JPS56169689A - 3-substituted-5-fluorouracil derivative and its preparation - Google Patents
3-substituted-5-fluorouracil derivative and its preparationInfo
- Publication number
- JPS56169689A JPS56169689A JP7471780A JP7471780A JPS56169689A JP S56169689 A JPS56169689 A JP S56169689A JP 7471780 A JP7471780 A JP 7471780A JP 7471780 A JP7471780 A JP 7471780A JP S56169689 A JPS56169689 A JP S56169689A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- substituted
- preparation
- fluorouracil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 3-substituted-5-fluorouracil derivative of formula I (n is O or an integer 1-2). EXAMPLE:3-(Tetrahydro-2-thienyl)-5-fluorouracil. USE:An antitumor agent and an antiviral agent. PROCESS:A compound of formula II (R1 is alkyl) is silylated with hexamethyldisilazane, etc. and the resultant compound is then reacted with a compound of formula III (R2 is halogen, alkoxyl or acyloxy) to give a compound of formula IV, which is then dealkylsulfonylated with a basic substance, e.g. NaOH, to afford the compound of formula I (n is 0). The resultant compound is then treated with an oxidizing agent, e.g. H2O2, if necessary to afford the compound of formula I (n is 1 or 2).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7471780A JPS56169689A (en) | 1980-06-02 | 1980-06-02 | 3-substituted-5-fluorouracil derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7471780A JPS56169689A (en) | 1980-06-02 | 1980-06-02 | 3-substituted-5-fluorouracil derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56169689A true JPS56169689A (en) | 1981-12-26 |
JPS626717B2 JPS626717B2 (en) | 1987-02-13 |
Family
ID=13555243
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7471780A Granted JPS56169689A (en) | 1980-06-02 | 1980-06-02 | 3-substituted-5-fluorouracil derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56169689A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
US7119202B1 (en) | 1989-02-08 | 2006-10-10 | Glaxo Wellcome Inc. | Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties |
-
1980
- 1980-06-02 JP JP7471780A patent/JPS56169689A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5047407A (en) * | 1989-02-08 | 1991-09-10 | Iaf Biochem International, Inc. | 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties |
US7119202B1 (en) | 1989-02-08 | 2006-10-10 | Glaxo Wellcome Inc. | Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties |
Also Published As
Publication number | Publication date |
---|---|
JPS626717B2 (en) | 1987-02-13 |
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