EE03383B1 - Kolesterooli biosünteesi inhibiitori ja kolesterooli absorptsiooni ß-laktaaminhibiitori kombinatsioon - Google Patents
Kolesterooli biosünteesi inhibiitori ja kolesterooli absorptsiooni ß-laktaaminhibiitori kombinatsioonInfo
- Publication number
- EE03383B1 EE03383B1 EE9400341A EE9400341A EE03383B1 EE 03383 B1 EE03383 B1 EE 03383B1 EE 9400341 A EE9400341 A EE 9400341A EE 9400341 A EE9400341 A EE 9400341A EE 03383 B1 EE03383 B1 EE 03383B1
- Authority
- EE
- Estonia
- Prior art keywords
- inhibitor
- cholesterol
- pct
- combination
- lactam
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99548892A | 1992-12-23 | 1992-12-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
EE9400341A EE9400341A (et) | 1996-04-15 |
EE03383B1 true EE03383B1 (et) | 2001-04-16 |
Family
ID=25541876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EE9400341A EE03383B1 (et) | 1992-12-23 | 1994-11-23 | Kolesterooli biosünteesi inhibiitori ja kolesterooli absorptsiooni ß-laktaaminhibiitori kombinatsioon |
Country Status (32)
Country | Link |
---|---|
US (1) | US5661145A (cs) |
EP (1) | EP0675714B1 (cs) |
JP (1) | JP3992728B2 (cs) |
KR (1) | KR100306936B1 (cs) |
CN (1) | CN1090479C (cs) |
AT (1) | ATE175872T1 (cs) |
AU (1) | AU680864B2 (cs) |
CA (1) | CA2152351C (cs) |
CZ (1) | CZ287125B6 (cs) |
DE (1) | DE69323213T2 (cs) |
DK (1) | DK0675714T3 (cs) |
EE (1) | EE03383B1 (cs) |
ES (1) | ES2128552T3 (cs) |
FI (1) | FI952916A0 (cs) |
GR (1) | GR3029405T3 (cs) |
HR (1) | HRP931515B1 (cs) |
HU (1) | HU221724B1 (cs) |
IL (1) | IL108112A (cs) |
LT (1) | LT3300B (cs) |
LV (1) | LV10919B (cs) |
MX (1) | MX9308053A (cs) |
MY (1) | MY109538A (cs) |
NO (1) | NO311325B1 (cs) |
NZ (1) | NZ259790A (cs) |
PL (1) | PL174128B1 (cs) |
SG (1) | SG45147A1 (cs) |
SI (1) | SI9300677A (cs) |
SK (1) | SK281173B6 (cs) |
TW (1) | TW319698B (cs) |
WO (1) | WO1994014433A1 (cs) |
YU (1) | YU49060B (cs) |
ZA (1) | ZA939552B (cs) |
Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
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US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
WO1996009827A2 (en) * | 1994-09-20 | 1996-04-04 | Pfizer Inc. | Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor |
US5633246A (en) * | 1994-11-18 | 1997-05-27 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5624920A (en) * | 1994-11-18 | 1997-04-29 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
KR20040029459A (ko) | 1995-11-02 | 2004-04-06 | 워너-램버트 캄파니 엘엘씨 | 지질 농도를 조절하는 제약 조성물 및 방법 |
US20030153541A1 (en) * | 1997-10-31 | 2003-08-14 | Robert Dudley | Novel anticholesterol compositions and method for using same |
SI20109A (sl) * | 1998-12-16 | 2000-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Stabilna farmacevtska formulacija |
WO2000063703A1 (en) * | 1999-04-16 | 2000-10-26 | Schering Corporation | Use of azetidinone compounds |
EP1192963A4 (en) * | 2000-04-05 | 2004-08-25 | Toray Industries | ADSORBENTS FOR PROTEINS OF THE HIGH MOBILITY PROTEIN AND PILLAR GROUP FOR CLEANING BODY LIQUIDS |
US6979462B1 (en) * | 2000-10-03 | 2005-12-27 | Mutual Pharmaceutical Co., Inc. | Stabilization of solid drug formulations |
US6584357B1 (en) * | 2000-10-17 | 2003-06-24 | Sony Corporation | Method and system for forming an acoustic signal from neural timing difference data |
US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
EP1911462A3 (en) | 2001-01-26 | 2011-11-30 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
CN1915429B (zh) * | 2001-01-26 | 2010-12-15 | 先灵公司 | 过氧化物酶体增殖物激活受体(ppar)活化剂和甾醇吸收抑制剂的组合药 |
CZ304929B6 (cs) | 2001-03-28 | 2015-01-28 | Merck Sharp & Dohme Corp. | Enantioselektivní syntéza azetidinonových meziproduktů |
US20030119757A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s) |
DK1429756T3 (da) * | 2001-09-21 | 2007-03-19 | Schering Corp | Behandling af xanthoma med azetidinonderivater som sterolabsorptionsinhibitorer |
AU2002348276A1 (en) | 2001-11-16 | 2003-06-10 | Bristol-Myers Squibb Company | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein |
US20030204096A1 (en) * | 2002-03-25 | 2003-10-30 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
GB0215579D0 (en) * | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
US7135556B2 (en) * | 2002-07-19 | 2006-11-14 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
AR040588A1 (es) * | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
ES2350977T3 (es) | 2002-11-05 | 2011-01-28 | Glaxo Group Limited | Agentes antibacterianos. |
ES2318274T3 (es) * | 2003-03-07 | 2009-05-01 | Schering Corporation | Compuestos de azetidinona sustituida, formulaciones y uso de los mismos para el tratamiento de hipercolesterolemia. |
JP5137228B2 (ja) * | 2003-03-07 | 2013-02-06 | メルク・シャープ・アンド・ドーム・コーポレーション | 高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用 |
EP1810971B1 (en) * | 2003-03-07 | 2013-12-25 | Merck Sharp & Dohme Corp. | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
MXPA05009502A (es) * | 2003-03-07 | 2005-10-18 | Schering Corp | Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
JP2005015434A (ja) * | 2003-06-27 | 2005-01-20 | Kotobuki Seiyaku Kk | 血清コレステロール低下剤或はアテローム性硬化症の予防又は治療剤 |
US20060089374A1 (en) * | 2003-07-17 | 2006-04-27 | Glenn Cornett | Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease |
GB2423927A (en) * | 2003-08-29 | 2006-09-13 | Cotherix Inc | Combination Of Cicletanine And An Oral Antidiabetic And/Or Blood Lipid-Lowering Agent For Treating Diabetes And Metabolic Syndrome |
US7371759B2 (en) | 2003-09-25 | 2008-05-13 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
EP1918000A2 (en) | 2003-11-05 | 2008-05-07 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
US7420059B2 (en) | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
JP2007516287A (ja) * | 2003-12-23 | 2007-06-21 | メルク エンド カムパニー インコーポレーテッド | 抗高コレステロール血症化合物 |
WO2005061452A1 (en) * | 2003-12-23 | 2005-07-07 | Astrazeneca Ab | Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity |
GB0329778D0 (en) * | 2003-12-23 | 2004-01-28 | Astrazeneca Ab | Chemical compounds |
EP1723414A4 (en) * | 2004-01-16 | 2008-03-26 | Merck & Co Inc | NPC1L1 (NPC3) AND METHOD FOR IDENTIFYING ITS LIGANDS |
AR049655A1 (es) * | 2004-07-01 | 2006-08-23 | Schering Corp | Antagonistas de nk1 |
US7572805B2 (en) | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
US20060046996A1 (en) * | 2004-08-31 | 2006-03-02 | Kowa Co., Ltd. | Method for treating hyperlipidemia |
US20060154959A1 (en) * | 2005-01-13 | 2006-07-13 | Navitas Pharma | Combination therapies of cicletanine and carvedilol |
MX2007003732A (es) * | 2004-09-29 | 2007-04-23 | Schering Corp | Combinaciones de azetidononas sustituidas y antagonistas de receptor de canabinoide 1. |
US7517991B2 (en) | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
WO2006076598A2 (en) | 2005-01-12 | 2006-07-20 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid receptor modulators |
US7368458B2 (en) | 2005-01-12 | 2008-05-06 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid receptor modulators |
US7361766B2 (en) | 2005-01-12 | 2008-04-22 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid receptor modulators |
US20070141174A1 (en) * | 2005-01-13 | 2007-06-21 | Navitas Pharma, Inc. | Enantiomeric compositions of cicletanine, in combination with other agents, for the treatment of hypertension |
US20080096915A1 (en) * | 2005-01-13 | 2008-04-24 | Greenberg Traurig LLP | Compositions for the treatment of metabolic disorders |
WO2006078697A1 (en) | 2005-01-18 | 2006-07-27 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid receptor modulators |
WO2006086464A2 (en) | 2005-02-10 | 2006-08-17 | Bristol-Myers Squibb Company | Dihydroquinazolinones as 5ht modulators |
US7317012B2 (en) | 2005-06-17 | 2008-01-08 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoind-1 receptor modulators |
US7452892B2 (en) | 2005-06-17 | 2008-11-18 | Bristol-Myers Squibb Company | Triazolopyrimidine cannabinoid receptor 1 antagonists |
US7629342B2 (en) | 2005-06-17 | 2009-12-08 | Bristol-Myers Squibb Company | Azabicyclic heterocycles as cannabinoid receptor modulators |
US7632837B2 (en) | 2005-06-17 | 2009-12-15 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid-1 receptor modulators |
US7572808B2 (en) | 2005-06-17 | 2009-08-11 | Bristol-Myers Squibb Company | Triazolopyridine cannabinoid receptor 1 antagonists |
CA2610959A1 (en) | 2005-06-20 | 2007-01-04 | Schering Corporation | Piperidine derivatives useful as histamine h3 antagonists |
UY29607A1 (es) * | 2005-06-20 | 2007-01-31 | Astrazeneca Ab | Compuestos quimicos |
AR057380A1 (es) * | 2005-06-22 | 2007-11-28 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona y uso terapeutico de los mismos |
AR054482A1 (es) * | 2005-06-22 | 2007-06-27 | Astrazeneca Ab | Derivados de azetidinona para el tratamiento de hiperlipidemias |
MY148538A (en) * | 2005-06-22 | 2013-04-30 | Astrazeneca Ab | Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions |
SA06270191B1 (ar) * | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
AR057383A1 (es) * | 2005-06-22 | 2007-12-05 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto |
US7795436B2 (en) | 2005-08-24 | 2010-09-14 | Bristol-Myers Squibb Company | Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists |
AR056155A1 (es) | 2005-10-26 | 2007-09-19 | Bristol Myers Squibb Co | Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica |
US20070105817A1 (en) * | 2005-11-09 | 2007-05-10 | Jim Page | Use of cicletanine and other furopyridines for treatment of systolic-predominant hypertension, isolated systolic hypertension, elevated pulse pressure, and general hypertension |
JP2009521452A (ja) * | 2005-12-21 | 2009-06-04 | シェーリング コーポレイション | コレステロール降下剤およびh3受容体アンタゴニスト/逆アゴニストを使用する非アルコール性脂肪性肝疾患の処置 |
US7553836B2 (en) | 2006-02-06 | 2009-06-30 | Bristol-Myers Squibb Company | Melanin concentrating hormone receptor-1 antagonists |
US7910698B2 (en) * | 2006-02-24 | 2011-03-22 | Schering Corporation | NPC1L1 orthologues |
AR060623A1 (es) * | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
US20070275052A1 (en) * | 2006-05-24 | 2007-11-29 | Glenmark Pharmaceuticals Limited | Pharmaceutical compositions containing sterol inhibitors |
MX2009002398A (es) * | 2006-09-05 | 2009-03-16 | Schering Corp | Combinaciones farmaceuticas para manejo de lipidos y en el tratamiento de aterosclerosis y estatosis hepatica. |
CA2674367A1 (en) * | 2007-01-03 | 2008-07-17 | Glenn V. Cornett | Cicletanine and pkc inhibitors in the treatment of pulmonary and cardiac disorders |
US20090011994A1 (en) | 2007-07-06 | 2009-01-08 | Bristol-Myers Squibb Company | Non-basic melanin concentrating hormone receptor-1 antagonists and methods |
PE20091928A1 (es) | 2008-05-29 | 2009-12-31 | Bristol Myers Squibb Co | Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos |
WO2010021681A2 (en) * | 2008-08-18 | 2010-02-25 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
CN102448456A (zh) | 2009-03-27 | 2012-05-09 | 百时美施贵宝公司 | 用dpp-iv抑制剂预防重度有害心血管事件的方法 |
EP2892897A1 (en) | 2012-09-05 | 2015-07-15 | Bristol-Myers Squibb Company | Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists |
EP2892896B1 (en) | 2012-09-05 | 2016-06-29 | Bristol-Myers Squibb Company | Pyrrolone or pyrrolidinone melanin concentrating hormore receptor-1 antagonists |
MX2021000601A (es) | 2018-07-19 | 2021-04-13 | Astrazeneca Ab | Metodos de tratamiento de hfpef empleando dapagliflozina y composiciones que comprenden la misma. |
US11919879B2 (en) | 2021-06-16 | 2024-03-05 | Celgene Corporation | Carboxylic acid containing azetidinyl compounds for the treatment of neurodegenerative diseases |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4680391A (en) * | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
US4983597A (en) * | 1989-08-31 | 1991-01-08 | Merck & Co., Inc. | Beta-lactams as anticholesterolemic agents |
US5120729A (en) * | 1990-06-20 | 1992-06-09 | Merck & Co., Inc. | Beta-lactams as antihypercholesterolemics |
US5085473A (en) * | 1990-10-09 | 1992-02-04 | Yuhe Yang | Air actuated car curtain device |
JP2525125B2 (ja) * | 1991-07-23 | 1996-08-14 | シェリング・コーポレーション | 血清コレステロ―ル低下薬として有用な置換β−ラクタム化合物およびそれらの製法 |
US9205972B2 (en) | 2012-01-26 | 2015-12-08 | Intralot S.A.—Integrated Lottery Systems and Services | Methods and systems for dispensing |
-
1993
- 1993-12-03 LT LTIP1514A patent/LT3300B/lt not_active IP Right Cessation
- 1993-12-13 MX MX9308053A patent/MX9308053A/es unknown
- 1993-12-21 WO PCT/US1993/012291 patent/WO1994014433A1/en active IP Right Grant
- 1993-12-21 ES ES94904854T patent/ES2128552T3/es not_active Expired - Lifetime
- 1993-12-21 MY MYPI93002792A patent/MY109538A/en unknown
- 1993-12-21 ZA ZA939552A patent/ZA939552B/xx unknown
- 1993-12-21 AT AT94904854T patent/ATE175872T1/de active
- 1993-12-21 SG SG1996000543A patent/SG45147A1/en unknown
- 1993-12-21 YU YU80293A patent/YU49060B/sh unknown
- 1993-12-21 SK SK783-95A patent/SK281173B6/sk not_active IP Right Cessation
- 1993-12-21 PL PL93309636A patent/PL174128B1/pl not_active IP Right Cessation
- 1993-12-21 KR KR1019950702608A patent/KR100306936B1/ko not_active IP Right Cessation
- 1993-12-21 CA CA002152351A patent/CA2152351C/en not_active Expired - Fee Related
- 1993-12-21 HU HU9501854A patent/HU221724B1/hu not_active IP Right Cessation
- 1993-12-21 US US08/454,348 patent/US5661145A/en not_active Expired - Lifetime
- 1993-12-21 NZ NZ259790A patent/NZ259790A/en not_active IP Right Cessation
- 1993-12-21 DE DE69323213T patent/DE69323213T2/de not_active Expired - Lifetime
- 1993-12-21 AU AU58720/94A patent/AU680864B2/en not_active Ceased
- 1993-12-21 TW TW082110824A patent/TW319698B/zh not_active IP Right Cessation
- 1993-12-21 JP JP51530594A patent/JP3992728B2/ja not_active Expired - Fee Related
- 1993-12-21 IL IL10811293A patent/IL108112A/en not_active IP Right Cessation
- 1993-12-21 CZ CZ19951643A patent/CZ287125B6/cs not_active IP Right Cessation
- 1993-12-21 DK DK94904854T patent/DK0675714T3/da active
- 1993-12-21 EP EP94904854A patent/EP0675714B1/en not_active Expired - Lifetime
- 1993-12-22 SI SI9300677A patent/SI9300677A/sl not_active IP Right Cessation
- 1993-12-22 CN CN93112663A patent/CN1090479C/zh not_active Expired - Fee Related
- 1993-12-22 HR HR07/995,488A patent/HRP931515B1/xx not_active IP Right Cessation
-
1994
- 1994-11-23 EE EE9400341A patent/EE03383B1/xx not_active IP Right Cessation
-
1995
- 1995-06-14 FI FI952916A patent/FI952916A0/fi unknown
- 1995-06-22 LV LVP-95-189A patent/LV10919B/en unknown
- 1995-06-23 NO NO19952529A patent/NO311325B1/no not_active IP Right Cessation
-
1999
- 1999-02-16 GR GR990400487T patent/GR3029405T3/el unknown
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