NO322458B1 - Benzimidazoler og imidazopyridiner, deres fremstilling og sammensetninger omfattende dem, samt deres anvendelse - Google Patents

Benzimidazoler og imidazopyridiner, deres fremstilling og sammensetninger omfattende dem, samt deres anvendelse Download PDF

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Publication number
NO322458B1
NO322458B1 NO20016369A NO20016369A NO322458B1 NO 322458 B1 NO322458 B1 NO 322458B1 NO 20016369 A NO20016369 A NO 20016369A NO 20016369 A NO20016369 A NO 20016369A NO 322458 B1 NO322458 B1 NO 322458B1
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NO
Norway
Prior art keywords
formula
methyl
amine
pyridinyl
piperidinyl
Prior art date
Application number
NO20016369A
Other languages
English (en)
Norwegian (no)
Other versions
NO20016369L (no
NO20016369D0 (no
Inventor
Koenraad Jozef Lodewij Andries
Kathleen Petrus Meersman
Frans Eduard Janssens
Francois Maria Sommen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20016369D0 publication Critical patent/NO20016369D0/no
Publication of NO20016369L publication Critical patent/NO20016369L/no
Publication of NO322458B1 publication Critical patent/NO322458B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
NO20016369A 1999-06-28 2001-12-27 Benzimidazoler og imidazopyridiner, deres fremstilling og sammensetninger omfattende dem, samt deres anvendelse NO322458B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99202088 1999-06-28
PCT/EP2000/005675 WO2001000612A2 (en) 1999-06-28 2000-06-20 Respiratory syncytial virus replication inhibitors

Publications (3)

Publication Number Publication Date
NO20016369D0 NO20016369D0 (no) 2001-12-27
NO20016369L NO20016369L (no) 2002-02-20
NO322458B1 true NO322458B1 (no) 2006-10-09

Family

ID=8240373

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20016369A NO322458B1 (no) 1999-06-28 2001-12-27 Benzimidazoler og imidazopyridiner, deres fremstilling og sammensetninger omfattende dem, samt deres anvendelse

Country Status (33)

Country Link
US (3) US6747028B1 (es)
EP (1) EP1196409B1 (es)
JP (1) JP2003503402A (es)
KR (1) KR100731271B1 (es)
CN (1) CN1210275C (es)
AR (1) AR035991A1 (es)
AT (1) ATE258928T1 (es)
AU (1) AU778218B2 (es)
BG (1) BG65328B1 (es)
BR (1) BR0012047A (es)
CA (1) CA2376676C (es)
DE (1) DE60008112T2 (es)
DK (1) DK1196409T3 (es)
EA (1) EA005027B1 (es)
EE (1) EE04591B1 (es)
ES (1) ES2215683T3 (es)
HK (1) HK1045997A1 (es)
HR (1) HRP20010935A2 (es)
HU (1) HUP0201869A3 (es)
IL (2) IL147327A0 (es)
MX (1) MXPA02000120A (es)
MY (1) MY127687A (es)
NO (1) NO322458B1 (es)
NZ (1) NZ515664A (es)
PL (1) PL200674B1 (es)
PT (1) PT1196409E (es)
SI (1) SI1196409T1 (es)
SK (1) SK19122001A3 (es)
TR (1) TR200103806T2 (es)
TW (1) TWI278454B (es)
UA (1) UA74787C2 (es)
WO (1) WO2001000612A2 (es)
ZA (1) ZA200110479B (es)

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CA2495245A1 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
WO2004014316A2 (en) 2002-08-09 2004-02-19 Viropharma Incorporated Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases
JP2006505570A (ja) * 2002-10-17 2006-02-16 アムジエン・インコーポレーテツド ベンズイミダゾール誘導体およびそれのバニロイド受容体リガンドとしての使用
CA2541618C (en) 2003-10-30 2011-12-13 Boehringer Ingelheim (Canada) Ltd. Rsv polymerase inhibitors
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TWI349007B (en) * 2003-12-18 2011-09-21 Tibotec Pharm Ltd Piperidine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
US20090036466A1 (en) 2003-12-18 2009-02-05 Jean-Francois Bonfanti Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication
BRPI0417273A (pt) * 2003-12-18 2007-03-27 Tibotec Pharm Ltd derivados de benzimidazola 5- ou 6-substituìdos como inibidores de replicação do vìrus sincical respiratório
AR046959A1 (es) * 2003-12-18 2006-01-04 Tibotec Pharm Ltd Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
ATE435222T1 (de) * 2003-12-18 2009-07-15 Tibotec Pharm Ltd Aminobenzimidazole und benzimidazole als inhibitoren der replikation von respiratory syncytial virus
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ATE529424T1 (de) 2005-06-20 2011-11-15 Tibotec Pharm Ltd 1-ää2-amino-3-(substituiertes alkyl)-3h- benzimidazolylümethylü-3-substituierte-1,3- dihydrobenzimidazol-2-one als replikationshemmer des respiratorischen syncytialvirus
CA2612264C (en) 2005-06-20 2014-09-23 Tibotec Pharmaceuticals Ltd. Heterocyclylaminoalkyl substituted benzimidazoles
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TWI530495B (zh) 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
HUE035069T2 (en) 2011-12-28 2018-05-02 Global Blood Therapeutics Inc Substituted benzaldehyde compounds and their use to increase tissue oxygenation
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ES2632914T3 (es) 2012-06-15 2017-09-18 Janssen Sciences Ireland Uc Derivados de 1,3-dihidro-2H-bencimidazol-2-ona sustituidos con heterociclos como agentes antivirales para el virus respiratorio sincicial
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
PE20161035A1 (es) 2013-03-15 2016-11-13 Global Blood Therapeutics Inc Compuestos y usos de estos para la modulacion de la hemoglobina
CA2903022C (en) 2013-03-15 2021-11-09 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
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Also Published As

Publication number Publication date
EP1196409A2 (en) 2002-04-17
JP2003503402A (ja) 2003-01-28
UA74787C2 (en) 2006-02-15
AU778218B2 (en) 2004-11-25
HUP0201869A3 (en) 2003-12-29
AU5816600A (en) 2001-01-31
HRP20010935A2 (en) 2003-06-30
EA200200088A1 (ru) 2002-06-27
DK1196409T3 (da) 2004-06-07
EE04591B1 (et) 2006-02-15
US7528149B2 (en) 2009-05-05
ES2215683T3 (es) 2004-10-16
WO2001000612A2 (en) 2001-01-04
SK19122001A3 (sk) 2003-01-09
MY127687A (en) 2006-12-29
DE60008112T2 (de) 2004-09-16
DE60008112D1 (en) 2004-03-11
PL352378A1 (en) 2003-08-25
PL200674B1 (pl) 2009-01-30
SI1196409T1 (en) 2004-06-30
EE200100688A (et) 2003-04-15
AR035991A1 (es) 2004-08-04
BG65328B1 (bg) 2008-02-29
KR20020003884A (ko) 2002-01-15
PT1196409E (pt) 2004-06-30
WO2001000612A3 (en) 2001-03-29
BG106286A (en) 2002-10-31
IL147327A (en) 2007-06-03
MXPA02000120A (es) 2002-07-02
CA2376676C (en) 2009-01-20
NO20016369L (no) 2002-02-20
HUP0201869A2 (hu) 2002-11-28
CN1210275C (zh) 2005-07-13
ATE258928T1 (de) 2004-02-15
NO20016369D0 (no) 2001-12-27
HK1045997A1 (zh) 2002-12-20
CN1358181A (zh) 2002-07-10
EA005027B1 (ru) 2004-10-28
US20070015747A1 (en) 2007-01-18
TR200103806T2 (tr) 2002-06-21
ZA200110479B (en) 2003-03-20
US6747028B1 (en) 2004-06-08
IL147327A0 (en) 2002-08-14
NZ515664A (en) 2004-01-30
EP1196409B1 (en) 2004-02-04
US7179811B2 (en) 2007-02-20
TWI278454B (en) 2007-04-11
BR0012047A (pt) 2002-03-12
KR100731271B1 (ko) 2007-06-21
US20070135404A1 (en) 2007-06-14
CA2376676A1 (en) 2001-01-04

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