EE9800390A - Karboliini derivaadid - Google Patents

Karboliini derivaadid

Info

Publication number
EE9800390A
EE9800390A EE9800390A EE9800390A EE9800390A EE 9800390 A EE9800390 A EE 9800390A EE 9800390 A EE9800390 A EE 9800390A EE 9800390 A EE9800390 A EE 9800390A EE 9800390 A EE9800390 A EE 9800390A
Authority
EE
Estonia
Prior art keywords
carboline derivatives
carboline
derivatives
Prior art date
Application number
EE9800390A
Other languages
English (en)
Estonian (et)
Inventor
Bombrun Agnes
Original Assignee
Icos Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9609777.9A external-priority patent/GB9609777D0/en
Priority claimed from GBGB9609820.7A external-priority patent/GB9609820D0/en
Application filed by Icos Corporation filed Critical Icos Corporation
Publication of EE9800390A publication Critical patent/EE9800390A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
EE9800390A 1996-05-10 1997-05-05 Karboliini derivaadid EE9800390A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9609777.9A GB9609777D0 (en) 1996-05-10 1996-05-10 Chemical compounds
GBGB9609820.7A GB9609820D0 (en) 1996-05-10 1996-05-10 Chemical compounds
PCT/EP1997/002277 WO1997043287A1 (en) 1996-05-10 1997-05-05 Carboline derivatives

Publications (1)

Publication Number Publication Date
EE9800390A true EE9800390A (et) 1999-06-15

Family

ID=26309303

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800390A EE9800390A (et) 1996-05-10 1997-05-05 Karboliini derivaadid

Country Status (26)

Country Link
US (2) US6117881A (zh)
EP (1) EP0912567B1 (zh)
JP (1) JP3418405B2 (zh)
KR (1) KR20000010918A (zh)
CN (1) CN1067071C (zh)
AP (1) AP9801365A0 (zh)
AT (1) ATE215950T1 (zh)
AU (1) AU711885B2 (zh)
BG (1) BG102879A (zh)
BR (1) BR9709230A (zh)
CA (1) CA2253948C (zh)
CZ (1) CZ358598A3 (zh)
DE (1) DE69711882T2 (zh)
EA (1) EA199800907A1 (zh)
EE (1) EE9800390A (zh)
ES (1) ES2175404T3 (zh)
HU (1) HUP9901478A3 (zh)
IL (1) IL126951A0 (zh)
IS (1) IS4864A (zh)
NO (1) NO985222L (zh)
OA (1) OA10920A (zh)
PL (1) PL329875A1 (zh)
SK (1) SK154498A3 (zh)
TR (1) TR199802282T2 (zh)
WO (1) WO1997043287A1 (zh)
YU (1) YU49898A (zh)

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JP2002539247A (ja) 1999-03-24 2002-11-19 ハーバー ブランチ オーシャノグラフィック インスティテューション インク． マンズアミンの抗炎症作用の使用
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JP2004500425A (ja) 2000-04-19 2004-01-08 リリー　アイコス　リミテッド　ライアビリティ　カンパニー パーキンソン病の処置に対する環状ｇｍｐ特異的ホスホジエステラーゼインヒビターの使用
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AU2001263278A1 (en) 2000-06-23 2002-01-08 Lilly Icos Llc Cyclic gmp-specific phosphodiesterase inhibitors
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
EP1360185B1 (en) 2001-02-12 2005-08-24 Lilly Icos LLC Carboline derivatives
WO2002064591A2 (en) * 2001-02-12 2002-08-22 Lilly Icos Llc Carboline derivatives
CA2441792C (en) * 2001-04-25 2010-08-03 Lilly Icos Llc Carboline derivatives as inhibitors of phosphodiesterase 5 (pdes) for the treatment of cardiovascular diseases and erectile dysfunction
JP2004536816A (ja) 2001-06-05 2004-12-09 リリー アイコス リミテッド ライアビリティ カンパニー Ｐｄｅ５阻害剤としてのカルボリン誘導体
EP1397361B1 (en) * 2001-06-21 2006-08-09 Lilly Icos LLC Carboline derivatives as pdev inhibitors
EP1442042A1 (en) 2001-11-09 2004-08-04 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
US7335680B2 (en) * 2001-12-20 2008-02-26 Laboratoires Serono Sa Pyrrolidine derivatives as prostaglandin modulators
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US7595311B2 (en) 2002-05-24 2009-09-29 Exelixis, Inc. Azepinoindole derivatives as pharmaceutical agents
EP3342420A1 (en) * 2003-06-13 2018-07-04 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2004113300A1 (ja) * 2003-06-23 2004-12-29 Ono Pharmaceutical Co., Ltd. 新規三環性複素環化合物
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
EP1737461B1 (en) * 2004-03-15 2012-12-12 PTC Therapeutics, Inc. Carboline derivatives useful in the inhibition of angiogenesis
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
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EP1829874B1 (en) 2004-12-22 2014-02-12 Ono Pharmaceutical Co., Ltd. Tricyclic compound and use thereof
US8506934B2 (en) 2005-04-29 2013-08-13 Robert I. Henkin Methods for detection of biological substances
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JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
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CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
NZ568694A (en) 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions
WO2007058304A1 (ja) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. シンナミド化合物の塩またはそれらの溶媒和物
WO2007058305A1 (ja) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. シンナミド誘導体の製造方法
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NZ568050A (en) 2005-11-24 2010-09-30 Eisai R&D Man Co Ltd Morpholine type cinnamide compound
US20070117839A1 (en) * 2005-11-24 2007-05-24 Eisai R&D Management Co., Ltd. Two cyclic cinnamide compound
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
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WO2008095136A2 (en) 2007-01-31 2008-08-07 Henkin Robert I Methods for detection of biological substances
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JPWO2008140111A1 (ja) * 2007-05-16 2010-08-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 シンナミド誘導体のワンポット製造方法
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
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EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2014055801A1 (en) 2012-10-05 2014-04-10 Henkin Robert I Phosphodiesterase inhibitors for treating taste and smell disorders
CN106233141B (zh) 2014-02-18 2018-08-21 罗伯特·I·汉金 用于诊断和治疗味觉或嗅觉的损失和/或失真的方法和组合物
AU2016326718B2 (en) 2015-09-23 2022-12-15 Minerva Biotechnologies Corporation Method of screening for agents for differentiating stem cells

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Also Published As

Publication number Publication date
ES2175404T3 (es) 2002-11-16
IS4864A (is) 1998-10-13
YU49898A (sh) 2000-03-21
NO985222L (no) 1999-01-11
PL329875A1 (en) 1999-04-12
US6117881A (en) 2000-09-12
BR9709230A (pt) 1999-08-10
CA2253948A1 (en) 1997-11-20
JP3418405B2 (ja) 2003-06-23
KR20000010918A (ko) 2000-02-25
NO985222D0 (no) 1998-11-09
WO1997043287A1 (en) 1997-11-20
EP0912567A1 (en) 1999-05-06
OA10920A (en) 2003-02-21
HUP9901478A2 (hu) 1999-08-30
SK154498A3 (en) 2000-01-18
CA2253948C (en) 2005-07-26
CN1067071C (zh) 2001-06-13
US6306870B1 (en) 2001-10-23
DE69711882D1 (en) 2002-05-16
IL126951A0 (en) 1999-09-22
EP0912567B1 (en) 2002-04-10
EA199800907A1 (ru) 1999-04-29
JP2000513717A (ja) 2000-10-17
AU2891097A (en) 1997-12-05
CZ358598A3 (cs) 1999-03-17
DE69711882T2 (de) 2002-10-31
TR199802282T2 (xx) 1999-03-22
AU711885B2 (en) 1999-10-21
ATE215950T1 (de) 2002-04-15
AP9801365A0 (en) 1998-12-31
HUP9901478A3 (en) 1999-11-29
BG102879A (en) 1999-09-30
CN1218471A (zh) 1999-06-02

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