EE03383B1 - Combination of a cholesterol biosynthesis inhibitor and a β-lactam inhibitor of cholesterol absorption - Google Patents

Combination of a cholesterol biosynthesis inhibitor and a β-lactam inhibitor of cholesterol absorption

Info

Publication number
EE03383B1
EE03383B1 EE9400341A EE9400341A EE03383B1 EE 03383 B1 EE03383 B1 EE 03383B1 EE 9400341 A EE9400341 A EE 9400341A EE 9400341 A EE9400341 A EE 9400341A EE 03383 B1 EE03383 B1 EE 03383B1
Authority
EE
Estonia
Prior art keywords
inhibitor
cholesterol
pct
combination
lactam
Prior art date
Application number
EE9400341A
Other languages
Estonian (et)
Other versions
EE9400341A (en
Inventor
R. Davis Harry
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of EE9400341A publication Critical patent/EE9400341A/en
Publication of EE03383B1 publication Critical patent/EE03383B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

PCT No. PCT/US93/12291 Sec. 371 Date Jun. 20, 1995 Sec. 102(e) Date Jun. 20, 1995 PCT Filed Dec. 21, 1993 PCT Pub. No. WO94/14433 PCT Pub. Date Jul. 7, 1994Methods of reducing plasma cholesterol levels and treating or preventing atherosclerosis comprising administering an effective amount of a combination of a cholesterol biosynthesis inhibitor and a beta -lactam cholesterol absorption inhibitor, as well as pharmaceutical compositions and kits useful in those methods, are disclosed.
EE9400341A 1992-12-23 1994-11-23 Combination of a cholesterol biosynthesis inhibitor and a β-lactam inhibitor of cholesterol absorption EE03383B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99548892A 1992-12-23 1992-12-23

Publications (2)

Publication Number Publication Date
EE9400341A EE9400341A (en) 1996-04-15
EE03383B1 true EE03383B1 (en) 2001-04-16

Family

ID=25541876

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9400341A EE03383B1 (en) 1992-12-23 1994-11-23 Combination of a cholesterol biosynthesis inhibitor and a β-lactam inhibitor of cholesterol absorption

Country Status (32)

Country Link
US (1) US5661145A (en)
EP (1) EP0675714B1 (en)
JP (1) JP3992728B2 (en)
KR (1) KR100306936B1 (en)
CN (1) CN1090479C (en)
AT (1) ATE175872T1 (en)
AU (1) AU680864B2 (en)
CA (1) CA2152351C (en)
CZ (1) CZ287125B6 (en)
DE (1) DE69323213T2 (en)
DK (1) DK0675714T3 (en)
EE (1) EE03383B1 (en)
ES (1) ES2128552T3 (en)
FI (1) FI952916A0 (en)
GR (1) GR3029405T3 (en)
HR (1) HRP931515B1 (en)
HU (1) HU221724B1 (en)
IL (1) IL108112A (en)
LT (1) LT3300B (en)
LV (1) LV10919B (en)
MX (1) MX9308053A (en)
MY (1) MY109538A (en)
NO (1) NO311325B1 (en)
NZ (1) NZ259790A (en)
PL (1) PL174128B1 (en)
SG (1) SG45147A1 (en)
SI (1) SI9300677A (en)
SK (1) SK281173B6 (en)
TW (1) TW319698B (en)
WO (1) WO1994014433A1 (en)
YU (1) YU49060B (en)
ZA (1) ZA939552B (en)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5807834A (en) * 1994-09-20 1998-09-15 Pfizer Inc. Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor
US5624920A (en) * 1994-11-18 1997-04-29 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5656624A (en) * 1994-12-21 1997-08-12 Schering Corporation 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents
CN1679953A (en) 1995-11-02 2005-10-12 沃尼尔·朗伯公司 Pharmaceutical composition for regulating lipid concentration
US20030153541A1 (en) * 1997-10-31 2003-08-14 Robert Dudley Novel anticholesterol compositions and method for using same
SI20109A (en) * 1998-12-16 2000-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Stable pharmaceutical formulation
WO2000063703A1 (en) 1999-04-16 2000-10-26 Schering Corporation Use of azetidinone compounds
AU783457B2 (en) * 2000-04-05 2005-10-27 Toray Industries, Inc. Adsorbents for high mobility group proteins and column for purifying body fluid
US6979462B1 (en) * 2000-10-03 2005-12-27 Mutual Pharmaceutical Co., Inc. Stabilization of solid drug formulations
US6584357B1 (en) * 2000-10-17 2003-06-24 Sony Corporation Method and system for forming an acoustic signal from neural timing difference data
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
JP4711600B2 (en) 2001-01-26 2011-06-29 シェーリング コーポレイション Use of substituted azetidinone compounds for the treatment of sitosterolemia
CN1915429B (en) * 2001-01-26 2010-12-15 先灵公司 Combinations of peroxisome proliferator-activated receptor (PPAR) activators and sterol absorption inhibitors
SI1413331T1 (en) * 2001-01-26 2008-02-29 Schering Corp Combinations of the peroxisome proliferator-activated receptor (PPAR) activator fenofibrate with sterol absorption inhibitor ezetimibe for vascular indications
EP1911462A3 (en) 2001-01-26 2011-11-30 Schering Corporation Compositions comprising a sterol absorption inhibitor
EA006898B1 (en) 2001-03-28 2006-04-28 Шеринг Корпорейшн Enantioselective synthesis of azetidinone intermediate compounds
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
ATE411018T1 (en) * 2001-09-21 2008-10-15 Schering Corp METHOD FOR TREATING OR PREVENTING VASCULAR INFLAMMATION WITH STEROL ABSORPTION INHIBITOR(S)
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7132415B2 (en) 2001-09-21 2006-11-07 Schering Corporation Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
US6984645B2 (en) 2001-11-16 2006-01-10 Bristol-Myers Squibb Company Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
US20030204096A1 (en) * 2002-03-25 2003-10-30 Schering Corporation Enantioselective synthesis of azetidinone intermediate compounds
DE10227508A1 (en) * 2002-06-19 2004-01-08 Aventis Pharma Deutschland Gmbh Acid group-substituted diphenylazetidinones, processes for their preparation, pharmaceutical compositions containing them and their use
GB0215579D0 (en) * 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
US7135556B2 (en) * 2002-07-19 2006-11-14 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
AR040588A1 (en) 2002-07-26 2005-04-13 Schering Corp PHARMACEUTICAL FORMULATION INCLUDING AN INHIBITOR OF CHOLESTEROL ABSORPTION AND AN INHIBITOR OF A HMGCO TO REDUCTASE
AU2003291227A1 (en) 2002-11-05 2004-06-07 Smithkline Beecham Corporation Antibacterial agents
CA2504878A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
EP1810971B1 (en) * 2003-03-07 2013-12-25 Merck Sharp & Dohme Corp. Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
CN100439361C (en) 2003-03-07 2008-12-03 先灵公司 Substituted 2-azetidinone compounds, their formulations and their use in the treatment of hypercholesterolemia
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN1756755A (en) * 2003-03-07 2006-04-05 先灵公司 Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
JP4589919B2 (en) * 2003-03-07 2010-12-01 シェーリング コーポレイション Substituted azetidinone compounds, their formulations and uses for the treatment of hypercholesterolemia
JP2005015434A (en) * 2003-06-27 2005-01-20 Kotobuki Seiyaku Kk Serum cholesterol lowering agent or preventive or therapeutic agent for atherosclerosis
US20050113314A1 (en) * 2003-08-29 2005-05-26 Fong Benson M. Cicletanine in combination with oral antidiabetic and/or blood lipid-lowering agents as a combination therapy for diabetes and metabolic syndrome
US20060089374A1 (en) * 2003-07-17 2006-04-27 Glenn Cornett Enantiomeric compositions of cicletanine, alone and in combination with other agents, for the treatment of disease
US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
EP1918000A2 (en) 2003-11-05 2008-05-07 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
CA2550215A1 (en) * 2003-12-23 2005-07-07 Astrazeneca Ab Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
GB0329778D0 (en) * 2003-12-23 2004-01-28 Astrazeneca Ab Chemical compounds
EP1699760B1 (en) * 2003-12-23 2017-05-17 Merck Sharp & Dohme Corp. Anti-hypercholesterolemic compounds
EP1723414A4 (en) * 2004-01-16 2008-03-26 Merck & Co Inc NPC1L1 (NPC3) AND METHODS FOR IDENTIFYING LIGANDS THEREOF
CN101006074B (en) * 2004-07-01 2012-02-15 欧科生医股份有限公司 Piperidine derivatives as NK1 antagonists
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
US20060046996A1 (en) * 2004-08-31 2006-03-02 Kowa Co., Ltd. Method for treating hyperlipidemia
US20060154959A1 (en) * 2005-01-13 2006-07-13 Navitas Pharma Combination therapies of cicletanine and carvedilol
EP1807070A1 (en) * 2004-09-29 2007-07-18 Schering Corporation Combinations of substituted azetidinones and cb1 antagonists
US7517991B2 (en) 2004-10-12 2009-04-14 Bristol-Myers Squibb Company N-sulfonylpiperidine cannabinoid receptor 1 antagonists
US7361766B2 (en) 2005-01-12 2008-04-22 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
WO2006076597A1 (en) 2005-01-12 2006-07-20 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
US7314882B2 (en) 2005-01-12 2008-01-01 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
US20080096915A1 (en) * 2005-01-13 2008-04-24 Greenberg Traurig LLP Compositions for the treatment of metabolic disorders
US20070141174A1 (en) * 2005-01-13 2007-06-21 Navitas Pharma, Inc. Enantiomeric compositions of cicletanine, in combination with other agents, for the treatment of hypertension
WO2006078697A1 (en) 2005-01-18 2006-07-27 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid receptor modulators
WO2006086464A2 (en) 2005-02-10 2006-08-17 Bristol-Myers Squibb Company Dihydroquinazolinones as 5ht modulators
US7452892B2 (en) 2005-06-17 2008-11-18 Bristol-Myers Squibb Company Triazolopyrimidine cannabinoid receptor 1 antagonists
US7629342B2 (en) 2005-06-17 2009-12-08 Bristol-Myers Squibb Company Azabicyclic heterocycles as cannabinoid receptor modulators
TW200726765A (en) 2005-06-17 2007-07-16 Bristol Myers Squibb Co Triazolopyridine cannabinoid receptor 1 antagonists
US7317012B2 (en) 2005-06-17 2008-01-08 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoind-1 receptor modulators
US7632837B2 (en) 2005-06-17 2009-12-15 Bristol-Myers Squibb Company Bicyclic heterocycles as cannabinoid-1 receptor modulators
UY29607A1 (en) * 2005-06-20 2007-01-31 Astrazeneca Ab CHEMICAL COMPOUNDS
EP1902046B1 (en) * 2005-06-20 2009-12-02 Schering Corporation Piperidine derivatives useful as histamine h3 antagonists
AR057383A1 (en) * 2005-06-22 2007-12-05 Astrazeneca Ab CHEMICAL COMPOUNDS DERIVED FROM 2-AZETIDINONE, PHARMACEUTICAL FORMULATION AND A COMPOUND PREPARATION PROCESS
AR057072A1 (en) * 2005-06-22 2007-11-14 Astrazeneca Ab CHEMICAL COMPOUNDS DERIVED FROM 2-AZETIDINONE, PHARMACEUTICAL FORMULATION AND A COMPOUND PREPARATION PROCESS
SA06270191B1 (en) 2005-06-22 2010-03-29 استرازينيكا ايه بي Novel 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors for the Treatment of Hyperlipidaemic Conditions
AR054482A1 (en) * 2005-06-22 2007-06-27 Astrazeneca Ab DERIVATIVES OF AZETIDINONE FOR THE TREATMENT OF HYPERLIPIDEMIAS
AR057380A1 (en) * 2005-06-22 2007-11-28 Astrazeneca Ab CHEMICAL COMPOUNDS DERIVED FROM 2-AZETIDINONE AND THERAPEUTIC USE OF THE SAME
US7795436B2 (en) 2005-08-24 2010-09-14 Bristol-Myers Squibb Company Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
US8618115B2 (en) 2005-10-26 2013-12-31 Bristol-Myers Squibb Company Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them
US20070105817A1 (en) * 2005-11-09 2007-05-10 Jim Page Use of cicletanine and other furopyridines for treatment of systolic-predominant hypertension, isolated systolic hypertension, elevated pulse pressure, and general hypertension
US20070161578A1 (en) * 2005-12-21 2007-07-12 Hwa Joyce J Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and/or H3 receptor antagonist/inverse agonist
US7553836B2 (en) 2006-02-06 2009-06-30 Bristol-Myers Squibb Company Melanin concentrating hormone receptor-1 antagonists
EP1986489A2 (en) * 2006-02-24 2008-11-05 Schering Corporation Npc1l1 orthologues
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
US20070275052A1 (en) * 2006-05-24 2007-11-29 Glenmark Pharmaceuticals Limited Pharmaceutical compositions containing sterol inhibitors
WO2008030382A1 (en) * 2006-09-05 2008-03-13 Schering Corporation Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
WO2008085872A1 (en) * 2007-01-03 2008-07-17 Cornett Glenn V Cicletanine and pkc inhibitors in the treatment of pulmonary and cardiac disorders
US20090011994A1 (en) 2007-07-06 2009-01-08 Bristol-Myers Squibb Company Non-basic melanin concentrating hormone receptor-1 antagonists and methods
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US20100092479A1 (en) * 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
CA2756786A1 (en) 2009-03-27 2010-09-30 Bristol-Myers Squibb Company Methods for preventing major adverse cardiovascular events with dpp-iv inhibitors
EP2892897A1 (en) 2012-09-05 2015-07-15 Bristol-Myers Squibb Company Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
WO2014039411A1 (en) 2012-09-05 2014-03-13 Bristol-Myers Squibb Company Pyrrolone or pyrrolidinone melanin concentrating hormore receptor-1 antagonists
WO2020016335A1 (en) 2018-07-19 2020-01-23 Astrazeneca Ab Methods of treating hfpef employing dapagliflozin and compositions comprising the same
JP2024522718A (en) 2021-06-16 2024-06-21 セルジーン コーポレーション Azetidinyl compounds containing a carboxylic acid group for the treatment of neurodegenerative diseases - Patent Application 20070229633

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US4983597A (en) * 1989-08-31 1991-01-08 Merck & Co., Inc. Beta-lactams as anticholesterolemic agents
US5120729A (en) * 1990-06-20 1992-06-09 Merck & Co., Inc. Beta-lactams as antihypercholesterolemics
US5085473A (en) * 1990-10-09 1992-02-04 Yuhe Yang Air actuated car curtain device
CZ14294A3 (en) 1991-07-23 1994-07-13 Schering Corp Substituted beta-lactam compounds usable as hypocholesterol pharmaceutical preparations and process for preparing thereof
CN104302567B (en) 2012-01-26 2017-03-08 集成彩票系统与服务股份有限公司 Method and system for dispensing

Also Published As

Publication number Publication date
FI952916A7 (en) 1995-06-14
EE9400341A (en) 1996-04-15
CA2152351C (en) 2009-09-22
SI9300677A (en) 1994-09-30
IL108112A0 (en) 1994-04-12
ES2128552T3 (en) 1999-05-16
YU80293A (en) 1997-12-05
DE69323213T2 (en) 1999-07-08
NZ259790A (en) 1997-02-24
HUT72081A (en) 1996-03-28
ATE175872T1 (en) 1999-02-15
EP0675714B1 (en) 1999-01-20
SK281173B6 (en) 2000-12-11
SK78395A3 (en) 1996-05-08
EP0675714A1 (en) 1995-10-11
JPH08505141A (en) 1996-06-04
GR3029405T3 (en) 1999-05-28
LTIP1514A (en) 1994-10-25
IL108112A (en) 1999-11-30
CA2152351A1 (en) 1994-07-07
CN1095591A (en) 1994-11-30
ZA939552B (en) 1994-10-12
FI952916L (en) 1995-06-14
LV10919B (en) 1996-04-20
HRP931515A2 (en) 1996-12-31
MX9308053A (en) 1994-06-30
NO952529D0 (en) 1995-06-23
PL309636A1 (en) 1995-10-30
TW319698B (en) 1997-11-11
MY109538A (en) 1997-02-28
US5661145A (en) 1997-08-26
AU5872094A (en) 1994-07-19
AU680864B2 (en) 1997-08-14
KR100306936B1 (en) 2001-11-30
FI952916A0 (en) 1995-06-14
CZ287125B6 (en) 2000-09-13
WO1994014433A1 (en) 1994-07-07
SG45147A1 (en) 1998-01-16
CZ164395A3 (en) 1996-03-13
JP3992728B2 (en) 2007-10-17
LT3300B (en) 1995-06-26
HU221724B1 (en) 2002-12-28
CN1090479C (en) 2002-09-11
DK0675714T3 (en) 1999-09-13
YU49060B (en) 2003-08-29
DE69323213D1 (en) 1999-03-04
LV10919A (en) 1995-12-20
HRP931515B1 (en) 2000-02-29
NO952529L (en) 1995-06-23
HU9501854D0 (en) 1995-08-28
NO311325B1 (en) 2001-11-19
PL174128B1 (en) 1998-06-30

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