EE04591B1 - Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt - Google Patents
Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produktInfo
- Publication number
- EE04591B1 EE04591B1 EEP200100688A EEP200100688A EE04591B1 EE 04591 B1 EE04591 B1 EE 04591B1 EE P200100688 A EEP200100688 A EE P200100688A EE P200100688 A EEP200100688 A EE P200100688A EE 04591 B1 EE04591 B1 EE 04591B1
- Authority
- EE
- Estonia
- Prior art keywords
- preparation
- intermediates
- product
- pharmaceutical composition
- respiratory syncytial
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99202088 | 1999-06-28 | ||
PCT/EP2000/005675 WO2001000612A2 (en) | 1999-06-28 | 2000-06-20 | Respiratory syncytial virus replication inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200100688A EE200100688A (et) | 2003-04-15 |
EE04591B1 true EE04591B1 (et) | 2006-02-15 |
Family
ID=8240373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200100688A EE04591B1 (et) | 1999-06-28 | 2000-06-20 | Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt |
Country Status (33)
Country | Link |
---|---|
US (3) | US6747028B1 (et) |
EP (1) | EP1196409B1 (et) |
JP (1) | JP2003503402A (et) |
KR (1) | KR100731271B1 (et) |
CN (1) | CN1210275C (et) |
AR (1) | AR035991A1 (et) |
AT (1) | ATE258928T1 (et) |
AU (1) | AU778218B2 (et) |
BG (1) | BG65328B1 (et) |
BR (1) | BR0012047A (et) |
CA (1) | CA2376676C (et) |
DE (1) | DE60008112T2 (et) |
DK (1) | DK1196409T3 (et) |
EA (1) | EA005027B1 (et) |
EE (1) | EE04591B1 (et) |
ES (1) | ES2215683T3 (et) |
HK (1) | HK1045997A1 (et) |
HR (1) | HRP20010935A2 (et) |
HU (1) | HUP0201869A3 (et) |
IL (2) | IL147327A0 (et) |
MX (1) | MXPA02000120A (et) |
MY (1) | MY127687A (et) |
NO (1) | NO322458B1 (et) |
NZ (1) | NZ515664A (et) |
PL (1) | PL200674B1 (et) |
PT (1) | PT1196409E (et) |
SI (1) | SI1196409T1 (et) |
SK (1) | SK19122001A3 (et) |
TR (1) | TR200103806T2 (et) |
TW (1) | TWI278454B (et) |
UA (1) | UA74787C2 (et) |
WO (1) | WO2001000612A2 (et) |
ZA (1) | ZA200110479B (et) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6495580B1 (en) | 1998-01-29 | 2002-12-17 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
PT1196408E (pt) * | 1999-06-28 | 2005-01-31 | Janssen Pharmaceutica Nv | Inibidores da replicacao do virus sincicial respiratorio |
NZ515664A (en) | 1999-06-28 | 2004-01-30 | Janssen Pharmaceutica Nv | Benzimidazole derivatives useful as respiratory syncytial virus replication inhibitors |
US6506738B1 (en) | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
US6774134B2 (en) | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
US7030150B2 (en) * | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
US6919331B2 (en) | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
CA2495245A1 (en) | 2002-08-09 | 2004-02-19 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
EP1545513A2 (en) | 2002-08-09 | 2005-06-29 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
WO2004035549A1 (en) * | 2002-10-17 | 2004-04-29 | Amgen Inc. | Benzimidazole derivatives and their use as vanilloid receptor ligands |
EP1682547B1 (en) | 2003-10-30 | 2012-10-24 | Boehringer Ingelheim (Canada) Ltd. | Rsv polymerase inhibitors |
MY140893A (en) * | 2003-12-18 | 2010-01-29 | Tibotec Pharm Ltd | Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication |
CA2548657A1 (en) * | 2003-12-18 | 2005-06-30 | Tibotec Pharmaceuticals Ltd. | Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication |
PL1711485T3 (pl) * | 2003-12-18 | 2009-11-30 | Tibotec Pharm Ltd | Pochodne aminobenzoimidazoli jako inhibitory replikacji wirusa zespólni układu oddechowego |
RU2369606C2 (ru) | 2003-12-18 | 2009-10-10 | Тиботек Фармасьютикалз Лтд. | Производные 5- или 6-замещенных бензимидазолов в качестве ингибиторов репликации респираторного синцитиального вируса |
AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
DE602004031776D1 (de) | 2003-12-18 | 2011-04-21 | Tibotec Pharm Ltd | Piperidinamino-benzimidazol-derivate al respiratorisches syncytialvirus replikation inhibitoren |
DE102004010207A1 (de) * | 2004-03-02 | 2005-09-15 | Aventis Pharma S.A. | Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate |
BRPI0606278B8 (pt) | 2005-03-17 | 2021-05-25 | Janssen R & D Ireland | aminas de 1,3-diidro-benzimidazol-2-ilideno como inibidores de replicação de vírus sincicial respiratório, seu processo de preparação e composição farmacêutica |
RU2419613C2 (ru) | 2005-06-20 | 2011-05-27 | Тиботек Фармасьютикалз Лтд | Гетероциклиламиноалкилзамещенные бензимидазолы |
US8034835B2 (en) | 2005-06-20 | 2011-10-11 | Tibotec Pharmaceuticals Ltd. | 1-[[2-amino-3-(substituted alkyl)-3H-benzimidazolyl[methyl]-3-substituted-1,3-dihydro-benzoimidazol-2-ones and structural analogs |
PL1896450T3 (pl) * | 2005-06-20 | 2013-01-31 | Janssen Sciences Ireland Uc | 2-podstawione benzimidazole |
WO2011097607A1 (en) * | 2010-02-08 | 2011-08-11 | Southern Research Institute | Anti-viral treatment and assay to screen for anti-viral agent |
TWI527814B (zh) * | 2010-12-16 | 2016-04-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類 |
TWI541241B (zh) * | 2010-12-16 | 2016-07-11 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類 |
TWI501967B (zh) * | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
TWI530495B (zh) | 2010-12-16 | 2016-04-21 | 健生科學愛爾蘭無限公司 | 苯并咪唑呼吸道融合病毒抑制劑 |
TWI515187B (zh) | 2010-12-16 | 2016-01-01 | 健生科學愛爾蘭無限公司 | 作為呼吸道融合病毒抗病毒劑之吲哚類 |
SI2797416T1 (sl) | 2011-12-28 | 2017-12-29 | Global Blood Therapeutics, Inc. | Substituirane spojine benzaldehida in metode njihove uporabe pri povečanju oksigenacije tkiva |
US9012450B2 (en) | 2011-12-28 | 2015-04-21 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
JP6259451B2 (ja) | 2012-06-15 | 2018-01-10 | ヤンセン・サイエンシズ・アイルランド・ユーシー | Rsウイルス抗ウイルス薬としての、複素環によって置換された新規1,3−ジヒドロ−2h−ベンゾイミダゾル−2−オン誘導体 |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
BR112015021982B1 (pt) | 2013-03-15 | 2022-12-13 | Global Blood Therapeutics, Inc | Compostos e seus usos para a modulação de hemoglobina |
AP2015008721A0 (en) | 2013-03-15 | 2015-09-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
EP2968299B1 (en) | 2013-03-15 | 2021-01-20 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
EA202092627A1 (ru) | 2013-11-18 | 2021-09-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
CN114181195A (zh) | 2014-02-07 | 2022-03-15 | 全球血液疗法股份有限公司 | 一种化合物的结晶多晶型物 |
JP2016079168A (ja) * | 2014-10-17 | 2016-05-16 | 塩野義製薬株式会社 | 9員縮合環誘導体 |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
SG11201804647TA (en) | 2015-12-04 | 2018-06-28 | Global Blood Therapeutics Inc | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
TWI752307B (zh) | 2016-05-12 | 2022-01-11 | 美商全球血液治療公司 | 新穎化合物及製造化合物之方法 |
TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
US11014884B2 (en) | 2018-10-01 | 2021-05-25 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1140119A (en) | 1978-04-03 | 1983-01-25 | Joseph Torremans | N-heterocyclyl-4-piperidinamines |
US4556660A (en) * | 1982-07-12 | 1985-12-03 | Janssen Pharmaceutica N.V. | N-(Bicyclic heterocyclyl)-4-piperidinamines |
US4634704A (en) | 1983-10-06 | 1987-01-06 | Janssen Pharmaceutica, N.V. | Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines |
US4695569A (en) | 1983-11-30 | 1987-09-22 | Janssen Pharmaceutica N.V. | Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines |
EP0144101B1 (en) | 1983-11-30 | 1991-02-06 | Janssen Pharmaceutica N.V. | Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines |
US4588722A (en) | 1984-01-09 | 1986-05-13 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives |
PH23995A (en) | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
EG17993A (en) | 1986-02-03 | 1991-08-30 | Janssen Pharmaceutica Nv | Anti-histaminic compositions containing n-heterocyclyl-4-piperidinanines |
NZ223654A (en) | 1987-03-09 | 1990-03-27 | Janssen Pharmaceutica Nv | 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions |
US4897401A (en) | 1987-06-19 | 1990-01-30 | Janssen Pharmaceutical N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases |
CA1317939C (en) * | 1987-07-01 | 1993-05-18 | Janssen Pharmaceutica Naamloze Vennootschap | ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines |
GB8716313D0 (en) | 1987-07-10 | 1987-08-19 | Janssen Pharmaceutica Nv | 2-(heterocyclylalkyl)imidazopyridines |
KR100190299B1 (ko) | 1990-07-19 | 1999-06-01 | 디르크 반테 | 신규한 옥사졸릴 유도체 |
US5360807A (en) * | 1990-07-19 | 1994-11-01 | Janssen Pharmaceutica N.V. | Substituted thiazolyl and substituted pyridinyl derivatives |
NZ238863A (en) * | 1990-07-19 | 1993-03-26 | Janssen Pharmaceutica Nv | Substituted thiazolyl and pyridinyl derivatives |
US5693661A (en) | 1995-06-07 | 1997-12-02 | Eli Lilly And Company | Anti-viral compounds |
PE107598A1 (es) | 1996-09-11 | 1999-01-29 | Ucb Sa | Cetirizina util para el tratamiento de enfermedades de tipo virico |
AU6031898A (en) | 1997-01-22 | 1998-08-07 | Eli Lilly And Company | Anti-viral compounds |
CA2293508A1 (en) | 1997-06-04 | 1998-12-10 | Louis Nickolaus Jungheim | Anti-viral compounds |
NZ515664A (en) | 1999-06-28 | 2004-01-30 | Janssen Pharmaceutica Nv | Benzimidazole derivatives useful as respiratory syncytial virus replication inhibitors |
-
2000
- 2000-06-20 NZ NZ515664A patent/NZ515664A/xx unknown
- 2000-06-20 CA CA002376676A patent/CA2376676C/en not_active Expired - Fee Related
- 2000-06-20 EP EP00943840A patent/EP1196409B1/en not_active Expired - Lifetime
- 2000-06-20 EE EEP200100688A patent/EE04591B1/et not_active IP Right Cessation
- 2000-06-20 US US10/019,380 patent/US6747028B1/en not_active Expired - Fee Related
- 2000-06-20 DE DE60008112T patent/DE60008112T2/de not_active Expired - Fee Related
- 2000-06-20 UA UA2002010360A patent/UA74787C2/uk unknown
- 2000-06-20 AU AU58166/00A patent/AU778218B2/en not_active Ceased
- 2000-06-20 DK DK00943840T patent/DK1196409T3/da active
- 2000-06-20 KR KR1020017015295A patent/KR100731271B1/ko not_active IP Right Cessation
- 2000-06-20 SK SK1912-2001A patent/SK19122001A3/sk unknown
- 2000-06-20 ES ES00943840T patent/ES2215683T3/es not_active Expired - Lifetime
- 2000-06-20 HU HU0201869A patent/HUP0201869A3/hu unknown
- 2000-06-20 AT AT00943840T patent/ATE258928T1/de not_active IP Right Cessation
- 2000-06-20 MX MXPA02000120A patent/MXPA02000120A/es active IP Right Grant
- 2000-06-20 BR BR0012047-2A patent/BR0012047A/pt not_active Application Discontinuation
- 2000-06-20 JP JP2001507021A patent/JP2003503402A/ja not_active Withdrawn
- 2000-06-20 IL IL14732700A patent/IL147327A0/xx active IP Right Grant
- 2000-06-20 PT PT00943840T patent/PT1196409E/pt unknown
- 2000-06-20 CN CNB008095442A patent/CN1210275C/zh not_active Expired - Fee Related
- 2000-06-20 TR TR2001/03806T patent/TR200103806T2/xx unknown
- 2000-06-20 PL PL352378A patent/PL200674B1/pl not_active IP Right Cessation
- 2000-06-20 EA EA200200088A patent/EA005027B1/ru not_active IP Right Cessation
- 2000-06-20 SI SI200030315T patent/SI1196409T1/xx unknown
- 2000-06-20 WO PCT/EP2000/005675 patent/WO2001000612A2/en active IP Right Grant
- 2000-06-26 TW TW089112478A patent/TWI278454B/zh not_active IP Right Cessation
- 2000-06-27 MY MYPI20002907A patent/MY127687A/en unknown
- 2000-06-27 AR ARP000103221A patent/AR035991A1/es not_active Application Discontinuation
-
2001
- 2001-12-19 HR HR20010935A patent/HRP20010935A2/hr not_active Application Discontinuation
- 2001-12-20 ZA ZA200110479A patent/ZA200110479B/xx unknown
- 2001-12-26 IL IL147327A patent/IL147327A/en not_active IP Right Cessation
- 2001-12-27 NO NO20016369A patent/NO322458B1/no unknown
-
2002
- 2002-01-08 BG BG106286A patent/BG65328B1/bg unknown
- 2002-10-21 HK HK02107622.9A patent/HK1045997A1/zh unknown
-
2004
- 2004-04-02 US US10/817,472 patent/US7179811B2/en not_active Expired - Fee Related
-
2007
- 2007-01-22 US US11/625,648 patent/US7528149B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EE04591B1 (et) | Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt | |
EE04592B1 (et) | Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt | |
EE04590B1 (et) | Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende kasutamine ja valmistamismeetod, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt | |
EE05086B1 (et) | Primidiini derivaadid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja selle valmistamismeetod, kombinatsioon ning saadus | |
EE200300207A (et) | Heterotsüklüülalküülpiperidiini derivaadid, nendevalmistamismeetodid ja farmatseutiline kompositsioon | |
IL208891A0 (en) | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation | |
EE200200017A (et) | Kinuklidiinderivaadid, nende valmistamismeetod, vaheühendid, farmatseutiline kompositsioon ja nendekasutamine | |
EE04464B1 (et) | Indalüülasendatud benseenkarboksamiidid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid | |
EE200300327A (et) | Uurea derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutiline kompositsioon | |
NO329884B1 (no) | Indolderivater, farmasoytisk formulering, anvendelse av forbindelsene, fremgangsmate for fremstilling derav samt mellomprodukter for anvendelse i fremgangsmaten | |
EE05217B1 (et) | Atslitud indanlamiinid, nende valmistamismeetod, kasutamine ja farmatseutiline preparaat | |
NO20040282L (no) | Hepatit C virus-polymerase-inhibitorer, samt anvendelse og fremgangsmåte for fremstilling derav og farmasøytisk preparat | |
EE200100431A (et) | 16-halogenoepotilooni derivaadid, nende valmistamismeetod ja farmatseutiline kasutamine | |
EE200000596A (et) | Tienüülasolüülalkoksüetaanamiinderivaadid, nende ja nende soolade valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja kasutamine ning vaheühend ja selle valmistamismeetod | |
EE200000620A (et) | 3-(amino- või aminoalküül)püridinooni derivaadid,nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon | |
HUP0301683A3 (en) | Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral indopeptidase, their intermediates, process for their preparation, pharmaceutical compositions containing them and their use | |
AU2003299790A8 (en) | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation | |
EE03767B1 (et) | Arüülglütsiinamiidi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline preparaat | |
EE200200655A (et) | 5-kloro-3-(4-metaansulfonüülfenüül)-6'-metüül[2,3']bipüridinüüli polümorfne vorm, selle valmistamismeetod, kasutamine ja farmatseutiline kompositsioon | |
EE04917B1 (et) | Antihistamiinsed spirohendid, vahehendid ja farmatseutiline kompositsioon ning nende valmistamismeetodid ja kasutamine | |
EE200100653A (et) | Indolüülpiperidiinühendid, nende valmistamismeetod, kompositsioon ja nende kasutamine | |
FR2872164B1 (fr) | Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent | |
EE200100173A (et) | 2-fenüülpüraan-4-ooni derivaadid, nende valmistamismeetod ja kasutamine, vaheühendite kasutamine jafarmatseutiline kompositsioon | |
EE200000569A (et) | PDE IV inhibeerivad püridiini derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon ja selle valmistamismeetod | |
EE200200637A (et) | Torasemiidi uudne polümorf V, selle valmistamismeetod, kasutamine ja ravimvorm |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20101231 |
|
MM4A | Lapsed by not paying the annual fees |
Effective date: 20100620 |