo Kk | 3-substituted-5-fluorouracil derivative and its preparation |
JPS5738774A (en) * | 1980-08-19 | 1982-03-03 | Chugai Pharmaceut Co Ltd | Uracil derivative and its preparation |
SU1035023A1 (ru) * | 1982-03-23 | 1983-08-15 | Ордена Трудового Красного Знамени Институт Органической И Физической Химии Им.А.Е.Арбузова | Способ получени 3-(тииранил-2-метил)-6-метилурацилов |
DE3324769A1 (de) * | 1983-07-08 | 1985-01-17 | Bayer Ag, 5090 Leverkusen | 5-aminomethyl-1,3-oxathiolane |
EP0206497B1 (en) * | 1985-05-15 | 1994-07-20 | The Wellcome Foundation Limited | Therapeutic nucleosides and their preparation |
CA1294960C (en) * | 1986-10-24 | 1992-01-28 | Thomas C. Malone | 7-deazaguanines as immunomodulators |
DE3712735A1 (de) * | 1987-04-15 | 1988-11-10 | Boehringer Mannheim Gmbh | Neue pyrazolo(3,4-d)pyrimidine, verfahren zu ihrer herstellung und verwendung als arzneimittel |
ES2075040T3 (es) * | 1988-02-16 | 1995-10-01 | Lilly Co Eli | 2',3'-dideoxi-2',2'-difluoronucleosidos. |
US5047407A (en) | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
NZ228645A (en) * | 1988-04-11 | 1991-09-25 | Iaf Biochem Int | 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections |
-
1989
- 1989-02-08 US US07/308,101 patent/US5047407A/en not_active Expired - Lifetime
-
1990
- 1990-02-07 HU HU90708A patent/HU208134B/hu unknown
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- 1990-02-08 CA CA002009637A patent/CA2009637C/en not_active Expired - Lifetime
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- 1990-02-08 ES ES95120531T patent/ES2206476T3/es not_active Expired - Lifetime
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- 1990-02-08 PT PT93094A patent/PT93094B/pt active IP Right Grant
- 1990-02-08 DE DE1996175032 patent/DE19675032I2/de active Active
- 1990-02-08 AU AU49201/90A patent/AU630913B2/en not_active Expired
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991011186A1 (en) * | 1990-02-01 | 1991-08-08 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
Cited By (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5270315A (en) * | 1988-04-11 | 1993-12-14 | Biochem Pharma Inc. | 4-(purinyl bases)-substituted-1,3-dioxlanes |
US6175008B1 (en) | 1988-04-11 | 2001-01-16 | Biochem Pharma Inc. | Processes for preparing substituted 1,3-oxathiolanes with antiviral properties |
US6350753B1 (en) | 1988-04-11 | 2002-02-26 | Biochem Pharma Inc. | 2-Substituted-4-substituted-1,3-dioxolanes and use thereof |
US5151426A (en) * | 1989-02-08 | 1992-09-29 | Biochem Pharma Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
WO1994014802A1 (en) * | 1989-02-08 | 1994-07-07 | Biochem Pharma Inc. | Process for preparing substituted 1,3-oxathiolanes with antiviral properties |
US6153751A (en) * | 1990-02-01 | 2000-11-28 | Emory University | Method and compositions for the synthesis of BCH-189 and related compounds |
EP0513200A1 (en) * | 1990-02-01 | 1992-11-19 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
EP0513200B2 (en) † | 1990-02-01 | 2004-04-28 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
US5210085A (en) * | 1990-02-01 | 1993-05-11 | Emory University | Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds |
US5814639A (en) * | 1990-02-01 | 1998-09-29 | Emory University | Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds |
US5914400A (en) * | 1990-02-01 | 1999-06-22 | Emory University | Method and compositions for the synthesis of BCH-189 and related compounds |
US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
EP0513200A4 (en) * | 1990-02-01 | 1993-04-07 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
EP1062950A2 (en) * | 1990-05-02 | 2000-12-27 | Biochem Pharma Inc | 1,3 Oxathiolane nucleoside analogues |
WO1991017159A1 (en) * | 1990-05-02 | 1991-11-14 | Iaf Biochem International Inc. | 1,3-oxathiolane nucleoside analogues |
WO1992008717A1 (en) * | 1990-11-13 | 1992-05-29 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties |
US6369066B1 (en) | 1990-11-13 | 2002-04-09 | Biochem Pharma, Inc. | Substituted 1,3-oxathiolanes with antiviral properties |
US6228860B1 (en) | 1990-11-13 | 2001-05-08 | Biochem Pharma Inc. | Substituted 1,3-oxathiolanes with antiviral properties |
US5587480A (en) * | 1990-11-13 | 1996-12-24 | Biochem Pharma, Inc. | Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties |
WO1992010496A1 (en) * | 1990-12-05 | 1992-06-25 | University Of Georgia Research Foundation, Inc. | ENANTIOMERICALLY PURE β-L-(-)-1,3-OXATHIOLANE NUCLEOSIDES |
US5179104A (en) * | 1990-12-05 | 1993-01-12 | University Of Georgia Research Foundation, Inc. | Process for the preparation of enantiomerically pure β-D-(-)-dioxolane-nucleosides |
US5248776A (en) * | 1990-12-05 | 1993-09-28 | University Of Georgia Research Foundation, Inc. | Process for enantiomerically pure β-L-1,3-oxathiolane nucleosides |
US5767122A (en) * | 1990-12-05 | 1998-06-16 | Emory University | Enantiomerically pure β-d-dioxolane nucleosides |
WO1992011852A1 (en) * | 1991-01-03 | 1992-07-23 | Biochem Pharma Inc. | Use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis b |
EP0494119A1 (en) * | 1991-01-03 | 1992-07-08 | Biochem Pharma Inc. | Use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis B |
AU660650B2 (en) * | 1991-01-03 | 1995-07-06 | Shire Canada Inc. | Use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis B |
EP0984013A2 (en) * | 1991-02-22 | 2000-03-08 | Emory University | Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1, 3-oxathiolane |
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WO1992014729A1 (en) * | 1991-02-22 | 1992-09-03 | Emory University | Antiviral 1,3-dioxolane nucleosides and synthesis thereof |
WO1992015309A1 (en) * | 1991-03-06 | 1992-09-17 | The Wellcome Foundation Limited | Antiviral nucleoside combination |
US5234913A (en) * | 1991-03-06 | 1993-08-10 | Burroughs Wellcome Co. | Antiviral nucleoside combination |
AU662130B2 (en) * | 1991-03-06 | 1995-08-24 | Emory University | Use of 5-fluoro-2'-deoxy-3'-thiacytidine for the treatment of hepatitis B |
WO1992015308A1 (en) * | 1991-03-06 | 1992-09-17 | The Wellcome Foundation Limited | Use of 5-fluoro-2'-deoxy-3'-thiacytidine for the treatment of hepatitis b |
WO1992019246A1 (en) * | 1991-05-02 | 1992-11-12 | The Wellcome Foundation Limited Of Unicorn House | Use of a 1,3-oxathiolan derivative for the treatment of hepatitis b infection |
EP0513917A1 (en) * | 1991-05-16 | 1992-11-19 | Glaxo Group Limited | Antiviral combinations containing nucleoside analogs |
WO1992020344A1 (en) * | 1991-05-16 | 1992-11-26 | Glaxo Group Limited | Antiviral combinations containing nucleoside analogs |
EP0515157A1 (en) * | 1991-05-21 | 1992-11-25 | Biochem Pharma Inc. | Processes for the diastereoselective synthesis of nucleosides |
EP0515156A1 (en) * | 1991-05-21 | 1992-11-25 | Biochem Pharma Inc | Processes for the diastereo-selective synthesis of nucleosides |
WO1992020696A1 (en) * | 1991-05-21 | 1992-11-26 | Biochem Pharma Inc. | Processes for the diastereoselective synthesis of nucleosides |
AU655973B2 (en) * | 1991-05-21 | 1995-01-19 | Shire Canada Inc. | Processes for the diastereoselective synthesis of nucleosides |
US5744596A (en) * | 1991-05-21 | 1998-04-28 | Biochem Pharma Inc. | Nucleoside analogues and synthetic intermediates |
WO1992020669A1 (en) * | 1991-05-21 | 1992-11-26 | Biochem Pharma Inc. | Processes for the diastereoselective synthesis of nucleosides |
US5756706A (en) * | 1991-05-21 | 1998-05-26 | Biochem Pharma Inc. | Processes for the diastereoselective synthesis of nucleoside analogues |
US5663320A (en) * | 1991-05-21 | 1997-09-02 | Biochem Pharma, Inc. | Processes for the diastereoselective separation of nucleoside analogue synthetic intermediates |
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US5696254A (en) * | 1991-05-21 | 1997-12-09 | Biochem Pharma Inc. | Processes for the diastereoselective synthesis of nucleoside analogues |
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US5905082A (en) * | 1991-06-03 | 1999-05-18 | Glaxo Group Limited | Crystalline oxathiolane derivatives |
EP0517145A1 (en) * | 1991-06-03 | 1992-12-09 | Glaxo Group Limited | Crystalline oxathiolane derivatives |
AU659668B2 (en) * | 1991-08-01 | 1995-05-25 | Shire Canada Inc. | 1,3-oxathiolane nucleoside analogues |
WO1993003027A1 (en) * | 1991-08-01 | 1993-02-18 | Biochem Pharma Inc. | 1,3-oxathiolane nucleoside analogues |
US5538975A (en) * | 1991-08-01 | 1996-07-23 | Biochem Pharma, Inc. | 1,3-oxathiolane nucleoside compounds and compositions |
US5618820A (en) * | 1991-08-01 | 1997-04-08 | Biochem Pharma, Inc. | 1,3-oxathiolane nucleoside analogues and methods for using same |
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AP321A (en) * | 1991-08-01 | 1994-02-28 | Iaf Biochem Int | 1,3-Oxathiolane nucleoside analogues. |
US5527900A (en) * | 1991-09-04 | 1996-06-18 | Stitching Rega Vzw | N3-alkyl-2',5'-0-silylated-3'-spiro-thymidine derivatives |
EP0530407A1 (en) * | 1991-09-04 | 1993-03-10 | Stichting REGA V.Z.W. | Substituted, nucleoside derivatives, methods for their preparation and pharmaceutical compositions containing them |
US6177435B1 (en) | 1992-05-13 | 2001-01-23 | Glaxo Wellcome Inc. | Therapeutic combinations |
WO1993023021A2 (en) * | 1992-05-13 | 1993-11-25 | The Wellcome Foundation Limited | Therapeutic combinations |
WO1993023021A3 (en) * | 1992-05-13 | 1994-03-03 | Wellcome Found | Therapeutic combinations |
US6127540A (en) * | 1992-12-23 | 2000-10-03 | Biochem Pharma, Inc. | Antiviral compounds |
US6005107A (en) * | 1992-12-23 | 1999-12-21 | Biochem Pharma, Inc. | Antiviral compounds |
US6194576B1 (en) | 1992-12-23 | 2001-02-27 | Biochem Pharma, Inc. | Process for preparing antiviral 2-phosponate nucleotide analogs |
US5955610A (en) * | 1992-12-23 | 1999-09-21 | Biochem Pharma, Inc. | Antiviral compounds |
US5789394A (en) * | 1992-12-23 | 1998-08-04 | Nguyen-Ba; Nghe | Anti-viral compounds |
US6444656B1 (en) | 1992-12-23 | 2002-09-03 | Biochem Pharma, Inc. | Antiviral phosphonate nucleotides |
AU668829B2 (en) * | 1993-06-07 | 1996-05-16 | Shire Canada Inc. | Stereoselective synthesis of nucleoside analogues using bicyclic intermediate |
US5763606A (en) * | 1993-06-07 | 1998-06-09 | Biochem Pharma, Inc. | Stereoselective synthesis of nucleoside analogues using bicyclic intermediate |
US6214833B1 (en) | 1997-03-28 | 2001-04-10 | Zambon Group S.P.A. | Pyrimidinone-1,3-oxathiolane derivatives with antiviral activity |
US6410546B1 (en) | 1997-04-07 | 2002-06-25 | Triangle Pharmaceuticals, Inc. | Use of MKC-442 in combination with other antiviral agents |
US6215004B1 (en) | 1998-08-12 | 2001-04-10 | Emory University | Method of manufacture of 1,3-oxathiolane nucleosides |
US6518425B1 (en) | 1998-08-12 | 2003-02-11 | Emory University | Method of manufacture of 1,3-oxathiolane nucleosides |
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US7572800B2 (en) | 1998-11-02 | 2009-08-11 | Gilead Sciences, Inc. | Combination therapy to treat hepatitis B virus |
US6458773B1 (en) | 1998-11-05 | 2002-10-01 | Emory University | Nucleoside with anti-hepatitis B virus activity |
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