US20090043264A1 - Injection Device - Google Patents

Injection Device Download PDF

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Publication number
US20090043264A1
US20090043264A1 US11911871 US91187106A US2009043264A1 US 20090043264 A1 US20090043264 A1 US 20090043264A1 US 11911871 US11911871 US 11911871 US 91187106 A US91187106 A US 91187106A US 2009043264 A1 US2009043264 A1 US 2009043264A1
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US
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Patent type
Prior art keywords
injection device
housing
dose setting
injection
thread
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11911871
Inventor
Kristian Glejbol
Steven Linnebjerg
Claus Schmidt Moller
Michael Ejstrup Hansen
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Novo Nordisk AS
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Novo Nordisk AS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/3155Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/3152Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31535Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541Means preventing setting of a dose beyond the amount remaining in the cartridge
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/31556Accuracy improving means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/31556Accuracy improving means
    • A61M5/31558Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/3156Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533Dosing mechanisms, i.e. setting a dose
    • A61M5/31545Setting modes for dosing
    • A61M5/31548Mechanically operated dose setting member
    • A61M5/31561Mechanically operated dose setting member using freely adjustable volume steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566Means improving security or handling thereof
    • A61M5/31573Accuracy improving means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566Means improving security or handling thereof
    • A61M5/31573Accuracy improving means
    • A61M5/31575Accuracy improving means using scaling up or down transmissions, e.g. gearbox

Abstract

An injection device for injection of set doses of medicine from a cartridge has a nut (13) that is screwed up along a threaded piston rod (4) during a dose setting operation. The nut is screwed along the piston rod by rotating a dose setting member (17. A rotational coupling mechanism includes an axially displaceable coupling member (25) which is rotated as a function of axial displacement. During dose setting, the nut is allowed to rotate relative to the coupling member. During injection, the coupling member is rotationally locked to the nut. This provides a dose setting and injection mechanism wherein the nut member is both rotated during dose setting and during injection.

Description

  • The present invention relates to syringes having a piston drive element for engaging and moving a piston within a medication cartridge, by which a dose can be set by rotating a nut along the piston drive element during dose setting, and wherein a set dose can be expelled by driving the nut to its initial position.
  • BACKGROUND OF THE INVENTION
  • An almost classic pen which adopts the above described dose setting and injecting scheme is described in EP 327 910.
  • By setting a dose on this pen a tubular member forming an injection button is screwed up along a threaded piston rod a distance corresponding to the distance said piston rod must be moved to inject the set dose. The tubular member simply forms a nut which is during the dose setting screwed away form a stop and which is during the injection pressed back to abutment with said stop and the force exerted on the button is directly transmitted to the a piston closing one end of an ampoule in the syringe which ampoule contains the medicament to be injected. When the piston is pressed into the ampoule the medicament is pressed out through a needle mounted through a closure at the other end of the ampoule.
  • By time it has been wanted to store larger amount in the ampoules, typically 3 ml instead of 1.5 ml. As it has not been appropriate to make the syringe longer the ampoule is instead given a larger diameter, i.e. the area of the piston facing the medicament in the ampoule has been doubled and consequently the force which has to be exerted on the piston to provide the same pressure as previously inside the ampoule has been doubled. Further the distance the piston has to be moved to inject one unit of the medicament has been halved.
  • This development is not quite favourable, as especially users having reduced finger strength have their difficulties in pressing the injection button, a problem that is further increased when still thinner needles are used to reduce the pain by injection. Also with quite small movements of the button it is difficult to feel whether the button is moved at all and by injection of one unit from a 3 ml ampoule the piston and consequently the injection button has to be moved only about 0.1 mm.
  • Consequently a wish for a gearing between the injection button and the piston has occurred so that the button has a larger stroke than has the piston. By such a gearing the movement of the injection button is made larger and the force, which has to be exerted on the injection button, is correspondingly reduced.
  • In EP 608 343 a gearing is obtained by the fact that a dose setting element is screwed up along a spindle having a thread with a high pitch. When said dose setting element is pressed back in its axial direction the thread will induce a rotation of said dose setting element, which rotation is via a coupling transmitted to a driver nut with a fine pitch which driver nut will force a threaded not rotatable piston rod forward.
  • A similar gearing is provided in WO 99/38554 wherein the thread with the high pitch is cut in the outer surface of a dose setting member and is engaged by a mating thread on the inner side of the cylindrical housing. However, by this kind of gearing relative large surfaces are sliding over each other so that most of the transformed force is lost due to friction between the sliding surfaces. Therefore a traditional gearing using mutual engaging gear wheels and racks is preferred.
  • From WO 96/26754 is known an injection device wherein two integrated gear wheels engages a rack fixed in the housing and a rack inside a plunger, respectively. When the plunger is moved axially in the housing the rack inside this plunger can drive the first gear wheel to make the other integral gear wheel move along the fixed rack in the housing. Thereby the gear wheel is moved in the direction of the plunger movement but a shorter distance than is this plunger and this axial movement of the integrated gear wheels is via a housing encompassing said gear wheels transmitted to a piston rod which presses the piston of an ampoule further into this ampoule. However, the rack inside the plunger is one of a number axial racks provided inside said plunger. These racks alternates with untoothed recesses, which allow axial movement of the plunger without the first gear wheel being in engagement with a rack in this plunger. This arrangement is provided to allow the plunger to be moved in a direction out of the housing when a dose is set. When the plunger is rotated to set a dose it is moved outward a distance corresponding to one unit during the part of the rotation where the first gear wheel passes the untoothed recess, thereafter the first gear wheel engages one of the racks so the set unit can be injected, or the rotation can be continued to make the first gear wheel pass the next recess during which passing the set dose is increased by one more unit and so on until a dose with the wanted number of units is set.
  • A disadvantage by this construction is that the teeth of the racks and gearwheels alternating have to be brought in and out of engagement with each other with the inherit danger of clashing. As only a few racks separated by intermediary untoothed recess can be placed along the inner surface of the plunger only few increments can be made during a 360° rotation.
  • In U.S. Pat. No. 6,663,602 is disclosed an injection device, wherein a direct gearing, i.e. a gearing by which more transformations of rotational movement to linear movement and linear movement to rotational movement are avoided, between the injection button and the piston rod.
  • The injection device shown in U.S. Pat. No. 6,663,602 comprises a housing wherein a piston rod threaded with a first pitch is non rotatable but longitudinally displaceable guided, a nut engaging the thread of the piston rod which nut can be screwed along the threaded piston rod away from a defined position in the housing to set a dose and can be pressed back to said defined position carrying the piston rod with it when the set dose is injected, a dose setting member which can be screwed outward in the housing along a thread with a second pitch to lift an injection button with it up from the proximal end of the housing. This injection device is provided with a gearbox which provides a gearing between the axial movements of the injection button and the nut relative to the housing which gearing has a gearing ratio corresponding to the ratio of said second and first pitch.
  • Although broadly being considered state of the art, the injection device disclosed in U.S. Pat. No. 6,663,602 presents important mechanical constraints due to the construction principle of the linear gearing system which acts during dosing. According to the injection device of U.S. Pat. No. 6,663,602, the length of the nut/piston rod assembly is increased during the dose setting by rotating the nut in a thread on the piston rod. During dosing, the linear displacement of the nut and the injection button are coupled such that there is proportionality between the movement of the nut and the injection button, the proportionality given by the transmission ratio of the gear box. As the nut is rotationally confined relatively to the piston rod during dosing, the translation of the nut corresponds to the translation of the piston rod and thus ultimately to the dose of medication administered.
  • As the gear is an integrated part of the construction and as the gear can only be designed to certain transmission ratios, the gear implies important constraints on the obtainable ratio of movement of the injection button relative to the movement of the piston. Due to the direct proportionality between the movement of the piston rod and the administered dose of medication, the same syringe can not easily be adapted to different medications. Although adaptation is possible by changing the transmission ratio of the linear gear, this solution will in general be very complex and imply a complete redesign of the syringe.
  • DISCLOSURE OF THE INVENTION
  • The injection devices disclosed in U.S. Pat. No. 6,663,602 comprises dose setting and injection mechanisms wherein the nut is held rotationally fixed during dose delivery. However, according to the present invention, the nut may be rotated relative to the housing, also during dose delivery.
  • According to one aspect of the present invention, the injection device comprises:
  • a. a housing for a dose setting and injecting mechanism, the housing having a proximal end and a distal end,
  • b. a rotatable dose setting member,
  • c. an axially displaceable piston rod having a first thread and an additional longitudinally extending track,
  • d. a central opening in the housing for engaging the additional longitudinally extending track of the piston rod, thus guiding the angular movement of the piston rod during axial translation of the piston rod,
  • e. a threaded nut engaging the first thread of the piston rod, the nut being rotatably locked to the dose setting member during dose setting,
  • f. a rotational coupling mechanism having a coupling member which is axially displaceable from a first position to a second position, the rotational coupling mechanism allowing rotational movement of the nut relative to the coupling member during dose setting while preventing rotational movement during injection. The coupling member is rotationally coupled to the housing so as to be urged to rotate as a function of axial displacement of the coupling member relative to the housing during at least a part of the axial displacement from said first to said second position.
  • According to such a configuration, a prolongation or reduction of the stroke of the injection button compared to the stroke of the piston rod may be obtained. Further, as this configuration implies a change in the rate of rotation of the dose setting member for a given dose to be injected, a dose scale reading with a different layout may be obtained. In this way, a scale reading with increased distance between consecutive numbers may be obtained, which provides the possibility of increasing the font size of the labels of the scale reading. Also, this configuration provides the possibility of fine tuning the gearing ratio, if the injection device is so configured.
  • According to a second aspect of the invention, the dose setting member is axially displaceable as a result of rotation of the dose setting member relative to the housing, while the coupling member is coupled to the dose setting member such that axial displacement of the dose setting member substantially corresponds to axial displacement of the coupling member.
  • According to a third aspect of the invention, the coupling member has a thread and is threadedly engaged with a helical thread disposed in the housing, the thread of the housing having a constant pitch. According to this aspect, a particularly simple solution is obtained.
  • According to a fourth aspect of the invention, the coupling member has a thread which engage a longitudinally extending track disposed in the housing wherein the longitudinally extending track has a variable pitch along the extension of the track. According to this aspect, the rotation of the dose setting member is nonlinear with respect to the various specific dose selections. Thus, a dose setting member with a nonlinear scale is obtainable, e.g. a scale can be provided having comparable larger steps for smaller doses to be injected than for larger doses. This implies improved resolution in the low range of injectable doses. Also, an injection button can be provided having a stroke that is nonlinear with respect to the specific amount of drug to be injected, e.g. having a prolonged stroke for smaller doses compared to the solutions provided for in U.S. Pat. No. 6,663,602.
  • According to a fifth aspect of the invention, the rotational coupling mechanism comprises an incremental feedback mechanism providing incremental clicks during dose setting corresponding to dose volume. This aspect provides an easy adjustment of the rotational movement of the dose setting drum for each click, relatively to the housing part. In combination with the third aspect, an increase or a decrease of distance between the numbers on the dose setting drum or dose setting scale and thus the rotation for each click can be varied by choosing a specific pitch of the thread of the housing which engages the thread of the coupling member. By varying the inclination of the track along the extension of the track, it is possible to vary the rotation per click in a nonlinear way.
  • According to a sixth aspect of the invention, an injection button is operatively connected to a gear box assembly coupling axial movement of the injection button with axial movement of the nut. A gearing between the movements of the injection button and the nut may be obtained by the gearbox comprising at least one gear wheel carried by a connector which projects from the gear box longitudinally displaceable but non rotatable relative to said gearbox and is integral with the nut, a first rack integral with a first element of the gearbox, which element is rotational but not longitudinally displaceable relative to the housing, and second element carrying a second rack projecting from said gearbox longitudinally displaceable but non rotatable relative to said first element and being coupled to the injection button to follow longitudinal movements of said button, the at least one gear wheel engaging the first and the second rack, respectively, and being dimensioned to provide a gearing by which a longitudinal movement of the second rack is transformed to a longitudinal movement of the connector with a gearing ratio for the mentioned longitudinal movements of the second rack and the connector relative to the housing, which gearing ratio substantially corresponds to the ratio of said second to said first pitch.
  • In such a device only the forces necessary to drive the dose setting member are transformed by a thread with a high pitch whereas the forces necessary to move the piston by injection is transmitted to said piston through a conventional gear with constantly engaging gears and racks.
  • In a seventh aspect of the invention, the piston rod is provided with a stop for the movement of the nut along the thread of said piston rod, thereby forming an end-of-content stop. This way a dose setting limiter is provided in the classic way, which involves no additional members to prevent setting of a dose exceeding the amount of liquid left in the ampoule.
  • According to an eighth aspect of the invention, the additional longitudinally extending track on the piston rod is helically disposed on the external surface of the piston rod thereby forming a second thread on the piston rod. By forming this track in a helical fashion, the piston rod is rotated as a result of axial displacement of the piston rod relative to the housing. By rotating the piston rod and the coupling member a similar angle during dosing, it is possible to set smaller or bigger dose volume per click, and still have an EOC (End-Of-Content) stop between the piston rod and the nut.
  • As used herein, the term “drug delivery device” according to the instant invention shall mean a single-dose or multi-dose, disposable or re-useable device designed to dispense a selected dose of a medicinal product, preferably multiple selected doses, e.g. insulin, growth hormones, low molecular weight heparins, and their analogues and/or derivatives etc. Said device may be of any shape, e.g. compact or pen-type. Dose delivery may be provided through a mechanical (optionally manual) or electrical drive mechanism or stored energy drive mechanism, such as a spring, etc. Dose selection may be provided through a manual mechanism or electronic mechanism. Additionally, said device may contain components designed to monitor physiological properties such as blood glucose levels, etc. Furthermore, the said device may comprise a needle or may be needle-free. In particular, preferred embodiment the term drug delivery device shall mean a disposable multi-dose pen-type device having mechanical and manual dose delivery and dose selection mechanisms, which is designed for regular use by persons without formal medical training such as patients. Preferably, the drug delivery device is of the injector-type.
  • The term “housing” according to instant invention shall preferably mean an exterior housing (“main housing”, “body”, “shell”) or interior housing (“inner body”, “insert”) having internal and external threads. The housing may be designed to enable the safe, correct, and comfortable handling of the drug delivery device or any of its mechanisms. Usually, it is designed to house, fix, protect, guide, and/or engage with any of the inner components of the drug delivery device (e.g., the drive mechanism, cartridge, plunger, piston rod) by limiting the exposure to contaminants, such as liquid, dust, dirt etc. In general, the housing may be unitary or a multipart component of tubular or non-tubular shape. Usually, the exterior housing serves to house a cartridge from which a number of doses of a medicinal product may by dispensed. However, a cartridge may be directly coupled to the housing so as to be partly or fully external to the housing.
  • The term “engaged” according to instant invention shall particularly mean the interlocking of two or more components of the drive mechanism/drug delivery device, e.g. a spline or thread connection, preferably the interlocking of helical threads of components (“threadedly engaged”). The term “engaged” encompasses the use of intermediary components coupling threadedly engaged threads.
  • The term “thread” according to instant invention shall preferably mean a full or part thread, e.g., a cylindrical spiral rib/groove, usually of helical nature or comprising linear inclined parts, located on the internal and/or external surface of a component of the drug delivery device (“internal thread” and/or “external thread”), having an essentially triangular or square or rounded section designed to allow continuous free rotational and/or axial movement between components. Optionally, a thread may be further designed to prevent rotational or axial movement of certain components in one direction.
  • The term “dose setting member” according to instant invention shall mean an essentially tubular component of essentially circular cross-section having either: a) both an internal and external thread, or b) an internal thread, or c) an external thread. The dose setting member may be designed to indicate a selected dose of a dispensable product. This may be achieved by use of markings, symbols, numerals, etc., e.g. printed on the external surface of the dose setting member or an odometer, or the like. Also, a separate dose scale may be used, either comprising a mechanical or an electronic display.
  • The term “lead” according to instant invention shall preferably mean the axial distance a nut would advance in one complete revolution; preferably “lead” shall mean the axial distance through which a component having a helical thread, i.e. dose setting member, nut, piston rod, etc., of the drive mechanism travels during one rotation. Therefore lead is a function of the pitch of the thread of the relevant component.
  • The term “pitch” according to instant invention shall preferably mean the distance between consecutive contours on a helical thread, measured parallel to the axis of the helical thread.
  • The term “piston rod” according to instant invention shall mean a component adapted to operate through/within the housing, designed to translate axial movement through/within the drug delivery device, preferably from the nut to the piston, for the purpose of discharging/dispensing an injectable product. Said piston rod may be flexible or not. It may be a simple rod, a lead-screw, or the like. The “piston rod” according to instant invention shall further mean a component having a non-circular cross-section and preferably having one or more threads located partly or fully extending along its length. It may be made of any suitable material known by a person skilled in the art.
  • The term “incremental feedback mechanism” according to instant invention shall mean a mechanism providing the dose setting to occur in a number of discrete incremental steps, e.g. one incremental click for each international unit being set, the incremental feedback mechanism preferably providing a tactile or audible click which can be sensed or heard by a user operating the pen.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • In the following the invention is described in further details with references to the drawing, wherein
  • FIG. 1 schematically shows a sectional view of an injection device according to the invention, and
  • FIG. 2 shows schematically a sectional view of the gear box along the line I-I in FIG. 1,
  • FIG. 3 shows a longitudinal sectional view in the dose setting part of another embodiment of an injection device according to the invention,
  • FIG. 4 shows a longitudinal sectional view perpendicular to the view in FIG. 3,
  • FIG. 5 shows an exploded view of the of the device shown in FIGS. 3 and 4,
  • FIG. 6 a shows a large scale view of the tubular part 105 of FIG. 5 according to one embodiment of the invention, and
  • FIG. 6 b shows a large scale view of the corresponding part 105 of a prior art injection device.
  • DESCRIPTION OF EXEMPLARY EMBODIMENTS
  • The device shown in the appended drawings is shown as an injector pen, which pen has an elongated body with a central axis. However, other forms are within the scope of the invention.
  • In the device shown in FIG. 1 an elongated cylindrical housing 1 has a partitioning wall 2 which divides the housing in a compartment containing a dose setting mechanism and a compartment 3 designed for the accommodation of a not shown ampoule. The partitioning wall 2 is provided with an opening extending there through. Alternatively, the wall may be replaced by an insert which is secured against rotational and axial motion with respect to the main structure of the housing 1, the opening being formed in said insert. A piston rod 4 having a first thread 4 a and an additional longitudinally extending track 4 b formed in or on the piston rod 4, extends through the opening 2 b, which is provided with one or more ribs which mates and engages the additional longitudinal extending track 4 b.
  • In accordance with the specific design of the additional longitudinally extending track 4 b and the mating opening 2 b in partition wall 2, the piston rod 4 is rotationally guided as a function of axial displacement of the piston rod. To obtain a piston rod 4 which is longitudinally displaceable while being rotationally locked relative to the housing, the additional longitudinally extending track 4 b is formed as a rectilinear track which extends parallel to the axis of the piston rod 4. Alternatively, to obtain a piston rod 4 which is being rotated as a function of axial displacement of the piston rod 4, the additional longitudinal track 4 b is formed as a helical groove or thread which mates and engages with helical ribs or threads formed in opening 2 b in the partition wall 2.
  • In accordance with the specific design of the injection device, the first thread 4 a and the additional longitudinally extending track 4 b may be disposed on opposite ends of the piston rod 4, may be partly overlapping or fully overlapping in the axial direction of the piston rod 4. Furthermore, the thread 4 a may be disposed with a larger depth than the additional longitudinally extending track 4 b or vice versa. In FIG. 1, the threads 4 a and 4 b and the threaded opening 2 b are schematically represented.
  • Concentrically with the housing 1 the wall 2 carries on its side turning away from the compartment 3 a tubular element 5 which is at a part of it adjacent to the wall 2 provided with an outer thread 6 and which has at its free end a circumferential recess 7. A ring shaped coupling element 8 on a gear box 9 engages the recess 7. By this coupling the gearbox is fixed in the housing 1 in a way that allows the gearbox 9 to rotate in the housing but not to be axially displaced relative to said housing.
  • In the gearbox 9 a gear wheel assembly comprising two integral gear wheels is journaled on a shaft 11, which runs perpendicular to the longitudinal axis of the device between two axial connection bars 12. The connection bars 12 project from the gear box towards the partition wall 2 and are connected to a nut 13 which engages the first thread 4 a of the piston rod 4. The gear wheel assembly comprises a gear wheel 14 with a large diameter engaging the teeth of a rack 15 which is guided in the gear box to be displaced in the longitudinal direction of the device, and a gear wheel 16 with a small diameter engaging a rack 10 in FIG. 2 extending in the longitudinal direction of the device on the inner wall of the gearbox 9. The gear wheel 16 with the small diameter may be divided into two gear wheels placed on each side of the of the gear wheel 14, and the rack on the inner wall of the gearbox 9 may have a longitudinal recess without any teeth to make room for the gear wheel 14.
  • A tubular dose setting member 17 fitting into the housing 2 is at an end provided with an internal thread mating and engaging the outer thread 6 of the tubular element 5 and has at its other end a part with enlarged diameter forming a dose setting button 18. Due to the engagement with the thread 6 the dose setting member 17 may be screwed in and out of the housing to show a number on a not shown helical scale on its outer surface in a not shown window in the housing 1.
  • A bottom 19 in a deep cup shaped element, which has a tubular part 20 fitting into the dose setting member 17 and encompassing the gearbox 9, forms an injection button. Coupling means between the dose setting member 17 and the cup shaped element ensures that rotation of the dose setting member 17 is transmitted to the cup shaped element. Further the inner wall of the tubular part 20 has longitudinal recesses 22 engaged by protrusions 23 on the gearbox 9 so that rotation of the dose setting member 17 via the cup shaped element is transmitted to the gearbox 9.
  • At the edge of the open end of the cup shaped element a rosette of V-shaped teeth are provided, which teeth engage a corresponding rosette of V-shaped teeth 24 on a coupling member 25 which is pressed against the edge of the cup shaped element by a spring 26 which is compressed between a not toothed side of the coupling member 25 and a round going shoulder 27 on the inner wall of the dose setting member 17 at an inner end of the inner thread of this member. The coupling member 25 is provided with one or more inner protrusions forming a thread 28, which is engaged by a thread or track 37 on the tubular element 5 so that the coupling member 25 will be forced to rotate when it is displaced axially relative to the housing. The track 37 may be designed as a helical thread with a constant pitch along the extension of the track. Alternatively, the layout of the pitch may be formed with a variable pitch along the extension of the track, e.g. by forming a track with inclined as well non-inclined rectilinear steps, or curved parts.
  • The track 37 is so shaped that the dose setting member 17 rotates relative to the coupling member 25, when a user dials a dose by rotating the dose setting button 18. In this way a click coupling is established which makes a click noise when the V-shaped teeth at the edge of the cup shaped element by rotation of this element rides over the V-shaped teeth of the coupling member 25, i.e. an incremental feedback mechanism is provided.
  • A head 29 on the projecting end of the rack 15 is with a play fixed at the bottom of the cup shaped element between the bottom 19 forming the injection button and an inner wall 30 near this bottom. The rack is fixed in a position with its head pressed against the wall 30 by a spring 31 between the bottom 19 and the head 29.
  • To set a dose the dose setting button 18 is rotated to advance the dose-setting member 17 in the proximal direction in accordance with the thread 6. Due to the coupling 21 the cup shaped element will follow the rotation of the dose-setting member 17 and will be lifted concurrently with this member up from the end of the housing 1. During dose setting, the respective amount of axial displacement of the dose setting member 17 and the injection button 19 depends on the pitch of the thread 6, the pitch of the first thread on the piston rod 4 and the gear ratio. Also, if the piston rod 4 is allowed to move during dose setting, the axial and rotational movement of the piston rod 4 influences the amount that the injection button will be displaced. By the rotation of the cup shaped element the V-shaped teeth 24 at the edge of its open end will ride over the V-shaped teeth of the coupling member 25 to make a click sound for each unit the dose is changed. A too high set dose can be reduced by rotating the dose setting button 18 in the opposite direction of the direction for increasing the dose. When the dose setting member is screwed along the thread 6 on the tubular element 5, the coupling member 25 will follow the dose setting member in its axial movement as the spring 26 is supported on the shoulder 27. The spring will keep the V-shaped teeth of the coupling member 25 and the cup shaped element in engagement and maintain in engagement the coupling 21, which may comprise A-shaped protrusions 32 on the cup shaped element engaging Λ-shaped recesses in an inner ring 33 in the dose setting button 18.
  • Due to the axial displacement of the dose setting member 17 during dose setting, the coupling member 25 is axially displaced as well. According to the specific design of the threads or tracks 28 and 37, the coupling member 25 is forced to rotate as the coupling member 25 is axially displaced. In some embodiments, the thread 37 is formed as a helical thread which has a constant pitch along the length of the total axial distance that the coupling member is allowed to move. Depending on the direction of rotation of track 37, the dose setting button 18 has to be rotated a larger or smaller angle for each click to occur compared to a situation where the coupling member is kept rotationally fixed. A corresponding amendment of the layout of the scale reading may be provided, e.g. by forming the dose scale with larger or smaller spaces between neighboring dose values.
  • The rotation of the dose setting button 18 and the cup shaped element is further transmitted to the gearbox 9 through the protrusions 23 on this gearbox engaging the longitudinal recesses 22 in the inner wall of the tubular part 20 of said cup shaped element. The rotation of the gearbox 9 is through the connection bars 12 transmitted to the nut 13, which in this way is advanced along the first thread 4 a of the piston rod 4 and lifted away from its abutment with the wall 2 when a dose it set. As the dose is set by moving the nut 13 on the piston rod which operates the piston in the not shown ampoule in the compartment 3, a dose setting limiter, which ensures that the size of the set dose does not exceed the amount of medicament left in the ampoule, can easily be established by providing the piston rod 4 with a stop 35 which limits the movement of the nut 13 up along the piston rod 4.
  • Due to the confinement of the head 29 in the space between the bottom 19 and the wall 30 of the cup shaped element, the rack 15 is drawn with the injection button outward. Depending on the specific gear ratio of the gear assembly, the outward movement of the rack 15 corresponds to an outward movement of nut 13. As the nut 13 is rotated during dose setting, the length of the piston rod/nut assembly is prolonged, depending on the mutual pitch of the piston rod/nut threads and depending on the actual design of the additional longitudinally extending track 4 b. By varying the pitch of the different threads or the gear ratio, the piston rod is either moved distally, proximally or held stationary during dose setting.
  • Ideally, if no axial movement of the piston rod 4 is wanted during dose setting the pitch of the thread 6 and the thread formed in the piston rod 4 a as well as the pitch of the outer recess (6) should be matched exactly to the gearing ratio of the gear box depicted in FIG. 2.
  • However, tolerances in the machining of the components comprising the pen may lead to a slight unintended mismatch of the pitches relatively to the transmission ratio of the gearbox 9. Especially the situation where the piston rod 4 advances slightly during dose setting is highly undesirable as the injection device during dose setting will expel a small amount of medication.
  • This situation is avoided by mismatching one or more of the above mentioned pitches to the transmission ratio of the gearbox such that the piston rod 4 is slightly withdrawn during dose setting. The mismatch of pitches is most simply implemented by modification of the pitch of the recess 4 a made in the piston rod 4 and the corresponding thread in the nut 13. In addition, if the additional longitudinally extending track 4 b on piston rod forms a helical thread, i.e. allowing the piston rod 4 to rotate with respect to the housing (1), this threaded connection has to be taken into account when designing the mechanism.
  • Alternatively, the injection device is designed such that the recess in the piston rod is initially designed to be axially aligned with the piston rod. On assembled production prototypes the advance of the piston rod during dose setting is measured. Hereafter the axial aligned recess is redesigned to a helical recess where the superimposed rotation of the piston rod during dose setting compensates for the tolerances in the machining.
  • According to one embodiment of the invention the pitches of the threaded parts and the linear gearing are matched such that the piston rod retracts between 0% and 2% of the full linear translation relatively to the cartridge during dose setting.
  • A corresponding solution can be provided in the injection device shown in U.S. Pat. No. 6,663,602 which contains an injection device having a coupling member 25, which is kept rotationally locked with respect to the housing. For that particular injection device, a slight mismatch of either the thread 6 or the thread of piston rod 4 to the transmission ratio of the gearbox can be provided such that the piston rod 4 is slightly withdrawn during dose setting.
  • In the device according to the instant invention, to inject a set dose the injection button is pressed by pressing on the bottom 19. In the initial phase of the pressing, the spring 31 is compressed where after the pressing force is directly transmitted to the head 29 of the rack 15 and this way to the rack 15 itself. Through the gear box 9 the force is transformed and is transmitted through the connection bars 12 to the nut 13 which will press the piston rod 4 into the compartment 3 until the dose-setting member 17 abuts the wall 2.
  • During the initial phase of the movement of the injection button the Δ-shaped protrusions 32 on the cup shaped element will be drawn out of their engagement with the Λ-shaped recesses in the ring 33. The dose-setting member 17 can now rotate relative to the injection button and will do so when the Δ-shaped protrusions 32 press against a shoulder 34 at the bottom of the dose setting button 18. Only a force sufficient to make the dose setting member rotate to screw itself downward along the thread 6 is necessary as the force necessary to make the injection is transmitted to the piston rod 4 through the gearbox 9. A helical reset spring 36 concentric with the dose setting member can be mounted at the lower end of this member and can have one end anchored in the dose setting member 17 and the other end anchored in the wall 2. During setting of a dose this spring may be tighter coiled so that on the dose setting member it exerts a torque approximately corresponding to the torque necessary to overcome the friction in the movement of the dose setting member along the thread 6 that the force which the user have to exert on the injection button is only the force necessary to drive the piston rod into an ampoule to inject the set dose.
  • It shall be noticed that use of only one size gear wheel which engages as well the rack 15, which is movable relative to the gear box 9, as the rack 10, which is unmovable relative to the gear box, provides a gearing ratio of 2:1 for the longitudinal movement relative to the syringe housing 1 for the movable rack 15 and the connector 12, which carries the shaft 11 of the gear wheel.
  • FIGS. 3 and 4 shows an embodiment wherein only one size gear wheel is used and wherein elements corresponding to elements in FIGS. 1 and 2 are given the same references as these elements with a prefixed “1”.
  • For manufacturing reasons minor changes are made. So the partitioning wall 102 and the tubular element 105 are made as two parts which are by the assembling of the device connected to each other to make the assembled parts act as one integral part. The same way the dose setting member 117 and the dose setting button 118 are made as two parts, which are fixed firmly together.
  • A circumferential recess 107 is provided as an outer recess at the free end of the tubular part 105 and a ring shaped coupling element is provided as an inner bead 108 on the gearbox element 109 which bead engages the recess 107 to provide a rotatable but not axially displaceable connection between the tubular part 105 and the gearbox.
  • A tubular element 120 having ridges 122 which engages recesses 123 on the gearbox is at its upper end closed by a button 119 from which a force provided by pressing this button is transmitted to the tubular element 120.
  • The gearbox is formed by two shells, which together form a cylinder fitting into the tubular element where the shells are guided by the engagement between the ridges 122 and the recesses 123. Racks 110 and 115 are provided along edges of the shells facing each other. One shell forming the gearbox part 109 is provided with the inner bead 108, which engages the circumferential recess 107 at the end of the central tubular part 105 and carries the rack 110. The other shell is axially displaceable in the tubular element 120 and forms the rack 115. At its outer end projecting from the gearbox the shell carrying the rack 115 is provided with a flange 140 which is positioned in a cut out 141 in the end of the tubular element 120 carrying the button 119 so that this button and the tubular element 120 can be moved so far inward in the device that the engagement of the teeth 132 and 133 can be released before the button 119 abuts the flange 140.
  • A tubular connection element 112 connects the threaded piston rod 104 with the gearbox. At its end engaging the piston rod 104 the connection element has a nut 113 with an internal thread mating the external thread 104 a of the piston rod 104. At its end engaging the gear box the connection element is provided with two pins 111 projecting perpendicular to the longitudinal axis of the connection element 112 at each side of this element. Each pin 111 carries a gear wheel 114 which is placed between and engages the two racks 110 and 115. This way the connection element 112 will be rotated with the gear box but can be displaced axially relative to said gear box when the racks 110 and 115 are moved relative to each other. In practice it will be the rack 115, which is moved relative to the gearbox element 109 and the housing 1 and will by the shown construction result in a movement of the connection element 112 relative to housing a distance which is half the distance which the rack 115 is moved. A coupling member 125 which is at its periphery provided with a rosette of teeth 124 and has a central bore fitting over the central tube in the housing 101 so that this coupling member 125 can be axially displaced along said central tube 105. One or more internal protrusions 128 on the central bore of the coupling member 125 is shown in FIGS. 3 and 4. The protrusions engage mating helical recessed tracks or threads 137 (not shown in FIGS. 3 and 4) in the central tube to make the coupling member 125 confined with respect to rotational movements, that is, the coupling member 125 being angularly moved in accordance with the axial displacement of the coupling member 125 along the tracks or threads 137. Due to this rotational confinement or rotational guiding in the housing, a rosette of teeth at the edge of the tubular element 120 can click over the teeth 124 of the coupling member when said tubular element is rotated together with the dose setting member 117. A spring 126 working between the coupling member 125 and an internal shoulder 127 provided in the dose setting member 117 makes the coupling member follow the tubular element 120 when this element with the dose setting member is moved longitudinally in the housing. To make the dose setting member easy rotatable, especially when said dose setting member is pressed inward in the housing, a roller bearing having an outer ring 142 supported by the shoulder 127 and an inner ring 143 supporting a pressure bushing 144 which supports the spring 126. By the provision of this smooth running support only very small axial forces are needed to rotate the dose setting member 117 back to its zero position when a set dose is injected. This solution replaces the provision of a reset spring as the spring 36 in FIG. 1. The bearing is shown as a radial bearing but can be replaced by an axial bearing.
  • Whereas the track 137 is not shown in FIGS. 3 and 4, this track can be viewed in FIG. 5 which depicts an exploded view of the embodiment shown in FIGS. 3 and 4. The central tubular part 105 is further shown in a greater scale in FIG. 6 a while FIG. 6 b the corresponding part of prior art injection shown in U.S. Pat. No. 6,663,602.
  • Table 1 is a list showing different configurations of the above-described injection device. In table 1, configuration no. 1 corresponds to the device which is disclosed in U.S. Pat. No. 6,663,602, i.e. a device having a piston rod that is non-rotational but axially displaceable and having a track 37, 137 which is a rectilinear track which extends parallel to the axis of the injection device. Configurations no. 2-6 correspond to embodiments having the same pitch of the threads 6, 106 on the dose setting member and the first thread 4 a, 104 a on the piston rod as in configuration no. 1. In configuration no. 2-6, the track 37, 137 is formed as a helical track having a constant pitch along the extension of the track, each of the configurations corresponding to specific pitches of the track. Configurations 1-4 have a piston rod that is non-rotational but axially displaceable. Configurations no. 5 and 6 has a helical track 4 b, 104 b which mates and engages the threaded opening 2 b in the housing.
  • TABLE 1
    (Positive pitch values indicates left handed threads, negative pitch values indicates right
    handed threads, 0 (Zero) indicates a non rotational longitudinally track).
    Pitch (28, 128) on
    Pitch of dose setting coupling member Pitch of piston rod Pitch of piston rod
    member relative to relative to housing relative to nut (13, relative to housing
    housing Second pitch on 113) Second pitch (4b,
    First pitch (6, 106) on the tubular part First pitch (4a, 104a) 104b) on the piston
    Configuration the tubular part (37, 137) on the piston rod rod
    1 7.2 0 3.6 0
    2 7.2 −14.4 3.6 0
    3 7.2 −7.2 3.6 0
    4 7.2 14.4 3.6 0
    5 7.2 −7.2 3.6 −3.6
    6 7.2 −14.4 3.6 −7.2
  • TABLE 2
    Output Output
    Input Relative rotation between Delivered axial
    Rotation of the dose the dose setting member displacement
    setting member (17, and the coupling member of the
    Example 117) (25, 125) piston rod (4, 104)
    # Configuration (in degrees) (in degrees) (in mm)
    1 1 15 15 0.15
    2 2 10 15 0.15
    3 3 7.5 15 0.15
    4 3 15 30 0.3
    5 4 30 15 0.15
    6 5 7.5 15 0.075
    7 6 10 15 0.1
  • Table 2 lists examples with different dose settings for the configurations 1-6 wherein the third column of table 2 shows the angular amount that the dose setting drum 17, 117 has been dialed. Corresponding rotational movement of the dose setting drum relative to the coupling member 25, 125 is listed in column 4 and the resulting axial displacement of the piston rod is listed in column 5.
  • Comparing examples 1-3 and 5 in table 2, it becomes clear that variation of the pitch of track 37, 137 changes the amount of the rotation that the dose setting member has to be dialed in order to expel a desired dose. Thereby an easy adjustment method is provided where the amount that the dose setting member has to be rotated for advancing the dose setting button one click, can be altered. Also, this provides the possibility of changing the angular distance between consecutive numbers on the dose scale. Hence, to obtain a dose scale layout with enlarged font size or, alternatively, a decreased font size, the pitch of the track 37, 137 is chosen in accordance herewith.
  • Comparing example 3 and 6, it is readily apparent that introducing a threaded coupling between the piston rod and the housing, i.e. making the piston rod rotatable with respect to the housing, provides for the possibility of obtaining an injection device with altered dosing amounts, e.g. a half-increment injection device.
  • When introducing a coupling member 25, 125 that rotates relative to the housing, the end-of-content mechanism as described above may not work in an optimal way. However, by choosing the same pitch for the additional longitudinally extending track 4 b, 104 b on the piston rod as for the pitch of the track 37, 137 it is ensured that the end-of-content limitation that the user may experience when setting a dose for injection, corresponds to the exact amount that will be expelled during dosing. In this way, a cartridge may be fully emptied when injecting the dose which corresponds to the end-of-content setting, i.e. the situation where the piston rod 4, 104 is fully retracted relative to the nut 13, 113,
  • In further embodiments, the track 37, 137 may be designed to have a varying pitch along the track, i.e. having linear parts with inclined or non-inclined stretches as well as curved stretches. Also, the rotational direction of the track may be changed from one part of the track to another part of the track. One specific embodiment may be designed for larger relative dose button movements for small dose settings than for dose settings corresponding to large doses. Thereby it is ensured that the resolution for small dose settings is held at a comparative high level.
  • Although the above described embodiments show different specific gearbox assemblies, it is to be noted that, within the scope of the present invention, various other types of gearboxes can be used. Also, the functionality of the gearbox can be omitted while the injection device still being within the scope of the present invention.
  • In addition, alternative embodiments having a dose setting member which is kept axially fixed during dose setting/dosing will be applicable with the present invention and within the scope of the appended claims. One non-limiting embodiment comprises an additional slave member which is rotationally coupled to the dose setting member, and which can be used for inducing axial movement on the coupling member during dose setting.
  • Further, a frictional coupling may be provided instead of the above-described incremental feedback mechanism, whereby doses may be set among a continuous selection of dose amounts.
  • All references, including publications, patent applications, and patents, cited herein are hereby incorporated by reference in their entirety and to the same extent as if each reference were individually and specifically indicated to be incorporated by reference and were set forth in its entirety herein (to the maximum extent permitted by law).
  • All headings and sub-headings are used herein for convenience only and should not be construed as limiting the invention in any way.
  • The use of any and all examples, or exemplary language (e.g., “such as”) provided herein, is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention unless otherwise claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the invention. The citation and incorporation of patent documents herein is done for convenience only and does not reflect any view of the validity, patentability, and/or enforceability of such patent documents.
  • This invention includes all modifications and equivalents of the subject matter recited in the claims appended hereto as permitted by applicable law.

Claims (21)

  1. 1. An injection device comprising:
    a. a housing for a dose setting and injecting mechanism, the housing having a proximal end and a distal end,
    b. a rotatable dose setting member,
    c. an axially displaceable piston rod having a first thread and an additional longitudinally extending track,
    d. a central opening in the housing for engaging the additional longitudinally extending track of the piston rod, thus guiding the angular movement of the piston rod during axial translation of the piston rod,
    e. a threaded nut engaging the first thread of the piston rod, the nut being rotatably locked to the dose setting member during dose setting,
    f. a rotational coupling mechanism having a coupling member which is axially displaceable from a first position to a second position, the rotational coupling mechanism allowing angular movement of the nut relative to the coupling member during dose setting while preventing angular movement between the nut and the coupling member during injection, wherein the coupling member is angularly coupled to the housing so as to be forced to move angularly as a function of axial displacement of the coupling member relative to the housing during at least a part of the axial displacement from said first to said second position.
  2. 2. The injection device as defined in claim 1, wherein the dose setting member is axially displaceable as a result of rotation of the dose setting member relative to the housing, and that the coupling member is so coupled to the dose setting member that axial displacement of the dose setting member substantially corresponds to axial displacement of the coupling member.
  3. 3. The injection device as defined in claim 1, wherein the coupling member has a thread and is threadedly engaged with a helical thread disposed in the housing, the thread of the housing having a constant pitch.
  4. 4. The injection device as defined in claim 1, wherein the coupling member has a protrusion which mates and engages a longitudinally extending track disposed in the housing the longitudinally extending track having a variable pitch along the extension of the track.
  5. 5. The injection device as defined in claim 1, wherein the rotational coupling mechanism comprises an incremental feedback mechanism providing incremental clicks during dose setting corresponding to dose volume.
  6. 6. The injection device as defined in claim 1, wherein the injection device further comprises an injection button and a gear box assembly coupling axial movement of the injection button with axial movement of the nut.
  7. 7. The injection device as defined in claim 6, wherein the gear box assembly provides a gearing causing the nut to move a distance in the distal direction during injection that is less than the distance moved by the injection button.
  8. 8. The injection device as defined in claim 1, wherein the additional longitudinally extending track on the piston rod is helically disposed thereby forming a second thread on the piston rod.
  9. 9. The injection device as defined in claim 8, wherein the first thread and the longitudinally extending track on the piston rod are oppositely disposed.
  10. 10. The injection device as defined in claim 8, wherein the coupling member has a thread and is threadedly engaged with a helical thread disposed in the housing, the thread of the housing having a constant pitch substantially corresponding to the pitch of the additional longitudinally extending track on the piston rod.
  11. 11. The injection device as defined in claim 2, wherein the coupling member has a thread and is threadedly engaged with a helical thread disposed in the housing, the thread of the housing having a constant pitch.
  12. 12. The injection device as defined in claim 2, wherein the coupling member has a protrusion which mates and engages a longitudinally extending track disposed in the housing the longitudinally extending track having a variable pitch along the extension of the track.
  13. 13. The injection device as defined in claim 9, wherein the coupling member has a thread and is threadedly engaged with a helical thread disposed in the housing, the thread of the housing having a constant pitch substantially corresponding to the pitch of the additional longitudinally extending track on the piston rod.
  14. 14. The injection device as defined in claim 2, wherein the rotational coupling mechanism comprises an incremental feedback mechanism providing incremental clicks during dose setting corresponding to dose volume.
  15. 15. The injection device as defined in claim 3, wherein the rotational coupling mechanism comprises an incremental feedback mechanism providing incremental clicks during dose setting corresponding to dose volume.
  16. 16. The injection device as defined in claim 4, wherein the rotational coupling mechanism comprises an incremental feedback mechanism providing incremental clicks during dose setting corresponding to dose volume.
  17. 17. The injection device as defined in claim 2, wherein the injection device further comprises an injection button and a gear box assembly coupling axial movement of the injection button with axial movement of the nut.
  18. 18. The injection device as defined in claim 3, wherein the injection device further comprises an injection button and a gear box assembly coupling axial movement of the injection button with axial movement of the nut.
  19. 19. The injection device as defined in claim 4, wherein the injection device further comprises an injection button and a gear box assembly coupling axial movement of the injection button with axial movement of the nut.
  20. 20. The injection device as defined in claim 5, wherein the injection device further comprises an injection button and a gear box assembly coupling axial movement of the injection button with axial movement of the nut.
  21. 21. The injection device as defined in claim 6, wherein the injection device further comprises an injection button and a gear box assembly coupling axial movement of the injection button with axial movement of the nut.
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Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050209570A1 (en) * 2000-06-16 2005-09-22 Novo Nordisk A/S Injection device
US20090062748A1 (en) * 2006-03-10 2009-03-05 Novo Nordisk A/S Injection Device Having a Gearing Arrangement
US20090209920A1 (en) * 2006-05-18 2009-08-20 Novo Nordisk A/S Injection Device with Mode Locking Means
US20090254027A1 (en) * 2006-03-10 2009-10-08 Novo Nordisk A/S Injection Device and a Method of Changing a Cartridge in the Device
US20100016806A1 (en) * 2005-04-24 2010-01-21 Novo Nordisk A/S Injection Device
US20100022964A1 (en) * 2006-05-16 2010-01-28 Novo Nordisk A/S Gearing Mechanism for an Injection Device
US20100106099A1 (en) * 2006-12-21 2010-04-29 Novo Nordisk A/S Syringe Device
US20100114025A1 (en) * 2007-03-23 2010-05-06 Novo Nordisk A/S Injection device comprising a locking nut
US20100324498A1 (en) * 2006-12-15 2010-12-23 Novo Nordisk A/S Medical delivery system comprising a container and a dosing assembly with radially moving fastening means
US20120004640A1 (en) * 2008-12-09 2012-01-05 Melissa Rosen Open and closed valve medication delivery system for high pressure injections
US20130310761A1 (en) * 2010-10-06 2013-11-21 Sanofi-Aventis Deutschland Gmbh Drive Mechanism for a Drug Delivery Device and Drug Delivery Device
JP2014502890A (en) * 2010-12-23 2014-02-06 ノボ ノルディスク ヘルス ケア アーゲー The piston rod drive for the drug delivery device
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
USRE46363E1 (en) 2004-10-21 2017-04-11 Novo Nordisk A/S Dial-down mechanism for wind-up pen
US9670261B2 (en) 2012-12-21 2017-06-06 Sanofi Functionalized exendin-4 derivatives
US9694053B2 (en) 2013-12-13 2017-07-04 Sanofi Dual GLP-1/glucagon receptor agonists
US9751926B2 (en) 2013-12-13 2017-09-05 Sanofi Dual GLP-1/GIP receptor agonists
US9750788B2 (en) 2013-12-13 2017-09-05 Sanofi Non-acylated exendin-4 peptide analogues
US9758561B2 (en) 2014-04-07 2017-09-12 Sanofi Dual GLP-1/glucagon receptor agonists derived from exendin-4
US9771406B2 (en) 2014-04-07 2017-09-26 Sanofi Peptidic dual GLP-1/glucagon receptor agonists derived from exendin-4
US9775904B2 (en) 2014-04-07 2017-10-03 Sanofi Exendin-4 derivatives as peptidic dual GLP-1/glucagon receptor agonists
US9789165B2 (en) 2013-12-13 2017-10-17 Sanofi Exendin-4 peptide analogues as dual GLP-1/GIP receptor agonists
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
US9982029B2 (en) 2015-07-10 2018-05-29 Sanofi Exendin-4 derivatives as selective peptidic dual GLP-1/glucagon receptor agonists
KR101880028B1 (en) 2010-10-06 2018-07-20 사노피-아벤티스 도이칠란트 게엠베하 Drive mechanism for a drug delivery device and drug delivery device
KR101880027B1 (en) 2010-10-06 2018-07-20 사노피-아벤티스 도이칠란트 게엠베하 Drive mechanism for a drug delivery device and drug delivery device

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60323729D1 (en) 2002-02-11 2008-11-06 Antares Pharma Inc Intradermal injection device
JP5216328B2 (en) 2005-01-24 2013-06-19 アンタレス ファーマ インコーポレイテッド Pre-filled needles auxiliary syringe jet injector
DE102005023824A1 (en) * 2005-05-24 2006-12-07 Tecpharma Licensing Ag Dosing device for an injection device
WO2007131025A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Injector with adjustable dosing
WO2007131013A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Two-stage reconstituting injector
DE102006038101A1 (en) * 2006-08-14 2008-02-21 Tecpharma Licensing Ag Injection device with claws assurance
DE102007026083A1 (en) * 2007-05-25 2008-11-27 Haselmeier S.A.R.L. injection device
WO2009039851A8 (en) * 2007-09-25 2010-05-14 Moeller Claus Schmidt Dose delivery device with gearing mechanism
US8814834B2 (en) 2008-03-10 2014-08-26 Antares Pharma, Inc. Injector safety device
US9545483B2 (en) * 2008-12-02 2017-01-17 Sanofi-Aventis Deutschland Gmbh Drive assembly suitable for use in a medication delivery device and medication delivery device
EP2370135A4 (en) 2008-12-09 2014-04-30 Becton Dickinson Co Lever and gear force multiplier medication delivery system for high pressure injection system
WO2010112409A1 (en) * 2009-03-30 2010-10-07 Sanofi-Aventis Deutschland Gmbh Drug delivery device with an improved piston rod
US10034982B2 (en) * 2009-06-01 2018-07-31 Sanofi-Aventis Deutschland Gmbh Spindle for a drug delivery device
JP5756468B2 (en) * 2009-09-30 2015-07-29 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Assembly for use in a drug delivery device
CN103492004B (en) 2011-03-16 2016-11-16 贝克顿·迪金森公司 Multipurpose disposable injection pen
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US20160263329A1 (en) * 2011-12-08 2016-09-15 Unitract Syringe Pty Ltd Accurate Dose Control Mechanisms and Drug Delivery Syringes
US9486583B2 (en) 2012-03-06 2016-11-08 Antares Pharma, Inc. Prefilled syringe with breakaway force feature
EP2833944A4 (en) 2012-04-06 2016-05-25 Antares Pharma Inc Needle assisted jet injection administration of testosterone compositions
WO2013169804A1 (en) 2012-05-07 2013-11-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
WO2014124464A1 (en) 2013-02-11 2014-08-14 Travanty Michael Needle assisted jet injection device having reduced trigger force
CA2905031C (en) 2013-03-11 2018-01-23 Hans PFLAUMER Dosage injector with pinion system
EP2968784A1 (en) * 2013-03-13 2016-01-20 Sanofi-Aventis Deutschland GmbH Assembly for a drug delivery device comprising a feedback feature
JP2016531689A (en) * 2013-09-03 2016-10-13 サノフイ Drug delivery device comprising a piston rod and a piston rod for medication delivery device
WO2016083347A1 (en) * 2014-11-24 2016-06-02 Sanofi Display and drug delivery device herewith

Citations (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2392196A (en) * 1945-02-24 1946-01-01 Arthur E Smith Syringe
US3556099A (en) * 1968-05-27 1971-01-19 Johnson & Johnson Hypodermic syringe assembly
US3880162A (en) * 1973-04-25 1975-04-29 Lee G Simmons Pole-syringe for injecting from a remote distance
US4313439A (en) * 1980-03-24 1982-02-02 Biotek, Inc. Automated, spring-powered medicament infusion system
US4314556A (en) * 1980-04-21 1982-02-09 Ma Austin C Emergency syringe
US4368731A (en) * 1980-02-12 1983-01-18 Schramm Heinrich W Pistol-type syringe
USRE31315E (en) * 1979-07-02 1983-07-19 Imed Corporation Apparatus for converting a pump to a controller
US4430079A (en) * 1978-11-08 1984-02-07 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4498904A (en) * 1981-02-12 1985-02-12 Turner Robert C Dose metering plunger devices for use with syringes
US4568335A (en) * 1981-08-28 1986-02-04 Markwell Medical Institute, Inc. Device for the controlled infusion of medications
US4585439A (en) * 1983-09-07 1986-04-29 Disetronic Ag. Portable infusion unit
US4676122A (en) * 1984-06-15 1987-06-30 Daltex Medical Sciences, Inc. Fail-safe mechanical drive for syringe
US4749109A (en) * 1983-11-15 1988-06-07 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4833379A (en) * 1988-01-13 1989-05-23 Sherwood Medical Company Motor control fail-safe circuit
US4919596A (en) * 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
US4936833A (en) * 1987-06-12 1990-06-26 Hypoguard (Uk) Limited Cartridge-holder assembly for medication dispensing unit
US4988337A (en) * 1988-08-10 1991-01-29 Terumo Kabushiki Kaisha Syringe pump apparatus
US4994033A (en) * 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5000744A (en) * 1989-10-23 1991-03-19 Gte Products Corporation Hypodermic syringe
US5078698A (en) * 1991-02-19 1992-01-07 Sterling Drug Inc. Axial eject hypodermic syringe holder
US5112317A (en) * 1988-01-22 1992-05-12 Nosta Ag Injection device
US5176646A (en) * 1991-02-19 1993-01-05 Takayuki Kuroda Motorized syringe pump
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5226342A (en) * 1989-02-07 1993-07-13 Agence Spatiale Europeenne Linear or circular rachet-type locking device with automatic unlocking and self-locking
US5226895A (en) * 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
US5279585A (en) * 1992-02-04 1994-01-18 Becton, Dickinson And Company Medication delivery pen having improved dose delivery features
US5281198A (en) * 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
US5284480A (en) * 1990-11-09 1994-02-08 Medtronic, Inc. Inflation/deflation syringe with threaded plunger
US5304152A (en) * 1990-03-29 1994-04-19 Bernard Sams Dispensing device
US5314412A (en) * 1991-04-17 1994-05-24 Novo Nordisk A S Manifold for a two barrel syringe
US5318540A (en) * 1990-04-02 1994-06-07 Pharmetrix Corporation Controlled release infusion device
US5320609A (en) * 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
US5331954A (en) * 1990-12-21 1994-07-26 Novo Nordisk A/S Device for nasal delivery of liquid medications
US5383865A (en) * 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5408387A (en) * 1991-11-30 1995-04-18 Meitaku System Co., Ltd. Edge light panel and its production
US5492534A (en) * 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5496286A (en) * 1994-08-17 1996-03-05 Sterling Winthrop Hypodermic syringe holder with disposable body
US5505697A (en) * 1994-01-14 1996-04-09 Mckinnon, Jr.; Charles N. Electrically powered jet injector
US5505704A (en) * 1993-04-02 1996-04-09 Eli Lilly And Company Manifold medication injection apparatus and method
US5591136A (en) * 1991-04-15 1997-01-07 Medico Development Investment Company Injection device
US5599314A (en) * 1992-09-19 1997-02-04 Hypoguard (Uk) Limited Syringe with incrementally actuated plunger
US5611783A (en) * 1991-11-29 1997-03-18 Novo Nordisk A/S Pen-shaped syringe
US5611784A (en) * 1993-06-30 1997-03-18 Hamilton Company Manual dispensing aid for a syringe
US5626566A (en) * 1991-10-18 1997-05-06 Novo Nordisk A/S Large dose pen
US5637095A (en) * 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
US5645052A (en) * 1991-04-26 1997-07-08 The Boc Group Plc Anaesthetic vaporizer with expandable/contractable reservoir for pumping liquid anaesthetic
US5709662A (en) * 1996-08-23 1998-01-20 Becton Dickinson France, S.A. Cartridge for an injection device
US5716990A (en) * 1987-03-09 1998-02-10 Cancer Research Campaign Technology Limited Drug delivery systems
US5725080A (en) * 1995-03-24 1998-03-10 Fichtel & Sachs Ag Clutch for motor vehicles having a clutch disc with spring elements connected in series
US5728559A (en) * 1993-07-09 1998-03-17 Novo Nordisk A/S Separation of proteins
US5743889A (en) * 1992-12-18 1998-04-28 Sams; Bernard Incrementing dosage mechanism for syringe
US5755692A (en) * 1994-09-28 1998-05-26 Manicom; Anthony William Method and apparatus for administering a drug to a patient
US5782633A (en) * 1996-04-10 1998-07-21 Muehlbauer; Ernst Applicator for a dental compound
US5882718A (en) * 1994-09-20 1999-03-16 Novo Nordisk A/S Method for treating an aqueous protein solution to kill microorganisms therein without causing coagulation and composition thereof
US5898028A (en) * 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US5921966A (en) * 1997-08-11 1999-07-13 Becton Dickinson And Company Medication delivery pen having an improved clutch assembly
US6010485A (en) * 1996-09-20 2000-01-04 Novo Nordisk A/S Working cylinder
US6033377A (en) * 1997-02-04 2000-03-07 Novo Nordisk A/S Device for the administration of a liquid medicament suspension
US6033376A (en) * 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
US6036675A (en) * 1999-02-03 2000-03-14 Specialized Health Products, Inc. Safety sterile cartride unit apparatus and methods
US6048336A (en) * 1997-03-03 2000-04-11 Medico Injection device
US6074372A (en) * 1997-06-09 2000-06-13 Novo Nordisk A/S Dose setting mechanism and an injection syringe having such a dose setting mechanism
US6193698B1 (en) * 1997-07-18 2001-02-27 Disetronic Licensing Ag System for locking a dosing button in a device for the adminstration of a product to be injected
US6221053B1 (en) * 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US6221046B1 (en) * 1995-03-07 2001-04-24 Eli Lilly And Company Recyclable medication dispensing device
US6231540B1 (en) * 1997-07-14 2001-05-15 Novo Nordisk A/S Injection member
US6235004B1 (en) * 1998-01-30 2001-05-22 Novo Nordisk A/S Injection syringe
US6248090B1 (en) * 1996-02-23 2001-06-19 Novo Nordisk A/S Syringe with electronic representation of parameters
US6248095B1 (en) * 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
US20020007154A1 (en) * 2000-05-04 2002-01-17 Steffen Hansen Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
US6340357B1 (en) * 1996-07-05 2002-01-22 Novo Nordisk A/S Dose setting device
US6379339B1 (en) * 1996-09-13 2002-04-30 Nova Nordisk A/S Syringe
US20020052578A1 (en) * 2000-06-16 2002-05-02 Moller Claus Schmidt Injection device
US6383167B2 (en) * 1996-04-02 2002-05-07 Disetronic Licensing Ag Injection device
US20020077852A1 (en) * 1992-10-15 2002-06-20 The General Hospital, Massachusetts Corporation Infusion pump with an electronically loadable drug library and a user interface for loading the library
US6514230B1 (en) * 1999-10-12 2003-02-04 Novo Nordisk A/S Air shot mechanism for electronic injection devices
US20030039679A1 (en) * 1998-02-13 2003-02-27 Duirs Graham Francois Drug delivery system
US6547763B2 (en) * 2000-05-18 2003-04-15 Novo Nordisk A/S Dose display for injection device
US6547764B2 (en) * 2000-05-31 2003-04-15 Novo Nordisk A/S Double pointed injection needle
US6562011B1 (en) * 1998-07-08 2003-05-13 Novo Nordisk A/S Medication delivery device
US6569126B1 (en) * 1997-07-14 2003-05-27 Novo Nordisk A/S Cylinder ampoule
US6716198B2 (en) * 2000-05-18 2004-04-06 Novo Nordisk A/S Injection device
US6752798B2 (en) * 2000-07-28 2004-06-22 Mdc Investment Holdings, Inc. Retractable needle medical device for injecting fluid from a pre-filled cartridge
US20050004529A1 (en) * 2003-04-10 2005-01-06 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices
US20050019400A1 (en) * 2003-01-27 2005-01-27 Deveney Thomas William Controlled-release drug delivery system
US6852404B2 (en) * 2002-03-29 2005-02-08 Tdk Corporation Magnetic recording medium
US20050033244A1 (en) * 2003-03-03 2005-02-10 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices
US20050055011A1 (en) * 2001-01-05 2005-03-10 Christian Enggaard Automatic injection device with reset feature
US6893415B2 (en) * 2000-09-22 2005-05-17 Novo Nordisk A/S Medication delivery device
US6899698B2 (en) * 2000-03-24 2005-05-31 Bernard Sams One-way clutch mechanisms and injector devices
US7008399B2 (en) * 2001-02-14 2006-03-07 Novo Nordisk A/S Electronically controlled device
US7175055B2 (en) * 2002-08-29 2007-02-13 Novo Nordisk, A/S Frontloaded injection device

Family Cites Families (221)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US854399A (en) 1906-04-18 1907-05-21 Walter G Bridge Syringe.
US854390A (en) 1906-08-16 1907-05-21 Twitchell Co S Apparatus for carbonating liquids.
GB664044A (en) 1948-03-02 1951-01-02 Becton Dickinson Co Injection device
US2956563A (en) 1958-10-02 1960-10-18 Cartrix Corp Hypodermic syringe devices
US3110310A (en) 1961-07-20 1963-11-12 Ideal Instr & Mfg Co Inc Metering hypodermic syringe
US3115135A (en) 1962-03-12 1963-12-24 Stanley J Sarnoff Aspirating piston and plunger coupling
US3144178A (en) 1962-03-12 1964-08-11 Stanley J Sarnoff Cartridge holder
US3729003A (en) 1971-02-11 1973-04-24 Ampoules Inc Variable dosage ampoule applicator
US4026288A (en) 1975-10-21 1977-05-31 Insulin Injector Inc. Syringe injecting device
US4634431A (en) * 1976-11-12 1987-01-06 Whitney Douglass G Syringe injector
DE2812729A1 (en) 1978-03-23 1979-09-27 Michael Becker Injection device for injection intramuskulaeren, primarily by insulin
US4298000A (en) 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
DE2906830C2 (en) 1979-02-22 1981-07-16 B. Braun Melsungen Ag, 3508 Melsungen, De
US4277227A (en) 1979-07-02 1981-07-07 Imed Corporation Apparatus for converting a pump to a controller
US4275727B1 (en) 1980-01-07 1985-11-05
DE3048135A1 (en) 1980-12-19 1982-07-15 Imed Corp Intravenous liquid administration by pump - with external pressure sensing cartridge regulating discharge pressure
US4393723A (en) 1981-04-16 1983-07-19 Glen Brand Fluid flow meter
DE3204178C2 (en) 1982-02-06 1986-03-20 Eppendorf Geraetebau Netheler + Hinz Gmbh, 2000 Hamburg, De
US4515584A (en) 1982-07-06 1985-05-07 Fujisawa Pharmaceutical Co., Ltd. Artificial pancreas
DE3236374A1 (en) 1982-10-01 1984-04-05 Bbc Brown Boveri & Cie Security paper
US4465478A (en) 1982-10-14 1984-08-14 Collagen Corporation Syringe force amplification device
US4493704A (en) * 1982-11-29 1985-01-15 Oximetrix, Inc. Portable fluid infusion apparatus
ES277095Y (en) 1984-01-25 1985-02-16 Fernandez-Tresguerres Hernandez Jesus A. Supplier-dosing of injectable products
WO1986001728A3 (en) 1984-09-07 1986-05-09 Wolfgang Wagner Injection device with sensor
CA1254091A (en) 1984-09-28 1989-05-16 Vladimir Feingold Implantable medication infusion system
US4812724A (en) * 1984-11-13 1989-03-14 Liebel-Flarsheim Corporation Injector control
FR2583291A1 (en) 1985-06-14 1986-12-19 Hazon Bernard Device for step-by-step advance of syringe plungers by means of a double coaxial screw with control of the injection rate. Application to repetitive intradermic medicinal injections
DE3670768D1 (en) 1985-11-08 1990-06-07 Disetronic Ag Injektionsgeraet.
DE3609555A1 (en) 1986-03-21 1987-09-24 Josef Porner Blood-collecting syringe
DE3638984C2 (en) 1986-11-14 1993-11-18 Wilhelm Haselmeier Gmbh & Co, 7000 Stuttgart, De
NL8701091A (en) 1987-05-08 1988-12-01 Spruyt Hillen Bv Injection.
US4838860A (en) 1987-06-26 1989-06-13 Pump Controller Corporation Infusion pump
GB8720477D0 (en) * 1987-08-29 1987-10-07 Bick P A Resynchronisation of body clock
FR2622457A1 (en) 1987-11-03 1989-05-05 Piccinali Eric Mesotherapeutic injector with microprocessor
US4898578A (en) * 1988-01-26 1990-02-06 Baxter International Inc. Drug infusion system with calculator
US4973318A (en) 1988-02-10 1990-11-27 D.C.P. Af 1988 A/S Disposable syringe
DK166948B1 (en) 1988-02-10 1993-08-09 Dcp Af 1988 As Dosage unit for dosing a number of measured quantities of a liquid, such as insulin, from a glastubule
GB8809115D0 (en) 1988-04-18 1988-05-18 Turner R C Syringes
DE3833821A1 (en) 1988-10-05 1990-04-12 Braun Melsungen Ag injection device
US5244465A (en) 1988-10-19 1993-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Reusable injection device for distributing a preselected dose
GB2229497B (en) 1989-03-10 1992-06-03 Graseby Medical Ltd Infusion pump
DE3923079C2 (en) 1989-07-13 1991-12-19 Fresenius Ag, 6380 Bad Homburg, De
US5002537A (en) * 1989-10-23 1991-03-26 Gte Products Corporation Hypodermic syringe
US5122317A (en) 1990-01-12 1992-06-16 The Regents Of The University Of Michigan Method of superplastically deforming zirconia materials
DK17890D0 (en) 1990-01-22 1990-01-22 Novo Nordisk As Method and apparatus for mixing and injecting a medicinal product
US5064098A (en) 1990-02-23 1991-11-12 Physical Systems, Inc. Dual component dispenser gun
US5226896A (en) 1990-04-04 1993-07-13 Eli Lilly And Company Dose indicating injection pen
US5104388A (en) * 1990-05-08 1992-04-14 Fbk International Corporation Membrane splittable tubing
US5257987A (en) 1990-05-21 1993-11-02 Pharmetrix Corporation Controlled release osmotic infusion system
US5113869A (en) 1990-08-21 1992-05-19 Telectronics Pacing Systems, Inc. Implantable ambulatory electrocardiogram monitor
GB9026191D0 (en) 1990-12-01 1991-01-16 Harris Pharma Ltd Breath actuated dispensing device
US5135485A (en) 1991-02-25 1992-08-04 Louis Cohen Capacitance-type fluid level sensor for i.v. and catheter bags
DE59202070D1 (en) 1991-07-24 1995-06-08 Medico Dev Investment Co Injector.
US5163904A (en) 1991-11-12 1992-11-17 Merit Medical Systems, Inc. Syringe apparatus with attached pressure gauge
DK194291D0 (en) 1991-11-29 1991-11-29 Novo Nordisk As Micro-syringe automatic injection.
US5221268A (en) 1991-12-06 1993-06-22 Block Medical, Inc. Multiple dose control apparatus
US5246417A (en) 1991-12-11 1993-09-21 Alza Corporation Indicator for iontophoresis system
WO1993018812A1 (en) 1992-03-25 1993-09-30 Tebro S.A. Powder jet dispenser for medicament inhalation therapies
US5271527A (en) 1992-04-02 1993-12-21 Habley Medical Technology Corporation Reusable pharmaceutical dispenser with full stroke indicator
FR2697434A1 (en) 1992-11-02 1994-05-06 Godillon Jean Francois Surgical syringe plunger withdrawal attachment - has lever and transmission member which allow plunger to be withdrawn with one hand, leaving other one free
US5378233A (en) * 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
JP2530150Y2 (en) 1993-01-06 1997-03-26 城田電気炉材株式会社 The injection device of the anesthetic or the like for dental
US5383856A (en) * 1993-03-19 1995-01-24 Bersin; Robert M. Helical spiral balloon catheter
US5584815A (en) 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
US5292976A (en) * 1993-04-27 1994-03-08 Mobil Oil Corporation Process for the selective conversion of naphtha to aromatics and olefins
GB9309151D0 (en) 1993-05-04 1993-06-16 Zeneca Ltd Syringes and syringe pumps
US5957889A (en) 1993-09-27 1999-09-28 Novo Nordisk A/S Displacement system for controlled infusion of a liquid
CA2129284C (en) 1993-11-24 1999-03-09 Kenneth J. Niehoff Controlling plunger drives for fluid injection in animals
ES2176312T3 (en) 1993-12-22 2002-12-01 Continental Teves Ag & Co Ohg Device for detecting rotational or angular movements.
US5478316A (en) 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
US5562623A (en) 1994-02-14 1996-10-08 Univec Single-use syringe assembly including spring clip lock and plunger
US5536249A (en) 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
DE4414744C1 (en) 1994-04-27 1995-11-02 Eppendorf Geraetebau Netheler repeater pipette
EP0762904B1 (en) 1994-05-30 2002-10-02 B D Medico S.a.r.l. Injection device
DE4419235C2 (en) 1994-06-01 1999-03-11 Thomas Braeger Syringe with a receptacle
CA2197671A1 (en) 1994-06-15 1995-12-21 Hubert Menendez Locking device for syringe or like instrument
US5827232A (en) 1994-06-22 1998-10-27 Becton Dickinson And Company Quick connect medication delivery pen
US5725508A (en) * 1994-06-22 1998-03-10 Becton Dickinson And Company Quick connect medication delivery pen
US6110148A (en) 1994-07-22 2000-08-29 Health Hero Network, Inc. Capacitance-based dose measurements in syringes
US5720733A (en) * 1994-07-22 1998-02-24 Raya Systems, Inc. Apparatus for determining and recording injection doses in syringes using electrical capacitance measurements
US5440976A (en) 1994-08-23 1995-08-15 Fred Giuliano Adjustable dispensing stirrer for soluble sweeteners
US5549575A (en) 1994-09-13 1996-08-27 Becton Dickinson And Company Cartridge retainer assembly for medication delivery pen
GB2309644B (en) 1995-05-22 2000-05-31 Wolfgang Wagner A method and device for diagnosis and injection
US5582598A (en) 1994-09-19 1996-12-10 Becton Dickinson And Company Medication delivery pen with variable increment dose scale
DE19503230A1 (en) 1995-02-02 1996-08-08 Dietmar Dr Med Enk Syringe with a built-in damping the piston and pressure sensing device and methods for equalized and pressure-controlled injection using this syringe
GB9503969D0 (en) * 1995-02-28 1995-04-19 Sams Bernard Incrementing mechanism
US20010016571A1 (en) 1996-03-13 2001-08-23 Fujisawa Pharmaceutical Co., Ltd. N-[ (R) -1-{3- (4- piperidyl) propionyl } -3-piperidylcarbonyl] -2 (S) -acetylamino-beta -alanine as fibrinogen receptor antagonist
US5700904A (en) 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder
DE29513214U1 (en) 1995-08-21 1997-02-13 Adamaszek Franz Heinz Metering and automatic injection system
US5674204A (en) 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US5688251A (en) 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
US5989221A (en) 1995-10-20 1999-11-23 Pharmacia & Upjohn Ab Arrangement in electronically controlled injection devices
US6159161A (en) 1995-10-20 2000-12-12 Hodosh; Milton Microprocessor-controlled fluid dispensing apparatus
US5807334A (en) 1995-10-20 1998-09-15 Hodosh; Milton Fluid dispensing apparatus
FR2740345A1 (en) 1995-10-26 1997-04-30 Neftel Frederic Device for self-medication
US5741211A (en) * 1995-10-26 1998-04-21 Medtronic, Inc. System and method for continuous monitoring of diabetes-related blood constituents
US5899879A (en) 1995-12-19 1999-05-04 Genesis Medical Technologies, Inc. Spring-actuated needleless injector
US5628309A (en) 1996-01-25 1997-05-13 Raya Systems, Inc. Meter for electrically measuring and recording injection syringe doses
US5814022A (en) 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
FR2745637B1 (en) * 1996-03-04 1998-05-22 Motorola Semiconducteurs Device has semiconductor chemical sensor and a thermocouple formation method therefor device
DE69735089T2 (en) 1996-03-12 2006-08-31 Novo Nordisk A/S Injection device with electronic display of set dosages
US6086567A (en) 1996-04-02 2000-07-11 Disetronic Licensing Ag Injection device
KR20000010631A (en) 1996-04-24 2000-02-25 한센 핀 베네드, 안네 제헤르 Injection needle
DE69724784T2 (en) 1996-07-05 2004-07-15 Novo Nordisk A/S Device for the automatic insertion of a needle
WO1998001173A1 (en) 1996-07-05 1998-01-15 Novo Nordisk A/S Flexible piston rod
DE19632402C1 (en) 1996-08-02 1998-04-09 Schering Ag A process for producing a prefilled, sterile syringe
US5843036A (en) 1996-08-23 1998-12-01 Becton Dickinson And Company Non-dosing cartridge for an injection device
US6110149A (en) 1996-09-13 2000-08-29 Novo Nordisk A/S Syringe
US5947934A (en) 1996-09-13 1999-09-07 Novo Nordisk A/S Dose display for an injection syringe
US5830194A (en) 1996-09-20 1998-11-03 Azam Anwar Power syringe
US6146361A (en) 1996-09-26 2000-11-14 Becton Dickinson And Company Medication delivery pen having a 31 gauge needle
US5954689A (en) 1996-12-20 1999-09-21 Novo Nordisk A/S Jet injector
GB2321419B (en) 1997-01-27 2001-02-07 Medic Aid Ltd Atomizer
US20010020155A1 (en) 1997-03-25 2001-09-06 Soren Mikkelsen Injection system
RU2111019C1 (en) 1997-05-22 1998-05-20 Сергей Александрович Хворостов General-purpose injector
DE19723647C1 (en) * 1997-06-05 1998-12-24 Disetronic Licensing Ag Fluid dosing unit indicator for e.g. insulin or for pipetting laboratory fluids
US6003736A (en) 1997-06-09 1999-12-21 Novo Nordisk A/S Device for controlled dispensing of a dose of a liquid contained in a cartridge
US5961496A (en) 1997-06-17 1999-10-05 Novo Nordisk A/S Syringe with tiltable nut for quick piston disengagement
US6796970B1 (en) 1997-06-17 2004-09-28 Novo Nordisk A/S Dose setting device
JP2001509426A (en) 1997-07-11 2001-07-24 ノボ ノルディスク アクティーゼルスカブ Device for the display of the setting of medical devices
US6171276B1 (en) * 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
FR2767479B1 (en) 1997-08-22 1999-10-22 Aguettant Lab A drug injection
US6312413B1 (en) 1997-10-30 2001-11-06 Novo Nordisk A/S Cylinder ampoule
US5954700A (en) 1998-01-13 1999-09-21 Minimed Inc. Medication cartridge for an electronic pen-type injector, or the like, and method of making the same
US6096010A (en) 1998-02-20 2000-08-01 Becton, Dickinson And Company Repeat-dose medication delivery pen
JP3436683B2 (en) 1998-03-17 2003-08-11 株式会社日立ユニシアオートモティブ The rotation angle detection device
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
JP3017167B2 (en) 1998-05-20 2000-03-06 インターナショナル・ビジネス・マシーンズ・コーポレイション Binarizing method and apparatus for re-one de signal from de Ichita storage medium
EP1085880A2 (en) 1998-06-11 2001-03-28 Cerus Corporation Use of alkylating compounds for inhibiting proliferation of arterial smooth muscle cells
GB9812472D0 (en) 1998-06-11 1998-08-05 Owen Mumford Ltd A dose setting device for medical injectors
US6743202B2 (en) 1998-06-15 2004-06-01 Medrad, Inc. Encoding of syringe information
EP1087808B1 (en) 1998-06-15 2003-12-03 Medrad Inc. Encoding of syringe information
US5933671A (en) 1998-07-07 1999-08-03 Eastman Kodak Company Camera with touch sensitive switch
US5993423A (en) 1998-08-18 1999-11-30 Choi; Soo Bong Portable automatic syringe device and injection needle unit thereof
DE19838760A1 (en) 1998-08-26 2000-04-20 Bauer Jlona Injection unit, especially for injecting medicines such as insulin, consists of a housing with a chamber for holding a needle, a cartridge and a release mechanism.
US6605067B1 (en) 1998-11-20 2003-08-12 Novo Nordisk A/S Injection needle
DE19900792C1 (en) * 1999-01-12 2000-06-15 Disetronic Licensing Ag Injection unit forming part of e.g. pen-type self-injection syringe has continuous dosing stop in spiral form with constant pitch ensuring close fine control and accuracy in use
DE29900482U1 (en) 1999-01-14 2000-10-05 Medico Dev Investment Co injection device
JP2000237308A (en) 1999-02-22 2000-09-05 Ckd Corp Infusion pump
US6258062B1 (en) 1999-02-25 2001-07-10 Joseph M. Thielen Enclosed container power supply for a needleless injector
DE19909602A1 (en) 1999-03-05 2000-09-07 Roche Diagnostics Gmbh Device for withdrawing blood for diagnostic purposes
US6245046B1 (en) 1999-05-03 2001-06-12 University Of New Mexico Reciprocating syringes
US6277099B1 (en) 1999-08-06 2001-08-21 Becton, Dickinson And Company Medication delivery pen
US6585698B1 (en) 1999-11-01 2003-07-01 Becton, Dickinson & Company Electronic medical delivery pen having a multifunction actuator
US6673033B1 (en) * 1999-11-24 2004-01-06 Medrad, Inc. Injectors, injector systems and injector control
US6558320B1 (en) * 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US20020173752A1 (en) 2000-02-16 2002-11-21 Polzin U1F Method for reconstituting an injection liquid and an injection appliance for carrying out such a method
US6485465B2 (en) * 2000-03-29 2002-11-26 Medtronic Minimed, Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
US6558382B2 (en) 2000-04-27 2003-05-06 Medtronic, Inc. Suction stabilized epicardial ablation devices
US7080936B1 (en) 2001-06-13 2006-07-25 Simpson Frank B Wrap spring clutch syringe ram and frit mixer
JP2004503337A (en) 2000-07-14 2004-02-05 ノボ ノルディスク アクティーゼルスカブNovo Nordisk Aktie Selsxab Method for injecting a liquid medication injection device and desired dosage
CA2418941A1 (en) 2000-08-10 2003-02-10 Synthes (U.S.A.) Device for the introduction of medical items
US6994261B2 (en) * 2000-08-10 2006-02-07 Novo Nirdisk A/S Support for a cartridge for transferring an electronically readable item of information from the cartridge to an electronic circuit
JP4975208B2 (en) * 2000-10-03 2012-07-11 株式会社根本杏林堂 Automatic injection device
US7500959B2 (en) 2000-10-05 2009-03-10 Novo Nordisk A/S Medication delivery system with improved dose accuracy
US6537251B2 (en) * 2000-10-05 2003-03-25 Novo Nordisk A/S Medication delivery device with bended piston rod
WO2002055127A3 (en) 2000-11-24 2004-01-08 Ckm Diagnostics Inc Nerve stimulator output control needle with depth determination capability and method of use
GB0107607D0 (en) 2001-03-27 2001-05-16 Dca Design Int Ltd Improvements in and relating to an injection device
US6854620B2 (en) * 2001-04-13 2005-02-15 Nipro Diabetes, Systems, Inc. Drive system for an infusion pump
EP2258425B1 (en) 2001-05-16 2013-01-30 Eli Lilly and Company Medication injector apparatus
GB0113881D0 (en) 2001-06-07 2001-08-01 Innovate Biomed Ltd Foil cutting system
US6752781B2 (en) 2001-06-08 2004-06-22 Sergio Landau Durable hypodermic jet injector apparatus and method
DE10133216B4 (en) 2001-07-09 2005-01-27 Tecpharma Licensing Ag position detection
DE10163326A1 (en) 2001-07-30 2003-02-27 Disetronic Licensing Ag Administering apparatus having a metering device
DK200100240U3 (en) 2001-09-18 2001-11-23 Niels Tessing garlic Crusher
EP2319561B1 (en) 2001-12-13 2013-07-17 Panasonic Corporation Administration instrument for medical use
GB0130138D0 (en) 2001-12-18 2002-02-06 Dca Design Int Ltd Improvements in an relating to a medicament injection apparatus
DE10201875C1 (en) 2002-01-18 2003-05-22 Austriamicrosystems Ag Magnetic or electrical field sensor system has modulators with non-inverting and inverting conditions providing for different sensor configurations
US6980852B2 (en) 2002-01-25 2005-12-27 Subqiview Inc. Film barrier dressing for intravascular tissue monitoring system
US8016798B2 (en) 2003-02-24 2011-09-13 Integrated Sensing Systems, Inc. Fluid delivery system and sensing unit therefor
JP2005520646A (en) * 2002-03-18 2005-07-14 イーライ・リリー・アンド・カンパニーEli Lilly And Company Gear set with a drug dispensing device which gives a mechanical advantage
US20040010204A1 (en) * 2002-03-28 2004-01-15 Pearl Technology Holdings, Llc Electronic/fiberoptic tissue differentiation instrumentation
JP4064138B2 (en) 2002-03-28 2008-03-19 スーガン株式会社 Medical tube switchgear
DE10226643A1 (en) * 2002-06-14 2004-01-15 Disetronic Licensing Ag Pistons for injection device, product container and injection device
DE10229138B4 (en) * 2002-06-28 2008-01-31 Tecpharma Licensing Ag Produktausschüttvorrichtung with Rod Eilrücksetzung
US7328064B2 (en) 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
JP2005532129A (en) 2002-07-10 2005-10-27 ノボ・ノルデイスク・エー/エス Injector comprising a dose setting limiter
EP1536853A1 (en) 2002-07-10 2005-06-08 Novo Nordisk A/S An injection device
US6945961B2 (en) 2002-07-10 2005-09-20 Novo Nordisk A/S Injection device
EP1391794A1 (en) 2002-07-23 2004-02-25 Lifescan, Inc. Device with time indicating means
US6929619B2 (en) * 2002-08-02 2005-08-16 Liebel-Flarshiem Company Injector
DE10240166A1 (en) 2002-08-30 2004-03-18 Disetronic Licensing Ag Injection syringe for dispensing insulin to treat diabetes has piston operated by flexible belt which is moved by manually-operated wheel with teeth which cooperate with catches set to give predetermined dose
DE10240165A1 (en) 2002-08-30 2004-03-18 Disetronic Licensing Ag Dispensing unit for use in infusion pumps comprises reservoir for infusion liquid fitted with spring-loaded piston, toothed wheel cooperating with locking bar to prevent piston moving
US20040051368A1 (en) * 2002-09-17 2004-03-18 Jimmy Caputo Systems and methods for programming pumps
EP1557163A4 (en) 2002-09-26 2009-03-18 Japan Science & Tech Agency Therapeutic causing contraction of mucosal tissue, method of treating diseases relating to mucosal tissues, injector and therapeutic set
WO2004035113A3 (en) 2002-10-15 2004-06-03 Jared Alden Judson Medication dispensing apparatus with squeezable actuator
GB0304823D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304824D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0306642D0 (en) 2003-03-22 2003-04-30 Dca Design Int Ltd Improvements in and relating to an injector for a medical product
EP1608305B1 (en) 2003-03-24 2008-07-30 Novo Nordisk A/S Transparent electronic marking of a medicament container
KR20060005389A (en) 2003-04-23 2006-01-17 바소겐 아일랜드 리미티드 Dispensing systems
US7641668B2 (en) 2003-05-16 2010-01-05 Scimed Life Systems, Inc. Fluid delivery system and related methods of use
FR2857654B1 (en) 2003-07-16 2007-04-27 Prodonta Device for ejecting a liquid or pasty
CN100531813C (en) 2003-08-12 2009-08-26 伊莱利利公司 Medication dispensing apparatus with triple screw threads for mechanical advantage
US7708732B2 (en) 2003-10-16 2010-05-04 Nps Pharmaceuticals, Inc. Methods of administering therapeutic injections
DE20317377U1 (en) 2003-11-03 2005-04-21 B D Medico S A R L injection device
EP1541185A1 (en) 2003-12-08 2005-06-15 Novo Nordisk A/S Automatic syringe with priming mechanism
WO2005084732A1 (en) 2004-03-03 2005-09-15 Nemoto Kyorindo Co., Ltd. Medical solution injection system
GB0406088D0 (en) 2004-03-18 2004-04-21 Smiths Group Plc Infusion apparatus and methods
CN100581607C (en) 2004-03-30 2010-01-20 伊莱利利公司 Medication dispensing apparatus with spring drive locking member activated by feeding the final medicine formulation
CA2557897C (en) 2004-03-30 2012-08-28 Eli Lilly And Company Medication dispensing apparatus with spring-driven locking feature enabled by administration of final dose
US7448385B2 (en) 2004-06-07 2008-11-11 Purepharm Inc. Nasal adaptation of an oral inhaler device
JP4925828B2 (en) 2004-07-14 2012-05-09 株式会社根本杏林堂 Chemical liquid injection system
DE102004046003A1 (en) 2004-09-17 2006-03-30 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Pharmaceutical package, as a syringe or vial or capsule, has an integrated microchip and antenna to give a unique and tamper-proof identity
EP1645301A1 (en) 2004-10-11 2006-04-12 Novo Nordisk A/S Injection device
WO2006039930A1 (en) 2004-10-14 2006-04-20 Novo Nordisk A/S Syringe with dosis mechanism
RU2388498C2 (en) 2004-10-21 2010-05-10 Ново Нордиск А/С Device for injections furnished with torsional spring and rotary indicator
WO2006045525A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Injection device with a processor for collecting ejection information
CN100571805C (en) 2005-01-21 2009-12-23 诺和诺德公司 An automatic injection device with a top release mechanism
JP2006250582A (en) 2005-03-08 2006-09-21 Hitachi Plant Technologies Ltd Rfid tag with load sensor
WO2006114395A1 (en) 2005-04-24 2006-11-02 Novo Nordisk A/S An injection device with a gearbox
US20090043264A1 (en) * 2005-04-24 2009-02-12 Novo Nordisk A/S Injection Device
WO2006116997A1 (en) 2005-04-29 2006-11-09 Novo Nordisk A/S Handheld injection device with integrated force sensor
DK200500116U3 (en) 2005-05-23 2005-06-24 Novo Nordisk As Motorized injection device
US7327261B2 (en) * 2005-07-27 2008-02-05 Zih Corp. Visual identification tag deactivation
CA2625359A1 (en) 2005-10-11 2007-04-19 Blake Podaima Smart medical compliance method and system
JP5183499B2 (en) * 2006-03-10 2013-04-17 ノボ・ノルデイスク・エー/エス Injection device
US9008764B2 (en) 2006-03-20 2015-04-14 Novo Nordisk A/S Determination of position of injection needle
EP1999441B1 (en) 2006-03-20 2013-06-19 Novo Nordisk A/S Determination of cartridge content by capacitive means
JP5588678B2 (en) 2006-10-26 2014-09-10 マリンクロッド エルエルシー Medical fluid injector having a thermal mechanical drive unit
US20080306443A1 (en) 2007-06-06 2008-12-11 Mallinckrodt Inc. Medical Fluid Injector Having Wireless Pressure Monitoring Feature

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2392196A (en) * 1945-02-24 1946-01-01 Arthur E Smith Syringe
US3556099A (en) * 1968-05-27 1971-01-19 Johnson & Johnson Hypodermic syringe assembly
US3880162A (en) * 1973-04-25 1975-04-29 Lee G Simmons Pole-syringe for injecting from a remote distance
US4430079A (en) * 1978-11-08 1984-02-07 Minnesota Mining And Manufacturing Company Fluid dispensing device
USRE31315E (en) * 1979-07-02 1983-07-19 Imed Corporation Apparatus for converting a pump to a controller
US4368731A (en) * 1980-02-12 1983-01-18 Schramm Heinrich W Pistol-type syringe
US4313439A (en) * 1980-03-24 1982-02-02 Biotek, Inc. Automated, spring-powered medicament infusion system
US4314556A (en) * 1980-04-21 1982-02-09 Ma Austin C Emergency syringe
US4498904A (en) * 1981-02-12 1985-02-12 Turner Robert C Dose metering plunger devices for use with syringes
US4568335A (en) * 1981-08-28 1986-02-04 Markwell Medical Institute, Inc. Device for the controlled infusion of medications
US4585439A (en) * 1983-09-07 1986-04-29 Disetronic Ag. Portable infusion unit
US4749109A (en) * 1983-11-15 1988-06-07 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4676122A (en) * 1984-06-15 1987-06-30 Daltex Medical Sciences, Inc. Fail-safe mechanical drive for syringe
US5716990A (en) * 1987-03-09 1998-02-10 Cancer Research Campaign Technology Limited Drug delivery systems
US4936833A (en) * 1987-06-12 1990-06-26 Hypoguard (Uk) Limited Cartridge-holder assembly for medication dispensing unit
US4919596A (en) * 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
US4833379A (en) * 1988-01-13 1989-05-23 Sherwood Medical Company Motor control fail-safe circuit
US5112317A (en) * 1988-01-22 1992-05-12 Nosta Ag Injection device
US4988337A (en) * 1988-08-10 1991-01-29 Terumo Kabushiki Kaisha Syringe pump apparatus
US5226342A (en) * 1989-02-07 1993-07-13 Agence Spatiale Europeenne Linear or circular rachet-type locking device with automatic unlocking and self-locking
US4994033A (en) * 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5308340A (en) * 1989-06-05 1994-05-03 Eli Lilly And Company Multiple dose injection pen
US5226895A (en) * 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
US5000744A (en) * 1989-10-23 1991-03-19 Gte Products Corporation Hypodermic syringe
US5304152A (en) * 1990-03-29 1994-04-19 Bernard Sams Dispensing device
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5318540A (en) * 1990-04-02 1994-06-07 Pharmetrix Corporation Controlled release infusion device
US5492534A (en) * 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5284480A (en) * 1990-11-09 1994-02-08 Medtronic, Inc. Inflation/deflation syringe with threaded plunger
US5331954A (en) * 1990-12-21 1994-07-26 Novo Nordisk A/S Device for nasal delivery of liquid medications
US5078698A (en) * 1991-02-19 1992-01-07 Sterling Drug Inc. Axial eject hypodermic syringe holder
US5176646A (en) * 1991-02-19 1993-01-05 Takayuki Kuroda Motorized syringe pump
US5591136A (en) * 1991-04-15 1997-01-07 Medico Development Investment Company Injection device
US5314412A (en) * 1991-04-17 1994-05-24 Novo Nordisk A S Manifold for a two barrel syringe
US5645052A (en) * 1991-04-26 1997-07-08 The Boc Group Plc Anaesthetic vaporizer with expandable/contractable reservoir for pumping liquid anaesthetic
US5626566A (en) * 1991-10-18 1997-05-06 Novo Nordisk A/S Large dose pen
US5611783A (en) * 1991-11-29 1997-03-18 Novo Nordisk A/S Pen-shaped syringe
US5408387A (en) * 1991-11-30 1995-04-18 Meitaku System Co., Ltd. Edge light panel and its production
US5279585A (en) * 1992-02-04 1994-01-18 Becton, Dickinson And Company Medication delivery pen having improved dose delivery features
US5279586A (en) * 1992-02-04 1994-01-18 Becton, Dickinson And Company Reusable medication delivery pen
US5281198A (en) * 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
US5599314A (en) * 1992-09-19 1997-02-04 Hypoguard (Uk) Limited Syringe with incrementally actuated plunger
US20020077852A1 (en) * 1992-10-15 2002-06-20 The General Hospital, Massachusetts Corporation Infusion pump with an electronically loadable drug library and a user interface for loading the library
US5320609A (en) * 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
US5743889A (en) * 1992-12-18 1998-04-28 Sams; Bernard Incrementing dosage mechanism for syringe
US5383865A (en) * 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5505704A (en) * 1993-04-02 1996-04-09 Eli Lilly And Company Manifold medication injection apparatus and method
US5611784A (en) * 1993-06-30 1997-03-18 Hamilton Company Manual dispensing aid for a syringe
US5728559A (en) * 1993-07-09 1998-03-17 Novo Nordisk A/S Separation of proteins
US5505697A (en) * 1994-01-14 1996-04-09 Mckinnon, Jr.; Charles N. Electrically powered jet injector
US5496286A (en) * 1994-08-17 1996-03-05 Sterling Winthrop Hypodermic syringe holder with disposable body
US5882718A (en) * 1994-09-20 1999-03-16 Novo Nordisk A/S Method for treating an aqueous protein solution to kill microorganisms therein without causing coagulation and composition thereof
US5755692A (en) * 1994-09-28 1998-05-26 Manicom; Anthony William Method and apparatus for administering a drug to a patient
US5637095A (en) * 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
US6221046B1 (en) * 1995-03-07 2001-04-24 Eli Lilly And Company Recyclable medication dispensing device
US5725080A (en) * 1995-03-24 1998-03-10 Fichtel & Sachs Ag Clutch for motor vehicles having a clutch disc with spring elements connected in series
US6248090B1 (en) * 1996-02-23 2001-06-19 Novo Nordisk A/S Syringe with electronic representation of parameters
US6383167B2 (en) * 1996-04-02 2002-05-07 Disetronic Licensing Ag Injection device
US5782633A (en) * 1996-04-10 1998-07-21 Muehlbauer; Ernst Applicator for a dental compound
US6340357B1 (en) * 1996-07-05 2002-01-22 Novo Nordisk A/S Dose setting device
US5709662A (en) * 1996-08-23 1998-01-20 Becton Dickinson France, S.A. Cartridge for an injection device
US6379339B1 (en) * 1996-09-13 2002-04-30 Nova Nordisk A/S Syringe
US6010485A (en) * 1996-09-20 2000-01-04 Novo Nordisk A/S Working cylinder
US6033377A (en) * 1997-02-04 2000-03-07 Novo Nordisk A/S Device for the administration of a liquid medicament suspension
US6048336A (en) * 1997-03-03 2000-04-11 Medico Injection device
US5898028A (en) * 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US6074372A (en) * 1997-06-09 2000-06-13 Novo Nordisk A/S Dose setting mechanism and an injection syringe having such a dose setting mechanism
US6231540B1 (en) * 1997-07-14 2001-05-15 Novo Nordisk A/S Injection member
US6569126B1 (en) * 1997-07-14 2003-05-27 Novo Nordisk A/S Cylinder ampoule
US6193698B1 (en) * 1997-07-18 2001-02-27 Disetronic Licensing Ag System for locking a dosing button in a device for the adminstration of a product to be injected
US5921966A (en) * 1997-08-11 1999-07-13 Becton Dickinson And Company Medication delivery pen having an improved clutch assembly
US6235004B1 (en) * 1998-01-30 2001-05-22 Novo Nordisk A/S Injection syringe
US20030039679A1 (en) * 1998-02-13 2003-02-27 Duirs Graham Francois Drug delivery system
US6221053B1 (en) * 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US6248095B1 (en) * 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
US6562011B1 (en) * 1998-07-08 2003-05-13 Novo Nordisk A/S Medication delivery device
US6033376A (en) * 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
US6036675A (en) * 1999-02-03 2000-03-14 Specialized Health Products, Inc. Safety sterile cartride unit apparatus and methods
US6514230B1 (en) * 1999-10-12 2003-02-04 Novo Nordisk A/S Air shot mechanism for electronic injection devices
US6726661B2 (en) * 1999-10-12 2004-04-27 Novo Nordisk A/S Air shot mechanism for electronic injection devices
US6899698B2 (en) * 2000-03-24 2005-05-31 Bernard Sams One-way clutch mechanisms and injector devices
US20020007154A1 (en) * 2000-05-04 2002-01-17 Steffen Hansen Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
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US6716198B2 (en) * 2000-05-18 2004-04-06 Novo Nordisk A/S Injection device
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US20040059299A1 (en) * 2000-06-16 2004-03-25 Moller Claus Schmidt Injection device
US20020052578A1 (en) * 2000-06-16 2002-05-02 Moller Claus Schmidt Injection device
US6752798B2 (en) * 2000-07-28 2004-06-22 Mdc Investment Holdings, Inc. Retractable needle medical device for injecting fluid from a pre-filled cartridge
US6893415B2 (en) * 2000-09-22 2005-05-17 Novo Nordisk A/S Medication delivery device
US6899699B2 (en) * 2001-01-05 2005-05-31 Novo Nordisk A/S Automatic injection device with reset feature
US20050055011A1 (en) * 2001-01-05 2005-03-10 Christian Enggaard Automatic injection device with reset feature
US7008399B2 (en) * 2001-02-14 2006-03-07 Novo Nordisk A/S Electronically controlled device
US6852404B2 (en) * 2002-03-29 2005-02-08 Tdk Corporation Magnetic recording medium
US7175055B2 (en) * 2002-08-29 2007-02-13 Novo Nordisk, A/S Frontloaded injection device
US20050019400A1 (en) * 2003-01-27 2005-01-27 Deveney Thomas William Controlled-release drug delivery system
US20070093761A1 (en) * 2003-03-03 2007-04-26 Dca Design International Ltd. Drive mechanisms suitable for use in drug delivery devices
US20050033244A1 (en) * 2003-03-03 2005-02-10 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices
US20050004529A1 (en) * 2003-04-10 2005-01-06 Veasey Robert Frederick Drive mechanisms suitable for use in drug delivery devices

Cited By (50)

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Publication number Priority date Publication date Assignee Title
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US8900204B2 (en) 2006-05-16 2014-12-02 Novo Nordisk A/S Gearing mechanism for an injection device
US9192727B2 (en) 2006-05-18 2015-11-24 Novo Nordisk A/S Injection device with mode locking means
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US8617125B2 (en) 2006-12-15 2013-12-31 Novo Nordisk A/S Medical delivery system comprising a container and a dosing assembly with radially moving fastening means
US20100324498A1 (en) * 2006-12-15 2010-12-23 Novo Nordisk A/S Medical delivery system comprising a container and a dosing assembly with radially moving fastening means
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US20100114025A1 (en) * 2007-03-23 2010-05-06 Novo Nordisk A/S Injection device comprising a locking nut
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US20120004640A1 (en) * 2008-12-09 2012-01-05 Melissa Rosen Open and closed valve medication delivery system for high pressure injections
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EP1877121B1 (en) 2015-09-23 grant
CN101163514B (en) 2012-01-25 grant
WO2006114396A1 (en) 2006-11-02 application
US20100016806A1 (en) 2010-01-21 application
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US8197450B2 (en) 2012-06-12 grant
US8641683B2 (en) 2014-02-04 grant

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