SI1196409T1 - Respiratory syncytial virus replication inhibitors - Google Patents

Respiratory syncytial virus replication inhibitors

Info

Publication number
SI1196409T1
SI1196409T1 SI200030315T SI200030315T SI1196409T1 SI 1196409 T1 SI1196409 T1 SI 1196409T1 SI 200030315 T SI200030315 T SI 200030315T SI 200030315 T SI200030315 T SI 200030315T SI 1196409 T1 SI1196409 T1 SI 1196409T1
Authority
SI
Slovenia
Prior art keywords
respiratory syncytial
syncytial virus
virus replication
replication inhibitors
inhibitors
Prior art date
Application number
SI200030315T
Other languages
English (en)
Slovenian (sl)
Inventor
Frans Eduard Janssens
Kathleen Petrus Marie-Jose Meersman
Francois Maria Sommen
Koenraad Jozef Lodewijk Marcel Andries
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of SI1196409T1 publication Critical patent/SI1196409T1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SI200030315T 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors SI1196409T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99202088 1999-06-28
PCT/EP2000/005675 WO2001000612A2 (en) 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors
EP00943840A EP1196409B1 (en) 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors

Publications (1)

Publication Number Publication Date
SI1196409T1 true SI1196409T1 (en) 2004-06-30

Family

ID=8240373

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030315T SI1196409T1 (en) 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors

Country Status (33)

Country Link
US (3) US6747028B1 (xx)
EP (1) EP1196409B1 (xx)
JP (1) JP2003503402A (xx)
KR (1) KR100731271B1 (xx)
CN (1) CN1210275C (xx)
AR (1) AR035991A1 (xx)
AT (1) ATE258928T1 (xx)
AU (1) AU778218B2 (xx)
BG (1) BG65328B1 (xx)
BR (1) BR0012047A (xx)
CA (1) CA2376676C (xx)
DE (1) DE60008112T2 (xx)
DK (1) DK1196409T3 (xx)
EA (1) EA005027B1 (xx)
EE (1) EE04591B1 (xx)
ES (1) ES2215683T3 (xx)
HK (1) HK1045997A1 (xx)
HR (1) HRP20010935A2 (xx)
HU (1) HUP0201869A3 (xx)
IL (2) IL147327A0 (xx)
MX (1) MXPA02000120A (xx)
MY (1) MY127687A (xx)
NO (1) NO322458B1 (xx)
NZ (1) NZ515664A (xx)
PL (1) PL200674B1 (xx)
PT (1) PT1196409E (xx)
SI (1) SI1196409T1 (xx)
SK (1) SK19122001A3 (xx)
TR (1) TR200103806T2 (xx)
TW (1) TWI278454B (xx)
UA (1) UA74787C2 (xx)
WO (1) WO2001000612A2 (xx)
ZA (1) ZA200110479B (xx)

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US6747028B1 (en) 1999-06-28 2004-06-08 Hanssen Pharmaceutica, N.V. Respiratory syncytial virus replication inhibitors
KR100731276B1 (ko) * 1999-06-28 2007-06-21 얀센 파마슈티카 엔.브이. 호흡기 신시티움 바이러스 복제 억제제
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US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
AU2003258177A1 (en) 2002-08-09 2004-02-25 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
WO2004014316A2 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
JP2006505570A (ja) * 2002-10-17 2006-02-16 アムジエン・インコーポレーテツド ベンズイミダゾール誘導体およびそれのバニロイド受容体リガンドとしての使用
CA2541618C (en) 2003-10-30 2011-12-13 Boehringer Ingelheim (Canada) Ltd. Rsv polymerase inhibitors
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
CN1894239A (zh) * 2003-12-18 2007-01-10 泰博特克药品有限公司 作为呼吸道合胞病毒复制的抑制剂的哌啶-氨基-苯并咪唑类衍生物
TWI382981B (zh) * 2003-12-18 2013-01-21 Tibotec Pharm Ltd 作為呼吸道融合病毒複製抑制劑之5-或6-經取代的苯并咪唑衍生物
WO2005058870A1 (en) * 2003-12-18 2005-06-30 Tibotec Pharmaceuticals Ltd. Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication
RU2379302C2 (ru) 2003-12-18 2010-01-20 Тиботек Фармасьютикалз Лтд. Аминобензимидазолы и бензимидазолы в качестве ингибиторов репликации респираторно-синцитиального вируса
MY140893A (en) * 2003-12-18 2010-01-29 Tibotec Pharm Ltd Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication
DE102004010207A1 (de) * 2004-03-02 2005-09-15 Aventis Pharma S.A. Neue 4-Benzimidazol-2-yl-pyridazin-3-on-Derivate
EP1951704B1 (en) 2005-03-17 2016-03-16 Janssen Sciences Ireland UC 1,3-dihydro-benzimidazol-2-ylidene amines useful for the treatment or prevention of viral infections
MX2007016537A (es) 2005-06-20 2008-03-06 Tibotec Pharm Ltd 1,3-dihidro-benzoimidazol-onas 1-(2-amino-3-(alquilo sustituido)-3h-bencimidazolilmetil)-3-sustituidas con actividad sobre virus respiratorios sinciciales.
EP1896449B1 (en) 2005-06-20 2013-11-06 Janssen R&D Ireland Heterocyclylaminoalkyl substituted benzimidazoles
JP5070207B2 (ja) * 2005-06-20 2012-11-07 テイボテク・フアーマシユーチカルズ 2−置換ベンズイミダゾール
US20130085133A1 (en) * 2010-02-08 2013-04-04 Sourthern Research Institute Office of Commercialization and Intellectual Prop. Anti-viral treatment and assay to screenfor anti-viral agent
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI541241B (zh) * 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
EP4289813A3 (en) 2011-12-28 2024-05-15 Global Blood Therapeutics, Inc. Intermediates to obtain substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation
US9012450B2 (en) 2011-12-28 2015-04-21 Global Blood Therapeutics, Inc. Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation
CN104540817B (zh) 2012-06-15 2017-03-01 爱尔兰詹森科学公司 作为呼吸道合胞病毒抗病毒剂的用杂环取代的1,3‑二氢‑2h‑苯并咪唑‑2‑酮衍生物
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
PE20161035A1 (es) 2013-03-15 2016-11-13 Global Blood Therapeutics Inc Compuestos y usos de estos para la modulacion de la hemoglobina
EP3919056A1 (en) 2013-03-15 2021-12-08 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
EP2968299B1 (en) 2013-03-15 2021-01-20 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
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DK3102208T3 (da) 2014-02-07 2021-03-08 Global Blood Therapeutics Inc Krystallinsk polymorf af den frie base af 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyd
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Also Published As

Publication number Publication date
NZ515664A (en) 2004-01-30
ES2215683T3 (es) 2004-10-16
HRP20010935A2 (en) 2003-06-30
CN1358181A (zh) 2002-07-10
IL147327A (en) 2007-06-03
EE200100688A (et) 2003-04-15
MY127687A (en) 2006-12-29
US20070135404A1 (en) 2007-06-14
NO20016369D0 (no) 2001-12-27
WO2001000612A2 (en) 2001-01-04
AU5816600A (en) 2001-01-31
TWI278454B (en) 2007-04-11
CA2376676A1 (en) 2001-01-04
CN1210275C (zh) 2005-07-13
BR0012047A (pt) 2002-03-12
EA005027B1 (ru) 2004-10-28
DE60008112T2 (de) 2004-09-16
UA74787C2 (en) 2006-02-15
DE60008112D1 (en) 2004-03-11
US7179811B2 (en) 2007-02-20
EE04591B1 (et) 2006-02-15
PL352378A1 (en) 2003-08-25
WO2001000612A3 (en) 2001-03-29
AU778218B2 (en) 2004-11-25
TR200103806T2 (tr) 2002-06-21
AR035991A1 (es) 2004-08-04
NO20016369L (no) 2002-02-20
PL200674B1 (pl) 2009-01-30
ZA200110479B (en) 2003-03-20
EA200200088A1 (ru) 2002-06-27
BG106286A (en) 2002-10-31
KR100731271B1 (ko) 2007-06-21
HUP0201869A2 (hu) 2002-11-28
CA2376676C (en) 2009-01-20
MXPA02000120A (es) 2002-07-02
SK19122001A3 (sk) 2003-01-09
US7528149B2 (en) 2009-05-05
JP2003503402A (ja) 2003-01-28
DK1196409T3 (da) 2004-06-07
HK1045997A1 (zh) 2002-12-20
BG65328B1 (bg) 2008-02-29
EP1196409B1 (en) 2004-02-04
ATE258928T1 (de) 2004-02-15
NO322458B1 (no) 2006-10-09
HUP0201869A3 (en) 2003-12-29
IL147327A0 (en) 2002-08-14
KR20020003884A (ko) 2002-01-15
EP1196409A2 (en) 2002-04-17
PT1196409E (pt) 2004-06-30
US6747028B1 (en) 2004-06-08
US20070015747A1 (en) 2007-01-18

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