CA2426710A1 - Anticorps a liaison immunospecifique avec les recepteurs "trail" - Google Patents

Anticorps a liaison immunospecifique avec les recepteurs "trail" Download PDF

Info

Publication number
CA2426710A1
CA2426710A1 CA002426710A CA2426710A CA2426710A1 CA 2426710 A1 CA2426710 A1 CA 2426710A1 CA 002426710 A CA002426710 A CA 002426710A CA 2426710 A CA2426710 A CA 2426710A CA 2426710 A1 CA2426710 A1 CA 2426710A1
Authority
CA
Canada
Prior art keywords
replaced
antibody
amino acid
polypeptide
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002426710A
Other languages
English (en)
Inventor
Theodora Salcedo
Viktor Roschke
Steven M. Ruben
Craig A. Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2426710A1 publication Critical patent/CA2426710A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des anticorps et des molécules connexes à liaison immunospécifique avec les récepteurs TRAIL. Ces anticorps sont utiles, par exemple, dans la prévention et le traitement du cancer et autres troubles proliférants. L'invention concerne également des molécules d'acides nucléiques codant des anticorps vis-à-vis des récepteurs TRAIL, des vecteurs et des cellules hôtes renfermant ces acides nucléiques, et des procédés relatifs à leur élaboration. L'invention concerne en outre des procédés et des compositions pour la prévention, la détection, le diagnostic, le traitement ou l'amélioration d'une maladie ou d'un trouble, en particulier le cancer et autres troubles hyperproliférants: on administre à un animal, de préférence un être humain, une quantité efficace d'un ou plusieurs anticorps ou bien de fragments ou de variants correspondants, ou encore des molécules connexes, à capacité de liaison spécifique avec le récepteur TRAIL.
CA002426710A 2000-11-08 2001-11-07 Anticorps a liaison immunospecifique avec les recepteurs "trail" Abandoned CA2426710A1 (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US24661200P 2000-11-08 2000-11-08
US60/246,612 2000-11-08
US24884700P 2000-11-16 2000-11-16
US60/248,847 2000-11-16
US25290400P 2000-11-27 2000-11-27
US60/252,904 2000-11-27
US29501801P 2001-06-04 2001-06-04
US60/295,018 2001-06-04
US32735901P 2001-10-09 2001-10-09
US60/327,359 2001-10-09
PCT/US2001/042996 WO2002079377A2 (fr) 2000-11-08 2001-11-07 Anticorps a liaison immunospecifique avec les recepteurs 'trail'

Publications (1)

Publication Number Publication Date
CA2426710A1 true CA2426710A1 (fr) 2002-10-10

Family

ID=27540243

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002426710A Abandoned CA2426710A1 (fr) 2000-11-08 2001-11-07 Anticorps a liaison immunospecifique avec les recepteurs "trail"

Country Status (4)

Country Link
EP (1) EP1339426A4 (fr)
AU (1) AU2001297702A1 (fr)
CA (1) CA2426710A1 (fr)
WO (1) WO2002079377A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7476383B2 (en) 2000-05-02 2009-01-13 The Uab Research Foundation Antibody selective for DR4 and uses thereof
US7279160B2 (en) 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
CA2447602C (fr) 2001-05-18 2011-11-01 Kirin Beer Kabushiki Kaisha Anticorps anti-trail-r
EP1531162A1 (fr) * 2003-11-14 2005-05-18 Heinz Vollmers Anticorps SAM-6, spécifique d'adénocarcinome, et ses utilisations
KR101292961B1 (ko) 2005-02-02 2013-08-02 더 유에이비 리서치 파운데이션 아폽토시스-유도 사멸 수용체 작용제에 대한 내성을 감소시키는데 관련된 약제 및 방법
WO2008094319A2 (fr) 2007-02-01 2008-08-07 The Board Of Regents Of The University Of Texas Sytem Procédés et compositions d'agonistes/activateurs du récepteur de mort trail
EP3424530A1 (fr) * 2013-03-15 2019-01-09 Zyngenia, Inc. Complexes multispécifiques monovalents et multivalents et leurs utilisations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69635480T2 (de) * 1995-06-29 2006-08-17 Immunex Corp., Thousand Oaks Apoptosis induzierendes cytokin
JP4450870B2 (ja) * 1997-01-28 2010-04-14 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド 死ドメイン含有レセプター４（ｄｒ４：死レセプター４）、ｔｎｆ−レセプタースーパーファミリーのメンバーおよびｔｒａｉｌへの結合
US6072047A (en) * 1997-02-13 2000-06-06 Immunex Corporation Receptor that binds trail
EP1012179A2 (fr) * 1997-09-12 2000-06-28 Apotech R&D S.A. Recepteurs "trail" riches en cysteine
AU2338299A (en) * 1998-01-26 1999-08-09 Genentech Inc. Antibodies to death receptor 4 (dr4) and uses thereof
WO1999064461A2 (fr) * 1998-06-12 1999-12-16 Genentech, Inc. Procede pour fabriquer des anticorps monoclonaux et anticorps a reaction croisee obtenus par ce procede
AU6842701A (en) * 2000-06-16 2002-01-14 Human Genome Sciences Inc Antibodies that immunospecifically bind to blys
GB0020685D0 (en) * 2000-08-22 2000-10-11 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
EP1339426A2 (fr) 2003-09-03
EP1339426A4 (fr) 2004-06-30
WO2002079377A2 (fr) 2002-10-10
AU2001297702A1 (en) 2002-10-15
WO2002079377A3 (fr) 2003-03-13

Similar Documents

Publication Publication Date Title
CA2446723C (fr) Anticorps se liant de maniere immunospecifique a des recepteurs de trail
US20030228309A1 (en) Antibodies that immunospecifically bind to TRAIL receptors
US20060062786A1 (en) Antibodies that immunospecifically bind to TRAIL receptors
US7361341B2 (en) Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
US7348003B2 (en) Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US20030180296A1 (en) Antibodies that immunospecifically bind to trail receptors
US20090226429A1 (en) Antibodies That Immunospecifically Bind to TRAIL Receptors
US20050129616A1 (en) Antibodies that immunospecifically bind to TRAIL receptors
US20050214209A1 (en) Antibodies that immunospecifically bind to TRAIL receptors
US20050214205A1 (en) Antibodies that immunospecifically bind to TRAIL receptors
US20050214208A1 (en) Antibodies that immunospecifically bind to TRAIL receptors
US7906119B1 (en) Antibodies against protective antigen
US20050214207A1 (en) Antibodies that immunospecifically bind toTRAIL receptors
AU2002309647A1 (en) Antibodies that immunospecifically bind to trail receptors
CA2524737A1 (fr) Anticorps se liant de maniere immunospecifique aux recepteurs trail
CA2426710A1 (fr) Anticorps a liaison immunospecifique avec les recepteurs "trail"
CA2494372C (fr) Anticorps se fixant de facon immunospecifique a des recepteurs trail
WO2003042367A2 (fr) Anticorps se liant specifiquement au niveau immunitaire a des recepteurs trail
AU2008201237A1 (en) Antibodies that Immunospecifically Bind to Trail Receptors
MXPA04006042A (es) Anticuerpos que se unen inmunoespecificamente a receptores de trail.

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued