EE03383B1 - Combination of a cholesterol biosynthesis inhibitor and a β-lactam inhibitor of cholesterol absorption - Google Patents

Combination of a cholesterol biosynthesis inhibitor and a β-lactam inhibitor of cholesterol absorption

Info

Publication number
EE03383B1
EE03383B1 EE9400341A EE9400341A EE03383B1 EE 03383 B1 EE03383 B1 EE 03383B1 EE 9400341 A EE9400341 A EE 9400341A EE 9400341 A EE9400341 A EE 9400341A EE 03383 B1 EE03383 B1 EE 03383B1
Authority
EE
Estonia
Prior art keywords
inhibitor
cholesterol
pct
combination
lactam
Prior art date
Application number
EE9400341A
Other languages
Estonian (et)
Other versions
EE9400341A (en
Inventor
R. Davis Harry
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of EE9400341A publication Critical patent/EE9400341A/en
Publication of EE03383B1 publication Critical patent/EE03383B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

PCT No. PCT/US93/12291 Sec. 371 Date Jun. 20, 1995 Sec. 102(e) Date Jun. 20, 1995 PCT Filed Dec. 21, 1993 PCT Pub. No. WO94/14433 PCT Pub. Date Jul. 7, 1994Methods of reducing plasma cholesterol levels and treating or preventing atherosclerosis comprising administering an effective amount of a combination of a cholesterol biosynthesis inhibitor and a beta -lactam cholesterol absorption inhibitor, as well as pharmaceutical compositions and kits useful in those methods, are disclosed.
EE9400341A 1992-12-23 1994-11-23 Combination of a cholesterol biosynthesis inhibitor and a β-lactam inhibitor of cholesterol absorption EE03383B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99548892A 1992-12-23 1992-12-23

Publications (2)

Publication Number Publication Date
EE9400341A EE9400341A (en) 1996-04-15
EE03383B1 true EE03383B1 (en) 2001-04-16

Family

ID=25541876

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9400341A EE03383B1 (en) 1992-12-23 1994-11-23 Combination of a cholesterol biosynthesis inhibitor and a β-lactam inhibitor of cholesterol absorption

Country Status (32)

Country Link
US (1) US5661145A (en)
EP (1) EP0675714B1 (en)
JP (1) JP3992728B2 (en)
KR (1) KR100306936B1 (en)
CN (1) CN1090479C (en)
AT (1) ATE175872T1 (en)
AU (1) AU680864B2 (en)
CA (1) CA2152351C (en)
CZ (1) CZ287125B6 (en)
DE (1) DE69323213T2 (en)
DK (1) DK0675714T3 (en)
EE (1) EE03383B1 (en)
ES (1) ES2128552T3 (en)
FI (1) FI952916A0 (en)
GR (1) GR3029405T3 (en)
HR (1) HRP931515B1 (en)
HU (1) HU221724B1 (en)
IL (1) IL108112A (en)
LT (1) LT3300B (en)
LV (1) LV10919B (en)
MX (1) MX9308053A (en)
MY (1) MY109538A (en)
NO (1) NO311325B1 (en)
NZ (1) NZ259790A (en)
PL (1) PL174128B1 (en)
SG (1) SG45147A1 (en)
SI (1) SI9300677A (en)
SK (1) SK281173B6 (en)
TW (1) TW319698B (en)
WO (1) WO1994014433A1 (en)
YU (1) YU49060B (en)
ZA (1) ZA939552B (en)

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US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
CN1915429B (en) * 2001-01-26 2010-12-15 先灵公司 Combinations of the peroxisome proliferator-activated receptor (ppar) activator and sterol absorption inhibitor
EP1911462A3 (en) 2001-01-26 2011-11-30 Schering Corporation Compositions comprising a sterol absorption inhibitor
CN1275949C (en) 2001-03-28 2006-09-20 先灵公司 Enantioselective synthesis of azetidinone intermediate compounds
BR0212907A (en) * 2001-09-21 2004-10-13 Schering Corp Methods for treating or preventing vascular inflammation using sterol absorption inhibitor (s)
ES2272776T3 (en) * 2001-09-21 2007-05-01 Schering Corporation TREATMENT OF XANTOMAS WITH DERIVATIVES OF AZETIDINONE AS INHIBITORS OF STEROL ABSORPTION.
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Also Published As

Publication number Publication date
NO952529L (en) 1995-06-23
ATE175872T1 (en) 1999-02-15
CN1095591A (en) 1994-11-30
TW319698B (en) 1997-11-11
WO1994014433A1 (en) 1994-07-07
JPH08505141A (en) 1996-06-04
EP0675714A1 (en) 1995-10-11
YU80293A (en) 1997-12-05
SK78395A3 (en) 1996-05-08
JP3992728B2 (en) 2007-10-17
CN1090479C (en) 2002-09-11
FI952916A (en) 1995-06-14
LV10919A (en) 1995-12-20
CZ164395A3 (en) 1996-03-13
DE69323213T2 (en) 1999-07-08
LT3300B (en) 1995-06-26
HU221724B1 (en) 2002-12-28
HRP931515A2 (en) 1996-12-31
CA2152351C (en) 2009-09-22
MX9308053A (en) 1994-06-30
PL309636A1 (en) 1995-10-30
DE69323213D1 (en) 1999-03-04
SK281173B6 (en) 2000-12-11
GR3029405T3 (en) 1999-05-28
IL108112A (en) 1999-11-30
KR100306936B1 (en) 2001-11-30
HUT72081A (en) 1996-03-28
LV10919B (en) 1996-04-20
EE9400341A (en) 1996-04-15
LTIP1514A (en) 1994-10-25
FI952916A0 (en) 1995-06-14
AU5872094A (en) 1994-07-19
NO311325B1 (en) 2001-11-19
PL174128B1 (en) 1998-06-30
SI9300677A (en) 1994-09-30
CZ287125B6 (en) 2000-09-13
AU680864B2 (en) 1997-08-14
MY109538A (en) 1997-02-28
HU9501854D0 (en) 1995-08-28
DK0675714T3 (en) 1999-09-13
NZ259790A (en) 1997-02-24
HRP931515B1 (en) 2000-02-29
ES2128552T3 (en) 1999-05-16
YU49060B (en) 2003-08-29
US5661145A (en) 1997-08-26
NO952529D0 (en) 1995-06-23
IL108112A0 (en) 1994-04-12
CA2152351A1 (en) 1994-07-07
EP0675714B1 (en) 1999-01-20
ZA939552B (en) 1994-10-12
SG45147A1 (en) 1998-01-16

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