EE04591B1 - Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt - Google Patents

Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt

Info

Publication number
EE04591B1
EE04591B1 EEP200100688A EEP200100688A EE04591B1 EE 04591 B1 EE04591 B1 EE 04591B1 EE P200100688 A EEP200100688 A EE P200100688A EE P200100688 A EEP200100688 A EE P200100688A EE 04591 B1 EE04591 B1 EE 04591B1
Authority
EE
Estonia
Prior art keywords
preparation
intermediates
product
pharmaceutical composition
respiratory syncytial
Prior art date
Application number
EEP200100688A
Other languages
English (en)
Estonian (et)
Inventor
Eduard Janssens Frans
Maria Sommen Fran�ois
Petrus Marie-Jos Meersman Kathleen
Jozef Lodewijk Marcel Andries Koenraad
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200100688A publication Critical patent/EE200100688A/xx
Publication of EE04591B1 publication Critical patent/EE04591B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
EEP200100688A 1999-06-28 2000-06-20 Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt EE04591B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99202088 1999-06-28
PCT/EP2000/005675 WO2001000612A2 (en) 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors

Publications (2)

Publication Number Publication Date
EE200100688A EE200100688A (et) 2003-04-15
EE04591B1 true EE04591B1 (et) 2006-02-15

Family

ID=8240373

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100688A EE04591B1 (et) 1999-06-28 2000-06-20 Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt

Country Status (33)

Country Link
US (3) US6747028B1 (es)
EP (1) EP1196409B1 (es)
JP (1) JP2003503402A (es)
KR (1) KR100731271B1 (es)
CN (1) CN1210275C (es)
AR (1) AR035991A1 (es)
AT (1) ATE258928T1 (es)
AU (1) AU778218B2 (es)
BG (1) BG65328B1 (es)
BR (1) BR0012047A (es)
CA (1) CA2376676C (es)
DE (1) DE60008112T2 (es)
DK (1) DK1196409T3 (es)
EA (1) EA005027B1 (es)
EE (1) EE04591B1 (es)
ES (1) ES2215683T3 (es)
HK (1) HK1045997A1 (es)
HR (1) HRP20010935A2 (es)
HU (1) HUP0201869A3 (es)
IL (2) IL147327A0 (es)
MX (1) MXPA02000120A (es)
MY (1) MY127687A (es)
NO (1) NO322458B1 (es)
NZ (1) NZ515664A (es)
PL (1) PL200674B1 (es)
PT (1) PT1196409E (es)
SI (1) SI1196409T1 (es)
SK (1) SK19122001A3 (es)
TR (1) TR200103806T2 (es)
TW (1) TWI278454B (es)
UA (1) UA74787C2 (es)
WO (1) WO2001000612A2 (es)
ZA (1) ZA200110479B (es)

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WO2004014316A2 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
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TWI349007B (en) * 2003-12-18 2011-09-21 Tibotec Pharm Ltd Piperidine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
US20090036466A1 (en) 2003-12-18 2009-02-05 Jean-Francois Bonfanti Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication
BRPI0417273A (pt) * 2003-12-18 2007-03-27 Tibotec Pharm Ltd derivados de benzimidazola 5- ou 6-substituìdos como inibidores de replicação do vìrus sincical respiratório
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
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TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
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TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
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Also Published As

Publication number Publication date
EP1196409A2 (en) 2002-04-17
JP2003503402A (ja) 2003-01-28
UA74787C2 (en) 2006-02-15
AU778218B2 (en) 2004-11-25
HUP0201869A3 (en) 2003-12-29
AU5816600A (en) 2001-01-31
HRP20010935A2 (en) 2003-06-30
EA200200088A1 (ru) 2002-06-27
DK1196409T3 (da) 2004-06-07
US7528149B2 (en) 2009-05-05
ES2215683T3 (es) 2004-10-16
WO2001000612A2 (en) 2001-01-04
SK19122001A3 (sk) 2003-01-09
MY127687A (en) 2006-12-29
DE60008112T2 (de) 2004-09-16
DE60008112D1 (en) 2004-03-11
NO322458B1 (no) 2006-10-09
PL352378A1 (en) 2003-08-25
PL200674B1 (pl) 2009-01-30
SI1196409T1 (en) 2004-06-30
EE200100688A (et) 2003-04-15
AR035991A1 (es) 2004-08-04
BG65328B1 (bg) 2008-02-29
KR20020003884A (ko) 2002-01-15
PT1196409E (pt) 2004-06-30
WO2001000612A3 (en) 2001-03-29
BG106286A (en) 2002-10-31
IL147327A (en) 2007-06-03
MXPA02000120A (es) 2002-07-02
CA2376676C (en) 2009-01-20
NO20016369L (no) 2002-02-20
HUP0201869A2 (hu) 2002-11-28
CN1210275C (zh) 2005-07-13
ATE258928T1 (de) 2004-02-15
NO20016369D0 (no) 2001-12-27
HK1045997A1 (zh) 2002-12-20
CN1358181A (zh) 2002-07-10
EA005027B1 (ru) 2004-10-28
US20070015747A1 (en) 2007-01-18
TR200103806T2 (tr) 2002-06-21
ZA200110479B (en) 2003-03-20
US6747028B1 (en) 2004-06-08
IL147327A0 (en) 2002-08-14
NZ515664A (en) 2004-01-30
EP1196409B1 (en) 2004-02-04
US7179811B2 (en) 2007-02-20
TWI278454B (en) 2007-04-11
BR0012047A (pt) 2002-03-12
KR100731271B1 (ko) 2007-06-21
US20070135404A1 (en) 2007-06-14
CA2376676A1 (en) 2001-01-04

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