EE05548B1 - Kasvaja nekroosifaktori sarnase apoptoosi indutseeriva ligandi retseptori suhtes selektiivne antikeha ja selle kasutamine - Google Patents

Kasvaja nekroosifaktori sarnase apoptoosi indutseeriva ligandi retseptori suhtes selektiivne antikeha ja selle kasutamine

Info

Publication number
EE05548B1
EE05548B1 EEP200200621A EEP200200621A EE05548B1 EE 05548 B1 EE05548 B1 EE 05548B1 EE P200200621 A EEP200200621 A EE P200200621A EE P200200621 A EEP200200621 A EE P200200621A EE 05548 B1 EE05548 B1 EE 05548B1
Authority
EE
Estonia
Prior art keywords
apoptosis
necrosis factor
tumor necrosis
ligand receptor
inducing ligand
Prior art date
Application number
EEP200200621A
Other languages
English (en)
Estonian (et)
Inventor
Zhou Tong
Ichikawa Kimihisa
P. Kimberly Robert
J. Koopman William
Original Assignee
Uab Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Research Foundation filed Critical Uab Research Foundation
Publication of EE200200621A publication Critical patent/EE200200621A/xx
Publication of EE05548B1 publication Critical patent/EE05548B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
EEP200200621A 2000-05-02 2001-05-02 Kasvaja nekroosifaktori sarnase apoptoosi indutseeriva ligandi retseptori suhtes selektiivne antikeha ja selle kasutamine EE05548B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20134400P 2000-05-02 2000-05-02
PCT/US2001/014151 WO2001083560A1 (fr) 2000-05-02 2001-05-02 Un anticorps selectif pour un recepteur de ligand induisant l'apoptose en relation avec le facteur de necrose tumorale et ses utilisations

Publications (2)

Publication Number Publication Date
EE200200621A EE200200621A (et) 2004-06-15
EE05548B1 true EE05548B1 (et) 2012-06-15

Family

ID=22745456

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200621A EE05548B1 (et) 2000-05-02 2001-05-02 Kasvaja nekroosifaktori sarnase apoptoosi indutseeriva ligandi retseptori suhtes selektiivne antikeha ja selle kasutamine

Country Status (28)

Country Link
US (6) US7244429B2 (fr)
EP (4) EP2065401B1 (fr)
JP (4) JP4156238B2 (fr)
KR (2) KR20060092292A (fr)
CN (2) CN100497388C (fr)
AT (1) ATE426615T1 (fr)
AU (2) AU2001259366B2 (fr)
BG (3) BG109275A (fr)
BR (1) BR0110547A (fr)
CA (1) CA2407965C (fr)
CY (1) CY1109179T1 (fr)
CZ (2) CZ304614B6 (fr)
DE (1) DE60138097D1 (fr)
DK (1) DK1287035T3 (fr)
EE (1) EE05548B1 (fr)
ES (1) ES2323448T3 (fr)
HK (3) HK1050372A1 (fr)
HU (2) HU230399B1 (fr)
IL (1) IL152605A0 (fr)
MX (1) MXPA02010823A (fr)
NO (2) NO329843B1 (fr)
NZ (1) NZ522881A (fr)
PL (1) PL211733B1 (fr)
PT (1) PT1287035E (fr)
RU (1) RU2298013C2 (fr)
TW (1) TWI318983B (fr)
WO (1) WO2001083560A1 (fr)
ZA (1) ZA200209230B (fr)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7528239B1 (en) 1997-02-13 2009-05-05 Immunex Corporation Receptor that binds trail
US6872568B1 (en) 1997-03-17 2005-03-29 Human Genome Sciences, Inc. Death domain containing receptor 5 antibodies
NZ337795A (en) 1997-03-17 2001-06-29 Human Genome Sciences Inc Death domain containing receptor 5 and it's use in the treatment of DR5 related disease
JP2002543151A (ja) * 1999-05-04 2002-12-17 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド 死ドメイン含有レセプター５
US7279160B2 (en) 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
US7476383B2 (en) 2000-05-02 2009-01-13 The Uab Research Foundation Antibody selective for DR4 and uses thereof
US20060062786A1 (en) * 2000-11-08 2006-03-23 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US20030228309A1 (en) * 2000-11-08 2003-12-11 Theodora Salcedo Antibodies that immunospecifically bind to TRAIL receptors
US8071740B2 (en) * 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
AU2003222427B8 (en) 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
CA2447602C (fr) * 2001-05-18 2011-11-01 Kirin Beer Kabushiki Kaisha Anticorps anti-trail-r
US7361341B2 (en) * 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
US7064189B2 (en) 2001-05-25 2006-06-20 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
US20050214209A1 (en) * 2001-05-25 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US20090226429A1 (en) * 2001-05-25 2009-09-10 Human Genome Sciences, Inc. Antibodies That Immunospecifically Bind to TRAIL Receptors
US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US20050129616A1 (en) * 2001-05-25 2005-06-16 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
EP1436313B1 (fr) 2001-10-19 2010-09-22 Vascular Biogenics Ltd. Constructions de polynucleotides, compositions pharmaceutiques et procedes de regulation negative de l'angiogenese et de therapie anticancereuse
IL161686A0 (en) * 2001-11-01 2004-09-27 Uab Research Foundation Combinations of antibodies selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and other therapeutic agents
ES2357225T3 (es) * 2001-11-01 2011-04-20 Uab Research Foundation Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos.
NZ532881A (en) * 2001-12-20 2008-04-30 Human Genome Sciences Inc Antibodies that immunospecifically bind to trail receptors
EP2075256A2 (fr) 2002-01-14 2009-07-01 William Herman Ligands ciblés
DE10210427A1 (de) * 2002-03-09 2003-10-09 Hans Konrad Mueller-Hermelink Humaner monoklonaler Antikörper
EP1521776A2 (fr) 2002-07-04 2005-04-13 Oncomab Gmbh Anticorps specifiques de neoplasme et utilisations associees
DE60334247D1 (de) 2002-11-27 2010-10-28 Irm Llc Verfahren und zusammensetzungen zur apoptoseinduktion in krebszellen
AU2008201431B2 (en) * 2002-11-27 2011-11-24 Irm, Llc Methods and compositions for inducing Apoptosis in cancer cells
DE10311248A1 (de) 2003-03-14 2004-09-30 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper
DE10353175A1 (de) 2003-11-14 2005-06-16 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper mit fettsenkender Wirkung
EP1531162A1 (fr) 2003-11-14 2005-05-18 Heinz Vollmers Anticorps SAM-6, spécifique d'adénocarcinome, et ses utilisations
AU2005227322A1 (en) 2004-03-23 2005-10-06 Biogen Idec Ma Inc. Receptor coupling agents and therapeutic uses thereof
CN100427505C (zh) * 2004-08-19 2008-10-22 中国医学科学院基础医学研究所 抗人肿瘤坏死因子相关凋亡诱导配体的受体dr5单克隆抗体（ad5-10）及其制法与用途
ZA200704473B (en) * 2004-12-13 2008-09-25 Evogenix Ltd Osteoprotegerin variant proteins
JP5562521B2 (ja) 2005-02-02 2014-07-30 ザ ユーエービー リサーチ ファンデーション アポトーシス誘導デスレセプターアゴニストに対する抵抗性を低減することに関する薬剤及び方法
US8029783B2 (en) * 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
JP5004154B2 (ja) * 2005-04-06 2012-08-22 一般財団法人化学及血清療法研究所 組換え抗ボツリヌス神経毒素抗体
US8901281B2 (en) 2005-06-17 2014-12-02 Merck Sharp & Dohme Corp. ILT3 binding molecules and uses therefor
PE20071101A1 (es) * 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
UA97096C2 (ru) * 2005-08-31 2012-01-10 Емджен Інк. Выделенное антитело, которое специфически связывает рецептор-2 trail (tr-2)
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
CN101605887B (zh) 2006-05-16 2012-09-05 协和发酵麒麟株式会社 蛋白的高分泌生产方法
EP2041180B8 (fr) * 2006-06-19 2014-03-05 Liquidating Trust Molécules se liant à l'ilt3 et leurs utilisations
KR100847010B1 (ko) * 2006-07-05 2008-07-17 아주대학교산학협력단 세포사멸 수용체 5 (ｄｒ5)에 특이적으로 결합하는 항체 및이를 포함하는 암 예방 또는 치료용 조성물
KR100804126B1 (ko) 2007-02-09 2008-02-19 아주대학교산학협력단 종양 괴사 인자―관련 세포사멸―유도 리간드의 수용체에특이적으로 결합하는 1가의 인간 단일클론 항체 및 그의항원결합 단편
WO2008154439A1 (fr) * 2007-06-08 2008-12-18 Irm Llc Procédés et compositions pour induire une apoptose dans des cellules cancéreuses
CA2695991A1 (fr) * 2007-08-09 2009-02-12 Daiichi Sankyo Company, Limited Immunoliposome induisant l'apoptose dans une cellule exprimant un recepteur comportant le domaine apoptotique
ES2537806T5 (es) 2007-10-31 2018-10-09 Daiichi Sankyo Company, Limited Método para la secreción y producción de alto nivel de proteína
WO2010047509A2 (fr) * 2008-10-24 2010-04-29 아주대학교 산학협력단 Anticorps dirigé contre le dr5 présentant une meilleure affinité et une meilleure stabilité, et composition destinée a prévenir ou traiter le cancer et contenant cet anticorps
US20110070248A1 (en) * 2009-09-24 2011-03-24 Seattle Genetics, Inc. Dr5 ligand drug conjugates
JP5746191B2 (ja) * 2009-10-19 2015-07-08 ハナル バイオファーマ カンパニーリミテッドＨａｎＡｌｌ Ｂｉｏｐｈａｒｍａ Ｃｏ．， Ｌｔｄ． 修飾されたヒト腫瘍壊死因子受容体−１ポリペプチドまたはその断片及びその製造方法
CN102666588A (zh) 2009-11-05 2012-09-12 Uab研究基金会 治疗基底细胞样基因型癌症
WO2011084623A1 (fr) 2009-12-16 2011-07-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Procédé de sensibilisation de cellules cancéreuses aux effets cytotoxiques de ligands des récepteurs de mort dans le traitement du cancer
US9120855B2 (en) 2010-02-10 2015-09-01 Novartis Ag Biologic compounds directed against death receptor 5
SG10201501095WA (en) 2010-02-12 2015-04-29 Pharmascience Inc Iap bir domain binding compounds
US8703712B2 (en) 2010-03-18 2014-04-22 The Uab Research Foundation Targeting cancer stem cells with DR5 agonists
SI2636736T1 (sl) * 2010-10-29 2016-09-30 Daiichi Sankyo Company, Limited Novo anti-dr5 protitelesce
WO2012123755A1 (fr) 2011-03-17 2012-09-20 The University Of Birmingham Immunothérapie redirigée
MX2013012716A (es) * 2011-05-03 2014-03-21 Genentech Inc Agentes de disociacion vascular y sus usos.
ES2723885T3 (es) 2012-07-19 2019-09-03 Daiichi Sankyo Co Ltd Anticuerpos anti-Siglec-15
SG11201500489YA (en) * 2012-07-25 2015-02-27 Kolltan Pharmaceuticals Inc Anti-kit antibodies and uses thereof
CN103074425B (zh) * 2012-12-29 2014-01-01 深圳市第三人民医院 Cd263基因的用途
WO2015051159A1 (fr) * 2013-10-02 2015-04-09 The Rockefeller University Anticorps de protofibrilles amyloïdes et leurs procédés d'utilisation
CN104710533A (zh) * 2013-12-12 2015-06-17 中国科学院深圳先进技术研究院 sDR5-Fc融合蛋白及其用途
DK3247728T3 (da) 2015-01-20 2020-07-13 Igm Biosciences Inc Tumornekrosefaktor-(tnf)-superfamiliereceptorbindende molekyler og anvendelser deraf
JP6602875B2 (ja) 2015-01-26 2019-11-06 マクロジェニクス，インコーポレーテッド Ｄｒ５結合ドメインを含む多価分子
CN105061604B (zh) * 2015-08-19 2018-03-16 河南大学 sDR5‑Fc融合蛋白突变体及其应用
WO2017075484A2 (fr) 2015-10-30 2017-05-04 Galaxy Biotech, Llc Anticorps hautement puissants se liant au récepteur de mort 4 et au récepteur de mort 5
CN106924735A (zh) * 2015-12-29 2017-07-07 上海交通大学医学院附属瑞金医院 多巴胺1类受体激动剂在制备肿瘤治疗药物中的用途
US10849912B2 (en) 2016-02-09 2020-12-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method of sensitizing cancer cells to the cytotoxic effects of apoptosis inducing ligands in cancer treatment
SG11201807437XA (en) 2016-03-01 2018-09-27 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Antibodies specific to human poliovirus receptor (pvr)
KR101926166B1 (ko) * 2016-05-24 2018-12-06 재단법인 아산사회복지재단 수용체 시너지 활성을 이용한 nk 세포의 활성도 검사 방법 및 이를 이용한 nk 세포의 활성도가 관련된 질환의 진단 방법
EP3574017A1 (fr) 2017-01-27 2019-12-04 Kymab Limited Anticorps anti-opg
KR101926834B1 (ko) 2017-03-21 2018-12-07 동아에스티 주식회사 항-dr5 항체 및 그의 용도
CN111328335A (zh) 2017-06-07 2020-06-23 根马布私人有限公司 基于突变igg六聚体的治疗性抗体
KR101951025B1 (ko) 2017-08-17 2019-02-21 서울대학교산학협력단 세포사멸 수용체 저해제를 유효성분으로 포함하는 cx3cl1 케모카인 과발현으로 인한 질환 예방 또는 치료용 조성물
AU2018338205A1 (en) * 2017-09-22 2020-05-07 Immunogen, Inc. Separation of triple-light chain antibodies using cation exchange chromatography
WO2019100194A1 (fr) * 2017-11-21 2019-05-31 深圳先进技术研究院 Anticorps anti-dr5, son procédé de préparation et son utilisation
WO2019100193A1 (fr) * 2017-11-21 2019-05-31 深圳先进技术研究院 Anticorps anti-dr5, son procédé de préparation et son utilisation
CN108251443A (zh) * 2018-01-23 2018-07-06 深圳市人民医院 一种tnfrsf10c重组质粒、制备方法及其应用
US12018045B2 (en) 2018-03-06 2024-06-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 17-beta-hydroxywithanolides and use thereof in treating cancer
CN117126279A (zh) 2018-03-20 2023-11-28 鸿运华宁（杭州）生物医药有限公司 Gipr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用
CA3120800A1 (fr) 2018-12-17 2020-06-25 Revitope Limited Recruteur de cellules immunitaires jumelles
WO2022154664A1 (fr) 2021-01-15 2022-07-21 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Inducteurs de sénescence, en combinaison avec un agoniste du récepteur 5 de mort (dr5) sélectif, destinés à être utilisés dans une méthode de traitement du cancer

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US6812327B1 (en) 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
US6433147B1 (en) * 1997-01-28 2002-08-13 Human Genome Sciences, Inc. Death domain containing receptor-4
DE69837806T3 (de) * 1997-01-28 2012-01-05 Human Genome Sciences, Inc. "death-domain"-enthaltender rezeptor 4 (dr4), ein mitglied der tnf-rezeptor superfamilie, welcher an trail (apo-2l) bindet
US6072047A (en) * 1997-02-13 2000-06-06 Immunex Corporation Receptor that binds trail
US6313269B1 (en) * 1997-03-14 2001-11-06 Smithkline Beecham Corporation Tumor necrosis factor related receptor, TR6
US6872568B1 (en) * 1997-03-17 2005-03-29 Human Genome Sciences, Inc. Death domain containing receptor 5 antibodies
NZ337795A (en) * 1997-03-17 2001-06-29 Human Genome Sciences Inc Death domain containing receptor 5 and it's use in the treatment of DR5 related disease
AU734758B2 (en) 1997-04-01 2001-06-21 Sankyo Company Limited Anti-fas antibodies
AU7126498A (en) 1997-04-16 1998-11-11 Millennium Pharmaceuticals, Inc. Tumor necrosis factor receptor related proteins tango-63d and tango-63e
ATE516354T1 (de) 1997-05-15 2011-07-15 Genentech Inc Apo-2-rezeptor
US6342369B1 (en) * 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
AU8400398A (en) 1997-07-11 1999-02-08 Trustees Of The University Of Pennsylvania, The Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use
EP0998561A4 (fr) * 1997-07-15 2004-08-18 Immunex Corp Recepteur de proteine trail
AU3710597A (en) 1997-08-06 1999-03-01 Laboratorio Medinfar-Produtos Farmaceuticos, Lda Dna integration into "mycobacterium spp." genome by trans-complementation using a site-specific integration system
AU8861898A (en) * 1997-08-13 1999-03-08 Ufe Solar Gmbh Sorption trap arrangement and method for storing heat
US6417328B2 (en) * 1997-08-15 2002-07-09 Thomas Jefferson Univeristy Trail receptors, nucleic acids encoding the same, and methods of use thereof
WO1999011791A2 (fr) 1997-09-05 1999-03-11 University Of Washington Recepteurs et ligands de la famille du facteur de necrose tumorale, acides nucleiques codants et agents de liaison associes
AU738688B2 (en) 1997-09-12 2001-09-27 Apoxis Sa Cysteine rich receptors-train
US7105640B2 (en) * 1997-10-17 2006-09-12 Genentech, Inc. Anti-pro792 antibodies
US20040120947A1 (en) 1998-01-26 2004-06-24 Genentech, Inc. DR4 antibodies and uses thereof
WO1999037684A1 (fr) 1998-01-26 1999-07-29 Genentech, Inc. Anticorps du recepteur 4 de la mort cellulaire (dr4) et leurs utilisations
US6252050B1 (en) * 1998-06-12 2001-06-26 Genentech, Inc. Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
IL145676A0 (en) * 1999-04-12 2002-06-30 Genentech Inc Tumor necrosis factor homologs and nucleic acids encoding the same
JP2002543151A (ja) 1999-05-04 2002-12-17 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド 死ドメイン含有レセプター５
AU4984300A (en) 1999-05-06 2000-11-21 Vishva M Dixit Death domain containing receptor 4
PT1181319E (pt) 1999-05-28 2009-07-14 Genentech Inc Anticorpos quiméricos contra dr4 e suas utilizações
CA2375149A1 (fr) 1999-06-09 2000-12-14 Genentech, Inc. Synergie d'agoniste des recepteurs de ligand apo-2 (apo-2l) et de cpt-11
US6294546B1 (en) 1999-08-30 2001-09-25 The Broad Of Trustees Of The Leland Stanford Junior University Uses of diterpenoid triepoxides as an anti-proliferative agent
EP1226161A2 (fr) 1999-09-15 2002-07-31 Genentech, Inc. Anticorps du recepteur d'apo-2
EP1272647B1 (fr) 2000-04-11 2014-11-12 Genentech, Inc. Anticorps multivalents et leurs utilisations
US7279160B2 (en) * 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
US7476383B2 (en) * 2000-05-02 2009-01-13 The Uab Research Foundation Antibody selective for DR4 and uses thereof
EP1339426A4 (fr) 2000-11-08 2004-06-30 Human Genome Sciences Inc Anticorps a liaison immunospecifique avec les recepteurs "trail"
US20030228309A1 (en) * 2000-11-08 2003-12-11 Theodora Salcedo Antibodies that immunospecifically bind to TRAIL receptors
US6965023B2 (en) * 2000-11-17 2005-11-15 The Burnham Institute Death domain proteins
CA2451680C (fr) 2001-07-03 2011-04-19 Genentech, Inc. Anticorps humains du dr4 et utilisations
IL161686A0 (en) 2001-11-01 2004-09-27 Uab Research Foundation Combinations of antibodies selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and other therapeutic agents
ES2357225T3 (es) 2001-11-01 2011-04-20 Uab Research Foundation Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos.

Also Published As

Publication number Publication date
NO329843B1 (no) 2011-01-10
NO20025253L (no) 2002-12-18
US7790165B2 (en) 2010-09-07
CN100497388C (zh) 2009-06-10
HUP0400951A3 (en) 2012-09-28
WO2001083560A1 (fr) 2001-11-08
DK1287035T3 (da) 2009-06-15
US20140308288A1 (en) 2014-10-16
HU229417B1 (hu) 2013-12-30
US20130243780A1 (en) 2013-09-19
NO20025253D0 (no) 2002-11-01
US20110008324A1 (en) 2011-01-13
RU2002132255A (ru) 2005-01-20
EP1287035A1 (fr) 2003-03-05
HK1126506A1 (zh) 2009-09-04
KR20030055177A (ko) 2003-07-02
KR20060092292A (ko) 2006-08-22
EP2368910A1 (fr) 2011-09-28
US20070298039A1 (en) 2007-12-27
NO20054145L (no) 2002-12-18
BR0110547A (pt) 2004-06-22
JP4575975B2 (ja) 2010-11-04
CA2407965C (fr) 2014-10-14
JP2007091749A (ja) 2007-04-12
US20030190687A1 (en) 2003-10-09
HUP0400951A2 (hu) 2004-07-28
EE200200621A (et) 2004-06-15
EP2065401A3 (fr) 2009-07-22
AU5936601A (en) 2001-11-12
CN101585881B (zh) 2014-11-26
US8715668B2 (en) 2014-05-06
CZ20023917A3 (cs) 2003-05-14
EP2065400A3 (fr) 2009-07-22
BG66153B1 (bg) 2011-08-31
JP2005232187A (ja) 2005-09-02
CZ306996B6 (cs) 2017-11-01
CZ304614B6 (cs) 2014-08-06
HK1162524A1 (zh) 2012-08-31
JP4156238B2 (ja) 2008-09-24
US20120076792A1 (en) 2012-03-29
CZ2006291A3 (cs) 2017-11-01
US8329180B2 (en) 2012-12-11
US8067001B2 (en) 2011-11-29
PT1287035E (pt) 2009-06-30
KR100817967B1 (ko) 2008-03-31
EP2065400A2 (fr) 2009-06-03
ATE426615T1 (de) 2009-04-15
CN101585881A (zh) 2009-11-25
BG65929B1 (bg) 2010-05-31
US7244429B2 (en) 2007-07-17
CY1109179T1 (el) 2014-07-02
JP2004502409A (ja) 2004-01-29
MXPA02010823A (es) 2004-05-05
HU0500800D0 (en) 2005-10-28
NZ522881A (en) 2005-05-27
CA2407965A1 (fr) 2001-11-08
EP2368910B1 (fr) 2016-02-10
NO338228B1 (no) 2016-08-08
EP2065400B1 (fr) 2014-11-05
EP2065401B1 (fr) 2016-08-10
ES2323448T3 (es) 2009-07-16
PL366195A1 (en) 2005-01-24
US9700618B2 (en) 2017-07-11
RU2298013C2 (ru) 2007-04-27
HU230399B1 (hu) 2016-04-28
PL211733B1 (pl) 2012-06-29
BG107275A (bg) 2004-09-30
EP1287035B1 (fr) 2009-03-25
DE60138097D1 (de) 2009-05-07
EP2065401A2 (fr) 2009-06-03
AU2001259366B2 (en) 2005-09-08
IL152605A0 (en) 2003-06-24
HK1050372A1 (en) 2003-06-20
TWI318983B (en) 2010-01-01
ZA200209230B (en) 2004-03-16
BG109275A (en) 2006-10-31
JP3892466B2 (ja) 2007-03-14
JP2009005707A (ja) 2009-01-15
CN1440424A (zh) 2003-09-03
EP1287035A4 (fr) 2004-09-29

Similar Documents

Publication Publication Date Title
EE05548B1 (et) Kasvaja nekroosifaktori sarnase apoptoosi indutseeriva ligandi retseptori suhtes selektiivne antikeha ja selle kasutamine
WO2004020404A3 (fr) Proteines hybrides de la transferrine-anticorps modifiees
LTPA2005005I1 (lt) Antikūnai prieš VEGF
EP0679093A1 (fr) Procede d'apport d'agents a des cellules cibles.
DK1427750T3 (da) Modificerede transferrin-fusionsproteiner
MXPA04005266A (es) Inmunocitocinas con selectividad modulada.
TR199902818T2 (xx) Be�eri kullan�m i�in antikorlar ve be�eri kullan�m i�in antikorlar olu�turmak i�in y�ntemler.
PL331240A1 (en) Cut off soluble tumour necrosis factor receptors of i and ii type
WO2003065003A3 (fr) Alterations de proteine de matrice nucleaire associees au cancer du colon et au cancer du colon avec metastase au foie, et utilisations associees
WO2003055908A3 (fr) Sequences de proteines et de nucleotides bag3 a utiliser dans la recherche, le diagnostic et le traitement de maladies impliquant la mort cellulaire, et a des fins de modulation de survie et/ou de mort cellulaire
WO2005080426A3 (fr) Ligands de proteine pour recepteurs nkg2d et ul16 et leurs utilisations
WO2006049983A3 (fr) Proteines de fusion de transferine modifiees par le peptide yy
AU2003270010A1 (en) Transferrin fusion protein libraries
EP1692179A4 (fr) Region variable d'un anticorps monoclonal dirige contre le facteur de necrose tumorale alpha humain, et gene codant ladite region variable
WO2000018803A3 (fr) Anticorps lies a un antigene mammalien de la cellule de langerhans et leurs utilisations
NZ592545A (en) Anti-ferroportin 1 monoclonal antibodies and uses thereof
AU2002246455A1 (en) Fusion proteins for specific treatment of cancer and auto-immune diseases
WO2000026242A3 (fr) Genes de regulation et de replication d'adn, leurs anticorps et leurs applications diagnostiques
WO2003056340A3 (fr) Nouveaux marqueurs de tumeurs et leurs applications biologiques
WO2023114515A3 (fr) Anticorps anti-pilra, leurs utilisations, et procédés et réactifs associés
AU2232297A (en) Gene that imparts selective proliferative activity
WO2002006340A3 (fr) Proteine tetraspan et ses utilisations
WO2002020567A3 (fr) Cystatine-8 mammalienne et utilisation de celle-ci pour inhiber la proteine cancereuse favorisant la coagulation