EA201792407A2 - Композиции, содержащие буфер, составы вакцин, которые содержат композиции, содержащие буфер, и пути их применения - Google Patents

Композиции, содержащие буфер, составы вакцин, которые содержат композиции, содержащие буфер, и пути их применения

Info

Publication number
EA201792407A2
EA201792407A2 EA201792407A EA201792407A EA201792407A2 EA 201792407 A2 EA201792407 A2 EA 201792407A2 EA 201792407 A EA201792407 A EA 201792407A EA 201792407 A EA201792407 A EA 201792407A EA 201792407 A2 EA201792407 A2 EA 201792407A2
Authority
EA
Eurasian Patent Office
Prior art keywords
containing buffer
compositions containing
compositions
vaccines
ways
Prior art date
Application number
EA201792407A
Other languages
English (en)
Other versions
EA201792407A3 (ru
EA035442B1 (ru
Inventor
Чарльз Ричардсон
Роберт Ф. Баргаце
Пол М. Мендельман
Original Assignee
Такеда Вэксинс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47506489&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201792407(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Такеда Вэксинс, Инк. filed Critical Такеда Вэксинс, Инк.
Publication of EA201792407A2 publication Critical patent/EA201792407A2/ru
Publication of EA201792407A3 publication Critical patent/EA201792407A3/ru
Publication of EA035442B1 publication Critical patent/EA035442B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Настоящее изобретение относится к парентеральным композициям вакцины однократной дозы, содержащим смеси моновалентных вирусоподобных частиц норовируса. Также раскрыты способы обеспечения защитного иммунитета к норовирусным инфекциям у субъектов, являющихся людьми, посредством введения таких композиций.
EA201792407A 2011-07-11 2012-07-11 Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения EA035442B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161506447P 2011-07-11 2011-07-11

Publications (3)

Publication Number Publication Date
EA201792407A2 true EA201792407A2 (ru) 2018-03-30
EA201792407A3 EA201792407A3 (ru) 2018-07-31
EA035442B1 EA035442B1 (ru) 2020-06-17

Family

ID=47506489

Family Applications (3)

Application Number Title Priority Date Filing Date
EA201490258A EA029470B1 (ru) 2011-07-11 2012-07-11 Способ стимулирования формирования защитного иммунитета против норовируса
EA201792407A EA035442B1 (ru) 2011-07-11 2012-07-11 Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения
EA202090699A EA202090699A3 (ru) 2011-07-11 2012-07-11 Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201490258A EA029470B1 (ru) 2011-07-11 2012-07-11 Способ стимулирования формирования защитного иммунитета против норовируса

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA202090699A EA202090699A3 (ru) 2011-07-11 2012-07-11 Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения

Country Status (29)

Country Link
US (5) US9801934B2 (ru)
EP (3) EP3299030B1 (ru)
JP (2) JP6208659B2 (ru)
KR (1) KR102096937B1 (ru)
CN (3) CN103874507A (ru)
AU (2) AU2012282658B2 (ru)
BR (1) BR112014000656A2 (ru)
CA (1) CA2841356C (ru)
CL (1) CL2014000082A1 (ru)
CR (2) CR20190540A (ru)
DK (1) DK3299030T3 (ru)
DO (2) DOP2014000004A (ru)
EA (3) EA029470B1 (ru)
EC (1) ECSP14013201A (ru)
ES (2) ES2656527T3 (ru)
GE (1) GEP201706668B (ru)
HK (3) HK1198136A1 (ru)
IL (1) IL230356B (ru)
MA (1) MA35414B1 (ru)
MX (1) MX356586B (ru)
MY (1) MY170746A (ru)
PE (1) PE20140845A1 (ru)
PH (1) PH12018501515B1 (ru)
PL (2) PL3299030T3 (ru)
SG (1) SG10201605644WA (ru)
TN (1) TN2014000008A1 (ru)
UA (1) UA117732C2 (ru)
WO (1) WO2013009849A1 (ru)
ZA (2) ZA201401012B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7955603B2 (en) 2006-09-29 2011-06-07 Ligocyte Pharmaceuticals, Inc. Norovirus vaccine formulations
CN104740624B (zh) 2007-09-18 2018-04-24 武田疫苗股份有限公司 赋予针对诺如病毒的保护性免疫应答的疫苗
US20100266636A1 (en) 2007-09-18 2010-10-21 Ligocyte Pharmaceuticals, Inc. Method of conferring a protective immune response to norovirus
ES2656527T3 (es) 2011-07-11 2018-02-27 Takeda Vaccines, Inc. Formulaciones parenterales de vacunas de norovirus
JP2016533172A (ja) 2013-10-03 2016-10-27 タケダ ワクチン，インコーポレイテッド 細胞株からラブドウイルスを検出および除去する方法
WO2015093452A1 (ja) 2013-12-16 2015-06-25 武田薬品工業株式会社 マイクロニードル
CN107184970A (zh) * 2017-02-16 2017-09-22 北京生物制品研究所有限责任公司 口服诺如病毒亚单位疫苗及lt作为该疫苗佐剂的用途
GB201703644D0 (en) 2017-03-07 2017-04-19 Elopak As Improvements in or relating to toller mounting arrangements
JP2020519666A (ja) * 2017-05-15 2020-07-02 ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． 安定性のウイルス含有組成物
JP2021514391A (ja) * 2018-02-15 2021-06-10 アイコン ジェネティクス ゲーエムベーハー ノロウイルスに対する免疫応答を生成するための免疫原性組成物及びワクチン
WO2019231712A1 (en) * 2018-05-29 2019-12-05 Stc.Unm Virus-like particle compositions and methods of using same
CN109265542B (zh) * 2018-09-27 2021-06-15 国药中生生物技术研究院有限公司 特异性结合诺如病毒gii.4基因型vp1蛋白或vlp的抗体及其制备方法和应用
AR117462A1 (es) * 2018-12-20 2021-08-04 Takeda Vaccines Inc Vacuna contra norovirus, formulaciones y métodos
US20230285534A1 (en) * 2020-01-08 2023-09-14 Bharat Biotech International Limited Viral vaccine compositions and methods of preparations thereof
AU2022248473A1 (en) 2021-03-29 2023-10-26 Denka Company Limited Peptide of norovirus origin, polynucleotide, antibody, composition, method for identifying neutralizing epitope for norovirus
JP2024519800A (ja) 2021-05-21 2024-05-21 タケダ ワクチン，インコーポレイテッド 固体組成物、フリーズドライ方法およびガラスバイアル

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6572862B1 (en) 1989-11-08 2003-06-03 Baylor College Of Medicine Methods and reagents to detect and characterize Norwalk and related viruses
AU1893592A (en) 1991-03-25 1992-10-21 Board Of Trustees Of The Leland Stanford Junior University Norwalk virus human gastroenteritis agent and molecular cloning of corresponding cdnas
JPH07509122A (ja) 1992-04-08 1995-10-12 ザ　ガバメント　オブ　ザ　ユナイテッド　ステイツ　オブ　アメリカ，アズ　レプリゼンテッド　バイ　ザ　セクレター，デパートメント　オブ　ヘルス　アンド　ヒューマン　サービシーズ 野生型麻疹ウイルス糖タンパク質：ワクチンおよびその検出方法
JPH08500250A (ja) 1992-09-07 1996-01-16 ベイラー・カレッジ・オブ・メディシン ノーウォークおよび関連ウイルスを検出し、かつ特徴付けるための方法並びに試薬
WO1994021292A1 (en) 1993-03-23 1994-09-29 Smithkline Beecham Biologicals (S.A.) Vaccine compositions containing 3-o deacylated monophosphoryl lipid a
US5788970A (en) 1994-03-29 1998-08-04 The University Of Maryland College Park Chimeric infectious bursal disease virus CDNA clones, expression products and vaccines based thereon
HUT76354A (en) 1994-05-16 1997-08-28 Merck & Co Inc Papillomavirus vaccines
US5645051A (en) 1995-04-21 1997-07-08 Dura Pharmaceuticals, Inc. Unit dose dry powder inhaler
US5861241A (en) 1995-08-16 1999-01-19 University Of Massachusetts Monoclonal antibodies for detecting Norwalk virus
GB9525083D0 (en) 1995-12-07 1996-02-07 Danbiosyst Uk Vaccine compositions
US5834015A (en) * 1996-09-11 1998-11-10 Albany Medical College Protein-lipid vesicles and autogenous vaccine comprising the same
US5953727A (en) 1996-10-10 1999-09-14 Incyte Pharmaceuticals, Inc. Project-based full-length biomolecular sequence database
US6491919B2 (en) 1997-04-01 2002-12-10 Corixa Corporation Aqueous immunologic adjuvant compostions of monophosphoryl lipid A
JP4598201B2 (ja) 1997-04-08 2010-12-15 メルク・シャープ・エンド・ドーム・コーポレイション 安定化ヒトパピローマウイルス製剤
WO1998050071A1 (en) 1997-05-01 1998-11-12 Chiron Corporation Use of virus-like particles as adjuvants
US20040265377A1 (en) 1997-10-27 2004-12-30 Harry Seager Solid dispersing vaccine composition for oral delivery
ATE324436T1 (de) 1998-08-14 2006-05-15 Merck & Co Inc Verfahren zur reinigung von menschlichen, dem papillomavirus ähnlichen partikeln.
WO2000035479A1 (en) 1998-12-17 2000-06-22 Merck & Co., Inc. Synthetic virus-like particles with heterologous epitopes
PT1150712E (pt) * 1999-02-05 2008-12-22 Merck & Co Inc Formulações para a vacina do vírus do papiloma humano
WO2000079280A1 (fr) 1999-06-22 2000-12-28 Japan As Represented By Director-General National Institute Of Infectious Diseases Materiel de detection de srsv
JP2002020399A (ja) 2000-07-10 2002-01-23 Osaka Prefecture ノルウォークウイルス（ｎｖ）を認識するモノクローナル抗体
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
WO2003068804A2 (en) 2002-02-14 2003-08-21 Novavax, Inc. Novel insect cell line
GB0206360D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
GB0206359D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
WO2003087327A2 (en) 2002-04-11 2003-10-23 Medimmune Vaccines, Inc. Preservation of bioactive materials by freeze dried foam
GB0302218D0 (en) 2003-01-30 2003-03-05 Chiron Sri Vaccine formulation & Mucosal delivery
AU2003237528A1 (en) 2002-06-07 2003-12-22 Kentucky Bioprocessing, Llc Flexible vaccine assembly and vaccine delivery platform
DE60335186D1 (de) 2002-06-20 2011-01-13 Cytos Biotechnology Ag Verpackte virusartige partikel in kombination mit cpg zur verwendung als adjuvantien mit allergenen. herstellungsverfahren und verwendung
US20050106178A1 (en) 2003-01-30 2005-05-19 Chiron Corporation Adjuvanted influenza vaccine
WO2004073652A2 (en) 2003-02-20 2004-09-02 Becton Dickinson And Company Powder formulations of recombinant staphylococcal enterotoxin b (rseb) made by atmospheric spray-freeze drying for improved vaccination
US8592197B2 (en) 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
US7879338B2 (en) 2003-07-21 2011-02-01 Boyce Thompson Institute For Plant Research Vectors and methods for immunization against norovirus using transgenic plants
WO2005030806A2 (en) 2003-09-24 2005-04-07 Montana State University Norovirus monoclonal antibodies and peptides
WO2005037223A2 (en) 2003-10-15 2005-04-28 Brigham And Women's Hospital, Inc. Methods and compositions for immunomodulation
US20050215501A1 (en) 2003-10-24 2005-09-29 Coley Pharmaceutical Group, Inc. Methods and products for enhancing epitope spreading
FR2863890B1 (fr) 2003-12-19 2006-03-24 Aventis Pasteur Composition immunostimulante
US7481997B1 (en) 2004-02-12 2009-01-27 Montana State University Snow mountain virus genome sequence, virus-like particles and methods of use
US20050260225A1 (en) 2004-05-18 2005-11-24 Goldberg Joanna B Intranasal recombinant Salmonella vaccine encoding heterologous polysaccharide antigens
CU23496A1 (es) 2004-09-03 2010-02-23 Ct Ingenieria Genetica Biotech Composición vacunal contra el virus de la hepatitis c
EP1809325B1 (en) 2004-10-20 2013-11-20 Sanofi Pasteur Biologics, LLC Vaccines against japanese encephalitis virus
GB0428394D0 (en) 2004-12-24 2005-02-02 Chiron Srl Saccharide conjugate vaccines
AU2006203985A1 (en) 2005-01-05 2006-07-13 Philadelphia Health And Education Corporation Delivery vehicles, bioactive substances and viral vaccines
US8168771B2 (en) 2005-01-31 2012-05-01 The Johns Hopkins University Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants
CA2598488A1 (en) 2005-02-18 2006-08-31 Novartis Vaccines And Diagnostics, Inc. Immunogens from uropathogenic escherichia coli
CN103203016A (zh) 2005-03-18 2013-07-17 赛托斯生物技术公司 猫变应原融合蛋白及其用途
JP2009501001A (ja) 2005-06-01 2009-01-15 ダウ グローバル テクノロジーズ インコーポレイティド 多価ウイルス様粒子の製造
EP1736538A1 (en) 2005-06-21 2006-12-27 Cytos Biotechnology AG Process for the preparative purification of virus-like-particles (VLPs)
WO2007081447A2 (en) 2005-11-22 2007-07-19 Novartis Vaccines And Diagnostics, Inc. Norovirus and sapovirus antigens
JP2007145775A (ja) 2005-11-29 2007-06-14 Falco Life Science:Kk ノロウイルスｇｉの高感度検出方法
US20080029915A1 (en) * 2006-08-02 2008-02-07 Courtoy Nv Rotary tablet press
US7955603B2 (en) 2006-09-29 2011-06-07 Ligocyte Pharmaceuticals, Inc. Norovirus vaccine formulations
NZ577405A (en) 2006-12-06 2012-08-31 Novartis Ag Vaccines including antigen from four strains of influenza virus
SG179488A1 (en) * 2007-03-14 2012-04-27 Ligocyte Pharmaceuticals Inc Virus like particle purification
US8648229B2 (en) 2007-09-12 2014-02-11 Australian Centre For Plant Functional Genomics Pty Ltd Plant seed active transcriptional control sequences
CN104740624B (zh) * 2007-09-18 2018-04-24 武田疫苗股份有限公司 赋予针对诺如病毒的保护性免疫应答的疫苗
US20100266636A1 (en) * 2007-09-18 2010-10-21 Ligocyte Pharmaceuticals, Inc. Method of conferring a protective immune response to norovirus
WO2010017542A1 (en) 2008-08-08 2010-02-11 Ligocyte Pharmaceuticals, Inc. Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity
EP2381959A1 (en) * 2009-01-22 2011-11-02 Pharmathene Inc. Stable vaccine compositions and methods of use
EP2942062A1 (en) * 2009-02-10 2015-11-11 Novartis AG Influenza vaccine regimens for pandemic-associated strains
US20110070260A1 (en) 2009-09-09 2011-03-24 Baric Ralph S Multivalent Immunogenic Compositions Against Noroviruses and Methods of Use
JP2013517773A (ja) 2010-01-21 2013-05-20 リゴサイト ファーマスーティカルズ，インコーポレイテッド カリシウイルスウイルス様粒子上の標的化異種抗原提示
EP3388081A1 (en) * 2010-05-26 2018-10-17 Selecta Biosciences, Inc. Multivalent synthetic nanocarrier vaccines
ES2656527T3 (es) 2011-07-11 2018-02-27 Takeda Vaccines, Inc. Formulaciones parenterales de vacunas de norovirus
JOP20130186B1 (ar) 2012-06-22 2021-08-17 Takeda Vaccines Montana Inc تنقية الجزيئات الشبيهة بالفيروسات
FI3827838T3 (fi) 2015-12-16 2023-06-19 Walter & Eliza Hall Inst Medical Res Sytokiini-indusoidun sh2-proteiinin estäminen nk-soluissa
GB2605540B (en) 2016-10-18 2022-12-21 Univ Minnesota Tumor infiltrating lymphocytes and methods of therapy
SG11202010763VA (en) 2018-05-03 2020-11-27 Univ Texas Natural killer cells engineered to express chimeric antigen receptors with immune checkpoint blockade
US20210308249A1 (en) 2018-08-20 2021-10-07 Takeda Vaccines, Inc. Vlp formulations
AR117462A1 (es) 2018-12-20 2021-08-04 Takeda Vaccines Inc Vacuna contra norovirus, formulaciones y métodos
SG11202108644UA (en) 2019-02-15 2021-09-29 Editas Medicine Inc Modified natural killer (nk) cells for immunotherapy

Also Published As

Publication number Publication date
EA201792407A3 (ru) 2018-07-31
ES2926487T3 (es) 2022-10-26
US9867876B2 (en) 2018-01-16
MA35414B1 (fr) 2014-09-01
US20230338503A1 (en) 2023-10-26
CN103874507A (zh) 2014-06-18
CA2841356C (en) 2022-03-01
AU2015200836A1 (en) 2015-03-12
JP6208659B2 (ja) 2017-10-04
EP3299030B1 (en) 2022-06-08
US11701420B2 (en) 2023-07-18
EA035442B1 (ru) 2020-06-17
CL2014000082A1 (es) 2014-07-04
MX356586B (es) 2018-06-05
ECSP14013201A (es) 2014-05-31
BR112014000656A2 (pt) 2017-02-14
DOP2022000030A (es) 2022-06-30
EP2731621B1 (en) 2017-11-01
US20130273102A1 (en) 2013-10-17
US9801934B2 (en) 2017-10-31
EP4112074A1 (en) 2023-01-04
JP2017214357A (ja) 2017-12-07
JP2014520852A (ja) 2014-08-25
HK1198136A1 (en) 2015-03-13
US10675341B2 (en) 2020-06-09
NZ710919A (en) 2017-12-22
UA117732C2 (uk) 2018-09-25
GEP201706668B (en) 2017-05-25
ZA201500915B (en) 2016-06-29
CN105031637A (zh) 2015-11-11
HK1199202A1 (en) 2015-06-26
US20160000899A1 (en) 2016-01-07
TN2014000008A1 (en) 2015-07-01
DK3299030T3 (da) 2022-09-05
EA029470B1 (ru) 2018-03-30
PH12018501515A1 (en) 2019-02-04
EA202090699A3 (ru) 2020-11-30
MX2014000411A (es) 2014-08-26
EP2731621A4 (en) 2015-03-25
PL2731621T3 (pl) 2018-10-31
AU2015200836B2 (en) 2016-08-25
HK1215154A1 (zh) 2016-08-19
EP3299030A1 (en) 2018-03-28
NZ620865A (en) 2015-08-28
ES2656527T3 (es) 2018-02-27
MY170746A (en) 2019-08-27
US20180185468A1 (en) 2018-07-05
PE20140845A1 (es) 2014-08-03
EA201490258A1 (ru) 2014-05-30
JP6613259B2 (ja) 2019-11-27
PH12018501515B1 (en) 2019-02-04
EA202090699A2 (ru) 2020-07-31
CR20140069A (es) 2014-06-27
AU2012282658B2 (en) 2014-11-27
WO2013009849A1 (en) 2013-01-17
CR20190540A (es) 2022-04-04
US20210085778A1 (en) 2021-03-25
KR102096937B1 (ko) 2020-04-03
ZA201401012B (en) 2015-05-27
PL3299030T3 (pl) 2022-12-05
SG10201605644WA (en) 2016-09-29
AU2012282658A1 (en) 2013-03-14
KR20140066160A (ko) 2014-05-30
DOP2014000004A (es) 2014-10-31
CA2841356A1 (en) 2013-01-17
EP2731621A1 (en) 2014-05-21
CN108567975A (zh) 2018-09-25
IL230356B (en) 2019-05-30

Similar Documents

Publication Publication Date Title
EA201792407A3 (ru) Композиции, содержащие буфер, составы вакцин, которые содержат композиции, содержащие буфер, и пути их применения
MX2018007627A (es) Vacuna contra el virus del zika.
EA201992133A1 (ru) Производные пиперидино-пиримидина для лечения вирусных инфекций
CY1122483T1 (el) Λυοφιλοποιημενες παρασκευες μελφαλανης φλουφεναμιδης
EA201391515A1 (ru) Инактивированная вакцина вируса денге
MX2016003419A (es) Metodos y composiciones para sindrome respiratorio coronavirus de oriente medio (mers-cov) inmunogenico.
EA202090547A3 (ru) Макроциклические деаза-оксипурины для лечения вирусных инфекций
EA201590343A1 (ru) Алкилпиримидиновые производные для лечения вирусных инфекций и дальнейших заболеваний
NZ711946A (en) Newcastle disease viruses and uses thereof
EA201591524A1 (ru) Производные 2-аминопиримидина для лечения вирусных инфекций
EA201500383A1 (ru) Производные 1,2,4-триазина для лечения вирусных инфекций
EA201590931A1 (ru) Гетероциклические замещенные производные 2-амино-хиназолина для лечения вирусных инфекций
EA201491548A1 (ru) 2'-замещенные карбануклеозидные аналоги для противовирусного лечения
MY168959A (en) Vaccine compositions for the prevention of dengue virus infection
EA201590667A1 (ru) Ациламинопиримидиновые производные для лечения вирусных инфекций и других заболеваний
PH12014502875A1 (en) Vaccine compositions for prevention against dengue virus infection
EA201590491A1 (ru) Иммуногенная композиция
MX2014004814A (es) Compuestos y metodos para mejorar las respuestas inmunes innatas.
MX2013013801A (es) Oligodesoxinucleotidos inmunoestimuladores.
UA114298C2 (uk) Пептид торк та вакцина, що його містить
MX2016000107A (es) Osteopontina lactea de mamifero para mejorar la capacidad de respuesta inmunitaria.
MX364946B (es) Sistema adyuvante mejorado para la administración de vacunas orales.
EA201592242A1 (ru) Производные пиридона для лечения вирусных инфекций и других заболеваний
EA201690378A1 (ru) Вакцинные композиции против наркотической зависимости
UA106111C2 (ru) Способ получения человеческого интерферона с использованием наночастиц оксида церия

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM