EG20539A - Process for preparing of dihydraphyridines and their use as pharmaceutical compositions in lowering blood pressure - Google Patents
Process for preparing of dihydraphyridines and their use as pharmaceutical compositions in lowering blood pressureInfo
- Publication number
- EG20539A EG20539A EG68994A EG68994A EG20539A EG 20539 A EG20539 A EG 20539A EG 68994 A EG68994 A EG 68994A EG 68994 A EG68994 A EG 68994A EG 20539 A EG20539 A EG 20539A
- Authority
- EG
- Egypt
- Prior art keywords
- hydrogen
- pct
- blood pressure
- chloro
- methyl
- Prior art date
Links
- 230000036772 blood pressure Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9303657A SE9303657D0 (sv) | 1993-11-05 | 1993-11-05 | Short-acting dihydropyridines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EG20539A true EG20539A (en) | 1999-07-31 |
Family
ID=20391655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EG68994A EG20539A (en) | 1993-11-05 | 1994-11-02 | Process for preparing of dihydraphyridines and their use as pharmaceutical compositions in lowering blood pressure |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US5856346A (https=) |
| EP (1) | EP0726894B1 (https=) |
| JP (1) | JP3712209B2 (https=) |
| KR (1) | KR100331663B1 (https=) |
| CN (1) | CN1049428C (https=) |
| AT (1) | ATE194330T1 (https=) |
| AU (1) | AU685532B2 (https=) |
| BR (1) | BR9407946A (https=) |
| CA (1) | CA2174969C (https=) |
| CZ (1) | CZ285691B6 (https=) |
| DE (1) | DE69425152T2 (https=) |
| DK (1) | DK0726894T3 (https=) |
| EE (1) | EE03230B1 (https=) |
| EG (1) | EG20539A (https=) |
| ES (1) | ES2150544T3 (https=) |
| FI (1) | FI110429B (https=) |
| FR (1) | FR12C0053I2 (https=) |
| GR (1) | GR3034469T3 (https=) |
| HU (1) | HU215591B (https=) |
| IL (1) | IL111127A (https=) |
| IS (1) | IS1674B (https=) |
| LU (1) | LU92209I2 (https=) |
| MY (1) | MY111770A (https=) |
| NO (1) | NO305656B1 (https=) |
| NZ (1) | NZ275915A (https=) |
| PL (1) | PL185099B1 (https=) |
| PT (1) | PT726894E (https=) |
| RU (1) | RU2139278C1 (https=) |
| SA (1) | SA94150250B1 (https=) |
| SE (1) | SE9303657D0 (https=) |
| SK (1) | SK281467B6 (https=) |
| TW (1) | TW279859B (https=) |
| UA (1) | UA45959C2 (https=) |
| WO (1) | WO1995012578A1 (https=) |
| ZA (1) | ZA947570B (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9804002D0 (sv) * | 1998-11-23 | 1998-11-23 | Astra Ab | New manufacturing process |
| EP1455804A4 (en) * | 2001-12-21 | 2005-01-05 | Alcon Inc | USE OF NANOTEILES AS CARRIERS OF BIOCIDES IN OPHTHALMIC COMPOSITIONS |
| FR2922439B1 (fr) * | 2007-10-18 | 2010-12-10 | Hill Rom Ind Sa | Procede de gonflage alterne d'un dispositif de support a cellules gonflables et dispositif pour sa mise en oeuvre |
| WO2010014727A1 (en) | 2008-08-01 | 2010-02-04 | The Medicines Company | Pharmaceutical compositions and methods for producing low impurity concentrations of the same |
| US20110076334A1 (en) * | 2009-09-30 | 2011-03-31 | Robert Cook | Methods and compositions for treatment of raynaud's phenomenon |
| CN101780036B (zh) * | 2010-03-30 | 2011-11-16 | 武汉武药科技有限公司 | 丁酸氯维地平脂微球注射液及其制备方法 |
| CA2701087A1 (en) * | 2010-04-12 | 2011-10-12 | Alphora Research Inc. | Preparation of clevidipine butyrate ring the same |
| EP2386544B1 (en) | 2010-05-07 | 2016-02-10 | Laboratorios Lesvi, S.L. | Preparation of dihydropyridines |
| US8455655B2 (en) | 2010-05-07 | 2013-06-04 | Laboratorios Lesvi, S.L. | Preparation of dihydropyridines |
| US8658676B2 (en) | 2010-10-12 | 2014-02-25 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
| PL2627173T5 (pl) | 2010-10-12 | 2019-11-29 | Chiesi Farm Spa | Formulacje emulsyjne klewidypiny zawierające środki przeciw mikrobom |
| CA2832066C (en) | 2011-04-01 | 2023-04-18 | The Medicines Company | Short-acting dihydropyridines (clevidipine) for use in reducing stroke damage |
| WO2013030725A1 (en) | 2011-08-26 | 2013-03-07 | Wockhardt Limited | Methods for treating cardiovascular disorders |
| CN103420899B (zh) * | 2012-05-25 | 2016-01-27 | 四川科伦药物研究有限公司 | 一种丁酸氯维地平的纯化方法 |
| KR102299073B1 (ko) | 2012-10-26 | 2021-09-09 | 치에시 파마슈티시 에스.피.아. | 심부전에서 혈압을 조절하고 호흡곤란을 감소시키는 방법 |
| CN103073485B (zh) * | 2013-01-17 | 2015-09-02 | 北京嘉林药业股份有限公司 | 一种丁酸氯维地平的制备方法 |
| CN103086956B (zh) * | 2013-01-17 | 2015-11-04 | 北京嘉林药业股份有限公司 | 一种丁酸氯维地平中间体的纯化方法 |
| CA2947486C (en) | 2014-05-19 | 2023-09-26 | The Medicines Company | Clevidipine nanoparticles and pharmaceutical compositions thereof |
| CN105367487A (zh) * | 2014-08-23 | 2016-03-02 | 南京海纳医药科技有限公司 | 一种丁酸氯维地平重要中间体新的合成方法 |
| CN104370802A (zh) * | 2014-09-24 | 2015-02-25 | 北京蓝丹医药科技有限公司 | 氯维地平衍生物及其制备方法 |
| CN107835818B (zh) | 2015-05-20 | 2022-04-29 | 勃林格殷格翰动物保健美国公司 | 驱虫缩酚酸肽化合物 |
| BR112018013369A2 (pt) | 2015-12-28 | 2019-02-19 | Merial, Inc. | compostos depsipeptídicos anti-helmínticos |
| EP3541789A1 (en) | 2016-11-16 | 2019-09-25 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| RU2755349C1 (ru) * | 2021-02-16 | 2021-09-15 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| US4154839A (en) * | 1975-11-05 | 1979-05-15 | Bayer Aktiengesellschaft | 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine |
| DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| KR940003492B1 (ko) * | 1988-10-27 | 1994-04-23 | 주식회사 유한양행 | 1,4-디하이드로피리딘유도체 및 그의 제조방법 |
| US5134139A (en) * | 1989-08-31 | 1992-07-28 | Tanabe Seiyaku Co., Ltd. | 1,5-benzothiazepine derivatives and preparation thereof |
| JPH0641075A (ja) * | 1990-09-01 | 1994-02-15 | Kazuo Achinami | 新規な１，４−ジヒドロピリジン化合物及びその製造方法 |
-
1993
- 1993-11-05 SE SE9303657A patent/SE9303657D0/xx unknown
-
1994
- 1994-09-28 ZA ZA947570A patent/ZA947570B/xx unknown
- 1994-09-29 TW TW083108995A patent/TW279859B/zh not_active IP Right Cessation
- 1994-09-30 IS IS4218A patent/IS1674B/is unknown
- 1994-10-03 IL IL11112794A patent/IL111127A/xx not_active IP Right Cessation
- 1994-10-19 SA SA94150250A patent/SA94150250B1/ar unknown
- 1994-11-02 EG EG68994A patent/EG20539A/xx active
- 1994-11-03 UA UA96041753A patent/UA45959C2/uk unknown
- 1994-11-03 HU HU9601187A patent/HU215591B/hu unknown
- 1994-11-03 DE DE69425152T patent/DE69425152T2/de not_active Expired - Lifetime
- 1994-11-03 BR BR9407946A patent/BR9407946A/pt not_active Application Discontinuation
- 1994-11-03 AU AU81196/94A patent/AU685532B2/en not_active Expired
- 1994-11-03 DK DK95900347T patent/DK0726894T3/da active
- 1994-11-03 ES ES95900347T patent/ES2150544T3/es not_active Expired - Lifetime
- 1994-11-03 EE EE9600051A patent/EE03230B1/xx unknown
- 1994-11-03 AT AT95900347T patent/ATE194330T1/de active
- 1994-11-03 CA CA002174969A patent/CA2174969C/en not_active Expired - Lifetime
- 1994-11-03 PL PL94314128A patent/PL185099B1/pl unknown
- 1994-11-03 CN CN94194500A patent/CN1049428C/zh not_active Expired - Lifetime
- 1994-11-03 JP JP51317095A patent/JP3712209B2/ja not_active Expired - Lifetime
- 1994-11-03 CZ CZ961273A patent/CZ285691B6/cs not_active IP Right Cessation
- 1994-11-03 NZ NZ275915A patent/NZ275915A/en not_active IP Right Cessation
- 1994-11-03 WO PCT/SE1994/001031 patent/WO1995012578A1/en not_active Ceased
- 1994-11-03 EP EP95900347A patent/EP0726894B1/en not_active Expired - Lifetime
- 1994-11-03 RU RU96112152A patent/RU2139278C1/ru active
- 1994-11-03 US US08/356,224 patent/US5856346A/en not_active Expired - Lifetime
- 1994-11-03 SK SK559-96A patent/SK281467B6/sk not_active IP Right Cessation
- 1994-11-03 PT PT95900347T patent/PT726894E/pt unknown
- 1994-11-03 KR KR1019960702346A patent/KR100331663B1/ko not_active Expired - Lifetime
- 1994-11-04 MY MYPI94002934A patent/MY111770A/en unknown
-
1996
- 1996-05-02 NO NO961776A patent/NO305656B1/no not_active IP Right Cessation
- 1996-05-06 FI FI961914A patent/FI110429B/fi not_active IP Right Cessation
-
2000
- 2000-09-21 GR GR20000402158T patent/GR3034469T3/el unknown
-
2012
- 2012-09-18 FR FR12C0053C patent/FR12C0053I2/fr active Active
-
2013
- 2013-06-10 LU LU92209C patent/LU92209I2/fr unknown
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