EA201992518A2 - Соединение гликозаминогликана, способ его получения и применение - Google Patents

Соединение гликозаминогликана, способ его получения и применение

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Publication number
EA201992518A2
EA201992518A2 EA201992518A EA201992518A EA201992518A2 EA 201992518 A2 EA201992518 A2 EA 201992518A2 EA 201992518 A EA201992518 A EA 201992518A EA 201992518 A EA201992518 A EA 201992518A EA 201992518 A2 EA201992518 A2 EA 201992518A2
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EA
Eurasian Patent Office
Prior art keywords
drug
glycosaminoglycan
compound
production
application
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Application number
EA201992518A
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English (en)
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EA038422B1 (ru
EA201992518A3 (ru
Inventor
Хуа-Ян Линь
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Хоули Стоун Баиотек Ко., Лтд.
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Application filed by Хоули Стоун Баиотек Ко., Лтд. filed Critical Хоули Стоун Баиотек Ко., Лтд.
Publication of EA201992518A2 publication Critical patent/EA201992518A2/ru
Publication of EA201992518A3 publication Critical patent/EA201992518A3/ru
Publication of EA038422B1 publication Critical patent/EA038422B1/ru

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Настоящее изобретение относится к конъюгату лекарственного средства с гликозаминогликаном, таким как гиалуроновая килота (HA), где лекарственное средство применимо для лечения заболеваний, таких как воспаление, аутоиммунное заболевание, аллергия, инфекция и предпочтительно рак. Конъюгированное соединение по настоящему изобретению может повысить концентрацию лекарственного средства в специфической области заболевания путем взаимодействия гликозаминогликана, используемого в качестве носителя для направленной доставки лекарственного средства, и рецептора поверхности клетки CD44, усиливая, таким образом, терапевтическую эффективность и снижая системное побочное действие доставленного в данную область лекарственного средства.
EA201992518A 2013-08-29 2014-06-27 Конъюгат гиалуроновой кислоты и гемцитабина, способ его получения и применение для лечения рака EA038422B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361871352P 2013-08-29 2013-08-29
US14/308,972 US9572832B2 (en) 2013-08-29 2014-06-19 Compound of glycosaminoglycan and its fabrication method as well as application

Publications (3)

Publication Number Publication Date
EA201992518A2 true EA201992518A2 (ru) 2020-03-31
EA201992518A3 EA201992518A3 (ru) 2020-05-31
EA038422B1 EA038422B1 (ru) 2021-08-26

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Family Applications (4)

Application Number Title Priority Date Filing Date
EA201992518A EA038422B1 (ru) 2013-08-29 2014-06-27 Конъюгат гиалуроновой кислоты и гемцитабина, способ его получения и применение для лечения рака
EA201690487A EA034600B1 (ru) 2013-08-29 2014-06-27 Конъюгаты гиалуроновой кислоты с антагонистами cox-2 и их применение для лечения рака
EA201992517A EA038278B1 (ru) 2013-08-29 2014-06-27 Конъюгат гиалуроновой кислоты и леналидомида, способ его получения и применение для лечения рака
EA201501166A EA031285B1 (ru) 2013-08-29 2014-08-27 Конъюгат гиалуроновой кислоты и стероида, способ его получения и применение

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Application Number Title Priority Date Filing Date
EA201690487A EA034600B1 (ru) 2013-08-29 2014-06-27 Конъюгаты гиалуроновой кислоты с антагонистами cox-2 и их применение для лечения рака
EA201992517A EA038278B1 (ru) 2013-08-29 2014-06-27 Конъюгат гиалуроновой кислоты и леналидомида, способ его получения и применение для лечения рака
EA201501166A EA031285B1 (ru) 2013-08-29 2014-08-27 Конъюгат гиалуроновой кислоты и стероида, способ его получения и применение

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US (5) US9572832B2 (ru)
EP (2) EP3038656B1 (ru)
JP (2) JP6404925B2 (ru)
KR (2) KR102283978B1 (ru)
CN (5) CN114010796A (ru)
AU (6) AU2014314536B2 (ru)
BR (2) BR112016004357B1 (ru)
CA (3) CA3133853C (ru)
DK (1) DK3038656T3 (ru)
EA (4) EA038422B1 (ru)
ES (2) ES2893329T3 (ru)
HK (2) HK1223291A1 (ru)
HU (1) HUE056434T2 (ru)
LT (1) LT3038656T (ru)
MY (1) MY180502A (ru)
PL (1) PL3038656T3 (ru)
PT (1) PT3038656T (ru)
TW (2) TWI526212B (ru)
WO (2) WO2015028172A1 (ru)

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Publication number Priority date Publication date Assignee Title
US9572832B2 (en) * 2013-08-29 2017-02-21 Holy Stone Healthcare Co., Ltd. Compound of glycosaminoglycan and its fabrication method as well as application
EA027663B1 (ru) * 2016-05-20 2017-08-31 Тютор С.А.С.И.Ф.И.А. Способ получения твёрдой лекарственной формы для перорального применения и твёрдая лекарственная форма для перорального применения, полученная согласно указанному способу
KR20210151062A (ko) 2019-06-03 2021-12-13 아이홀 코포레이션 히알루로난 접합체 및 이의 용도
US11458204B2 (en) 2020-06-02 2022-10-04 Aihol Corporation Method for improving substitution rate and/or substitution efficiency of hyaluronan-drug conjugates
AU2021289350B2 (en) * 2020-06-08 2023-10-19 Aihol Corporation Uses of hyaluronan conjugate
CN116782906A (zh) * 2021-06-18 2023-09-19 爱禾公司 透明质酸复合物的用途
CN114377139B (zh) * 2022-03-11 2023-07-04 四川省医学科学院·四川省人民医院 载体、药物递送系统及其应用
PL442924A1 (pl) * 2022-11-23 2024-05-27 Politechnika Śląska Prolek - glikokoniugat pochodny gemcytabiny, jako związek o działaniu przeciwnowotworowym, sposób otrzymywania i zastosowanie

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