EP0119386A1 - Procédé d'obtention de D,L-homocystine (II) - Google Patents

Procédé d'obtention de D,L-homocystine (II) Download PDF

Info

Publication number
EP0119386A1
EP0119386A1 EP84100180A EP84100180A EP0119386A1 EP 0119386 A1 EP0119386 A1 EP 0119386A1 EP 84100180 A EP84100180 A EP 84100180A EP 84100180 A EP84100180 A EP 84100180A EP 0119386 A1 EP0119386 A1 EP 0119386A1
Authority
EP
European Patent Office
Prior art keywords
homocysteine
disodium salt
homocystine
homocystin
ions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP84100180A
Other languages
German (de)
English (en)
Other versions
EP0119386B1 (fr
Inventor
Michael Dr. Dipl.-Chem. Karrenbauer
Axel Dr. Dipl.-Chem. Kleemann
Theodor Dr. Dipl.-Chem. Lüssling
Fritz Dr. Dipl.-Chem. Schäfer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Priority to AT84100180T priority Critical patent/ATE16279T1/de
Publication of EP0119386A1 publication Critical patent/EP0119386A1/fr
Application granted granted Critical
Publication of EP0119386B1 publication Critical patent/EP0119386B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups

Definitions

  • the invention relates to a process for the production of D, L-homocystine by oxidation of the disodium salt of D, L-homocysteine.
  • the initial pH is preferably adjusted to a value between 7.0 and 8.0 using an aqueous mineral acid, preferably hydrochloric acid.
  • the pH of the reaction mixture is adjusted to about 5.3, advantageously with an aqueous mineral acid, preferably hydrochloric acid. It is advantageous if the pH is adjusted at an elevated temperature, for example 50 ° C., and the reaction mixture is then slowly cooled to room temperature with stirring, for example over the course of an hour.
  • the D, L-homocystin is obtained when the stirring speed during the precipitation is measured so that the D, L-homocystin is just kept in suspension. It can then be separated particularly easily by filtration or centrifugation.
  • the precipitated D, L-homocystin is filtered off, washed with 100 ml of water at 80 ° C and dried in a vacuum drying cabinet to constant weight.
  • the yield of D, L-homocystin is 9.2 g, corresponding to 88% of theory.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP84100180A 1983-03-18 1984-01-10 Procédé d'obtention de D,L-homocystine (II) Expired EP0119386B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT84100180T ATE16279T1 (de) 1983-03-18 1984-01-10 Verfahren zur gewinnung von d,l-homocystin.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3309762 1983-03-18
DE3309762A DE3309762C1 (de) 1983-03-18 1983-03-18 Verfahren zur Herstellung von D,L-Homocystin (II)

Publications (2)

Publication Number Publication Date
EP0119386A1 true EP0119386A1 (fr) 1984-09-26
EP0119386B1 EP0119386B1 (fr) 1985-10-30

Family

ID=6193873

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84100180A Expired EP0119386B1 (fr) 1983-03-18 1984-01-10 Procédé d'obtention de D,L-homocystine (II)

Country Status (6)

Country Link
US (1) US4550200A (fr)
EP (1) EP0119386B1 (fr)
JP (1) JPS59176249A (fr)
AT (1) ATE16279T1 (fr)
CA (1) CA1223887A (fr)
DE (1) DE3309762C1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3620221B2 (ja) * 1996-11-25 2005-02-16 三菱化学株式会社 ホモシスチンの製造法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2406362A (en) * 1943-11-11 1946-08-27 Du Pont Process

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB621915A (en) * 1945-12-20 1949-04-22 Merck & Co Inc Process of preparing penicillamine disulphides
US3565959A (en) * 1968-05-24 1971-02-23 Nippon Oil Co Ltd Process for oxidizing mercaptans to disulfides
US3978137A (en) * 1975-03-14 1976-08-31 Universal Oil Products Company Oxidation of sulfur-containing compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2406362A (en) * 1943-11-11 1946-08-27 Du Pont Process

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Band 70, Nr. 19, 12. Mai 1969, Seite 13, Nr. 84330p, Columbus, Ohio, USA; D. CAVALLINI et al.: "Copper-catalyzed oxidation of cysteine to cystine" & ARCH. BIOCHEM. BIOPHYS. 1969, 130(1), 354-361 *

Also Published As

Publication number Publication date
EP0119386B1 (fr) 1985-10-30
ATE16279T1 (de) 1985-11-15
JPS59176249A (ja) 1984-10-05
CA1223887A (fr) 1987-07-07
DE3309762C1 (de) 1984-03-01
US4550200A (en) 1985-10-29
JPH0417189B2 (fr) 1992-03-25

Similar Documents

Publication Publication Date Title
DE3615348A1 (de) Verfahren zur herstellung von basischem zinkcarbonat
DE1248654B (de) Verfahren zur Herstellung von Phosphonsäuren und deren Salzen
EP0119386B1 (fr) Procédé d'obtention de D,L-homocystine (II)
EP0120182B1 (fr) Procédé d'obtention de D,L-homocystine (I)
DE2245892B2 (de) Verfahren zur Herstellung von Citronensäure
DE1545554A1 (de) Verfahren zur Herstellung von 1,3-Benzoxazin-2,4-dion
AT403916B (de) Verfahren zur herstellung von calziumpyruvat und dessen hydraten
EP0320447B1 (fr) Procédé de préparation de colorants azo métallisables
EP0590556B1 (fr) Procédé de réduction du contenu en phosphates dans les effluents aqueux provenant de la préparation de sels metalliques du mono phosphate-2 de l'acide ascorbique
DE2214827B2 (de) Verfahren zur Herstellung von Alkaliferrocyaniden
DE1276635B (de) Verfahren zur Herstellung von Kaliumsorbat
DE2006967A1 (de) Verfahren zur Herstellung von Allantoin-Polygalacturonsäure-Verbindungen
DE1944585C (de) Verfahren zur Herstellung von festem, weißem Natriumstannat aus technischen Natriumstann atlaugen
DE2014783C3 (de) Verfahren zur Abtrennung von Schwefelsäure aus einem Reaktionsgemisch
DE2433889C2 (de) Verfahren zur Herstellung reiner allcls-Cyclopentan-1,2,3,4-tetracarbonsäure bzw. ihre Salze
DE2119119C3 (de) Verfahren zum Entfernen von Cyanidionen aus Abwässern
DE2510139C3 (de) Verfahren zur Herstellung von Monochlorbenzoesäuren
DD209838A1 (de) Verfahren zur grosstechnischen herstellung hochwertiger dispergiermittel
DE68908135T2 (de) Verfahren zur Herstellung von einem Acexamsäurederivat.
DE1254635B (de) Verfahren zur Herstellung von optisch aktivem oder inaktivem gamma-Methylglutamat-Hydrochlorid
DE2035496B2 (de) Verfahren zur kontinuierlichen Herstellung von Cumolhydroperoxid
DE1063133B (de) Verfahren zur Verringerung des Eisengehaltes wasserloeslicher Silicate
DE2159128A1 (de) Verfahren zur Gewinnung hochreiner Manganverbindungen
DE1954519A1 (de) Verfahren zum Herstellen von 0-Acylthiamindisulfiden
DE1200808B (de) Verfahren zur Herstellung von Bis-(2-hydroxy-2-carboxyaethyl)-disulfid oder dessen Salzen

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19840110

AK Designated contracting states

Designated state(s): AT BE CH FR GB IT LI LU NL SE

ITF It: translation for a ep patent filed
GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Designated state(s): AT BE CH FR GB IT LI LU NL SE

REF Corresponds to:

Ref document number: 16279

Country of ref document: AT

Date of ref document: 19851115

Kind code of ref document: T

ET Fr: translation filed
PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 19911211

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: SE

Payment date: 19911213

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 19911224

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 19911230

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 19920103

Year of fee payment: 9

Ref country code: AT

Payment date: 19920103

Year of fee payment: 9

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 19920115

Year of fee payment: 9

ITTA It: last paid annual fee
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 19920131

Year of fee payment: 9

EPTA Lu: last paid annual fee
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19930110

Ref country code: GB

Effective date: 19930110

Ref country code: AT

Effective date: 19930110

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Effective date: 19930111

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Effective date: 19930131

Ref country code: CH

Effective date: 19930131

Ref country code: BE

Effective date: 19930131

BERE Be: lapsed

Owner name: DEGUSSA A.G.

Effective date: 19930131

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Effective date: 19930801

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 19930110

NLV4 Nl: lapsed or anulled due to non-payment of the annual fee
PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Effective date: 19930930

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

EUG Se: european patent has lapsed

Ref document number: 84100180.3

Effective date: 19930810