EP0085854B1 - Pipettiervorrichtung - Google Patents

Pipettiervorrichtung Download PDF

Info

Publication number
EP0085854B1
EP0085854B1 EP83100409A EP83100409A EP0085854B1 EP 0085854 B1 EP0085854 B1 EP 0085854B1 EP 83100409 A EP83100409 A EP 83100409A EP 83100409 A EP83100409 A EP 83100409A EP 0085854 B1 EP0085854 B1 EP 0085854B1
Authority
EP
European Patent Office
Prior art keywords
locking
syringe
stop
actuating
piston
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP83100409A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0085854A2 (de
EP0085854A3 (en
Inventor
Horst Sabloewski
Rolf Zickermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eppendorf SE
Original Assignee
Eppendorf Netheler Hinz GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eppendorf Netheler Hinz GmbH filed Critical Eppendorf Netheler Hinz GmbH
Priority to AT83100409T priority Critical patent/ATE41110T1/de
Publication of EP0085854A2 publication Critical patent/EP0085854A2/de
Publication of EP0085854A3 publication Critical patent/EP0085854A3/de
Application granted granted Critical
Publication of EP0085854B1 publication Critical patent/EP0085854B1/de
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0234—Repeating pipettes, i.e. for dispensing multiple doses from a single charge

Definitions

  • the invention relates to a pipetting device as a holding mechanism for a detachable syringe, consisting of a syringe housing and piston for stepless adjustment of the desired working volume with two mutually movable, toothed racks and connected by a gear slide, one of which is connected to a lifting rod for the piston .
  • the pipetting device relates to a mechanical actuating part in combination with a syringe, in particular a syringe housing, in which a piston can be moved, the stroke of which can be adjusted in fractions of the volume of the syringe housing.
  • the cited literature reference also shows an embodiment with only one actuating lever.
  • this embodiment is subject to the disadvantage that a strong spring must be used, which must be dimensioned to return the entire mechanism, including the syringe plunger. This also leads to the disadvantage of fatigue. If the spring in the other known embodiment with the two slides is also avoided because the forces may be somewhat lower in spite of the friction values involved and the counterweight, this also results in the disadvantages described above.
  • the invention has for its object to improve a pipetting device of the type mentioned with two slides connected by a gear in that the ease of use is increased and the operating forces are reduced at all.
  • the object is achieved in that only one actuating lever is arranged for the piston movements and an actuating device is provided between it and the slides, which has a stop element that can be switched alternately into the path of the other slider depending on a return of the actuating lever to the starting position, wherein a feedback device has at least one weak tension spring, which automatically brings about the feedback.
  • the stop element is particularly advantageously engaged with a movable cam, through which the stop element can be displaced, and the cam is under the action of a pretension and a tensioning element which can be acted upon by at least one slide.
  • This cam practically leads to a negligible load on the actuating lever only in the first part of the way.
  • an expedient embodiment is that the stop element is designed as a cross slide with an actuating wedge which comes into contact with the cam, the cross slide being alternately laterally displaceable by running onto a counter flank of the cam.
  • the invention provides a simple switching device for actuating both slides by means of only one actuating lever.
  • This preferably includes a stop lock for the cross slide in the respective position with automatic detachment in the starting position of the actuating lever.
  • a locking slide with abutments is provided for its return springs.
  • This locking slide is designed with two parts that can be moved relative to one another, locking slide part and latching support, between which compression springs are arranged.
  • the stop element is transversely displaceably mounted on the locking carrier, with stops arranged in the housing for the end position of the locking slide, which come into engagement with abutments on the locking slide part, and the locking carrier can be moved by the actuating button.
  • the actuating device is movable against the return spring arrangement, which is provided for the return movement of only the actuating device with actuating lever, and in the starting position the stop element with end stops in the starting position of the actuating device is in each case with an end stop in front of a surface serving as a slide stop in the retracted position of the slide.
  • This also results in a weak return spring arrangement, because only the mechanics can be moved, while in the known embodiment, in the case of a return spring, the piston return stroke must also be carried out with the acting forces. In this respect, the ease of use of the invention is improved.
  • the invention advantageously has a continuously variable adjustment of the volume to be sucked in by means of a tight-tolerance screw spindle known per se for adjusting a volume-determining abutment and by a gear connected to the spindle, on the other side of which a digital display is arranged.
  • the value set in each case can be read on the digital display.
  • a window with a decimal point in the housing is used for this purpose.
  • the combination of infinitely variable adjustment by means of a tight-tolerance screw spindle with a drive mechanism, which has two mutually movable sliders, is a feature, especially in connection with the only one actuating lever, which only has to be acted upon by relatively weak return springs in relation to the piston movement.
  • the preferred embodiment has a stroke limiting frame which is fixedly arranged in the lower housing part and in which the abutment or stop is guided and through which on the other hand a lifting rod is guided which is connected to a piston rod of the syringe, whereby two abutments are formed.
  • the stroke limitation is easily adjustable, a further advantageous feature being that the piston rod head is designed with a groove in which a projection engages in an insert receptacle for the piston rod head, which insert receptacle is arranged in the guide block.
  • a locking arrangement advantageously has a guide block on which the lifting rod is fixedly arranged with a stop, and has a swivel bolt which is assigned an opening section for pivoting out at the syringe-side end of the housing, and by means of a double-sided pressure spring provided at the outer end of the recess Equipped u-shaped holder for the use of a syringe housing, which can be removed independently of the syringe plunger. The syringe plunger and the entire syringe housing can be replaced in the lower stop position.
  • the axially fixed arrangement of the piston rod head initially ensures proper transmission of the volume setting, and in connection with the stroke limiting frame, such a volume setting is easily transferred.
  • the ability to replace the syringe barrel, regardless of the syringe plunger, is a particular advantage in this context.
  • the infinitely variable setting is created in conjunction with an adjustment knob on which the spindle is guided so that it can rotate but can move axially, by means of a movement brake for the knob.
  • This is expediently designed as a brake shoe running on a rotating disk.
  • a diameter which is connected to the rotary knob and has a larger diameter than the spindle is also included Disc with locking recesses to which one or more spring-loaded locking teeth are assigned, with a locking distance of the order of 1/100 ml being provided.
  • the stop lock mentioned above in connection with the two-part design of the locking slide mentioned, advantageously has two locking recesses on the locking slide part for a locking tooth on the cross slide arranged on the locking support, the locking engagement being able to be canceled by moving the locking slide part and locking support apart by means of pressure springs arranged between them.
  • the housing forms a handle for the device and is composed of a lower housing part 1 and an upper housing part 2. Both housing parts can be screwed together, or they are held together in the longitudinal direction by parallel pushing together with wedge locks, not shown, which ensure lateral guidance and at the same time Have detents when the upper and lower parts of the housing are arranged to cover one another.
  • screw connections 3, 4, 5 can be provided in the side walls in accordance with the dash-dotted lines.
  • guide tracks 8, 9 for slides 10, 11 are provided within the outer longitudinal side walls 6, 7. These slides 10, 11 are formed on the inside at their lower edge as racks 12, 13.
  • a toothed wheel 14 meshes with these toothed racks, which is rotatably mounted in the lower housing part 1 on a pin 15 and ensures an exact opposite movement of the slides 10, 11.
  • the locking slide 16 is made in two parts and has a fork-like locking slide part 27 and a latching support 28 arranged at the same height, which are guided in the same longitudinal guide as the locking slide part in a direction parallel to the longitudinal axis of the housing. Between them, however, are arranged with their ends in recesses 29, 30 and 31, 32, respectively, springs 33, 34, which endeavor to press the two parts 27 and 28 apart.
  • springs 33, 34 which endeavor to press the two parts 27 and 28 apart.
  • a projection 38 is arranged on the locking slide, which according to FIG. 1 a has a step 39 downward and has two latching recesses 40, 41 at the end.
  • a locking tooth 42 which is arranged on a cross slide 43.
  • This cross slide 43 is guided by means of an elongated hole 44, in the extension thereof with respect to a pin 45 movable transversely to the longitudinal extent of the housing through a guide groove 47 in the latching support 28.
  • the pin 45 On the locking bracket the pin 45 is also attached.
  • the guide groove 47 is arranged transversely, in which a web 48 engages on the cross slide.
  • there is free transverse mobility of the cross slide 43 the end position being dimensioned by stops between the inner edge of the elongated hole 44 on the one hand and the pin 45 on the other hand, so that in each end position the locking tooth 42 can engage in one of the locking recesses 40, 41.
  • An actuating wedge 49 with equilateral flanks 62 is arranged centrally on the cross slide 43.
  • This actuating wedge 49 is assigned a movable cam 50 which is pivotably mounted about a pivot pin 51. This is located on a bridge 52 fastened to the upper housing part 2.
  • This movable cam has a wedge tip 53 which can be moved back and forth between two stops 54, 55 for dimensioning the largest deflection. Between these limit stops, a to-and-fro movement is effected on the one hand by a tension spring 56 which is fixed on the one hand to the bridge at 57 and on the other hand to the cam at 58 and is caused by a lever 59 which is pivotably mounted in the lower part (FIG. 1 a) is.
  • This lever 59 is moved by the slide 10, which is guided in the housing on the other side, when this slide 10 is in its furthest left with respect to FIG. H. of syringe housing 25, is in the correct position.
  • this slide 10 has a stop projection 115. It is in the stop position when the syringe plunger 116 is in its most advanced position in the syringe housing 25.
  • the lever 59 is part of a U-shaped lever, which is pivotally mounted with a web 117 in bearing openings 118 of the lower housing part 1 (FIG. 1 a), the lever 59, which has an arm 114 on the cam 50 on the other Side than that on which the spring 56 acts, comes into engagement, on which the leg 60 of the U-shaped lever is arranged. With the leg 61 (FIG. 4 a) on the other side, the stop lug 115 comes into contact. This creates a movement transmission with simple means, which is also caused by the use of the two oppositely driven sliders 10, 11.
  • the lever 59 is a continuation of the leg 60.
  • This pivot lever arrangement 60, 61, 117 ensures that when the associated slide 10 is moved to the left with respect to FIGS. 1 and 6, the cam 50 is brought into the position shown in FIG. 6 under tension of the spring 56. If, in this initial position, the flank 62 of the cross slide 43 meets the flank 63 of the cam 50 after the locking slides 28 have been lifted from the locking slide 27 by relieving the tension springs 33, 34, the cross slide 43 is moved to the other side position. The locking tooth 42 is then aligned with the locking recess 41.
  • an adjusting knob 65 is inserted with a cylindrical guide part 66 drawn into the interior of the housing, which is rotatably mounted in the pivot bearing 67, but axially not removable is.
  • this cylindrical guide part 66 two longitudinal grooves 68, 69 are provided in the axial direction. In this longitudinal grooves engage the ends 70, 71 of a diagonal approach on a screw spindle 72 which leads out of the guide part and passes through a bore 74 provided with an internal thread 73 in a stroke limiting frame 75 which is fixedly arranged in the lower housing part.
  • a guide block 80 which is axially movable in the housing Arranged, on which the slider 11 engages around an engaging projection 82 of the guide block 80 with a groove-like recess 81 directed towards the interior of the housing.
  • the guide block 80 can always be moved back and forth with the slide 11, so that with respect to the syringe housing 25, a piston 116 movable in it, which is connected to the guide block 80 in a manner yet to be described, is moved back and forth.
  • the guide block 80 has an insert receptacle 83 for a piston rod head 84, which is shown in broken lines in FIG. 4 b.
  • a projection 85 projects into the insert receptacle, which has a U-shaped shape and is open at the top, and engages in an associated recess or groove in the piston rod head. Due to the U-shaped shape of the insert receptacle 83, the piston rod head 84 can be removed upwards.
  • the guide block 80 also has a transversely arranged axis of rotation 86 for a pivot bolt 87 also shown in FIG. 1b, the handle of which is also shown in FIG. 5.
  • This pivot bolt 87 includes the side block 88 from the outside of the guide block 80, and it has a downward projection 113 between the flanks, which presses on the piston rod head 84, which is enlarged relative to the piston rod of the syringe piston, and secures it in its position.
  • the swivel bolt itself is held in its position by its side legs in elastic pressure and by side profiles.
  • the upper part has an opening 89 which is open at the top and widens towards the end, the widened section 90 of which at the end permits the pivot bolt to be folded out.
  • the adjoining, in contrast narrower, slit-like section 91 allows a tapered section 92 on the neck of the swivel lock 87 to move back with the operating movement of the piston rod, but without the tapered section 92 entering the narrower section 91 being able to fold out, as shown in FIG 1 b is shown in dashed lines.
  • the swivel latch can only be brought into the open position when the syringe plunger is in its most inserted position into the syringe housing 25.
  • the syringe plunger can be inserted or replaced in this position.
  • the piston rod head 84 remains locked.
  • the syringe housing 25 itself can be swung out of a U-shaped receptacle 93, the piston remaining on the housing. This is important if only the syringe housing 25 is to be replaced.
  • the receptacle 93 is a U-shaped groove which is arranged in the lower housing part 1 and is open to the separating joint between the housing parts and into which the flange 95 of the syringe housing can be inserted.
  • a pressure spring 94 which extends at least over the side flanks of the groove with bulging legs, is arranged on the wall, which is closer to the adjusting rotary knob. This ensures that the flange 95 of the syringe housing 25, which is inserted into the receptacle 93, is always held in a defined position in the wall 96 of the receptacle.
  • a gear in particular a gear 97, is connected to the adjusting knob 65, in particular its cylindrical guide part 66, which meshes with a gear 98, which is arranged on a shaft 99, which is mounted in the lower housing part.
  • a setting scale, counter or digital display with a number of dials 101, 102, 103 ... designated 100 as a whole, which are adjustable according to the decimal system.
  • a window 104 shown in FIG. 7 is arranged in the lower housing part 1, the height extension of which makes only one digit visible on each dial, so that this window 104 also forms a pointer for this setting scale.
  • a section of a side view of the lower housing part is drawn in FIG. 7. With the continuously variable setting of the syringe volume, the respective size can be seen in the window.
  • an element of a movement brake 111 is arranged on the cylindrical guide part 66 according to FIG. 2 or FIG. 1a.
  • This element is designed as a disk 105 which is rotatable with the cylindrical guide part 66.
  • This circumferential disc 105 is assigned a brake bracket 106, which is fixedly arranged in the lower housing part.
  • This brake bracket carries a weakly protruding locking tooth 107 on an elastically deflectable leg 108 of the brake bracket, and this locking tooth is assigned, according to FIG. 2, locking recesses 109, 110 on the disk.
  • Fig. 8 which contains an individual representation, it can be seen that the disc 105 is circular at the exit and a corresponding concave brake shoe 112 is arranged on the elastic leg 108, so that an actually stepless adjustment is possible. This allows even finer subdivisions than mentioned above.
  • the last dial of the setting scale 100 still has a subdivision in the area of each digit, so that the corresponding setting fractions can be read, with respect to to an edge of the window 104 marked as a pointer.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Rigid Pipes And Flexible Pipes (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Sampling And Sample Adjustment (AREA)
EP83100409A 1982-02-06 1983-01-19 Pipettiervorrichtung Expired EP0085854B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT83100409T ATE41110T1 (de) 1982-02-06 1983-01-19 Pipettiervorrichtung.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3204178A DE3204178C2 (de) 1982-02-06 1982-02-06 Pipettiervorrichtung
DE3204178 1982-02-06

Publications (3)

Publication Number Publication Date
EP0085854A2 EP0085854A2 (de) 1983-08-17
EP0085854A3 EP0085854A3 (en) 1985-12-04
EP0085854B1 true EP0085854B1 (de) 1989-03-08

Family

ID=6155026

Family Applications (1)

Application Number Title Priority Date Filing Date
EP83100409A Expired EP0085854B1 (de) 1982-02-06 1983-01-19 Pipettiervorrichtung

Country Status (6)

Country Link
US (1) US4470317A (enExample)
EP (1) EP0085854B1 (enExample)
JP (1) JPS58189045A (enExample)
AT (1) ATE41110T1 (enExample)
DE (1) DE3204178C2 (enExample)
FI (1) FI76006C (enExample)

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PL2656915T3 (pl) * 2012-04-23 2019-04-30 Eppendorf Ag Pipeta do uruchamiania strzykawki
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US9295986B2 (en) 2012-05-02 2016-03-29 Eppendorf Ag Pipette with releasable locking of rotational position of actuating element
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Publication number Priority date Publication date Assignee Title
EP3928868A1 (de) 2020-06-22 2021-12-29 Eppendorf AG Pipette für den gebrauch mit einer einen kolben und einen zylinder aufweisenden pipettenspitze oder spritze
US11951471B2 (en) 2020-06-22 2024-04-09 Eppendorf Ag Pipette for use with a pipette tip or syringe having a piston and a cylinder
EP4406655A3 (de) * 2020-06-22 2024-08-21 Eppendorf SE Pipette für den gebrauch mit einer einen kolben und einen zylinder aufweisenden pipettenspitze oder spritze

Also Published As

Publication number Publication date
EP0085854A2 (de) 1983-08-17
FI830157A0 (fi) 1983-01-18
DE3204178C2 (de) 1986-03-20
EP0085854A3 (en) 1985-12-04
US4470317A (en) 1984-09-11
JPH0153103B2 (enExample) 1989-11-13
JPS58189045A (ja) 1983-11-04
DE3204178A1 (de) 1983-08-18
FI830157L (fi) 1983-08-07
FI76006B (fi) 1988-05-31
FI76006C (fi) 1988-09-09
ATE41110T1 (de) 1989-03-15

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