EP1339426A4 - Anticorps a liaison immunospecifique avec les recepteurs "trail" - Google Patents

Anticorps a liaison immunospecifique avec les recepteurs "trail"

Info

Publication number
EP1339426A4
EP1339426A4 EP01273517A EP01273517A EP1339426A4 EP 1339426 A4 EP1339426 A4 EP 1339426A4 EP 01273517 A EP01273517 A EP 01273517A EP 01273517 A EP01273517 A EP 01273517A EP 1339426 A4 EP1339426 A4 EP 1339426A4
Authority
EP
European Patent Office
Prior art keywords
antibodies
immunospecifically bind
trail receptors
trail
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01273517A
Other languages
German (de)
English (en)
Other versions
EP1339426A2 (fr
Inventor
Theodora Salcedo
Victor Roschke
Steven M Ruben
Craig A Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Publication of EP1339426A2 publication Critical patent/EP1339426A2/fr
Publication of EP1339426A4 publication Critical patent/EP1339426A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
EP01273517A 2000-11-08 2001-11-07 Anticorps a liaison immunospecifique avec les recepteurs "trail" Withdrawn EP1339426A4 (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US24661200P 2000-11-08 2000-11-08
US246612P 2000-11-08
US24884700P 2000-11-16 2000-11-16
US248847P 2000-11-16
US25290400P 2000-11-27 2000-11-27
US252904P 2000-11-27
US29501801P 2001-06-04 2001-06-04
US295018P 2001-06-04
US32735901P 2001-10-09 2001-10-09
US327359P 2001-10-09
PCT/US2001/042996 WO2002079377A2 (fr) 2000-11-08 2001-11-07 Anticorps a liaison immunospecifique avec les recepteurs 'trail'

Publications (2)

Publication Number Publication Date
EP1339426A2 EP1339426A2 (fr) 2003-09-03
EP1339426A4 true EP1339426A4 (fr) 2004-06-30

Family

ID=27540243

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01273517A Withdrawn EP1339426A4 (fr) 2000-11-08 2001-11-07 Anticorps a liaison immunospecifique avec les recepteurs "trail"

Country Status (4)

Country Link
EP (1) EP1339426A4 (fr)
AU (1) AU2001297702A1 (fr)
CA (1) CA2426710A1 (fr)
WO (1) WO2002079377A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
US7279160B2 (en) 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
US7476383B2 (en) 2000-05-02 2009-01-13 The Uab Research Foundation Antibody selective for DR4 and uses thereof
CA2447602C (fr) 2001-05-18 2011-11-01 Kirin Beer Kabushiki Kaisha Anticorps anti-trail-r
EP1531162A1 (fr) * 2003-11-14 2005-05-18 Heinz Vollmers Anticorps SAM-6, spécifique d'adénocarcinome, et ses utilisations
US8129124B2 (en) 2005-02-02 2012-03-06 The Uab Research Foundation Agents and methods related to reducing resistance to apoptosis-inducing death receptor agonists
WO2008094319A2 (fr) 2007-02-01 2008-08-07 The Board Of Regents Of The University Of Texas Sytem Procédés et compositions d'agonistes/activateurs du récepteur de mort trail
BR112015023752B1 (pt) * 2013-03-15 2023-11-14 Zyngenia, Inc. Domínio de reconhecimento modular (mrd), complexo compreendendo mrd e cetuximabe, usos do complexo para inibir a angiogênese e tratar câncer e composição farmacêutica compreendendo o dito complexo

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032856A1 (fr) * 1997-01-28 1998-07-30 Human Genome Sciences, Inc. Recepteur 4 (dr4-recepteur 4 de mort cellulaire) contenant des domaines de mort cellulaire, membre de la superfamille du recepteur du facteur de necrose tumorale (tnf) et se liant a la queue (apo2-l)
WO1999037684A1 (fr) * 1998-01-26 1999-07-29 Genentech, Inc. Anticorps du recepteur 4 de la mort cellulaire (dr4) et leurs utilisations
WO1999064461A2 (fr) * 1998-06-12 1999-12-16 Genentech, Inc. Procede pour fabriquer des anticorps monoclonaux et anticorps a reaction croisee obtenus par ce procede
WO2002002641A1 (fr) * 2000-06-16 2002-01-10 Human Genome Sciences, Inc. Anticorps se liant de maniere immunospecifique a un stimulateur de lymphocyte b
WO2002016436A2 (fr) * 2000-08-22 2002-02-28 Novartis Ag ANTICORPS DE LA IL-1β HUMAINE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001633A1 (fr) * 1995-06-29 1997-01-16 Immunex Corporation Cytokine inductrice d'apoptose
US6072047A (en) * 1997-02-13 2000-06-06 Immunex Corporation Receptor that binds trail
WO1999013078A1 (fr) * 1997-09-12 1999-03-18 Biogen, Inc. Recepteurs 'train' riches en cysteine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032856A1 (fr) * 1997-01-28 1998-07-30 Human Genome Sciences, Inc. Recepteur 4 (dr4-recepteur 4 de mort cellulaire) contenant des domaines de mort cellulaire, membre de la superfamille du recepteur du facteur de necrose tumorale (tnf) et se liant a la queue (apo2-l)
WO1999037684A1 (fr) * 1998-01-26 1999-07-29 Genentech, Inc. Anticorps du recepteur 4 de la mort cellulaire (dr4) et leurs utilisations
WO1999064461A2 (fr) * 1998-06-12 1999-12-16 Genentech, Inc. Procede pour fabriquer des anticorps monoclonaux et anticorps a reaction croisee obtenus par ce procede
WO2002002641A1 (fr) * 2000-06-16 2002-01-10 Human Genome Sciences, Inc. Anticorps se liant de maniere immunospecifique a un stimulateur de lymphocyte b
WO2002016436A2 (fr) * 2000-08-22 2002-02-28 Novartis Ag ANTICORPS DE LA IL-1β HUMAINE

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 2 August 2000 (2000-08-02), XP002277545, retrieved from EBI Database accession no. AAY82615 *
DATABASE EMBL [online] 28 August 2001 (2001-08-28), XP002277565, retrieved from EBI Database accession no. AAB99378 *
DATABASE EMBL [online] 3 October 2000 (2000-10-03), XP002277544, retrieved from EBI Database accession no. AAY93734 *
DATABASE UNIPROT [online] 1 May 2000 (2000-05-01), XP002277546, retrieved from EBI Database accession no. Q9UL86 *
GRIFFITH T S ET AL: "FUNCTIONAL ANALYSIS OF TRAIL RECEPTORS USING MONOCLONAL ANTIBODIES", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 162, no. 5, 1 March 1999 (1999-03-01), pages 2597 - 2605, XP000918935, ISSN: 0022-1767 *
See also references of WO02079377A3 *

Also Published As

Publication number Publication date
WO2002079377A3 (fr) 2003-03-13
WO2002079377A2 (fr) 2002-10-10
CA2426710A1 (fr) 2002-10-10
AU2001297702A1 (en) 2002-10-15
EP1339426A2 (fr) 2003-09-03

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