EA201170179A1 - Способ получения композиции, включающей биологически активный материал - Google Patents

Способ получения композиции, включающей биологически активный материал

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Publication number
EA201170179A1
EA201170179A1 EA201170179A EA201170179A EA201170179A1 EA 201170179 A1 EA201170179 A1 EA 201170179A1 EA 201170179 A EA201170179 A EA 201170179A EA 201170179 A EA201170179 A EA 201170179A EA 201170179 A1 EA201170179 A1 EA 201170179A1
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EA
Eurasian Patent Office
Prior art keywords
polymer
biologically active
active material
scf
supercritical
Prior art date
Application number
EA201170179A
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English (en)
Other versions
EA018910B1 (ru
Inventor
Эндрю Нейлор
Эндрю Лестер Льюис
Лисбет Иллум
Original Assignee
Критикал Фармасьютикалз Лимитед
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39722153&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201170179(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Критикал Фармасьютикалз Лимитед filed Critical Критикал Фармасьютикалз Лимитед
Publication of EA201170179A1 publication Critical patent/EA201170179A1/ru
Publication of EA018910B1 publication Critical patent/EA018910B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A61K38/385—Serum albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Abstract

Способ получения микрочастиц, включающих биологически активный материал и полимер и имеющих средний размер частиц, выраженный как средний диаметр объема (VMD), равный от 10 до 500 мкм, в которых биологически активный материал существенно нерастворим в полимере, этот способ включает: a) контакт смеси биологически активного материала или его предшественника, полимера или его предшественника и вещества, улучшающего технологические свойства, со сверхкритическим флюидом (SCF), способным вызывать набухание полимера при температуре и давлении, необходимых для поддержания SCF в сверхкритическом состоянии; b) создание условий для проникновения SCF и переведения полимера в жидкое состояние, поддерживая при этом температуру и давление так, чтобы поддерживать SCF в сверхкритическом состоянии; c) сбрасывание давления для осаждения микрочастиц, включающих биологически активное соединение и полимер.
EA201170179A 2008-07-11 2009-07-10 Способ получения композиции, включающей биологически активный материал EA018910B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0812742.5A GB0812742D0 (en) 2008-07-11 2008-07-11 Process
PCT/GB2009/001711 WO2010004287A2 (en) 2008-07-11 2009-07-10 Process

Publications (2)

Publication Number Publication Date
EA201170179A1 true EA201170179A1 (ru) 2011-06-30
EA018910B1 EA018910B1 (ru) 2013-11-29

Family

ID=39722153

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170179A EA018910B1 (ru) 2008-07-11 2009-07-10 Способ получения композиции, включающей биологически активный материал

Country Status (15)

Country Link
US (2) US9226900B2 (ru)
EP (2) EP2320872B1 (ru)
JP (1) JP5687191B2 (ru)
KR (1) KR20110031378A (ru)
CN (1) CN102149409B (ru)
AU (1) AU2009269806A1 (ru)
BR (1) BRPI0915856A2 (ru)
CA (1) CA2730321C (ru)
CL (1) CL2011000064A1 (ru)
EA (1) EA018910B1 (ru)
ES (1) ES2569383T3 (ru)
GB (2) GB0812742D0 (ru)
MX (1) MX2011000238A (ru)
WO (1) WO2010004287A2 (ru)
ZA (1) ZA201100970B (ru)

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KR20110031378A (ko) 2011-03-25
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EP3011955A1 (en) 2016-04-27
US9226900B2 (en) 2016-01-05
ES2569383T3 (es) 2016-05-10
BRPI0915856A2 (pt) 2015-11-03
CA2730321A1 (en) 2010-01-14
EP2320872B1 (en) 2016-02-10
WO2010004287A3 (en) 2010-05-20
US20160074327A1 (en) 2016-03-17
CA2730321C (en) 2017-05-23
WO2010004287A2 (en) 2010-01-14
ZA201100970B (en) 2012-07-25
JP5687191B2 (ja) 2015-03-18
GB201102017D0 (en) 2011-03-23
EP2320872A2 (en) 2011-05-18
CN102149409A (zh) 2011-08-10
CN102149409B (zh) 2014-12-31
EA018910B1 (ru) 2013-11-29
GB0812742D0 (en) 2008-08-20
US20110172141A1 (en) 2011-07-14
AU2009269806A1 (en) 2010-01-14
GB2474002A (en) 2011-03-30
JP2011527328A (ja) 2011-10-27

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