EG24382A - Novel cyclic nucleoside phosphonate derivatives, salts thereof and process for preparation of the same - Google Patents

Novel cyclic nucleoside phosphonate derivatives, salts thereof and process for preparation of the same

Info

Publication number
EG24382A
EG24382A EG20020063A EG20020063A EG24382A EG 24382 A EG24382 A EG 24382A EG 20020063 A EG20020063 A EG 20020063A EG 20020063 A EG20020063 A EG 20020063A EG 24382 A EG24382 A EG 24382A
Authority
EG
Egypt
Prior art keywords
salts
preparation
same
novel cyclic
phosphonate derivatives
Prior art date
Application number
EG20020063A
Other languages
English (en)
Inventor
Choi Jong-Ryoo
Original Assignee
Lg Chem Investment Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chem Investment Ltd filed Critical Lg Chem Investment Ltd
Application granted granted Critical
Publication of EG24382A publication Critical patent/EG24382A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EG20020063A 2001-01-19 2002-01-19 Novel cyclic nucleoside phosphonate derivatives, salts thereof and process for preparation of the same EG24382A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20010003087 2001-01-19

Publications (1)

Publication Number Publication Date
EG24382A true EG24382A (en) 2009-04-05

Family

ID=36241797

Family Applications (1)

Application Number Title Priority Date Filing Date
EG20020063A EG24382A (en) 2001-01-19 2002-01-19 Novel cyclic nucleoside phosphonate derivatives, salts thereof and process for preparation of the same

Country Status (23)

Country Link
US (3) US7157448B2 (de)
EP (1) EP1358198B1 (de)
JP (1) JP3959348B2 (de)
KR (1) KR100441638B1 (de)
CN (1) CN100347185C (de)
AR (1) AR035933A1 (de)
AT (1) ATE478887T1 (de)
AU (1) AU2002230230B2 (de)
BR (1) BR0206165A (de)
CA (1) CA2433591C (de)
DE (1) DE60237429D1 (de)
DK (1) DK1358198T3 (de)
EG (1) EG24382A (de)
ES (1) ES2350197T3 (de)
HK (1) HK1062017A1 (de)
MX (1) MXPA03006001A (de)
MY (1) MY141789A (de)
NZ (1) NZ526632A (de)
PL (1) PL212730B1 (de)
PT (1) PT1358198E (de)
RU (1) RU2266294C2 (de)
WO (1) WO2002057288A1 (de)
ZA (1) ZA200304181B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY141789A (en) 2001-01-19 2010-06-30 Lg Chem Investment Ltd Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
CA2440809A1 (en) * 2001-03-01 2002-09-12 Conforma Therapeutics Corp. Methods for treating genetically-defined proliferative disorders with hsp90 inhibitors
EP2336133A1 (de) 2001-10-30 2011-06-22 Conforma Therapeutics Corporation Purinanaloga mit HSP90-inhibierender Wirkung
WO2004029064A1 (en) * 2002-09-26 2004-04-08 Lg Life Sciences Ltd. (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl) methyl nucleoside derivatives, process for the preparation of stereoisomers thereof, and use of antiviral agents thereof
BRPI0414533A (pt) * 2003-09-18 2006-11-07 Conforma Therapeutics Corp composto, composição farmacêutica, e, métodos para inibir um hsp90 e para tratar um indivìduo tendo um distúrbio mediado por hsp90
KR20050062940A (ko) * 2003-12-19 2005-06-28 주식회사 엘지생명과학 디이소프로필((1-((2-아미노-6-할로-9ｈ-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법
KR20050062944A (ko) * 2003-12-19 2005-06-28 주식회사 엘지생명과학 디이소프로필((1-((2-아미노-6-클로로-9ｈ-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법
TW200533358A (en) * 2004-02-17 2005-10-16 Anadys Pharmaceuticals Inc Nucleoside phosphonate derivatives useful in the treatment of hiv infections
KR101033290B1 (ko) * 2004-07-02 2011-05-09 주식회사 엘지생명과학 다이아이소프로필((1-(하이드록시메틸)-사이클로프로필)옥시)메틸포스포네이트의 새로운 제조 방법
EP1831235B1 (de) 2004-12-16 2013-02-20 The Regents of The University of California Arzneimittel für die lungen
EP1869027A4 (de) * 2005-03-30 2010-06-23 Conforma Therapeutics Corp Alkynyl-pyrrolopyrimidine und entsprechende analoga als hsp90-hemmer
WO2007100837A2 (en) * 2006-02-27 2007-09-07 Illumination Management Solutions, Inc. An improved led device for wide beam generation
US8434912B2 (en) * 2006-02-27 2013-05-07 Illumination Management Solutions, Inc. LED device for wide beam generation
GB0623493D0 (en) * 2006-11-24 2007-01-03 Univ Cardiff Chemical compounds
CL2008000070A1 (es) * 2007-01-17 2008-07-25 Lg Life Sciences Ltd Monosal del acido maleico (3-[({1-[(2-amino-9h-purin-9-il)metil]ciclopropil}oxi)metil]-8,8-dimetil-3,7-dioxo-2,4,6-trioxa-3 lambda 5-fosfanon-1-il-pivalato; composicion farmaceutica que comprende a dicha monosal; y uso para el tratamiento del virus h
EP2420239B1 (de) 2007-04-13 2015-01-14 Southern Research Institute Clomipramine als Anti-Angiogenese-Mittel
CA2684214C (en) * 2007-05-21 2012-04-17 Illumination Management Solutions, Inc. An improved led device for wide beam generation and method of making the same
MX2011001685A (es) * 2008-08-14 2011-08-17 Cooper Technologies Co Dispositivos de led para la generacion de dispersion amplia de haz.
WO2010065663A2 (en) * 2008-12-03 2010-06-10 Illumination Management Solutions, Inc. An led replacement lamp and a method of replacing preexisting luminaires with led lighting assemblies
CN102093422B (zh) 2009-12-10 2015-02-25 中国人民解放军军事医学科学院毒物药物研究所 无环核苷膦酸酯衍生物及其医药用途
CN102286026B (zh) * 2010-06-18 2014-07-02 中国人民解放军军事医学科学院毒物药物研究所 无环核苷酸类似物的盐及其晶型和药物组合物
NZ611438A (en) 2010-12-10 2015-06-26 Sigmapharm Lab Llc Highly stable compositions of orally active nucleotide analogues or orally active nucleotide analogue prodrugs
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
RS57796B1 (sr) 2013-03-15 2018-12-31 Univ California Diestri acikličnog nukleozid fosfonata
CN104119385B (zh) * 2014-07-24 2017-04-05 廖国超 核苷类似物的磷酸酯前药及其应用
SG11201701957XA (en) 2014-09-15 2017-04-27 Univ California Nucleotide analogs
CN106432330B (zh) * 2015-08-11 2019-02-01 天津科伦药物研究有限公司 Lb80380药物的中间体化合物及其制备方法和用途
EP3350191B9 (de) 2015-09-15 2021-12-22 The Regents of the University of California Nukleotidanaloga
CN107849074A (zh) * 2016-01-19 2018-03-27 四川海思科制药有限公司 一种核苷类似物的烷氧烷基酯前药及其应用
CN106977548A (zh) * 2016-01-19 2017-07-25 四川海思科制药有限公司 倍司福韦复合物及其制备方法和用途
KR102623581B1 (ko) 2016-07-18 2024-01-11 일동제약(주) 항바이러스성 약물의 오로트산염, 이의 제조 방법 및 상기 염을 포함하는 약제학적 조성물
CN108276443A (zh) * 2017-01-06 2018-07-13 米文君 一种新的化合物及其用途
KR102096144B1 (ko) * 2017-07-03 2020-04-01 주식회사 엘지화학 포스포네이트 뉴클레오사이드계 b형 간염 치료제 합성용 중간체 화합물의 연속식 제조방법
CN108997429B (zh) * 2018-07-27 2020-10-30 广州粤美医药科技有限公司 一种制备贝西福韦的方法
CN113735863A (zh) * 2021-09-29 2021-12-03 武汉九州钰民医药科技有限公司 Wee1抑制剂adavosertib的制备工艺
CN113880883A (zh) * 2021-11-11 2022-01-04 奥锐特药业股份有限公司 核苷类磷酸酯前药的制备方法
CN114560463B (zh) * 2022-03-23 2023-10-20 福州大学 一种核壳结构的氮掺杂碳壳包裹碳化钼核微米球材料的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1494321A (en) * 1974-08-08 1977-12-07 Ici Ltd Prostanoic acid derivatives
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
GB8922076D0 (en) 1989-09-28 1989-11-15 Beecham Group Plc Novel process
US5177104A (en) 1990-04-03 1993-01-05 E. R. Squibb & Sons, Inc. 6-α-hydroxy derivatives of mevinic acids
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
DK0465297T3 (da) * 1990-07-04 1996-02-19 Merrell Pharma Inc 9-Purinylphosphonsyre-derivater
DK0481214T3 (da) * 1990-09-14 1999-02-22 Acad Of Science Czech Republic Prolægemidler af phosphonater
ES2139588T3 (es) * 1991-03-05 2000-02-16 Ajinomoto Kk Derivado de ciclopropano.
US5817647A (en) * 1993-04-01 1998-10-06 Merrell Pharmaceuticals Inc. Unsaturated acetylene phosphonate derivatives of purines
ATE199906T1 (de) * 1993-06-29 2001-04-15 Mitsubishi Chem Corp Phosphonat-nukleotid ester-derivate
CA2171868A1 (en) * 1993-09-17 1995-03-23 Petr Alexander Method for dosing therapeutic compounds
WO1995022330A1 (en) 1994-02-17 1995-08-24 Commonwealth Scientific And Industrial Research Organisation Antiviral agents
IT1270008B (it) 1994-09-23 1997-04-16 Ist Superiore Sanita Derivati purinici ed 8-azapurinici atti al trattamento terapeutico dell'aids
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US5874577A (en) * 1996-04-03 1999-02-23 Medichem Research, Inc. Method for the preparing 9-12-(Diethoxyphosphonomethoxy)ethyl!adenine and analogues thereof
US5877166A (en) * 1996-04-29 1999-03-02 Sri International Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents
US5922695A (en) * 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
US5935946A (en) * 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
TR200000398T2 (tr) 1997-08-15 2000-07-21 Medivir Ab Hepatit B virüsü (HBV) retroviral ters transkriptaz ve DNA polimeraz inhibe edicilerini içeren antiviraller gibi nükleozidlerin analogları.
MY141789A (en) 2001-01-19 2010-06-30 Lg Chem Investment Ltd Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
EP1490015B1 (de) * 2002-03-15 2009-09-23 Wayne State University Neue 2-amino-9-((2-hydroxymethyl)cyclopropylidenmethyl)-purine als antivirale mittel
WO2004029064A1 (en) * 2002-09-26 2004-04-08 Lg Life Sciences Ltd. (+)-trans-isomers of (1-phosphonomethoxy-2-alkylcyclopropyl) methyl nucleoside derivatives, process for the preparation of stereoisomers thereof, and use of antiviral agents thereof

Also Published As

Publication number Publication date
MXPA03006001A (es) 2003-09-10
DK1358198T3 (da) 2010-10-04
DE60237429D1 (de) 2010-10-07
US7723319B2 (en) 2010-05-25
AR035933A1 (es) 2004-07-28
PL373670A1 (en) 2005-09-05
JP2004518675A (ja) 2004-06-24
JP3959348B2 (ja) 2007-08-15
EP1358198A4 (de) 2008-03-05
PL212730B1 (pl) 2012-11-30
AU2002230230B2 (en) 2005-05-26
BR0206165A (pt) 2004-02-03
US20040063668A1 (en) 2004-04-01
US20100004440A1 (en) 2010-01-07
MY141789A (en) 2010-06-30
ZA200304181B (en) 2004-10-06
KR100441638B1 (ko) 2004-07-23
EP1358198B1 (de) 2010-08-25
US7157448B2 (en) 2007-01-02
PT1358198E (pt) 2010-10-01
CA2433591A1 (en) 2002-07-25
CN100347185C (zh) 2007-11-07
ATE478887T1 (de) 2010-09-15
US7605147B2 (en) 2009-10-20
CA2433591C (en) 2009-07-28
US20060293284A1 (en) 2006-12-28
RU2003125372A (ru) 2005-01-20
WO2002057288A1 (en) 2002-07-25
KR20020062216A (ko) 2002-07-25
ES2350197T3 (es) 2011-01-20
RU2266294C2 (ru) 2005-12-20
NZ526632A (en) 2005-10-28
CN1487949A (zh) 2004-04-07
EP1358198A1 (de) 2003-11-05
HK1062017A1 (en) 2004-10-15

Similar Documents

Publication Publication Date Title
EG24382A (en) Novel cyclic nucleoside phosphonate derivatives, salts thereof and process for preparation of the same
AU2003233010A8 (en) Process for the preparation of 3,3,4,4-tetrafluoropyrrolidine and derivatives thereof
IL166710A0 (en) Process for the preparation of 4-ÄÄ4-ÄÄ-(2-cyanoethenyl)2,6-dimethylphenylÜaminoÜ-2-pyrimidinylÜaminoÜbenzonitrile
HUP0401083A3 (en) 4-amino-6-phenyl-pyrrolo [2,3-d] pyrimidine derivatives, pharmaceutical compositions containing them and process for the preparation of the compounds
HRP20050328A2 (en) Process for the preparation of (s,s)-cis-2-benzhyd
EP1432721A4 (de) Verfahren zur herstellung von rebeccamycin und analogen davon
GC0000391A (en) Process for the preparation of urea
HUP0202414A3 (en) Process for the preparation of perindopril, their analogous and their salts
IL143106A0 (en) Process for the preparation of acetamide derivatives
HUP0401600A3 (en) Process for the preparation of 14-hydroxymorphine derivatives
IL162385A0 (en) Process for the preparation of echinocandin derivatives
HUP0402475A3 (en) Process for the preparation of [1,4,5]-oxadiazepine derivatives
AU2003252467A1 (en) Process for preparation of 1,3-benzodioxole-2-spiro- cycloalkane derivatives
EP1176150A4 (de) Ein verfahren zur herstellung von trifluorothymidin-derivaten
IL165137A0 (en) Process for the preparation of thioalkylamine derivatives
MXPA03006606A (es) Proceso para preparacion de analogos de indeno heterociclico.
EP1554298A4 (de) Verfahren zur herstellung von 9-beta-anomeren nukleosidanaloga
HUP0401617A3 (en) Process for the preparation of (r)- or (s)-aminocarnitine inner salt, the salts and derivatives thereof
EP1295864A4 (de) Verfahren zur herstellung von 1,5-diaminonaphthalinen
IL162770A (en) Process for the preparation of 7??-methyl-estr-4-ene-3-one derivatives
EP1186612A4 (de) Verfahren zur herstellung von cytidin-derivaten
SI1406896T1 (sl) Stereoselektivna metoda za pripravo nukleozidnih analogov
NO20025385D0 (no) FremgangsmÕte for fremstilling av sulfonylbenzoylguanidiniumsalter
HUP0202011A3 (en) Novel cyclic alpha-amino-gamma-hydroxyamide derivatives, process for their preparation and pharmaceutical compositions containing them
AU2001270971A1 (en) Stable salts of s-adenosyl-l-methionine (same) and the process for their preparation