EE04262B1 - Östrogeeni ja 2-fenüül-1-[4-(2-aminoetoksü)bensüül]indooli ühendit sisaldav farmatseutiline kompositsioon ja produkt - Google Patents
Östrogeeni ja 2-fenüül-1-[4-(2-aminoetoksü)bensüül]indooli ühendit sisaldav farmatseutiline kompositsioon ja produktInfo
- Publication number
- EE04262B1 EE04262B1 EEP200000652A EEP200000652A EE04262B1 EE 04262 B1 EE04262 B1 EE 04262B1 EE P200000652 A EEP200000652 A EE P200000652A EE P200000652 A EEP200000652 A EE P200000652A EE 04262 B1 EE04262 B1 EE 04262B1
- Authority
- EE
- Estonia
- Prior art keywords
- aminoethoxy
- estrogen
- benzyl
- phenyl
- product
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7956198A | 1998-05-15 | 1998-05-15 | |
PCT/US1999/010217 WO1999059581A1 (en) | 1998-05-15 | 1999-05-11 | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200000652A EE200000652A (et) | 2002-04-15 |
EE04262B1 true EE04262B1 (et) | 2004-04-15 |
Family
ID=22151320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200000652A EE04262B1 (et) | 1998-05-15 | 1999-05-11 | Östrogeeni ja 2-fenüül-1-[4-(2-aminoetoksü)bensüül]indooli ühendit sisaldav farmatseutiline kompositsioon ja produkt |
Country Status (42)
Country | Link |
---|---|
EP (1) | EP1076558B1 (is) |
JP (3) | JP2002515431A (is) |
KR (1) | KR100620772B1 (is) |
CN (1) | CN1230163C (is) |
AP (1) | AP1424A (is) |
AR (1) | AR020074A1 (is) |
AT (1) | ATE245026T1 (is) |
AU (1) | AU760378B2 (is) |
BE (1) | BE2015C026I2 (is) |
BG (1) | BG64783B1 (is) |
BR (1) | BR9911040A (is) |
CA (1) | CA2329530A1 (is) |
CU (1) | CU23241B7 (is) |
CY (1) | CY2015020I1 (is) |
CZ (1) | CZ299334B6 (is) |
DE (1) | DE69909616T2 (is) |
DK (1) | DK1076558T3 (is) |
EA (1) | EA005932B1 (is) |
EE (1) | EE04262B1 (is) |
ES (1) | ES2203131T3 (is) |
FR (1) | FR15C0035I2 (is) |
GE (1) | GEP20033079B (is) |
HK (1) | HK1031691A1 (is) |
HR (1) | HRP20000778B1 (is) |
HU (2) | HU226587B1 (is) |
ID (1) | ID26890A (is) |
IL (1) | IL139130A (is) |
IN (1) | IN192220B (is) |
LT (1) | LTC1076558I2 (is) |
LU (1) | LU92699I2 (is) |
NO (2) | NO328129B1 (is) |
NZ (1) | NZ508200A (is) |
OA (1) | OA11552A (is) |
PL (1) | PL194750B1 (is) |
PT (1) | PT1076558E (is) |
SI (1) | SI1076558T1 (is) |
SK (1) | SK284666B6 (is) |
TR (1) | TR200003377T2 (is) |
TW (1) | TW565554B (is) |
UA (1) | UA66861C2 (is) |
WO (1) | WO1999059581A1 (is) |
ZA (1) | ZA200006959B (is) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL194750B1 (pl) * | 1998-05-15 | 2007-06-29 | Wyeth Corp | Kompozycja farmaceutyczna zawierająca indole i estrogeny, jej zastosowanie oraz produkt |
US7005428B1 (en) | 1998-06-11 | 2006-02-28 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
US6465445B1 (en) | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
PL208972B1 (pl) | 1999-07-06 | 2011-07-29 | Endorech | Zastosowanie selektywnego modulatora receptora estrogenu |
US20020013327A1 (en) * | 2000-04-18 | 2002-01-31 | Lee Andrew G. | Compositions and methods for treating female sexual dysfunction |
AU2001273125A1 (en) * | 2000-07-06 | 2002-01-21 | American Home Products Corporation | Combinations of bisphosphonates, estrogenic agents and optionally estrogens |
WO2002003992A2 (en) * | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted indole compounds for treating prosthesis-related bone degeneration |
WO2002003989A2 (en) * | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted indole compounds for treating sphincter incontinence |
BR0112365A (pt) * | 2000-07-06 | 2003-05-13 | Wyeth Corp | Combinações de estatinas, agentes estrogênicos e opcionalmente estrogênios |
US6376486B1 (en) | 2000-07-06 | 2002-04-23 | American Home Products Corporation | Methods of inhibiting sphincter incontinence |
US6455568B2 (en) | 2000-07-06 | 2002-09-24 | Wyeth | Combination therapy for inhibiting sphincter incontinence |
DE10117441A1 (de) * | 2001-04-03 | 2002-10-10 | Schering Ag | 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate |
PL367094A1 (en) | 2001-07-31 | 2005-02-21 | Pfizer Products Inc. | Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins |
KR100470274B1 (ko) | 2002-11-08 | 2005-02-05 | 진 장 | 덮개층을 이용한 비정질 물질의 상 변화 방법 |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
FR2880625B1 (fr) * | 2005-01-07 | 2007-03-09 | Sanofi Aventis Sa | Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
ES2543599T3 (es) | 2008-04-16 | 2015-08-20 | Karo Bio Ab | Nuevos ligandos de receptor de estrógeno |
AR072297A1 (es) * | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
CN102690225B (zh) * | 2012-04-11 | 2014-12-24 | 南京友杰医药科技有限公司 | 巴多昔芬的合成方法 |
CN103709090A (zh) * | 2014-01-16 | 2014-04-09 | 江苏万特制药有限公司 | 醋酸巴多昔芬的制备方法及其关键中间体 |
CN103739540B (zh) * | 2014-01-20 | 2016-05-04 | 华润赛科药业有限责任公司 | 一种醋酸巴多昔芬中间体的制备方法 |
CN105669518B (zh) * | 2014-12-04 | 2019-06-04 | 上海医药集团股份有限公司 | 醋酸巴多昔芬及其a晶型的制备方法 |
JP7287964B2 (ja) * | 2017-12-15 | 2023-06-06 | ブリストル-マイヤーズ スクイブ カンパニー | 置換インドールエーテル化合物 |
IT201800006562A1 (it) * | 2018-06-21 | 2019-12-21 | Procedimento e intermedi utili per la preparazione di indoli | |
US20230158152A1 (en) * | 2020-03-17 | 2023-05-25 | Medshine Discovery Inc. | Proteolysis regulator and method for using same |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4729999A (en) * | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
EP0639567A1 (en) * | 1992-05-08 | 1995-02-22 | Otsuka Pharmaceutical Factory, Inc. | Indole derivative |
TW366342B (en) * | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
GB9326332D0 (en) * | 1993-12-23 | 1994-02-23 | Karo Bio | Indole derivatives |
DE4426625A1 (de) * | 1994-07-27 | 1996-03-14 | Schering Ag | 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
NZ314601A (en) * | 1996-04-19 | 1999-09-29 | American Home Prod | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole derivatives as estrogenic agents and pharmaceutical compositions |
TW397821B (en) * | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
AU3620597A (en) * | 1996-07-09 | 1998-02-02 | Smithkline Beecham Laboratoires Pharmaceutiques | Indole derivatives for the treatment of osteoporosis |
US5672609A (en) * | 1996-07-18 | 1997-09-30 | Eli Lilly And Company | Pyridine compounds, intermediates compositions and methods of use |
DE69837210T2 (de) * | 1997-10-15 | 2007-12-27 | Wyeth | Neue aryloxy-alkyl-dialkylamine |
JP2001520997A (ja) * | 1997-10-28 | 2001-11-06 | メルク エンド カムパニー インコーポレーテッド | 性腺刺激ホルモン放出ホルモン拮抗薬 |
UA68365C2 (en) * | 1997-11-06 | 2004-08-16 | Wyeth Corp | Peroral contraception by combination of anti-estrogen and progestin |
PL194750B1 (pl) * | 1998-05-15 | 2007-06-29 | Wyeth Corp | Kompozycja farmaceutyczna zawierająca indole i estrogeny, jej zastosowanie oraz produkt |
-
1999
- 1999-05-11 PL PL99345268A patent/PL194750B1/pl unknown
- 1999-05-11 CA CA002329530A patent/CA2329530A1/en not_active Abandoned
- 1999-05-11 EE EEP200000652A patent/EE04262B1/xx active Protection Beyond IP Right Term
- 1999-05-11 ID IDW20002312A patent/ID26890A/id unknown
- 1999-05-11 GE GEAP19995675A patent/GEP20033079B/en unknown
- 1999-05-11 TR TR2000/03377T patent/TR200003377T2/xx unknown
- 1999-05-11 IL IL13913099A patent/IL139130A/xx not_active IP Right Cessation
- 1999-05-11 CZ CZ20004254A patent/CZ299334B6/cs not_active IP Right Cessation
- 1999-05-11 UA UA2000127184A patent/UA66861C2/uk unknown
- 1999-05-11 BR BR9911040-7A patent/BR9911040A/pt not_active Application Discontinuation
- 1999-05-11 DE DE69909616T patent/DE69909616T2/de not_active Expired - Lifetime
- 1999-05-11 KR KR1020007012821A patent/KR100620772B1/ko not_active IP Right Cessation
- 1999-05-11 OA OA1200000311A patent/OA11552A/en unknown
- 1999-05-11 NZ NZ508200A patent/NZ508200A/en not_active IP Right Cessation
- 1999-05-11 AU AU38944/99A patent/AU760378B2/en not_active Expired
- 1999-05-11 DK DK99921834T patent/DK1076558T3/da active
- 1999-05-11 SI SI9930339T patent/SI1076558T1/xx unknown
- 1999-05-11 PT PT99921834T patent/PT1076558E/pt unknown
- 1999-05-11 WO PCT/US1999/010217 patent/WO1999059581A1/en active IP Right Grant
- 1999-05-11 AP APAP/P/2000/001970A patent/AP1424A/en active
- 1999-05-11 AT AT99921834T patent/ATE245026T1/de active
- 1999-05-11 JP JP2000549246A patent/JP2002515431A/ja not_active Withdrawn
- 1999-05-11 ES ES99921834T patent/ES2203131T3/es not_active Expired - Lifetime
- 1999-05-11 CN CNB99808655XA patent/CN1230163C/zh not_active Expired - Lifetime
- 1999-05-11 HU HU0103096A patent/HU226587B1/hu active Protection Beyond IP Right Term
- 1999-05-11 EA EA200001193A patent/EA005932B1/ru not_active IP Right Cessation
- 1999-05-11 EP EP99921834A patent/EP1076558B1/en not_active Expired - Lifetime
- 1999-05-11 SK SK1720-2000A patent/SK284666B6/sk not_active IP Right Cessation
- 1999-05-13 TW TW088107747A patent/TW565554B/zh not_active IP Right Cessation
- 1999-05-14 AR ARP990102310A patent/AR020074A1/es not_active Application Discontinuation
-
2000
- 2000-11-08 BG BG104930A patent/BG64783B1/bg unknown
- 2000-11-14 NO NO20005770A patent/NO328129B1/no not_active IP Right Cessation
- 2000-11-15 CU CU20000255A patent/CU23241B7/es not_active IP Right Cessation
- 2000-11-15 HR HR20000778A patent/HRP20000778B1/xx not_active IP Right Cessation
- 2000-11-27 ZA ZA200006959A patent/ZA200006959B/en unknown
-
2001
- 2001-03-26 HK HK01102189A patent/HK1031691A1/xx not_active IP Right Cessation
- 2001-07-31 IN IN419CA2001 patent/IN192220B/en unknown
-
2008
- 2008-07-29 JP JP2008195115A patent/JP5607871B2/ja not_active Expired - Lifetime
-
2014
- 2014-05-12 JP JP2014098831A patent/JP5872624B2/ja not_active Expired - Lifetime
-
2015
- 2015-04-15 LT LTPA2015018C patent/LTC1076558I2/lt unknown
- 2015-04-17 HU HUS1500023C patent/HUS1500023I1/hu unknown
- 2015-04-24 LU LU92699C patent/LU92699I2/xx unknown
- 2015-04-28 BE BE2015C026C patent/BE2015C026I2/fr unknown
- 2015-05-06 FR FR15C0035C patent/FR15C0035I2/fr active Active
- 2015-05-29 CY CY2015020C patent/CY2015020I1/el unknown
- 2015-06-02 NO NO2015015C patent/NO2015015I2/no not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
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HC1A | Change of owner name | ||
KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20101231 |
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HC1A | Change of owner name | ||
AA1Y | Spc filed |
Free format text: PRODUCT NAME: KONJUGEERITUD OESTROGEENID JA BASEDOKSIFEEN;REG NO/DATE: EU/1/14/960 18.12.2014 Spc suppl protection certif: C20150021 Filing date: 20150529 |
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FG1Y | Spc granted |
Free format text: PRODUCT NAME: KONJUGEERITUD OESTROGEENID JA BASEDOKSIFEEN;REG NO/DATE: EU/1/14/960 18.12.2014 Spc suppl protection certif: C20150021 00158 Filing date: 20150529 Extension date: 20240511 |
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SPCT | Party data change related to a supplementary protection certificate |
Owner name: WYETH LLC, NY 10001 2192, US Spc suppl protection certif: 00158 |